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首届全国分子核医学暨分子影像学学术交流会

作者： zhang xiansong department of nuclear medicine, the first affiliated hospital, sun yat-sen university, guangzhou, china, 510080

Background Hoop et al. (J Nucl Med. 1976;17:473-479) observed 1 recurrent astrocytoma and 1 glioma showed reduced uptake of 13N-NH3 at the lesions. Schelstraete et al. (Br J Radiol. 1982;55:797-804) observed litter or no extra uptake of 13N-NH3 in 4 primary brain tumors. Benard et al. (Semi Nucl Med. 2003;33:148-162) thought 13N-13N-NH3 was unsuccessful in visualizing primary brain tumors. Purpose The aim of this study was re-evaluated the role of 13N-NH3 PET in brain tumor. Methods 13N- NH3 PET was performed in 47 patients (30male and 17 female patients;age range 18-62 years ) with suspected primary brain tumor or recurrent tumor detected by MRI. Five minutes after injection of 555-740 MBq of 13N-13N-NH3, attenuation-corrected brain images were obtained with a dedicated PET scanner. A histopathological diagnosis was made for 39 of them by open surgery or stereotatic biopsy, and the others were confirmed by clinical or radiologic follow-up, including 10 cases with astrocytoma grade Ⅰ or Ⅱ, 15 astrocytomas grade Ⅲ or Ⅳ(7 of them were tumor recurrence), 2 oligodendroglioma grade Ⅰ, 1 dysembryoplastic neuroepithelial tumor (DNT), 2 meningiomas, 2 metastatic tumors, 5 radiation necrosis, 7 encephalomyelitic foci, 2 ischemic lesions, 1 reactive gliosis. PET images were visually inspected, and the uptake ratios of lesion to contralateral normal brain tissue (T/N) were determined. Results Twenty-seven of thirty-two brain tumor exhibited markedly increased uptake of 13N-NH3. 2 oligodendroglioma, 1 DNT, 1 metastatic tumors and one low-grade astrocytoma in brain stem showed absent 13N-NH3 uptake. The 15 non-neoplastic lesions exhibited absent or less 13N-NH3 uptake. The sensitivity and specificity of 13N- NH3 PET for detecting brain tumor were 27 (84%) of 32 and 15 (100%) of 15, respectively. The sensitivity for detecting astrocytoma was 24 (96%) of 25. There were the significant differences between the T/N ratios in brain tumors and that in non-neoplastic lesions (T/W ratios

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Wnt3a signaling promotes proliferation,myogenic differentiation,and migration of rat bone marrow mesenchymal stem cells

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Acta Pharmacologica Sinica 2007年第11期28卷 1761-1774页

作者： Yan-chang SHANG~(2,3),Shu-hui WANG~4,Fu XIONG~5,Cui-ping ZHAO~2,Fu-ning PENG~2,Shan-wei FENG~2,Mei-shan LI~2,YongLI~5,Cheng zhang~(2,5,6)~2 department of Neurology first affiliated hospital,sun yat-sen university,guangzhou 510080,china,~3 department of Geriatric NeurologyChinese People's Liberation Army General hospital,Beijing 100853,china ~4 department of Neurology,Beijing Friendship hospital,CapitalMedical university,Beijing 100050,china,~5 Center for Stem Cell Biology and Tissue Engineering,sun yat-sen university guangzhou510080.china department of Neurology First Affiliated Hospital Sun Yat-sen University Guangzhou China department of Geriatric Neurology Chinese People's Liberation Army General Hospital Beijing China department of Neurology Beijing Friendship Hospital Capital Medical University Beijing China Center for Stem Cell Biology and Tissue Engineering Sun Yat-sen University Guangzhou China

Aim:To investigate the effects of the wingless-related MMTV integration site 3A(Wnt3a) signaling on the proliferation,migration,and the myogenic and adipogenicdifferentiation of rat bone marrow mesenchymal stem cells (rMSC).Methods:Primary MSC were isolated and cultured from Sprague-Dawley rats and character-ized by flow *** L cells were transfected with Wnt3a cDNA,andconditioned media containing active Wnt3a proteins were *** prolif-eration was evaluated by cell count and 5-bromodeoxyuridine incorporation *** migration of rMSC was performed by using a transwell migration and woundhealing *** myogenic and adipogenic differentiation in rMSC were exam-ined by light microscopy,immunofluorescence,and RT-PCR at different timepoints after myogenic or adipogenic ***:Wnt3a signaling in-duced β-catenin nuclear translocation and activated the Wnt pathway in *** the presence of Wnt3a,rMSC proliferated more rapidly than the control cells,keeping their differentiation ***,Wnt3a signaling induced 2.62%and 3.76% of rMSC-expressed desmin and myosin heavy chain after being cul-tured in myogenic *** myogenic differentiation genes,including Pax7,MyoD,Myf5,Myf4,and myogenin,were activated after Wnt3a *** theother hand,Wnt3a inhibited the adipogenic differentiation in rMSC through thedownregulated expression of CCAAT/enhancer-binding protein alpha (C/EBPalpha)and peroxisome proliferator-activated receptor gamma (PPARgamma).Furthermore,Wnt3a promoted the migration capacity of ***:The results indi-cate that Wnt3a signaling can induce myogenic differentiation in ***3asignaling is also involved in the regulation of the proliferation and migration *** results could provide a rational foundation for cell-based tissuerepair in humans.

关键词： Wingless-related MMTV integration site (Wnt) mesenchymal stem cells myogenic differentiation adipogenic differentiation proliferation migration

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Usefulness of 13N-ammonia PET in the evaluation of brain lesions that are hypometabolic on 18F-FDG PET

Usefulness of 13N-ammonia PET in the evaluation of brain les...

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首届全国分子核医学暨分子影像学学术交流会

作者： zhang Xiangsong, MD Correspondence to: Dr. zhang Xiangsong, department of nuclear medicine, the first affiliated hospital, sun yat-sen university, 58 Zhongshan Road Ⅱ, guangzhou 510080, china

The fact that some low-grade gliomas show hypometabolism compared with normal brain tissue on FDG PET has caused problems in the detection of primary or recurrent tumors and in the differentiation from benign lesions. We investigated the usefulness of 13N-ammonia PET in characterizing brain lesions which show hypometabolism on 18F-FDG PET. Methods Patients Twenty-nine consecutive patients with hypometabolic brain lesions on FDG PET were included in this study. In these 29 patients, FDG PET had been performed either for initial diagnosis (n=24) or for the evaluation of astrocytoma recurrence after treatment (n=5). Once the lesions had been seen to be hypometabolic on FDG PET, a second PET study with 13N-ammonia was performed within 3 days. Pathologic diagnosis was obtained by biopsy or open surgery in 21 patients. The remaining patients were assessed by radiologic and laboratory investigations and follow-up. Overall there are 17 brain tumors and 12 benign lesions. The brain tumors included 11 astrocytomas, two meningiomas, two oligodendrogliomas, one metastatic tumor, one dysembryoplastic neuroepithelial tumor (DMT). The benign lesions comprised four cases of radiation necrosis, one tuberculous granuloma, two ischemic lesions, five encephalitic foci. PET imaging PET scanning was performed using an ECAT HR+ scanner (Siemens/CTI). Patients were fasted for at least 6 h before PET scanning. PET images were acquired with the patients in the supine position, resting, with their eyes closed. Using a germanium-68 source, transmission images were obtained to correct for photon attenuation for 5 min. A dose of 370-555 MBq of 18F-FDG or 555-740 MBq of 13N-ammonia was injected intravenously. Emission images were obtained for 15 min, beginning 40 min after 18F-FDG injection or 4 min after 13N-ammonia injection.

关键词： astrocytoma ammonia nitrogen radioisotopes FDG PET

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Contribution of lymphoscintigraphy by SPECT/CT to preoperative sentinel lymph node localization in oral squamous cell carcinoma

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外科研究与新技术 2009年第3期 233-236页

作者：张弘蒋宁一梁九根 department of nuclear medicine The Second Affiliated Hospital of Sun Yat-sen University

Objective:sentinel lymph node biopsy(SLNB) is a minimally invasive method that helps to evaluate the status of the lymph node region of a primary tumor.A precise preoperative localization of the sentinel lymph node (SLN) may be helpful for surgical *** lymphoscintigraphy (LS) is important if the cancer is located in regions of anatomical *** it fails to elucidate the specific lymphatic drainage and the anatomical relationship of *** the present study the benefit of LS by SPECT/CT to the preoperative localization of SLNs was ***:21 clinically nodes-negative patients with T1 or T2-staged oral squamous cell carcinoma were *** were performed by submucosa injection of 37-74MB of 99mTc-DX at 4 to 6 points around the tumor followed by immediate dynamic,delay static imaging and skin marking of the *** the patients underwent SPECT/CT *** and fusion images were interpreted separately and *** dye method was carried ***:In all patients,fusion images confirmed the localization obtained by planar images and skin ***,in 9 of the 21 patients,the fusion images improved or corrected the preoperative localization of the SLNs in planar imaging:7 nodes that had been identified only on the fused images were located in basins other than or in addition to the basins identified on th planar images,and 1 node that was located closed to the injection sites was hidden by its scattered radiation signals in the planar images,and erroneous diagnosis occurred in 1 node resulted from the *** addition,multiple draining basins were identified on the fusion images in 6 of the 21 patients,however,planar images only in 1 of the ***:Our results showed the additional value of SPECT/CT fusion imaging in revealing SLNs compared to planar imaging and sharpen the localization of the SLN that were of clinical relevance to SLNB in patients with oral squamous cell ***

关键词： lymphoscintigraphy oral cancer sentinel lymph node SPECT fusion image

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SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-Bang Xu Wei-Jie Guan Yi-Lin zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing sun Jincun Zhao Wen-Liang Zhou Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

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Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1204-1221页

作者： Xiaohui Chen Meichun Gao Yongzhen Xia Xin Wang Jingbo Qin Hongying He Weirong Liu Xiaowei zhang Shuangzhou Peng Zhiping Zeng Ying Su Xiaokun zhang School of Pharmaceutical Science Fujian Provincial Key Laboratory of Innovative Drug Target ResearchXiamen UniversityXiamen 361002China NucMito Pharmaceuticals Co. Ltd.Xiamen 361000China department of Clinical Laboratory the Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China

The orphan nuclear receptor Nur77 is a critical regulator of the survival and death of tumor *** pro-death effect of Nur77 can be regulated by its interaction with Bcl-2,resulting in conversion of Bcl-2 from a survival to *** Bcl-2 is overexpressed in various cancers preventing them from apoptosis and promoting their resistance to chemotherapy,targeting the apoptotic pathway of Nur77/Bcl-2 may lead to new cancer ***,we report our identification of XS561 as a novel Nur77 ligand that induces apoptosis of tumor cells by activating the Nur77/Bcl-2 *** vitro and animal studies revealed an apoptotic effect of XS561 in a range of tumor cell lines including MDA-MB-231 triple-negative breast cancer(TNBC)and MCF-7/LCC2 tamoxifen-resistant breast cancer(TAMR)in a Nur77-dependent *** studies showed XS561 potently induced the translocation of Nur77 from the nucleus to mitochondria,resulting in mitochondria-related ***,XS561-induced accumulation of Nur77 at mitochondria was associated with XS561 induction of Nur77 phase separation and the formation of Nur77/Bcl-2 ***,our studies identify XS561 as a new activator of the Nur77/Bcl-2 apoptotic pathway and reveal a role of phase separation in mediating the apoptotic effect of Nur77 at mitochondria.

关键词： XS561 Nur77 Bcl-2 Apoptosis Mitochondria Phase separation TNBC TAMR

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Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao Wang Xiang‑Biao Qiu Jing‑Wen Li Wei Xu Tao Li Ze‑Bin Lin Chang‑Jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang sun Jing‑Yu Tang Rong zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu Guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu Guo‑Hui zhang Lin‑Hao zhang Mo‑Han zhang Qi‑Wei zhang Xian‑Peng zhang Yu‑Liang zhang Yue zhang Zhi‑Yong zhang Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the china Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

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One-neutron stripping process in the^(209)Bi(^(6)Li,^(5)Li)^(210)Bi*reaction reaction

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nuclear Science and Techniques 2024年第6期35卷 120-129页

作者： Gao-Long zhang Zhen-Wei Jiao Guang-Xin zhang E.N.Cardozo B.Paes Shi-Peng Hu Jian-Qiang Qian Daniele Mengoni Wei-Wei Qu Cong-Bo Li Yun Zheng Huan-Qiao zhang Hui-Bin sun Nan Wang Chun-Lei zhang J.J.Valiente-Dobón D.Testov M.Mazzocco A.Gozzelino C.Parascandolo D.Pierroutsakou M.La Commara A.Goasduff D.Bazzacco D.R.Napoli F.Galtarossa F.Recchia A.Illana S.Bakes I.Zanon S.Aydin Gde Angelis M.Siciliano R.Menegazzo S.M.Lenzi S.Akkoyun L.F.Canto J.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340 NiteróiRio de JaneiroBrazil Laboratorio TANDAR Comisión Nacional de Energía AtómicaBKNA1650 San MartíınArgentina Institute for Advanced Study in nuclear Energy and Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and Manufacture of High Purity Germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPaduaItaly Dipartimento di fisica Astronomia dell’Universita di padova PaduaItaly State Key Laboratory of Radiation medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China china Institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Laboratori Nazionali di Legnaro INFN35020 LegnaroItaly INFN Sezione di Napoli80126 NaplesItaly Dipartimento di Farmacia Universitàdi Napoli“Federico II”80131 NaplesItaly department of Natural and Mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkey Physics Division Argonne National LaboratoryLemontILUSA department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroRio de Janeiro CP 6852821941-972Brazil

One-neutron stripping process between^(6)Li and^(209)Bi was studied at 28,30,and 34 MeV using the in-beamγ-ray spectroscopy ***γ-γcoincident analysis clearly identified twoγ-rays feeding the ground and long-lived isomeric states,which were employed to determine the cross *** one-neutron stripping cross sections were similar to the cross sections of complete fusion in the^(6)Li+^(209)Bi system,but the one-neutron stripping cross sections decreased more gradually at the sub-barrier region.A coupled-reaction-channel calculation was performed to study the detailed reaction mechanism of the one-neutron stripping process in^(6)*** calculations indicated that the first excited state of 5 Li is critical in the actual one-neutron transfer mechanism,and the valence proton of 209Bi can be excited to the low-lying excited state in(^(6)Li,^(5)Li)reaction,unlike in the(d,p)reaction.

关键词： Transfer reaction Weakly bound nuclei Cross section

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Cytoplasmic Mislocalization of p27 kipl Protein Resulted from Akt Correlates with Poor Prognosis in Lung Adenocarcinoma

Cytoplasmic Mislocalization of p27 kipl Protein Resulted fro...

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2008年中国病理生理学会第十一届肿瘤和第十二届免疫专业委员会学术会议

作者： Yah Xie~(1a▲) Xin Wang~(1b▲) Huiling Yang~(1a※) Ruiying Zhao~2 Xiang Tao~(1a) Huizhong zhang~(1b) Chunhong Yan~(1a) Yubiao Guo~(1c) Chun-Hui Su~2 Changju Qu~(1a) Mong-Hong Lee~2 1.1a.department of Pathophysiology,the School of Preclincal medicine,1b.department of Thoracic Oncology and Pathology,Cancer Center,1c.Respiratory Division,The first affiliated hospital,sun yat-sen university,guangzhou 510080,P.R.china 2.department of Molecular and Cellular Oncology,university of Texas,MD Anderson Cancer Center,Houston,TX,USA

To cell cycle,Akt is a positive regulator,while nuclear p27Kipl is a negative *** was shown that Akt or P-Akt was related with p27Kipl in cancer cell *** non-small cell lung cancer (NSCLC),Akt was overexpressed,which was associated with the poor *** primary breast cancer,we found the P-S473Akt was upregulated,tumor suppressor 14-3-3σwas downregulated,and the down- regulated 14-3-3σand upregulated P-S473Akt were strongly inverse *** acute myelogenous leukemia,Akt regulated phosphorylation at Thr157 of ***, we detected the localization and expression of p27Kip1 and Akt protein,and evaluated the relationship of Akt and p27Kip1 and their impact on prognosis,stage or tumor grade in human lung adenocarcinoma *** observed that Akt (88%,52 of 59) and P-S473Akt (32%,21of 59) in tumor tissue were overexpressed compared with that in nornal tissue (23%,6 of 26 and 3.85%,1 of 26 respectively) (Pnuclear p27Kip1(Np27 Kip1) (37%,18 of 59) in tumor tissue was predominantly lower than that in normal tissues (21 of 26,81%) (P<0.01);the expression of cytoplasmic p27Kipl(Cp27 Kipl) (81%,48 of 59) in tumor tissue was predominantly higher than that(42.31%,11 of 26) in normal tissues (P<0.01).In the tumor tissues the statistical analysis revealed that Akt was positively associated with P-S473Akt (R=0.365, P<0.05),Np27Kip 1 correlated inversely with that of Cp27Kipl (R=-0.312,P<0.05),P-S473Akt was negatively related to Cp27Kipl (R=-0.347,P<0.01).P-S473Akt and Akt was positively associated with Cp27Kipl level (R=0.308 and 0.319,P<0.05).Moreover,the expressions of P-S473Akt and Np27Kip1 had significant correlations with many clinicopathologic variables (P<0.01 or 0.05) of human lung adenocarcinoma *** analysis identified P-S473Akt or N p27Kipl protein as a significant independent prognostic factor (P=0.04 and 0.014,respectively).Live-cell imaging and western blot analyses of the cell nu

关键词： Akt p27Kip 1 lung adenocarcinoma immunohistochemistry Live-cell imaging

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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui zhang Lin-Hao zhang Mo-Han zhang Qi-Wei zhang Xian-Peng zhang Yu-Liang zhang Yue zhang Zhi-Yong zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the china Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

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