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建筑机械化 2024年第6期45卷 18-21页

作者：褚鹏程张荣鑫张刊鲁园刘坤鑫浙江省建设工程机械集团有限公司浙江杭州311200

为解决塔式起重机的运行过程中由于小车的加减速和负载提升动作以及环境风速变化引起负载来回摆动的问题,提出一种双模糊PID控制策略,同时对小车的变幅位置和吊物的角度进行控制,并通过仿真实验验证了该方法的可行性。

关键词：塔式起重机防摇摆控制模糊PID 鲁棒性仿真实验

美国国立综合癌症网络直肠癌临床实践指南(2023.V1-V5)更新解读

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临床外科杂志 2024年第1期32卷 37-40页

作者：张荣欣米思源廖俊毅康达陈功中山大学肿瘤防治中心结直肠科华南肿瘤学重点实验室广州510060

结直肠癌(colorectal cancer,CRC)是美国第4大常见的肿瘤,也是美国肿瘤相关死亡的第2大原因。2022年,美国预计将出现44 850例直肠癌新病例(男性26 650例;女性18 200例)^([1])。同年,预计将有52 580人死于直肠癌和结肠癌。目前,国内学术... 详细信息

结直肠癌(colorectal cancer,CRC)是美国第4大常见的肿瘤,也是美国肿瘤相关死亡的第2大原因。2022年,美国预计将出现44 850例直肠癌新病例(男性26 650例;女性18 200例)^([1])。同年,预计将有52 580人死于直肠癌和结肠癌。目前,国内学术界比较流行的指南包括美国国立综合癌症网络(National Comprehensive Cancer Network,NCCN)肿瘤学临床实践指南,ESMO(European Society for medical oncology)直肠癌指南和CSCO指南(Chinese society of clinical oncology)。

关键词：直肠癌美国国立综合癌症网络指南解读

Prognostic value of preoperative prognostic nutritional index and its associations with systemic inflammatory response markers in patients with stage Ⅲ colon cancer

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Chinese Journal of Cancer 2017年第11期36卷 635-646页

作者： Jianhong Peng rongxin zhang Yixin Zhao Xiaojun Wu Gong Chen Desen Wan Zhenhai Lu Zhizhong Pan Department of Colorectal Surgery State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center 651 Dongfeng Road East GuangzhouGuangdong 510060 P. R. China

Background: The prognostic nutritional index(PNI) has been widely applied for predicting survival outcomes of patients with various malignant tumors. Although a low PNI predicts poor prognosis in patients with colorectal cancer after tumor resection, the prognostic value remains unknown in patients with stage Ⅲ colon cancer undergoing curative tumor resection followed by adjuvant chemotherapy. This study aimed to investigate the prognostic value of PNI in patients with stage III colon ***: Medical records of 274 consecutive patients with stage Ⅲ colon cancer undergoing curative tumor resection followed by adjuvant chemotherapy with oxaliplatin and capecitabine between December 2007 and December2013 were reviewed. The optimal PNI cutoff value was determined using receiver operating characteristic(ROC) curve analysis. The associations of PNI with systemic inflammatory response markers, including lymphocyte-to-monocyte ratio(LMR), neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), and C-reactive protein(CRP)level, and clinicopathologic characteristics were assessed using the Chi square or Fisher's exact test. Correlation analysis was performed using Spearman's correlation coefficient. Disease-free survival(DFS) and overall survival(OS)stratified by PNI were analyzed using Kaplan-Meier method and log-rank test, and prognostic factors were identified by Cox regression ***: The preoperative PNI was positively correlated with LMR(r= 0.483, P < 0.001) and negatively correlated with NLR(r =-0.441, P < 0.001), PLR(r =-0.607, P < 0.001), and CRP level(r =-0.333, P < 0.001). A low PNI(≤49.22)was significantly associated with short OS and DFS in patients with stage ⅢC colon cancer but not in patients with stage ⅢA/ⅢB colon *** addition, patients with a low PNI achieved a longer OS and DFS after being treated with6-8 cycles of adjuvant chemotherapy than did those with < 6 cycles. Multivariate analyses revealed that PNI was indepe

关键词： Prognostic nutritional index Colon cancer Systemic inflammatory response marker Prognosis

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区域互联下不对称交流电网运行控制系统设计

电子设计工程 2024年第1期32卷 86-90页

作者：王宜立张蓉馨杨再鹤单祖植徐晓亮云南电力调度控制中心调度科云南昆明650011 文山供电局电力调度控制中心云南文山663099 南京南瑞继保电气有限公司江苏南京210000

电力系统内部的交流电在产生不对称故障之后,会直接导致换流站母线电压不平衡,系统内部出现的负序分量和零序分量会影响系统交流和直流谐波分布,进而影响电网的正常运行。为了进一步实现不对称交流电网的控制,设计了一种控制系统。系统... 详细信息

电力系统内部的交流电在产生不对称故障之后,会直接导致换流站母线电压不平衡,系统内部出现的负序分量和零序分量会影响系统交流和直流谐波分布,进而影响电网的正常运行。为了进一步实现不对称交流电网的控制,设计了一种控制系统。系统硬件设计了锁相环控制器、电流环控制器、DSP控制器,锁相环控制器由相位鉴别、环路滤波和压控振荡三部分组成一个闭环。针对区域互联状况进行分析,确定谐波电压和谐波电流的传递规律,建立谐波分析程序和控制程序,通过矢量计算,对不对称交流电网电流进行运行控制。实验结果表明,所设计系统能够有效解决运行过程的输入量和输出量不均衡的问题,降低叠加放大状况,控制后电流和电压幅值波动为0,有效防止出现谐波不稳定现象。

关键词：区域互联不对称交流电网运行控制控制系统

Safety and efficacy of a modified XELOX adjuvant regimen for patients with operated stage III colon cancer:a Chinese single-center experience

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Cancer Communications 2019年第1期39卷 536-547页

作者： Jianhong Peng Weihao Li rongxin zhang Junzhong Lin Jinghua Tang Yongshan Wen Zhenhai Lu Xiaojun Wu Zhizhong Pan Department of Colorectal Surgery State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhouGuangdong 510060P.R.China

Background:A fixed 8-cycle oxaliplatin and capecitabine(XELOX)regimen has been the standard adjuvant therapy for patients with stage III colon ***,completing the full-cycle of oxaliplatin is often associated with severe *** spare patients from the toxic effects,without comprising the required efficacy,we evaluated the safety and efficacy of a modified XELOX(mXELOX)adjuvant chemotherapy regimen with 6 cycles of oxaliplatin and a full cycle of ***:We retrospectively analyzed 330 eligible patients with stage III colon cancer who underwent cura-tive tumor resection followed by mXELOX,standard XELOX or unfinished XELOX adjuvant chemotherapy between December 2007 and April *** prognostic factors were investigated and their disease-free survival(DFS)and overall survival(OS)rates were also determined and compared among the different regimen ***:Compared with the standard XELOX group,the mXELOX group had lower total incidence rates of neuro-toxicity(39.3%vs.76.2%,P<0.001),leucopenia(53.6%vs.69.8%,P=0.017)and thrombocytopenia(38.1%vs.56.3%,P=0.011).The standard XELOX and mXELOX adjuvant chemotherapy regimens presented with comparable 3-year DFS rates(86.3%vs.89.2%;P=0.838)and 3-year OS rates(92.7%vs.97.6%;P=0.227).Compared to unfinished XELOX chemotherapy,the oncologic benefits of the mXELOX regimen were greater for patients with T4 tumors(3-year DFS:Hazard ratio[HR],2.184;95%confidence interval[CI],1.051-4.540;P=0.036;3-year OS:HR,4.529;95%CI 1.245-16.479;P=0.022)and for high-risk patients(3-year DFS:HR,1.962;95%CI 0.964-3.993;P=0.044;3-year OS:HR,4.193;95%CI 1.182-14.874;P=0.026).Conclusions:The mXELOX adjuvant chemotherapy presented a comparable survival benefit and lower incidence of toxicity than standard XELOX *** could be an alternative treatment for high-risk patients with operated stage III colon cancer.

关键词： Colon cancer Adjuvant chemotherapy Oxaliplatin Capecitabine XELOX Efficacy Safety

Expression of *** sodium channel Nav1.5 in *** colon cancer and its associations with estrogen receptor(ER)-βexpression and clinical outcomes

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Chinese Journal of Cancer 2017年第12期36卷 694-703页

作者： Jianhong Peng Qingjian Ou Xiaojun Wu rongxin zhang Qian Zhao Wu Jiang Zhenhai Lu Desen Wan Zhizhong Pan Yujing Fang Department of Colorectal Surgery State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yatsen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Department of Experimental Research Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Statistics School of Public HealthGuangzhou Medical UniversityGuangzhou 510182GuangdongP.R.China

Background: Voltage-gated sodium channel 1.5(Nav1.5) potentially promotes the migratory and invasive behaviors of colon cancer cells. Hitherto, the prognostic significance of Nav1.5 expression remains undetermined. The present study aimed to explore the associations of Nav1.5 expression with clinical outcomes and estrogen receptor-β(ER-β)expression in non-metastatic colon cancer patients receiving radical ***: A total of 269 consecutive patients with pathologically confirmed stages Ⅰ-Ⅲ colon cancer who underwent radical resection were selected. Nav1.5 and ER-β expression was detected by using immunohistochemistry(IHC)on tissue microarray constructed from paraffin-embedded specimens. IHC score was determined according to the percentage and intensity of positively stained cells. Statistical analysis was performed with the X-tile method, k coefficient, Chi square test or Fisher's exact test, logistic regression, log-rank test, and Cox proportional hazards ***: We found that Nav1.5 was commonly expressed in tumor tissues with higher mean IHC score as compared with matched tumor-adjacent normal tissues(5.1 ± 3.5 vs. 3.5 ± 2.7, P < 0.001).The high expression of Nav1.5 in colon cancer tissues was associated with high preoperative carcinoembryonic antigen level [odds ratio(OR) = 2.980;95% confidential interval(CI)1.163-7.632; P = 0.023] and high ER-β expression(OR = 2.808; 95% CI 1.243-6.343;p = 0.00 3). Log-rank test results showed that high Nav1.5 expression contributed to a low 5-year disease-free survival(DFS) rate in colon cancer patients(77.2% vs. 92.1%, P = 0.048), especially in patients with high ER-β expression tumor(76.2% vs. 91.3%, P = 0.032). Analysis with Cox proportional hazards model demonstrated that high Nav1.5 expression[hazard ratio(HR) = 2.738; 95% CI 1.100-6.819;P = 0.030] and lymph node metastasis(HR = 2.633; 95% CI 1.632-4.248; P < 0.001) were prognostic factors for unfavorable DFS in colon cancer ***: High ex

关键词： Nav1.5 Estrogen receptor-β Colon cancer Clinical outcome

Radiotherapy enhances efficacy of PD-1 inhibitors in advanced hepatocellular carcinoma:A propensity-matched real-world study

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Chinese Medical Journal 2024年第11期137卷 1332-1342页

作者： Shujung Hsu Yencheng Chao Yong Hu Yang zhang Weifeng Hong Yixing Chen rongxin Chen Zhaochong Zeng Shisuo Du Department of Radiation Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pulmonary Medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of Liver Cancer Institute Zhongshan HospitalFudan UniversityShanghai 200032China

Background:To address the need for immunotherapy in patients with advanced primary hepatocellular carcinoma(HCC),combination with radiotherapy(RT)has emerged as a promising *** preclinical studies,irradiated tumors released tumor antigens to synergistically increase the antitumor effect of ***,we investigated whether RT enhances the efficacy of anti-programmed death receptor-1(PD-1)inhibitors in advanced HCC in real-world ***:Between August 2018 and June 2021,172 patients with advanced primary HCC were enrolled in the tertiary center(Zhongshan Hospital of Fudan University);95 were treated with a combination of RT and the inhibitor of PD-1(RT-PD1 cohort),and 77 were administered anti-PD-1 therapy(PD1 cohort).The first cycle of PD-1 inhibitors was administered within 60 days or concurrently with *** score matching for bias reduction was used to evaluate the clinical ***:Among 71 propensity-matched pairs,median progression-free survival was 5.7 months in the RT-PD1 cohort vs.2.9 months in the PD1 cohort(P<0.001).Median overall survival was 20.9 months in the RT-PD1 cohort vs.11.2 months in the PD1 cohort(P=0.018).Compared with patients in the PD1 cohort,patients in the RT-PD1 cohort had significantly higher objective response rates(40.8%,29/71 vs.19.7%,14/71,P=0.006)and disease control rates(62.0%,44/71 vs.31.0%,22/71,P<0.001).The incidences of toxic effects were not significantly different between the two ***:RT plus anti-PD-1 therapy is well *** enhances the efficacy of anti-PD-1 therapy in patients with advanced primary HCC by improving survival outcomes without increased toxic effects.

关键词： Radiotherapy Immune checkpoint inhibitor Programmed cell death receptor-1 Hepatocellular carcinoma Propensity score matching Treatment outcome Adverse effects

Isolating Scheme and Optimization Design of the Harness and the Pipe in the Car

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Isolating Scheme and Optimization Design of the Harness and ...

Multi-field Split Curvature Wavefront Sensing and its Application in the Large Field Survey Telescope

2018中国汽车工程学会年会

作者： zhang rongxin zhang Qiuju SUN Hong SAIC MOTOR

The system structure of the method standard of pipe and wiring harness in the *** with the traditional partition,the new design can be widely used in complicated situation and it has high practical value.

关键词： pipeline insulation harness isolation isolating clamp

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Research in Astronomy and Astrophysics 2024年第8期24卷 60-74页

作者： Zhixu Wu Yiming zhang Jianan Cong Hua Bai Yong Xia rongxin Tang Ming Li Zhengyang Li Xiangyan Yuan Institute of Space Science and Technology Nanchang UniversityNanchang 330031China Nanjing Institute of Astronomical Optics&Technology CASNanjing 210042China University of Chinese Academy of Sciences NanjingNanjing 211135China

The image quality of a large field survey telescope with a fast focal ratio of the primary mirror is high sensitivity to the optical elements’misalignments and the primary mirror’s *** maintain good optical performance,the perturbations need to be aligned,and the tomographic reconstruction of these perturbations can be derived from wavefront sensing with multi-field points for *** work undertakes a comprehensive examination related to the implementation and optimization of a multi-field split curvature wavefront sensing system,including defocus distance,signal pre-processing,deblending of overlapped doughnuts,field-dependent correction,and distorted coordinate *** also conduct experiments to demonstrate the application and performance of a multi-field split curvature wavefront sensing system in *** the context of the decentering of the secondary mirror,the coefficient of determination(R)attains a high value of 0.993,indicating a robust linearity between the coma coefficients and the decentering of the secondary mirror.A comparative analysis of the simulated and experimental results shows that the difference between them is less than 0.1λ.

关键词： Instrumentation high angular resolution-Techniques photometric-Techniques image processing

Loss of a fragile-site associated gene drives antitumor immunity via macrophage polarization

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Loss of a fragile-site associated gene drives antitumor immu...