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基于网络药理学研究当归-白芍治疗肾病综合征的作用机制

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中医临床研究 2024年第18期16卷 50-55页

作者：代丽娟苑伯菲汪新尧裴春鹏陈瑞艳张佩青黑龙江省中医药科学院黑龙江哈尔滨150036 黑龙江中医药大学附属第一医院黑龙江哈尔滨150040 黑龙江中医药大学黑龙江哈尔滨150040

目的:运用网络药理学方法和分子对接技术探讨当归-白芍治疗肾病综合征的作用机制。方法:通过中药系统药理学数据库与分析平台(TCMSP)数据库挖掘当归-白芍的主要活性成分,通过Pubchem数据库和Swiss Target Prediction数据库进行预测并筛... 详细信息

目的:运用网络药理学方法和分子对接技术探讨当归-白芍治疗肾病综合征的作用机制。方法:通过中药系统药理学数据库与分析平台(TCMSP)数据库挖掘当归-白芍的主要活性成分,通过Pubchem数据库和Swiss Target Prediction数据库进行预测并筛选出当归-白芍活性成分的潜在靶点。将“Nephrotic syndrome”作为关键词输入Disgenet、Genecards和Drugbank数据库进行检索,获取疾病作用靶点。使用Cytoscape软件和STRING数据库,构筑“药物-成分-疾病-靶点”网络图和蛋白相互作用网络,用R软件对关键靶基因进行基因本体论(GO)生物过程富集与京都基因与基因组百科全书(KEGG)信号通路富集分析,并绘制关键靶基因GO及KEGG条形图及气泡图,最后使用分子对接技术将活性成分和靶点进行对接验证。结果:筛选得到当归-白芍有效活性成分15个,涉及作用靶点360个,通过疾病靶点(肾病综合征)与药物靶点(当归-白芍)的重叠,获得与疾病靶点有关的潜在靶点为137个。当归-白芍主要涉及氧化应激过程、炎症反应等生物过程,通过调节磷脂酰肌醇3激酶-蛋白激酶B(Phosphatidylinositol 3-kinase-Akt,PI3K/Akt)、缺氧诱导因子(Hypoxia Inducible Factor,HIF)-1、程序性死亡受体1(Programmed Cell Death Protein 1,PD-1)/程序性死亡配体1(Programmed Deathligand-1,PD-L1)、丝裂原活化蛋白激酶(Mitogen-Activated Protein Kinase,MAPK)、Janus激酶2(Janus Kinase 2,JAK2)/信号转导及转录激活蛋白(Signal Transducer and Activator of Transcription,STAT)3等信号通路来发挥治疗肾病综合征的作用。分子对接结果证实阿魏酸、山柰酚与基质金属蛋白酶(Matrix Metallopeptidase,MMP)9、Toll样受体(Toll-like Receptor,TLR)4、STAT3具有较好的结合活性。结论:当归-白芍治疗肾病综合征的机制可能是通过抑制肾脏炎症反应及氧化应激反应,调节PI3K/Akt、HIF-1、PD-1/PD-L1、MAPK、JAK2/STAT3等信号通路的多途径、多信号通路,共同协调作用。

关键词：网络药理学肾病综合征作用机制

Re-usable Cd_(0.9)Zn_(0.1)S-ZnO@C/PVDF piezo-photocatalytic film with exceptional hydrogen evolution capability triggered by the synergetic advantages of piezoelectricity and S-Scheme heterojunction

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Journal of Energy Chemistry 2024年第9期96卷 164-176页

作者： Ping Su Dong zhang Minghui Zhu Tengteng Liang Nan Yang Huaihao Zhao Dafeng zhang Junchang Liu peiqing Cai Xipeng Pu School of Materials Science and Engineering Shandong Provincial Key Laboratory of Chemical Energy Science and Novel Cell TechnologyLiaocheng UniversityLiaocheng 252000ShandongChina School of Physics Science and Information Technology Shandong Key Laboratory of Optical Communication Sciencend TechnologyLiaocheng UniversityLiaocheng 252000ShandongChina College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018ZhejiangChina

Piezoelectric materials have advantages of fine-tuning photocatalytic performance through harvesting mechanical energy and open a new avenue in facilitating green catalytic ***,polyvinylidene fluoride(PVDF),a flexible piezoelectric material,was introduced to synthesize a novel Cd_(0.9)Zn_(0.1)S-ZnO@C/PVDF(CZS-ZO@C/PVDF)piezo-photocatalytic film by spin coating and immersion phase conversion *** from the piezoelectricity of PVDF and the internal electric field(IEF)of CZS-ZO@C Step-scheme(S-Scheme)heterojunction,CZS-ZO@C/PVDF was able to induce a hydrogen generation rate of 34.9 mmol g^(−1)h^(−1)activated by ultrasound and visible light(U-L),which is∼17.5 times of Cd_(0.9)Zn_(0.1)S/PVDF(CZS/PVDF)and∼7.4 times of the photocatalysis rate activated by visible light only(L).Piezoelectric measurements and COMSOL simulation illustrated the excellent piezoelectricity of CZS-ZO@C/PVDF film,which exhibits a piezoelectric coefficient(d33)of 9.9 pm V−1 and a piezoelectric potential of 874 mV(under 0.5 MPa).The reaction mechanism for the exceptional piezo-photocatalytic performance was finally disclosed through density functional theory(DFT)calculation and electrochemical *** study enriches the application scope of piezoelectric materials in sustainable energy catalysis and provides a new direction to develop efficient piezoelectric photocatalysts.

关键词： Piezo-photocatalysis Heterojunction Cd_(0.9)Zn_(0.1)S Zno@c PVDF

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浅论张佩青教授辨证施治胃痛经验

光明中医 2023年第5期38卷 862-864页

作者：刘婷张佩青黑龙江省中医药科学院黑龙江哈尔滨150036 黑龙江省中医药科学院肾病二科黑龙江哈尔滨150036

从张佩青教授辨证治疗胃痛的3则医案着手,浅析张佩青教授对于不同证型胃痛的选方用药经验及其独到的胃痛“十法”辨证理念。张佩青教授认为虽然引起胃痛的原因不尽相同但治疗所遵循的大方向应是相近的,即循古而揣新从多维度考虑“通”,... 详细信息

从张佩青教授辨证治疗胃痛的3则医案着手,浅析张佩青教授对于不同证型胃痛的选方用药经验及其独到的胃痛“十法”辨证理念。张佩青教授认为虽然引起胃痛的原因不尽相同但治疗所遵循的大方向应是相近的,即循古而揣新从多维度考虑“通”,将“通”贯穿治疗胃痛的全过程,气血阴阳通畅则胃痛愈。张佩青教授的这一新的治疗理念开拓了中医思路、指明了治疗胃痛的新方向。

关键词：胃痛张佩青辨证论治医案名医经验

Rational construction of CuFe_(2)O_(4)@C/Cd_(0.9)Zn_(0.1)S S-scheme heterojunction photocatalyst for extraordinary photothermal-assisted photocatalytic H_(2) evolution

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Journal of Energy Chemistry 2024年第5期92卷 240-249页

作者： Dong zhang Minghui Zhu Ran Qin Peixian Chen Maoye Yin Dafeng zhang Junchang Liu Hengshuai Li Xipeng Pu peiqing Cai School of Physics Science and Information Technology Shandong Key Laboratory of Optical Communication Science and TechnologyLiaocheng UniversityLiaocheng 252000ShandongChina School of Materials Science and Engineering Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell TechnologyLiaocheng UniversityLiaocheng 252000ShandongChina College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018ZhejiangChina

Rational design of photocatalyst to maximize the use of sunlight is one of the issues to be solved in photocatalysis *** this study,the CuFe_(2)O_(4)@C/Cd_(0.9)Zn_(0.1)S(CFO@C/CZS)S-scheme photocatalyst with photothermal effect was synthesized by ultrasonic self-assembly combined with *** dark CFO@C absorbed visible light and partly converted into heat to promote the hydrogen evolution *** presence of heterojunctions inhibited the photogenerated electron-hole *** graphite-carbon layer provided a stable channel for electron transfer,and the presence of magnetic CFO made recycle *** the action of photothermal assistance and heterojunction,the hydrogen evolution rate of the optimal CFO@C/CZS was 80.79 mmol g^(-1) h^(-1),which was 2.55 times and 260.61 times of that of pure CZS and CFO@C,***,the composite samples also exhibit excellent stability and a wide range of environmental *** experimental tests and first-principles simulation calculation methods,the plausible mechanism of photoactivity enhancement was *** work provided a feasible strategy of photothermal assistance for the development of heterojunction photocatalysts with distinctive hydrogen evolution.

关键词： Photothermal effect S-scheme heterojunction Photocatalytic hydrogen evolution First-principles calculations

Reducing Olefins in FCC Gasoline by Isomerization and Aromatization over Modified Nano-ZSM-5

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催化学报 2003年第3期24卷 159-160页

作者： zhangpeiqing WANGXiangsheng 等 StateKeyLaboratoryofFineChemicalsandInstituteofIndustrialCatalysts DalianUniversityofTechnologyDalian116012LiaoningChina StateKeyLaboratoryofFineChemicalsandInstituteofIndustrialCatalysts DalianUni

The rapid development of automobile and the greatly increased consumption of fuel have caused more and more serious air-pollution by the emission of tail gas~[1,2]. To reduce the emission of tail gas from gasoline-powered engines, governments all over the world have tightened regulations on the composition of gasoline and required the production and use of clean fuels via the reduction of sulfur and olefins in gasoline. A new standard of the composition of gasoline will soon become effective in our country in which the content of olefins must be under 35%(volume fraction, the same below)~[3]. However, approximately 80% of gasoline used in our country comes from FCC gasoline which contains olefins more than 50%. To decrease the content of olefins in gasoline, several measures have been developed, such as optimization of the FCC process, use of new FCC catalysts (GOR, LBO, RFG),hydrogenation, and so on. But the degree of reduction of olefins is not high(only by 6%-13%), and always accompanied by octane value decreasing. Therefore, it is urgent to develop a novel technique that can maintain the octane value while reducing the olefins in gasoline.

关键词：纳米分子筛 ZSM-5 催化剂 FCC汽油烯烃芳构化异构化

基于组合继电反馈的永磁同步直线电机推力波动辨识方法

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电工技术学报 2017年第9期32卷 1-9页

作者：张翔叶佩青张辉清华大学机械工程系北京100084 摩擦学国家重点实验室(清华大学) 北京100084

在永磁同步直线电机中,由齿槽效应和端部效应引起的推力波动是制约其动态性能的重要因素。提出一种基于组合继电反馈的推力波动辨识方法,且利用辨识结果实现推力波动的补偿。针对某直驱进给实验平台,首先建立其动力学模型,设计基于理想... 详细信息

在永磁同步直线电机中,由齿槽效应和端部效应引起的推力波动是制约其动态性能的重要因素。提出一种基于组合继电反馈的推力波动辨识方法,且利用辨识结果实现推力波动的补偿。针对某直驱进给实验平台,首先建立其动力学模型,设计基于理想继电环节和含有死区的迟滞继电环节相结合的信号激励源;其次利用描述函数对各非线性环节进行谐波线性化进而获取各环节的双输入描述函数,再根据非线性系统极限环存在条件确定系统待辨识参数的解析表达式;最后,通过仿真和实验验证了该方法的可行性和准确性。实验表明当直驱进给系统匀速运动时,含有推力波动补偿时伺服系统的推力电流波动比补偿前降低了46.3%,其跟踪误差的方均根由34.1μm降至19.3μm。

关键词：直线电机极限环参数辨识继电反馈推力波动

江苏新华发行集团提升市场竞争力的实践与思考

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出版发行研究 2006年第11期 19-23页

作者：张佩清江苏新华发行集团

改革开放以来,特别是"十五"期间,江苏出版发行业取得了持续快速发展.从"九五"末到"十五"末江苏新华发行集团总销售由51亿元增加到75亿元,年均增长8%,总利税由2.36亿元增长到4.09亿元,年均递增11.3%.

关键词：江苏新华发行集团市场竞争力 “十五”期间出版发行业 “十一五”期间实践持续快速发展改革开放以来

Three-Dimensional Shape Measuring Method Based on Dual-Frequency Digital Moiré Fringe

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激光与光电子学进展 2023年第8期60卷 394-401页

作者： Hu Hailing He Renji Chen Yang zhang peiqing Shen Xiang Da Shixun Song Baoan Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211ZhejiangChina The Research Institute of Advanced Technologies Ningbo UniversityNingbo 315211ZhejiangChina Key Laboratory of Photoelectric Detecting Materials and Devices of Zhejiang Province Ningbo 315211ZhejiangChina Ningbo Institute of Oceanography Ningbo UniversityNingbo 315211ZhejiangChina Engineering Research Center for Advanced Infrared Photoelectric Materials and Devices of Zhejiang Province Ningbo 315211ZhejiangChina

A dual-frequency digital Moiré measurement method(DFDM) is proposed for the three-dimensional(3D) shape measurement of an *** high-and low-frequency fringes are modulated separately along orthogonal direction using different carrier frequencies before being projected onto the measured *** collecting and demodulating the composite fringe,the digital π phase shift is used to remove the DC component of the demodulated fringes,resulting in high-precision Moiré fringes for calculating the wrapped *** unwrapping of the high-frequency wrapped phase is guided by the low-frequency phase to further realistically reconstruct the surface of the measured *** compared with existing single-shot digital Moiré profilometry,DFDM effectively removes the DC component of the fringe and calculates the phase more accurately.

关键词： 3D measurement dual-frequency digital Moiréfringe digitalπphase shift

张佩青教授应用加味参芪地黄汤治疗慢性肾功能衰竭经验

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中国中医药现代远程教育 2020年第23期18卷 53-56页

作者：李龙张佩青(指导) 遇昕黑龙江省中医药科学院心五科黑龙江哈尔滨150006 黑龙江省中医药科学院肾二科黑龙江哈尔滨150036 黑龙江省中医药科学院南岗分院心三科黑龙江哈尔滨150036

参芪地黄汤具有益气健脾,养阴补肾之功用,是中医治疗慢性肾功能衰竭的常用方剂,临床疗效被诸多现代医家所认可。本文通过探究张佩青教授应用加味参芪地黄汤治疗慢性肾功衰竭之经验。阐述了张佩青教授对慢性肾功能衰竭的病因、病机等方... 详细信息

参芪地黄汤具有益气健脾,养阴补肾之功用,是中医治疗慢性肾功能衰竭的常用方剂,临床疗效被诸多现代医家所认可。本文通过探究张佩青教授应用加味参芪地黄汤治疗慢性肾功衰竭之经验。阐述了张佩青教授对慢性肾功能衰竭的病因、病机等方面的认知和辨证思路。介绍了张教授善用参芪地黄汤加减变化的诊疗特色,并举效验医案一例。

关键词：张佩青参芪地黄汤慢性肾功能衰竭水肿腰痛癃闭虚劳名医经验