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Digital light processing 3D printing for microfluidic chips with enhanced resolution via dosing-and zoning-controlled vat photopolymerization

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Microsystems & Nanoengineering 2023年第4期9卷 315-327页

作者： Zhiming Luo Haoyue zhang Runze Chen Hanting Li Fang Cheng lijun zhang Jia Liu Tiantian Kong Yang zhang Huanan Wang School of Biomedical Engineering Shenzhen University Health Science CenterShenzhen 518000P.R.China State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringSchool of BioengineeringDalian University of TechnologyDalian 116024P.R.China Third People’s Hospital of Dalian Dalian Eye HospitalDalian 116024 P.R.China Central Laboratory The Second Affiliated Hospital of TheChinese University of Hong KongShenzhen 518172P.R.China

Conventional manufacturing techniques to fabricate microfluidic chips,such as soft lithography and hot embossing process,have limitations that include difficulty in preparing multiple-layered structures,cost-and labor-consuming fabrication process,and low *** light processing(DLP)technology has recently emerged as a costefficient microfabrication approach for the 3D printing of microfluidic chips;however,the fabrication resolution for microchannels is still limited to sub-100 microns at ***,we developed an innovative DLP printing strategy for high resolution and scalable microchannel fabrication by dosing-and zoning-controlled vat photopolymerization(DZC-VPP).Specifically,we proposed a modified mathematical model to precisely predict the accumulated UV irradiance for resin photopolymerization,thereby providing guidance for the fabrication of microchannels with enhanced *** fine-tuning the printing parameters,including optical irradiance,exposure time,projection region,and step distance,we can precisely tailor the penetration irradiance stemming from the photopolymerization of the neighboring resin layers,thereby preventing channel blockage due to UV overexposure or compromised bonding stability owing to insufficient resin ***,this strategy can allow the preparation of microchannels with cross-sectional dimensions of 20μm×20μm using a commercial printer with a pixel size of 10μm×10μm;this is significantly higher resolution than previous *** addition,this method can enable the scalable and biocompatible fabrication of microfluidic drop-maker units that can be used for cell *** general,the current DZC-VPP method can enable major advances in precise and scalable microchannel fabrication and represents a significant step forward for widespread applications of microfluidics-based techniques in biomedical fields.

关键词： printing resolution resin

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A genetic variant study of bortezomib-induced peripheral neuropathy in Chinese multiple myeloma patients

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Oncology Research 2024年第5期32卷 955-963页

作者： YAN zhang HEYANG zhang JING WANG XIN WEI YI QU FENG XU lijun zhang Department of Hematology The First Affiliated Hospital of China Medical UniversityShenyang110001China

Background:Bortezomib results in peripheral neuropathy(PN)in approximately 50%of patients,during multiple myeloma(MM)treatment,a complication known as Bortezomib-induced peripheral neuropathy(BIPN).The drug response varies among *** factor may play an important role in ***:A nextgeneration sequencing(NGS)panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib *** expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR(RT-qPCR).Serum homocysteine(Hcy)levels were detected in 40 samples by chemiluminescent microparticle immunoassay(CMIA).Results:Compared with the non-BIPN group(n=89),a total of 8 significantly associated single nucleotide polymorphisms(SNPs)were identified in the BIPN group(n=115):MTHFR(rs1801131,rs1801133,rs17421511),EPHX1(rs1051740),MME(rs2016848),ALDH1A1(rs6151031),HTR7(rs1935349)and CYP2A6(rs8192720).The mRNA expression level of MTHFR in newly diagnosed patients with peripheral neuritis after treatment(NP group)was lower than that of newly diagnosed patients without peripheral neuritis after treatment(NnP group)(1.70±0.77 vs.2.81±0.97,p=0.009).Serum Hcy levels were significantly higher in BIPN group than in non-BIPN group(11.66±1.79μmol/L vs.8.52±3.29μmol/L,p=0.016)and healthy controls(11.66±1.79μmol/L vs.8.55±2.13μmol/L,p≤0.001).Conclusion:CYP2A6,EPHX1,MTHFR,ALDH1A1,HTR7,MME and BIPN are linked in Chinese MM *** is more likely to occur in patients with lower MTHFR mRNA expression,which might result in higher serum Hcy levels.

关键词： Multiple Myeloma Peripheral neuropathy Bortezomib Bortezomib-induced peripheral neuropathy Next-generation sequencing MTHFR Serum Hcy

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Transcriptomics and Proteomics in the Study of H1N1 2009

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Genomics, Proteomics & Bioinformatics 2010年第3期8卷 139-144页

作者： lijun zhang Xiaojun zhang Qing Ma Fang Ma Honghao Zhou Department of Pharmacogenetics Institute of Clinical Pharmacology Central South University Changsha 410078 China Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China Department of Neurosurgery Fuzhou General Hospital Fuzhou 350025 China School of Pharmacy and Pharmaceutical Sciences University at Buffalo NY 14260 USA.

Influenza A virus （H1N1） 2009, a new swine-origin influenza A virus, has been spread worldwidely and caused great public fear. High-throughput transcriptomics and proteomics methods are now being used to identify H1N1 and H1Nl-host interaction. This article reviews recent transcriptomics and proteomics research in H1N1 diagnosis, treatment, and H1N1 virus-host interaction, to offer some help for further understanding the infection mechanism and controlling H1N1 transmission.

关键词： H 1N 1 proteomics transcriptomics host

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Exploration of B-site alloying in partially reducing Pb toxicity and regulating thermodynamic stability and electronic properties of halide perovskites

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Science China(Physics,Mechanics & Astronomy) 2023年第3期66卷 130-138页

作者： Xinjiang Wang Muhammad Faizan Kun Zhou Hongshuai Zou Qiaoling Xu Yuhao Fu lijun zhang State Key Laboratory of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China State Key Laboratory of Integrated Optoelectronics Key Laboratory of Automobile Materials of MOECollege of Materials Science and EngineeringJilin UniversityChangchun 130012China College of Physics and Electronic Engineering Center for Computational SciencesSichuan Normal UniversityChengdu 610068China International Center of Computational Method and Software Jilin UniversityChangchun 130012China

Alloying strategies provide a high degree of freedom for reducing lead toxicity,improving thermodynamic stability, tuning the optoelectronic properties of ABX3 halide perovskites by varying the alloying element species and their *** the key role of B-site cations in contributing band edge states and modulating structure factors in halide perovskites,the partial replacement of Pb2+with different B-site metal ions has been *** several experimental attempts have been made to date,the effect of B-site alloying on the stability and electronic properties of halide perovskites has not been fully ***,we take cubic CsPbBr3 perovskite as the prototype material and systematically explore the effects of B-site alloying on Pb-containing *** to the presence or absence of the corresponding perovskite phase,the ten alloying elements investigated are classified into three types(i.e.,Type Ⅰ:Sn Ge,Ca,Sr;Type Ⅱ:Cd,Mg,Mn;Type Ⅲ:Ba,Zn,Cu).Based on the first-principles calculations,we obtain the following ***,these B-site alloys will exist as disordered solid solutions rather than ordered structures at room temperature throughout the composition ***,the alloying of Sn and Ge enhances the thermodynamic stability of the cubic perovskite host,whereas the alloying of the other elements has no remarkable effect on the thermodynamic stability of the cubic perovskite ***,the underlying physical mechanism for bandgap tuning can be attributed to the atomic orbital energy mismatch or quantum confinement ***,the alloying of different elements demonstrates the diversity in the regulation of crystal structure and electronic properties,indicating potential applications in photovoltaic s and self-trapped exciton-based light-emitting *** work provides theoretical guidance for using alloying strategies to reduce lead toxicity,enhance stability,and optimize the electronic properties of halide perovsk

关键词： lead-based halide perovskites alloying thermodynamic stability first-principles calculations optoelectronic applications

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Control of a battery/supercapacitor hybrid energy storage system for electric vehicles 36

Control of a battery/supercapacitor hybrid energy storage sy...

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第36届中国控制会议

作者： lijun zhang Xiaohua Xia Farshad Barzegar Department of Electrical Electronic and Computer EngineeringUniversity of Pretoria

ISBN: (纸本)9781538629185

This study looks into the power flow control of a battery/supercapacitor hybrid energy storage system when applied to electric *** controller is based on advanced model predictive control method and aims at smoothing the power flow from/to the battery to protect it from undesirable fast discharging/*** second objective of the controller is to control the electric vehicle to track a predefined speed *** dynamics of the vehicle and the supercapacitors are modeled from first principles to facilitate the controller *** is assumed that the battery,as the primary energy source for the vehicle,is properly sized such that there is no need to control its *** addition,the controller is designed at the energy management level instead of power electronics control ***,it severs to optimize the power flows of the hybrid energy storage system instead of controlling the power converters *** based on two commonly used urban driving cycles are carried out to verify the effectiveness of the design.

关键词： Electric vehicle hybrid energy storage system power source coordination model predictive control power flow control

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Helium incorporation induced direct-gap silicides

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npj Computational Materials 2021年第1期7卷 809-816页

作者： Shicong Ding Jingming Shi Jiahao Xie Wenwen Cui Pan zhang Kang Yang Jian Hao lijun zhang Yinwei Li Laboratory of Quantum Functional Materials Design and Application School of Physics and Electronic EngineeringJiangsu Normal UniversityXuzhouChina State Key Laboratory of Superhard Materials Key Laboratory of Automobile Materials of MOEand College of Materials Science and EngineeringJilin UniversityChangchunChina Shandong Key Laboratory of Optical Communication Science and Technology School of Physical Science and Information Technology of Liaocheng UniversityLiaochengChina

The search of direct-gap Si-based semiconductors is of great interest due to the potential application in many technologically relevant *** work examines the incorporation of He as a possible route to form a direct band gap in *** predictions and first-principles calculations show that He and Si,at high pressure,form four dynamically stable phases of Si_(2)He(oP36-Si_(2)He,tP9-Si_(2)He,mC18-Si_(2)He,and mC12-Si_(2)He).All phases adopt host–guest structures consisting of a channel-like Si host framework filled with He guest *** Si frameworks in oP36-Si2He,tP9-Si2He,and mC12-Si_(2)He could be retained to ambient pressure after removal of He,forming three pure Si *** them,oP36-Si_(2)He and mC12-Si_(2)He exhibit direct band gaps of 1.24 and 1.34 eV,respectively,close to the optimal value(~1.3 eV)for solar cell *** shows that mC12-Si_(2)He with an electric dipole transition allowed band gap possesses higher absorption capacity than cubic diamond Si,which makes it to be a promising candidate material for thin-film solar cell.

关键词： allowed filled ambient

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An online maximum power point capturing technique for highefficiency power generation of solar photovoltaic systems

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Journal of Modern Power Systems and Clean Energy 2019年第2期7卷 357-368页

作者： lijun zhang Samson Shenglong YU Tyrone FERNANDO Herbert Ho-Ching IU Kit Po WONG Department of Electrical Electronic and Computer Engineering University of Western Australia

This paper proposes a novel high-efficiency generation technique for photovoltaic(PV) system,named maximum power point capturing(MPPC) technique. This is an aperiodic perturbation MPPC technique compared to the conventional periodic perturbation maximum power point tracking technique. Firstly, under a closed-loop circuit and an open-loop circuit,the complete I-V curves and P-V curves are defined. Secondly, the proposed MPPC technique is based on the complete I-V curves and a practical model of solar PV *** proposed method realizes that maximum power point(MPP) is captured online, and its control strategy is designed to set a steady operating area around MPP. The duty cycle keeps constant when the operating point is within the steady operating area, i.e., aperiodic perturbation, and when the operating point is outside the steady operating area, MPPC is triggered to capture a new MPP with an updated steady operating area. Simulation results demonstrate that no oscillations exist in steady-state;dynamic performances are improved;and only two perturbations are required to capture the new MPP. Using the proposed MPPC method,low voltage ride through and high voltage ride through can be prevented.

关键词： Photovoltaic systems Maximum power point tracking(MPPT) Maximum power point capturing(MPPC) Complete I–V curves

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Rare-Earth Metal Chlorides Catalyzed One-pot Syntheses of Quinolines under Solvent-free Microwave Irradiation Conditions

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Chinese Journal of Chemistry 2013年第4期31卷 465-471页

作者： lijun zhang Bing Wu Yongqing Zhou Jing Xia Shuangliu Zhou Shaowu Wang Laboratory of Functionalized Molecular Solids Ministry of Education Anhui Laboratory of Molecule-Based Materials Institute of Organic Chemistry College of Chemistry and Materials Science Anhui Normal University Wuhu Anhui 241000 China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Shanghai 200032 China

Under microwave irradiation and solvent-free conditions, rare-earth metal chlorides （RECl3） have been efficient catalysts for one-pot synthesis of quinoline derivatives to give products in good to excellent yields through the mul- ti-component reactions of aldehydes, amines, and alkynes. The rare-earth metal chlorides can be recycled for six times without notable loss of catalytic activities. This new synthetic approach has prominent features of a short re- action time, high yields of products, operational simplicity, broad substrate scopes, environmentally friendly prop- erty and commercially available catalysts. It extends the applications of rare-earth metal compounds as catalysts in organic synthesis.

关键词： rare earth quinoline multi-component reaction microwave irradiation recyclable

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First-principles investigation of structural and electronic properties of oxygen adsorbing phosphorene

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Progress in Natural Science:Materials International 2019年第3期29卷 316-321页

作者： Zhiqiang Wang Dianlong Zhao Shidong Yu Zikai Nie Yuwei Li lijun zhang Key Laboratory of Automobile Materials of MOE and School of Materials Science and Engineering Jilin University North China Institute of Aerospace Engineering

Two-dimensional （2D） phosphorene has been extensively studied for potential electronic and optoelectronic *** is easily oxidized by adsorbing oxygen in the air,exhibiting changed materials stability and *** the impact of oxygen concentrations on stability and electronic properties of oxygen adsorbing phosphorene has never been systematically *** this article,the oxygen adsorbing phosphorene at different oxygen concentrations are studied via first-principles crystal structure *** considered stoichiometries of P;O,P;O;) P;O and P;O;with both single-side and dual-side adsorption for selected case P;*** energetically stable structure of each stoichiometry is *** has been found that the band gaps show rather wide range change,strongly depending on the oxygen ***,at the higher oxygen concentration the relatively low band gaps and small carrier effective masses emerge,comparable with the pristine black *** may be associated with the appearance of bridged P-O-P bonds as oxygen concentration *** electronic properties are discussed in relation to structural features and chemical bonding.

关键词： Phosphorene Oxygen adsorption Electronic structures First-principles calculations

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The spatio-temporal variations of frost-free period in China from 1951 to 2012

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Journal of Geographical Sciences 2017年第1期27卷 23-42页

作者： NING Xiaoju LIU Gangjun zhang lijun QIN Xiaoyang ZHOU Shenghui QIN Yaochen College of Environment and Planning Key Laboratory of Geospatial Technology for Middle and Lower Yellow River RegionsHenan University College of Resources and Environment Henan Three New-Types Coordinated Development CenterHenan University of Economics and Law College of Science Engineering and HealthRMIT University124 LaTrobe Street Institute of Geography Henan Academy of Sciences

The frost-free period（FFP）first frost date（FFD） and last frost date（LFD） have been regard as the important climate variables for agricultural production. Understanding the spatio-temporal variations of the FFPFFD and LFD is beneficial to reduce the harmful impacts of climate change on agricultural production and enhance the agricultural adaptation. This study examined daily minimum temperatures for 823 national-level meteorological stationscalculated the values of FFDLFD and FFP for station-specific and region-specific from 1951 to 2012estimated the gradients of linear regression for station-specific moving averages of FFDLFD and FFPand assessed station-specific time series of FFP and detected the abrupt change. The results as follows： at both the station level and the regional levelthe FFP across China decreases with the increase of latitude from south to northand with the increase of altitude from east to west generally. At the station levelthe inter-annual fluctuations of FFDLFD and FFP in south and west agricultural regions are greater than those in north and east. At the regional levelexcluding the QT regiontemporal changes of FFP are relatively small in both the low-latitude and the high-latitude regionsbut for the mid-latitude regions. According to the linear trend gradients of the moving average values of station-specific FFDLFD and FFPFFD was delayedLFD advancedand FFP extended gradually over the 80% of China. Furthermorethe change magnitudes for FFDLFD and FFP in the north and east agricultural regions are higher than that in the southern and western. Among the 659 station-specific time series of FFP examined by the Mann-Kendall test341 stationslocated mainly in the north regionhave one identifiable and significant abrupt change. And at the 341 stations with identified abrupt changesmost（57%） abrupt changes occurred during 1991–2012followed by the periods of 1981–1990（28%）1971–1980（12%）and 1951–1970（3%）. The spatio-temporal variations of FFDLFD and FFP wou

关键词： frost-free period first frost date last frost date spatio-temporal variations agricultural region China

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