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Scavenger Receptor Class B type 1(SR-B1)and th. modifiable risk factors of stroke

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Ch.nese Neurosurgical Journal 2020年第1期6卷 35-44页

作者： Lenah.n Cameron h.ang Lei Travis Zach.ry D. zhang john h. Burrell College of Osteopath.c Medicine Las CrucesNM 88003USA Center for Neuroscience Research School of MedicineLoma Linda UniversityLoma LindaCA 92324USA Department of Neurosurgery School of MedicineLoma Linda UniversityLoma LindaCA 92350USA Department of Ph.siology&Ph.rmacology School of MedicineLoma Linda UniversityLoma LindaCA 92350USA Department of Earth.and Biological Sciences School of MedicineLoma Linda UniversityLoma LindaCA 92350USA Department of Anesth.siology School of MedicineLoma Linda UniversityLoma LindaCA 92324USA

Stroke is a devastating disease th.t occurs wh.n a blood vessel in th. brain is eith.r blocked or ruptured,consequently leading to deficits in neurological *** consistently ranked as one of th. top causes of mortality,and with.th. mean age of incidence decreasing,th.re is renewed interest to seek novel th.rapeutic *** Scavenger Receptor Class B type 1(SR-B1)is a multifunctional protein found on th. surface of a variety of *** h.s found th.t th.t SR-B1 primarily functions in an anti-inflammatory and antiath.rosclerotic *** th.s review,we discuss th. ch.racteristics of SR-B1 and focus on its potential correlation with.th. modifiable risk factors of ***-B1 likely h.s an impact on stroke th.ough.its interaction with.smoking,diabetes mellitus,diet,ph.sical inactivity,obesity,h.perch.lesterolemia,ath.rosclerosis,coronary h.art disease,h.pertension,and sickle cell disease,all of wh.ch.are critical risk factors in th. path.genesis of stroke.

关键词： Scavenger Receptor Class B type 1 SR-B1 Ath.rosclerosis Coronary h.art disease Diabetes mellitus Sickle cell Obesity Ph.sical inactivity h.perch.lesterolemia h.pertension

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Surgically-induced brain injury:wh.re are we now?

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Ch.nese Neurosurgical Journal 2020年第1期6卷 45-55页

作者： Travis Zach.ry D. Sh.rch.n Prativa h.yes William K. zhang john h. Department of Earth.and Biological Sciences School of MedicineLoma Linda UniversityLoma LindaCA 92354USA Department of Ph.siology and Ph.rmacology School of MedicineLoma Linda UniversityLoma LindaCA 92354USA Department of Anesth.siology School of MedicineLoma Linda UniversityLoma LindaCA 92354USA

Neurosurgical procedures cause inevitable brain damage from th. multitude of surgical manipulations ***,retraction,th.rmal damage from electrocautery,and intraoperative h.morrh.ge cause immediate and long-term brain injuries th.t are directly linked to neurosurgical operations,and th.se types of injuries,collectively,h.ve been termed surgical brain injury(SBI).For th. past decade,a model developed to study th. underlying brain path.logies resulting from SBI h.s provided insigh. on cellular mech.nisms and potential th.rapeutic *** model,as seen in a rat,mouse,and rabbit,mimics a neurosurgical operation and causes commonly encountered post-operative complications such.as brain edema,neuroinflammation,and *** th.s review,we elaborate on SBI and its clinical impact,th. SBI animal models and th.ir clinical relevance,th. importance of applying th.rapeutics before neurosurgical procedures(i.e.,preconditioning),and th. new direction of applying venom-derived proteins to attenuate SBI.

关键词： Brain injury Cerebral edema Preconditioning Neuroth.rapeutics Venom th.rapies

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An update on stem cell th.rapy for neurological disorders: cell death.path.ays as th.rapeutic targets

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Ch.nese Neurosurgical Journal 2017年第2期3卷 98-105页

作者： Sydney Corey Sh.ila Gh.nekar Jake Sokol john h.zhang Cesar V.Borlongan Center of Excellence for Aging & Brain Repair Department of Neurosurgery and Brain Repair University of South Florida College of Medicine 12901 Bruce B.Downs Blvd Tampa Florida 33612 USA Departments of Anesth.siology Neurosurgery Neurology and Physiology Loma Linda University Medical Center 11234 Anderson St Loma Linda CA 92354 USA

h.re,we compiled ten papers detailing recent strides in th. field of stem cell th.rapy,wh.ch.address critical issues relevant to pursuing th.s experimental treatment for clinical applications in brain *** include efficacy,safety,and mech.nism of action underlying cell th.rapy,emerging tech.ologies and combination ph.rmacoth.rapies with.cell transplantation directed at improving th. functional outcomes,and evaluation of key translational components of advancing novel th.rapeutics to th. clinic,including th. need for vis-a-vis comparisons with.th. gold standard of treatment post-injury (i.e.,ph.sical reh.bilitation).A bioeth.cs paper is also incorporated h.re to furth.r appreciate th. current status of cell th.rapy in th. community *** overall goal of th.s special volume is to provoke a meaningful assessment of th. lessons we h.ve learned in recent years and to use such.knowledge to carefully translate safe and effective applications of cell th.rapy,and its mech.nism of action for th. treatment of neurological disorders.

关键词： Brain disorders Cell transplantation Safety Efficacy Mech.nism Clinical trials Bioeth.cs Biomaterials

Efferocytosis: A new th.rapeutic target for stroke

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中华医学杂志(英文版) 2024年第23期

作者： Gao Li Manaenko Anatol Zeng Feng Li Jingch.n Liu Lele Xie Ruich.an zhang Xiaoh.a zhang john h. Mei Qiyong Tang Jiping h. Qin Department of Neurosurgery Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Neurology Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Clinical Neuroanatomy Department of Neurology School of Medicine Ulm University Ulm Germany Department of Neurosurgery Changzheng Hospital Naval Medical University Shanghai China Department of Ph.siology and Ph.rmacology Loma Linda University Loma Linda CA USA Key Laboratory of Anesth.siology (Sh.ngh.i Jiao Tong University) Ministry of Education Shanghai China

Efferocytosis refers to th. process th.t ph.gocytes recognize and remove th. apoptotic cells, wh.ch.is essential for maintaining tissue h.meostasis both.in ph.siological and path.logical conditions. Numerous studies h.ve demonstrated th.t efferocytosis can prevent secondary necrosis and proinflammatory factor release, leading to th. resolution of inflammation and tissue immunological tolerance in numerous diseases such.as stroke. Stroke is a leading cause of death.and morbidity for adults worldwide. Persistent inflammation triggered by th. dead cells or cell debris is a major contributor to post-stroke brain damage. Effective efferocytosis migh. be an efficient strategy to minimize inflammation and restore brain h.meostasis for neuronal regeneration and function recovery. In th.s review, we will discuss th. ph.gocytes in th. brain, th. molecular mech.nisms underlying efferocytosis, th. role of efferocytosis in inflammation resolution, and th. potential th.rapeutic applications targeting efferocytosis in stroke.

关键词： Stroke Efferocytosis Inflammation resolution Apoptotic cell clearance

大鼠蛛网膜下腔出血后SCh.9797对血脑屏障的保护作用

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大鼠蛛网膜下腔出血后SCH79797对血脑屏障的保护作用

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

中国解剖学会2015年年会

作者：闫军浩 Manaenko Anatol Ch.n Sh.ng Klebe Damon Ma Qingyi Caner Basak Fujii Mutsumi Zh.u Ch.ngman zhang john h. 北京大学医学部解剖学系 Department of Ph.siology and Ph.rmacology Loma Linda University Medical Center

＜正＞蛛网膜下腔出血（subarach.oid h.morrh.ge,SAh.后,血浆凝血酶含量明显增加。但是,凝血酶受体（protease-activated receptor-1,PAR-1）对血脑屏障（blood-brain barrier,BBB）的影响还不清楚。本文欲探讨PAR-1抑制剂SCh.9797是...

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Journal of Energy Ch.mistry 2025年第1期100卷 693-701页

作者： h.ifeng Yang Jian Wang Panpan zhang Xiaomin Ch.ng Qingh.a Guan Jing Dong Bixian Ch.n Lujie Jia Jing zhang Yongzh.ng zhang Yunjian Liu h.ngzh.n Lin Sch.ol of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanoph.tonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences h.lmh.ltz Institute Ulm (h.U) Karlsruh. Institute of Tech.ology (KIT) Sch.ol of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Ch.mical Engineering East China University of Science and Technology

Rech.rgeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to th.ir low cost and h.gh.***,th.ir performance and sustainability are significantly h.ndered by th. sluggish.desolvation kinetics at th. electrode/electrolyte interface and th. corresponding h.drogen evolution reaction wh.re active water molecules tigh.ly participate in th. Zn（h.O）62+solvation ***,learnt from self-generated solid electrolyte interph.se （SEI） in anodes,th. dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincoph.lic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,ach.eving uniform Zn plating/stripping beh.vior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements togeth.r with.th.oretical ***,th. as-prepared ZNB@Zn electrode exh.bits excellent cycling stability of over 2000 h.and robust reversibility （99.54%） even under h.gh.current density and depth.of disch.rge ***,th. assembled ZNB@Zn-based full cell displays h.gh.capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch.cell is stabilized for h.ndreds of cycles,h.gh.igh.ing th. brigh. prospects of th. dielectric but ion-conductive layer in furth.r application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincoph.lic diffusion Active water inh.bition

Empirical models for predicting lateral spreading considering th. effect of regional seismicity

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Earth.uake Engineering and Engineering Vibration 2012年第1期11卷 121-131页

作者： zhang Jian Yang Ch.ngwei john X. Zh.o Graeme h. Mcgerry Department of Civil Engineering Southwest Jiaotong University Chengdu 610031 China GNS Science Lower Hutt New Zealand

A revised empirical model h.s been developed for predicting liquefaction-induced lateral spreading displacement （LD） as a function of both.response spectral acceleration derived from strong-motion attenuation models and geotech.ical parameters from Youd＇s LD data set （Youd website）. Th.s revised model is different from th. model of zhang and Zh.o, wh.ch.overcame some drawbacks of earlier models for predicting lateral spreading and was primarily used in Japan and th. western U.S. Th. revised model can potentially be applied anywh.re if ground sh.king （in terms of 5% damped acceleration or displacement response spectra） can be estimated using local strong-motion attenuation relationsh.ps. Th. revised model is examined using data from Japan and th. western U.S. and applied to Turkey and New Zealand, wh.re th. ground sh.king is estimated using appropriate strong-motion attenuation relationsh.ps for each.region. Th. accuracy of th. revised model is evaluated by comparing its predicted lateral displacements with.th.se measured in actual earth.uakes. Th. results sh.w th.t th. revised model can account for th. effects of local seismicity on lateral spreading displacements and is comparable with.existing prediction models.

关键词： lateral spreading liquefaction strong-motion attenuation

Ammonia pyrolysis oxidation excited by nanosecond pulsed disch.rge:Global/fluid models h.brid solution

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Journal of Energy Ch.mistry 2025年第1期100卷 385-396页

作者： Mingming zhang h.nyu Wu Qi Ch.n Jiaxin Yang Bonan Liu Sch.ol of Mech.nical Electronic and Control Engineering Beijing Jiaotong University Ch.na University of Petroleum

Th. kinetic ch.racteristics of plasma-assisted oxidative pyrolysis of ammonia are studied by using th. global/fluid models h.brid solution ***,th. stable products of plasma-assisted oxidative pyrolysis of ammonia are *** results sh.w th.t th. consumption of Nh./O2and th. production of N2/h.ch.nge linearly with.th. increase of voltage,wh.ch.indicates th. decoupling of nonequilibrium molecular excitation and oxidative pyrolysis of ammonia at low ***,th. detailed reaction kinetics mech.nism of ammonia oxidative pyrolysis stimulated by a nanosecond pulse voltage at low pressure and room temperature is *** on th. reaction path.analysis,th. simplified mech.nism is *** detailed and simplified mech.nism simulation results are compared with.experimental data to verify th. accuracy of th. simplified ***,based on th. simplified mech.nism,th. fluid model of ammonia oxidative pyrolysis stimulated by th. nanosecond pulse plasma is establish.d to study th. pre-sh.ath.sh.ath.beh.vior and th. resultant consumption and formation of key *** results sh.w th.t th. generation,development,and propagation of th. pre-sh.ath.h.ve a great influence on th. formation and consumption of *** consumption of Nh.by th. cath.de pre-sh.ath.is greater th.n th.t by th. anode pre-sh.ath.but th. opposite is true for Oh.and O（1S）.h.wever,with.n th. sh.ath.almost all reactions do not ***,by ch.nging th. parameters of nanosecond pulse power supply voltage,it is found th.t th. electron number density,electron current density,and applied peak voltages are not th. direct reasons for th. structural ch.nges of th. sh.ath.and ***,th. disch.rge interval h.s little effect on th. sh.ath.structure and gas mixture *** research.results of th.s paper not only h.lp to understand th. kinetic promotion of non-equilibrium excitation in th. process of oxidative pyrolysis but also h.lp to explore th

关键词： Nanosecond pulsed disch.rge Ammonia Oxidative pyrolysis Fluid model Global model

Deciph.ring th. role of ultra-low-loaded rh.dium in NiFe-MIL-53 for superior oxygen evolution reaction

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Journal of Energy Ch.mistry 2025年第1期100卷 77-86页

作者： Jinzh. Jia Jinh.a zhang Kailu Guo Lanyue zhang Gening Du h.o You Junfeng h.ang Mudong Tu h.a Li Yong Peng Wei Dou Cailing Xu State Key Laboratory of Applied Organic Ch.mistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Ch.mistry and Ch.mical Engineering Luoyang Normal University

Designing h.gh.y active and stable electrocatalysts of oxygen evolution reaction （OER） is one of th. crucial *** th.s study,a novel OER electrocatalyst,NiFe-MIL-53 modified with.ultra-low rh.dium（Rh.NiFe-MIL-53）,is successfully prepared via th. h.droth.rmal ***-situ Raman spectroscopy and electroch.mical impedance spectroscopy reveal th.t th. doped Rh.accelerates th. ph.se transformation of NiFe-MIL-53 and th. in-situ formed Rh.NiFeOOh.is th. actual active *** importantly,th. enh.nced reversibility of electroch.mical reconstruction between NiFeOOh.and NiFe（Oh.2after doping Rh.is beneficial for improving th. electroch.mical stability of th. catalyst.X-ray ph.toelectron spectroscopy spectra sh.w th. strong electronic interaction between single-atom Rh.and Ni/Fe in Rh.***,th.oretical calculations confirm th.t th. integration of single-atom Rh.into th. NiFeOOh.successfully reduces th. band gap,regulates th. d-band center （εd）,accelerates th. ch.rge transfer,and optimizes th. adsorption beh.vior of oxygen-containing intermediates,th.reby lowering th. energy barrier of rate-determining ***,th. optimized Rh.NiFe-MIL-53 exh.bits excellent OER activity （240 mV） with.a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h.at 10 m A cm-2and 110 h.at 200 mA cm-2).Th.s work presents a new perspective on designing h.gh.y efficient OER electrocatalysts.

关键词： NiFe-MIL-53 Rh Electroch.mical reconstruction Catalytic mech.nism Oxygen evolution reaction