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A supramolecular nanoprodrug for prevention of gallstone formation

Chinese Chemical Letters 2025年第2期36卷 354-359页

作者： Xiangjun zhang Xiaodi Yang Yan Wang Zhongping Xu Sisi Yi tao Guo Yue Liao Xiyu Tang Jianxiang zhang Ruibing Wang College of Pharmacy Chongqing Medical University Chongqing University Fuling Hospital Department of Pharmaceutics College of PharmacyThird Military Medical University (Army Medical University) Yu-Yue Pathology Scientific Research Center State Key Laboratory of Trauma and Chemical Poisoning Third Military Medical University (Army Medical University) State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of Macau

Cholelithiasis affects approximately 10%-20% of the adult population globally. And cholesterol accumulation and nucleation of cholesterol crystals are commonly recognized as the primary process in the initiation and progression of gallstones. Hydroxypropyl-β-cyclodextrin(HPCD) is a supramolecular host compound that can solubilize cholesterol, potentially serving as a preventative or therapeutic agent for cholelithiasis. However, we found that the administration of HPCD treatment did not impede the formation of gallstones in mice, mainly attributed to the pre-complexation of its cavity during the transition process. Here we synthesized a prodrug of HPCD and prepared a HPCD nanoparticle(HPCD-NP), which can be transported efficiently to the gallbladder through the hepatobiliary system following an intravenous injection. In the bile, the HPCD-NP degraded into free HPCD, bound to cholesterol crystals and gallstones within the gallbladder and effectively increased cholesterol solubilization, leading to gallstones regression. Given the established safety of both HPCD and cyclodextrin-based nanoparticles in numerous animal and human studies, HPCD-NP shows considerable promise for the prevention and treatment of human cholelithiasis.

关键词： Gallstone Hepatobiliary transport Host-guest interaction Hydroxypropyl-β-cyclodextrin Solubilization

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Effect of pouring time on microstructure and mechanical properties of centrifugal cast Ti-46Al alloy tubes

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China Foundry 2025年第1期22卷 65-74页

作者： Gang Huang Qian Dang Cong-cong Su jing Zhao Chi zhang Guo-huai Liu Zhao-dong Wang The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

The grain size of TiAl alloy castings prepared by traditional casting process is coarse,thus showing poor mechanical *** this study,a new type of high performance Ti-46Al alloy tube prepared by vacuum centrifugal casting technology was *** research comprehensively examined the influence of pouring time on the microstructure and mechanical performance of the castings,employing both experimental approaches and ProCast simulation *** findings indicate that prolonging the pouring time facilitates a microstructural evolution from coarse columnar grains to refined equiaxed *** the condition of pouring temperature of 1,600℃,rotation speed of 800 r·min^(-1) and pouring time of 6 s,the tensile strength of Ti-46Al alloy at room temperature reaches 650 MPa,and the tensile strength at 800℃ reaches 705 MPa,which is significantly higher than that of traditional as-cast Ti-Al alloy.

关键词： vacuum induction melting centrifugal casting Ti-46Al alloy pouring time Ti-Al alloy tubes

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用ImageWare实现缺损点云的曲面重构

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农机化研究 2005年第5期27卷 90-92页

作者：张景涛卢章平江苏大学图形技术研究所江苏镇江212013

针对有缺损的点云数据,提出了在逆行工程软件ImageWare平台下进行曲面重构的途径;介绍了运用逆向工程技术进行CAD模型设计的操作流程;用平行面截取点云数据,拟合出曲线线条;通过对曲线条的桥接,利用完整的曲线条重构出曲面。

关键词：工业技术逆向工程理论研究缺损点云数据分割曲面重构

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Semiconductor clusters enable high-efficiency extraction of hot electrons from gold nanorods for photocatalytic organic conversions

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Science China Chemistry 2025年

作者： Jia-Xing Liu Hao Ma Shang-Fu Yuan jing-Ni zhang jing-Guan Liang Rui Zhou Dong-Sheng Li Wen-Bin Chen Ming-De Li tao Wu State Key Laboratory of Bioactive Molecules and Druggability Assessment Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University Department of Developmental and Regenerative Biology Jinan University College of Materials and Chemical Engineering Hubei Provincial Collaborative Innovation Center for New Energy Microgrid Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University College of Chemistry and Chemical Engineering Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou University

Plasmon-induced hot energy in metal nanostructures holds great promise for photocatalytic organic conversions. However,maintaining the high-energy state of hot electrons within these structures remains challenging, even in hybrid metal-semiconductor heterojunctions. The rapid relaxation of hot electrons（ 2 ns） high-energy states. As a proof of concept, the composite photocatalyst achieves near-infrared-lightdriven C（sp3）–S cross-coupling reactions for the first time. This protocol effectively produces over 50 alkylthioethers from a wide scope range of non-active alkyl bromides and chlorides, aryl and alkyl thiols. This work provides a new strategy for highefficiency extraction of hot electrons within plasmonic metal nanostructures and paves the way for hot electron-driven photocatalytic organic transformations.

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Construction of 3D porous Cu_(1.81)S/nitrogen-doped carbon frameworks for ultrafast and long-cycle life sodium-ion storage

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 191-200页

作者： Chen Chen Hongyu Xue Qilin Hu Mengfan Wang Pan Shang Ziyan Liu tao Peng Deyang zhang Yongsong Luo Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific ***,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs ***,the three-dimensional porous Cu_(1.81)S/nitrogen-doped carbon frameworks(Cu_(1.81)S/NC)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of Cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for ***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 *** work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.

关键词： copper sulfide nanoparticles porous carbon framework fast charging long-cycle performance sodium-ion full batteries

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The association of isocarbophos and isofenphos with different types of glucose metabolism:The role of inflammatory cells

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Journal of Environmental Sciences 2025年第1期147卷 322-331页

作者： Jintian Geng Dandan Wei Lulu Wang Qingqing Xu Juan Wang Jiayu Shi Cuicui Ma Mengzhen Zhao Wenqian Huo tao jing Chongjian Wang Zhenxing Mao Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhou 450001China Department of Occupational and Environmental Health Sciences College of Public HealthZhengzhou UniversityZhengzhou 450001China School of Public Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

To investigate the associations between isocarbophos and isofenphos with impaired fasting glucose(IFG)and type 2 diabetes mellitus(T2DM),and to assess the mediation roles of inflammation *** were 2701 participants in the case-control study,including 896 patients with T2DM,900 patients with IFG,905 subjects with *** isocarbophos and isofenphos concentrationsweremeasured using gas chromatography and triple quadrupole tandem mass *** linear models were used to calculate the relationships between plasma isofenphos and isocarbophos levels with inflammatory factor levels and *** cell was used as mediators to estimate the mediating effects on the above *** and isofenphos were positively related with T2DM after adjusting for other *** odds ratio(95%confidence interval)(OR(95%CI))for T2DM was 1.041(1.015,1.068)and for IFG was 1.066(1.009,1.127)per unit rise in *** prevalence of T2DM increased by 6.4%for every 1 unit more of ln-isofenphos(OR(95%CI):1.064(1.041,1.087)).Additionally,a 100%rise in ln-isocarbophos was linked to 3.3%higher ln-HOMA2IR and a 0.029 mmol/L higher glycosylated hemoglobin(HbA1c)(95%CI:0.007,0.051).While a 100%rise in ln-isofenphos was linked to increase in ln-HOMA2 and ln-HOMA2IR of 5.8%and 3.4%,***,white blood cell(WBC)and neutrophilic(NE)were found to be mediators in the relationship between isocarbophos and T2DM,and the corresponding proportions were 17.12%and 17.67%,*** and isocarbophos are associated with IFG and T2DM in the rural Chinese population,WBC and NE have a significant role in this relationship.

关键词： Isocarbophos Isofenphos Type 2 diabetes mellitus Inflammatory cells Mediation effect

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High-pressure Granulite-facies Metamorphism and Anatexis in Continental Collision Orogen:Evidence from the Mafic Granulite and Leucosomes in South Altun,Northwestern Qinghai-Tibet Plateau

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Acta Geologica Sinica(English Edition) 2025年第1期99卷 53-68页

作者： GUO jing LI Yunshuai zhang Jianxin School of Management Tianjin University of CommerceTianjin 300134China School of Earth System Science Institute of Surface-Earth System ScienceTianjin UniversityTianjin 300072China Key Laboratory of Continental Dynamics of Ministry of Natural Resources Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China

Deciphering high-pressure granulite-facies metamorphism and anatexis within a collisional orogeny can provide crucial constraints on geodynamic evolution and melt activity during subduction and *** petrographic observations,mineral chemistry,REE in Grt-Cpx thermobarometry,and previous work,at least four stages are suggested for the metamorphic evolution of the mafic granulites in the South Altun,including the protolith stage,the high-pressure granulite-facies stage(909-1037℃ and 17.3-30 kbar),medium-pressure granulite-facies overprint(9.1-11.9 kbar and 753-816℃),and subsequent late amphibolite-greenschist-facies *** U-Pb dating shows that the mafic granulites underwent high-pressure granulite-facies metamorphism at 497.2±3.7 Ma,while the leucosome formed at 498.2±2.9 ***,the leucosomes from the host mafic granulite may have been formed at the high-pressure granulite-facies metamorphic *** characteristics of zircon morphology,mineral inclusions,low Th/U values,HREE enrichment,and negative Eu anomalies indicate that these zircons from the leucosome were formed from the metamorphic *** characteristics of whole-rock major and trace elements as well as Hf isotopic features of zircons between the leucosomes and the host mafic granulite indicate that the melt may have been generated by the partial melting of the host mafic granulite.

关键词： anatexis zircon U-Pb dating HP mafic granulite leucosome South Altun

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开放大学系统推动有效在线教学的探索与研究

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成人教育 2022年第10期42卷 54-62页

作者：白晓晶张惊涛祁颖北京开放大学北京100081

随着在线教学的广泛探索以及技术与在线教学的深度融合,主要依托在线课程来落实教学过程的方式不足以支撑有效教学的开展,教师的教学作用亟待发挥,以切实提升学生的学习成效。为了进一步探索教师在在线教学中所应发挥的作用以及如何保... 详细信息

随着在线教学的广泛探索以及技术与在线教学的深度融合,主要依托在线课程来落实教学过程的方式不足以支撑有效教学的开展,教师的教学作用亟待发挥,以切实提升学生的学习成效。为了进一步探索教师在在线教学中所应发挥的作用以及如何保障教师作用的发挥,通过立足一所省级开放大学及其系统教学单位上万名学生开展了三个学期“系统一堂课”的在线教学改革,结合听评课、学生满意度调研、师生行为数据分析等方法,形成了借助开放大学系统力量推动有效在线教学的举措,基于明确课程、甄选师资、指导行为、组织保障、机制创新等要素构建了推动有效在线教学的实践探索框架,并就教学行为规范、优质师资共享、组织作用发挥、集体认知形成等内容进行了讨论,希望为开放大学系统提升在线教学质量提供参考。

关键词：有效教学在线教学开放大学优质师资教学行为

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Unraveling the complex interactions between plasmonic Ag nanoparticles and biomolecules for enhancing molecular chirality

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Science China Chemistry 2025年第2期68卷 543-551页

作者： Chen Wang Yunlong tao Qingqing Cheng Dandan Lu Chuang Liu Guizeng Yang Xuehao Sun Lichao Sun Qingfeng zhang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power SourcesWuhan UniversityWuhan 430072China Suzhou Institute of Wuhan University Suzhou 215123China

Plasmonic nanostructures have been widely employed to enhance the chiral light-matter interactions for chirality sensing owing to their intriguing optical ***,a quantitative understanding of the correlation between enhanced molecular chirality and plasmonic properties in plasmonic nanoparticle-molecule complexes remains a challenge yet to be *** we demonstrate the complex interactions between Ag nanoparticles and biomolecules that generate distinct plasmonic circular dichroism signals ranging from UV to visible *** deliberately changing the surface coverage of chiral molecules,the geometry of Ag nanoparticles,and the aggregation states of the complexes,three distinct underlying mechanisms were found to be intertwined and hybridized for enhancing circular dichroism *** further employed the chiral plasmonic nanoparticle-molecule complexes to quantify the enantiomeric purity of cysteine and explore their possible applications in other chiral *** insights gained from this work shed light on the underlying mechanisms dictating the enhanced circular dichroism signals of chiral plasmonic nanoparticle-molecule complexes.

关键词： chiral plasmonics plasmonic circular dichroism nanoparticle-molecule complexes Ag nanoparticles chirality sensing

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Rapid detection of colored and colorless macroand micro-plastics in complex environment via near-infrared spectroscopy and machine learning

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Journal of Environmental Sciences 2025年第1期147卷 512-522页

作者： Hui-Huang Zou Pin-jing He Wei Peng Dong-Ying Lan Hao-Yang Xian Fan Lü Hua zhang Institute of Waste Treatment&Reclamation College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

To better understand the migration behavior of plastic fragments in the environment,development of rapid non-destructive methods for in-situ identification and characterization of plastic fragments is ***,most of the studies had focused only on colored plastic fragments,ignoring colorless plastic fragments and the effects of different environmental media(backgrounds),thus underestimating their *** address this issue,the present study used near-infrared spectroscopy to compare the identification of colored and colorless plastic fragments based on partial least squares-discriminant analysis(PLS-DA),extreme gradient boost,support vector machine and random forest *** effects of polymer color,type,thickness,and background on the plastic fragments classification were ***-DA presented the best and most stable outcome,with higher robustness and lower misclassification *** models frequently misinterpreted colorless plastic fragments and its background when the fragment thickness was less than 0.1mm.A two-stage modeling method,which first distinguishes the plastic types and then identifies colorless plastic fragments that had been misclassified as background,was *** method presented an accuracy higher than 99%in different *** summary,this study developed a novel method for rapid and synchronous identification of colored and colorless plastic fragments under complex environmental backgrounds.

关键词： Colorless microplastics Near-infrared hyperspectral imaging Plastic identification Partial least squares discriminant analysis Machine learning

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