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Particle size spatial distribution in landslide dams

Journal of Mountain Science 2024年第6期21卷 1886-1903页

作者： zhang Jingyi zhang jianmin State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610064China

The particle composition and spatial distribution of landslide-induced dam bodies are critical geotechnical parameters for studying the hazards of dam-break ***,current research often neglects the influence of the initial particle composition and spatial distribution of the landslide on the particle composition and spatial distribution of the landslide *** study investigated the impact of initial particle size distribution,volume,and sliding length on the energy and velocity changes of characteristic particles during the sliding process and the spatial distribution of particle sizes in the landslide dam *** simulations and physical models were employed to examine the effects of sequential gradient arrangements(where particle sizes decrease from top to bottom)and four other different initial particle arrangements on the energy and velocity changes of particles and the spatial distribution of particle sizes in the dam *** study reveals the characteristics of translational and rotational energy of different particles and the laws of mechanical energy conversion,obtaining the spatial distribution patterns of particle sizes in landslide-induced *** results show that under the sequential gradient arrangement,the energy dissipation of the landslide movement is lower,with larger particles mainly distributed at the distal end and smaller particles at the proximal end of the landslide *** contrast,under the reverse gradient arrangement,the energy dissipation of the landslide movement is higher,and the distribution pattern of the dam particles is opposite to that of the sequential gradient *** the other arrangement modes,the spatial distribution of dam particles falls between the aforementioned *** is a positive correlation between particle size and translational kinetic energy within the particle flow during the landslide process,and rotational motion increases energy *** constant slope conditions,sliding

关键词： Particle size distribution Landslide Numerical simulation Discrete element method

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Effect of Vacancy Defects on the Properties of CoS_(2) and FeS_(2)

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 627-638页

作者：冯中营 zhang jianmin WANG Xiaowei YANG Wenjin JING Yinlan YANG Yan Department of Science Taiyuan Institute of TechnologyTaiyuan 030008China Computational Physics Research Center Taiyuan In-stitute of TechnologyTaiyuan 030008China College of Physics and Information Technology Shaanxi Normal UniversityXi’an 710119China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Department of Physics College of ScienceNorth University of ChinaTaiyuan 030051China

In order to explore the effect of vacancy defects on the structural,electronic,magnetic and optical properties of CoS_(2) and FeS_(2),first-principles calculation method was used to investigate the *** calculated results of materials without vacancy are consistent with those reported in the literatures,while the results of materials with vacancy defect were different from those of literatures due to the difference vacancy *** Co vacancy defect hardly changes the half-metallic characteristic of CoS_(2).The Fe vacancy defect changes FeS_(2) from semiconductor to half-metal,and the bottom of the spin-down conduction band changes from the p orbital state of S to the d(t_(2g))orbital state of Fe,while the top of the valence band remains the d orbital d(eg)state of *** half-metallic Co vacancy defects of CoS_(2) and Fe vacancy defects of FeS_(2) are expected to be used in spintronic devices.S vacancy defects make both CoS_(2) and FeS_(2) *** the Co and S vacancy defects lead to the decrease of the magnetic moment of CoS_(2),while both the Fe and S vacancy defects lead to the obvious magnetic property of FeS_(2).Vacancy defects enhance the absorption coefficient of infrared band and long band of visible light obviously,and produce obvious red shift phenomenon,which is expected to be used in photoelectric devices.

关键词： cobalt disulfide iron disulfide vacancy defect fist principles

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γδT cells:Major advances in basic and clinical research in tumor immunotherapy

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Chinese Medical Journal 2024年第1期137卷 21-33页

作者： Yueqi Zhao Peng Dong Wei He jianmin zhang Hui Chen Department of Immunology CAMS Key Laboratory for T Cell and ImmunotherapyState Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeBeijing 100005China Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy ChangzhouJiangsu 213000China Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China

γδT cells are a kind of innate immune T *** have not attracted sufficient attention because they account for only a small proportion of all immune cells,and many basic factors related to these cells remain ***,in recent years,with the rapid development of tumor immunotherapy,γδT cells have attracted increasing attention because of their ability to exert cytotoxic effects on most tumor cells without major histocompatibility complex(MHC)*** increasing number of basic studies have focused on the development,antigen recognition,activation,and antitumor immune response ofγδT ***,γδT cell-based immunotherapeutic strategies are being developed,and the number of clinical trials investigating such strategies is *** review mainly summarizes the progress of basic research and the clinical application ofγδT cells in tumor immunotherapy to provide a theoretical basis for further the development ofγδT cell-based strategies in the future.

关键词： Gamma-delta T-cells T cell receptor CD1a Tumor immunotherapy Receptors,chimeric antigen Vδ1 cells αβT cells

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Recent landscape and trends for industry-sponsored pediatric clinical trials in China from 2013 to 2022

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Pediatric Investigation 2024年第1期8卷 12-20页

作者： Chang Liu Yi Liu Ling Ou Yuenan Qi jianmin zhang Drug Clinical Trial Institution Children’s HospitalCapital Institute of PediatricsBeijingChina

Importance:Pediatric medication is a challenging issue *** trials of medications for children and implementing measures to encourage innovation for addressing unmet medical and health needs are ***:To explore the recent landscape of pediatric clinical trials of new investigational drugs conducted by pharmaceutical enterprises in China from 2013 to 2022 to provide insight into pediatric drug development in the pharmaceutical industry and regulatory policy ***:We performed a cross-sectional observational investigation of pediatric clinical trials registered from January 1,2013,to December 31,2022,on the Registration and Information Disclosure Platform for Drug Clinical Trials,the official registration platform established in 2013 for trials of new investigational drugs initiated by biopharmaceutical *** that included pediatric participants(under 18 years old)were retrieved,and their relevant characteristics were extracted and ***:In total,895 pediatric clinical trials were collected,accounting for 5.1%of the total registered clinical trials initiated prior to January 1,*** overall average annual growth rate for the number of pediatric clinical trials was 12%(P<0.001).Phase III trials accounted for the highest proportion(49.1%,439).Of the 895 trials included,736(82.2%)were domestic trials,and 159(17.8%)were international multicenter *** terms of tested drugs,investigations of biological products accounted for the largest proportion of trials(67.4%,603).Among pediatric clinical trials,studies of vaccines accounted for the largest proportion of trials(41.0%,367),followed by trials for rare diseases(17.2%,154).Furthermore,geographical distribution analysis revealed that the largest and smallest numbers of trials were conducted in North China(35.7%,320)and Northeast China(0.8%,7),***:The growth trends for industry-sponsored clinical trials involving children illust

关键词： Geographic distribution Pediatric clinical trials Pediatric medication Rare disease

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TSPO deficiency exacerbates acute lung injury via NLRP3 inflammasome-mediated pyroptosis

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Chinese Medical Journal 2024年第13期137卷 1592-1602页

作者： Jingyi Han Xue zhang Menghua Cai Feng Tian Yi Xu Hui Chen Wei He jianmin zhang Hui Tian Department of Thoracic Surgery Qilu Hospital of Shandong UniversityJinanShandong 250012China CAMS Key Laboratory of T Cell and Immunotherapy Department of ImmunologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeState Key Laboratory of Medical Molecular BiologyBeijing 100005China Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy ChangzhouJiangsu 213000China Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China

Background:Acute respiratory distress syndrome(ARDS)is a common cause of respiratory failure in many critically ill *** inflammasome activation plays an important role in the induction of acute lung injury(ALI)and ARDS,the regulatory mechanism of this process is still *** cells are stimulated by inflammation,the integrity and physiological function of mitochondria play a crucial part in ***,the underlying mechanisms and function of mitochondrial proteins in the process of pyroptosis are largely not yet ***,we identified the 18-kDa translocator protein(TSPO),a mitochondrial outer membrane protein,as an important mediator regulating nucleotide-binding domain,leucine-rich repeat,and pyrin domain-containing protein 3(NLRP3)inflammasome activation in macrophages during ***:TSPO gene knockout(KO)and lipopolysaccharide(LPS)-induced ALI/ARDS mouse models were employed to investigate the biological role of TSPO in the pathogenesis of *** macrophages were used to further characterize the effect of TSPO on the NLRP3 inflammasome *** of NLRP3 inflammasome was preformed through LPS+adenosine triphosphate(ATP)co-stimulation,followed by detection of mitochondrial membrane potential,reactive oxygen species(ROS)production,and cell death to evaluate the potential biological function of *** between two groups were performed with a two-sided unpaired ***:TSPO-KO mice exhibited more severe pulmonary inflammation in response to LPS-induced *** deficiency resulted in enhanced activation of the NLRP3 inflammasome pathway,promoting more proinflammatory cytokine production of macrophages in LPS-injured lung tissue,including interleukin(IL)-1β,IL-18,and macrophage inflammatory protein(MIP)-*** in TSPO-KO macrophages tended to depolarize in response to cellular *** increased production of mitochondrial damage-associated molecular pattern led to enhanced mitochondrial membr

关键词： Acute respiratory distress syndrome Acute lung injury 18-kDa translocator protein Macrophage NLRP3 inflammasome Inflammation

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Analysis Method and Application of Multiple Antiquities Sources in the Shahejie Formation of the Paleogene in the Southern Bohai Sea

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Open Journal of Applied Sciences 2024年第4期14卷 1070-1079页

作者： jianmin zhang Honglin Yue Xijie Wang Bohai Oilfield Research Institute Tianjin Branch of CNOOC Ltd. Tianjin China

B Oilfield is the most representative mid to deep oil field in the Bohai Sea, with the main oil bearing intervals being the upper and middle Shahejie-3 sections of the Paleogene Shahejie Formation. Through the development of ancient landforms, characterization of material source channels, analysis of missing heavy mineral sources, and seismic reflection characteristics of multiple material source missing, the material sources of the middle and upper Shahejie-3 sections are analyzed. During the sedimentation period of the II oil formation in the middle section of the Shasan Formation, the study area was mainly dominated by the Kendong Uplift source rocks;During the sedimentation period of the I oil formation in the middle section of the Shasan Formation, there were three material sources in the study area, namely the Kendong Uplift, the Laibei Low Uplift, and the Weibei Uplift. The Kendong Uplift was the main material source, followed by the Laibei Low Uplift;During the sedimentation period of the Upper Shasan Formation, the study area still had three sources of material supply simultaneously. At this time, the Laibei Low Uplift was the main source area, while the Kendong Uplift and Weibei Uplift had a relatively small supply capacity for the study area. In the analysis of archaeological sources, the distribution characteristics of the sedimentary system in the third section of the Shahejie Formation have been clarified, providing a research basis for the later development and adjustment of the oilfield.

关键词： Paleogeomorphology Characterization of Source Channels Tracing of Heavy Minerals Seismic Reflection Characteristics Sedimentary Systems

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Method and Description of Sedimentary System Characterization Based on Sequence Stratigraphy

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Journal of Geoscience and Environment Protection 2024年第5期12卷 60-68页

作者： jianmin zhang Hui Cai Honglin Yue Pengfei Mu Bohai Oilfield Research Institute Tianjin Branch of CNOOC Ltd. Tianjin China

A Oilfield is the most representative mid to deep oil field in the Bohai Sea, with the main oil bearing intervals being the upper and middle Shahejie-3 sections of the Paleogene Shahejie Formation. By combining well seismic analysis, the middle section of Shahejie-3 is divided into high-level system tract and forced lake retreat system tract, corresponding to the II oil formation and I oil formation, respectively. Using sequence stratigraphy methods, based on seismic profiles and drilling lithological cycles, the high stand system tract is divided into 5 stages of delta progradation. The first and second stages are high angle S-type progradation with large sedimentary thickness, the third stage is oblique progradation, and the fourth and fifth stages are S-oblique composite progradation;By combining seismic data, we characterized the large-scale (8 small-scale) progradation bodies of 5 periods, clarified the distribution characteristics of reservoir planes, and laid the foundation for the later exploration of oilfield potential.

关键词： Middle Section of Shasan Sequence Stratigraphy Sedimentary System Characterization

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Study on the Fine Configuration of Reservoir in River Facies Oilfield in Bohai Sea Area

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Open Journal of Applied Sciences 2024年第2期14卷 391-397页

作者： jianmin zhang Xijie Wang Pengfei Mu Shicong Lyu Jun Xie Bohai Oilfield Research Institute Tianjin Branch of CNOOC Ltd. Tianjin China

The geological conditions of offshore shallow water delta oil reservoirs were complex, with limited well data and large well spacing. Taking A Oilfield in the Bohai Sea Area, China as an example, the target sand body was formed in a shallow water delta sedimentary environment, with well-developed underwater distributary channels and frequent branching and diversion. The reservoir was strong non-uniformity and uneven plane water cut pressure. To this end, based on the existing work of predecessors, combined with seismic, logging, and production dynamics data, and based on the genesis mechanism of shallow water delta reservoirs, the boundary of composite river channels was identified through seismic facies, and logging facies were used to subdivide them into single river levels within the composite river channels. Then, seismic waveform characteristics were applied to track and characterize the plane distribution of single river channels, guiding the efficient development of offshore shallow water delta oil fields and achieving increased storage and production in Bohai Oilfield, China.

关键词： Shallow Water Delta Reservoir Configuration Seismic Facies Single Channel Dominant Channel

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拖拉机平视显示研究与分析--基于DeeplabV3+和眼动追踪技术

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农机化研究 2024年第6期46卷 240-247页

作者：邴媛张建敏贵州大学机械工程学院贵阳550025

为了提高拖拉机驾驶人员的驾驶安全系数,解决拖拉机驾驶人员经常扭头观看后方农机机具作业情况的问题,对拖拉机驾驶室使用平视显示(HUD)进行研究分析。首先,利用Deeplabv3+图像语义分割法与眼动追踪技术结合的方式,对拖拉机驾驶人员观... 详细信息

为了提高拖拉机驾驶人员的驾驶安全系数,解决拖拉机驾驶人员经常扭头观看后方农机机具作业情况的问题,对拖拉机驾驶室使用平视显示(HUD)进行研究分析。首先,利用Deeplabv3+图像语义分割法与眼动追踪技术结合的方式,对拖拉机驾驶人员观察后方农机机具的画面进行采集并对重要信息进行标注;然后,使用Pytorch深度学习框架来搭建所需的模型网络结构和完成相应的代码开发,最终得到较为清晰的分割图像;最后,对原始图像及分割后图像进行眼动追踪实验验证,提取被试者的眼动轨迹,发现分割后图像能更好地被观看者识别。研究结果表明:利用DeeplabV3+对图像进行分割增强,应用到平视显示技术中,可以有效提高拖拉机驾驶人员的驾驶安全性和工作效率。

关键词：拖拉机平视显示 DeeplabV3+ 眼动追踪深度学习

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非线性剪胀模型土石坝变形计算适用性评价

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水力发电学报 2024年第2期43卷 99-109页

作者：王克汤洪洁王睿张建民清华大学水圈科学与水利工程全国重点实验室北京100084 清华大学水利水电工程系北京100084 清华大学水利部水圈科学重点实验室北京100084 水利部水利水电规划设计总院北京100120

以有限元方法为代表的高土石坝变形数值模拟的准确性极大依赖于本构模型对坝料应力应变关系描述的准确性。本文在邓肯-张EB模型基础上,建立了用于分析坝体变形的考虑剪胀的实用性非线性模型(EB-Dilatancy模型,简称为EBD模型)。基于阿尔... 详细信息

以有限元方法为代表的高土石坝变形数值模拟的准确性极大依赖于本构模型对坝料应力应变关系描述的准确性。本文在邓肯-张EB模型基础上,建立了用于分析坝体变形的考虑剪胀的实用性非线性模型(EB-Dilatancy模型,简称为EBD模型)。基于阿尔塔什面板砂砾石坝的大坝变形监测数据,设计了3个反演方案,获得最优的EB模型和EBD模型参数。采用最优参数模拟常规三轴试验,并与实际物理试验进行比较。结果表明:在坝体变形方面,传统的EB模型难以同时准确模拟堆石坝的沉降和水平变形分布,而EBD模型则能够在维持沉降分布模拟精度的基础上提高水平变形的计算精度;EB模型无法实现在合理模拟大坝变形的前提下有效模拟材料单元应力-应变响应,相比之下EBD模型可以同时实现大坝变形和材料单元力学行为的良好模拟。

关键词：高土石坝本构模型剪胀变形监测反演分析三轴试验

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