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A Robust N-Terminal Pro-Brain Natriuretic Peptide Assay for Clinical Diagnosis of Heart Failure in Elderly Patients

Journal of Analysis and Testing 2024年第1期8卷 74-82页

作者： Xue Gong Jiangling Wu jiajia zhang Zhongwei Jiang Yi Wang Pu zhang Engineering Research Center for Biotechnology of Active Substances(Ministry of Education) Chongqing Key Laboratory of Green Synthesis and ApplicationsCollege of ChemistryChongqing Normal UniversityChongqing 401331China Chongqing Research Center for Pharmaceutical Engineering College of PharmacyChongqing Medical UniversityChongqing 400016China Department of Clinical Laboratory University Town Hospital of Chongqing Medical UniversityChongqing 401331China

Heart failure(HF)is a clinical hallmark of cardiovascular syndrome leading to substantial morbidity,repeated hospitalization,and enormous healthcare *** elderly populations continue to increase,biomarker-guided diagnosis and treatment for age-related cardiac decline have become *** evidence demonstrates that N-terminal proBNP(NT-proBNP)can provide a unique window into the diagnosis and risk stratification with ***,a simple yet robust aptasensor is developed for on-site recognizing the NT-proBNP by its targeting aptamer,thus achieving the accurate diagnosis of *** aptasensing system is prepared by absorbing the fluorophore-labeled aptamer strand onto the graphene oxide(GO),leading to efficient quenching without possible off-site signal *** aptamer strand can specifically identify target NT-proBNP molecules via a versatile conformational transformation,resulting in the desorption of the aptamer-NTproBNP complexes from GO and re-generation fluorescence signal,thus allowing sensitive detection of NT-proBNP in 37 clinical blood *** advantage of the high specificity of aptamer-guaranteed recognitions of NT-proBNP,this aptasensor system readily achieves better diagnostic performance for HF than commercially adopted chemiluminescence immunoassay(Siemens,CLIA)in hospitals in terms of accuracy(89.2%vs 83.8%),specificity(89.5%vs 84.2%),and positive predictive value(88.9%vs 83.3%).This work provides a stable option for the diagnosis and treatment of elderly HF-related diseases inclinics.

关键词： NT-proBNP Graphene oxide Aptamer Heart failure Clinical diagnosis

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Multidimensional hollow SiO_(2)/C nanofibers modified by magnetic nanocrystals for electromagnetic energy conversion and lithium battery storage

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Nano Research 2024年第8期17卷 7301-7314页

作者： Chen Han Qi Zheng Juncheng Jin jiajia zhang Wen-Qiang Cao Kun Xiang Min zhang Mao-Sheng Cao Anhui Provincial Laboratory of Biomimetic Sensor and Detecting Technology College of Materials and Chemical EngineeringWest Anhui UniversityLu’an 237012China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Department of Physics Beijing Technology and Business UniversityBeijing 100048China

Multifunctional materials are powerful tools to support the advancement of energy conversion *** with prominent electromagnetic and electrochemical properties can realize the conversion of electromagnetic energy and solve the subsequent storage ***,an electrospinning-thermal reduction method is employed to construct ultrafine nickel nanoparticle modified porous SiO_(2)/C(Ni-SiO_(2)/C)hollow nanofibers as promising materials for applications in both electromagnetic wave absorption(EMA)and lithium-ion ***,when used as an EMA material,the reflection loss(RL)of Ni-SiO_(2)/C can reach−47.8 dB at 15.8 GHz with a matching thickness of 2.2 *** excellent microwave absorption performance can be attributed to the enhanced conduction loss,polarization relaxation,synergistic magnetic loss,and preferred impedance matching,which result from multi-component magnetic/dielectric synergy and the unique interconnected multidimensional hollow ***,the electronic conductivity and electrochemical activity of the samples are significantly enhanced due to the uniform distribution of ultrafine Ni nanoparticles in the amorphous SiO_(2)/C ***,the hierarchical hollow porous structure provides sufficient free space for volume change during lithiation/delithiation ***,the Ni-SiO_(2)/C nanocomposite exhibits a high reversible capacity of 917.6 mAh·g^(−1)at 0.1 A·g^(−1).At a high current density of 2 A·g^(−1),a capacity of 563.9 mAh·g^(−1)can be maintained after 300 *** energy conversion-storage device is designed to store waste electromagnetic energy in the form of useful electrical *** work inspires the development of high-performance bifunctional materials.

关键词： Ni-SiO_(2)/C nanofiber electromagnetic absorption lithium-ion storage electrospinning multidimensional structure

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Characteristics and influencing factors of greenhouse gas emissions from reservoirs in the Yellow River Basin:A Meta-analysis

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Science China Earth Sciences 2024年第7期67卷 2210-2225页

作者： Shurui HUANG Peijia zhang Wenxiu ZHENG jiajia zhang Yang LI Yuanjian WANG Enhui JIANG Shaoda LIU Xinghui XIA State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 00875China Yellow River Institute of Hydraulic Research Yellow River Conservancy CommissionZhengzhou 450003China

Reservoir construction and operation profoundly alter the hydrological,hydrodynamic,and carbon and nitrogen cycling processes of ***,current research still lacks a systematic understanding of the characteristics of greenhouse gas(GHG)emissions from reservoirs in arid/semi-arid *** study integrates existing monitoring data to discuss the characteristics of GHG emissions from reservoirs in the Yellow River Basin and illustrate the controlling factors and underlying mechanism of these *** results indicate that while CO_(2) emission flux from reservoirs is lower than that from river channels,the emission fluxes of CH_(4) and N_(2)O are 1.9 times and 10 times those from rivers,respectively,indicating that the emission of GHG with stronger radiative effect is significantly enhanced in *** to the reservoirs in humid climates(e.g.,the Three Gorges Reservoir),reservoirs in the Yellow River Basin exhibit relatively lower emissions of CO_(2) and CH_4 due to lower organic matter concentrations,but significantly higher N_(2)O emissions due to higher nitrogen *** Carlo simulations for 237 reservoirs in the Yellow River Basin showed that total emission of the three GHGs is 3.05 Tg CO_(2)-eq yr^(-1),accounting for 0.39% of the total emission from global reservoirs and lower than the area percentage of the basin(0.53%).This study has important implications on revealing the GHG emission characteristics and control mechanisms of reservoirs in arid/semi-arid regions.

关键词： Yellow River Basin Reservoir Greenhouse gas Emission flux Water quality

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Single-cell transcriptomics reveals T-cell heterogeneity and immunomodulatory role of CD4+T native cells in Candida albicans infection

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BIOCELL 2024年第9期48卷 1355-1368页

作者： KERAN JIA YANHAO zhang MENGYU JIANG MENGGE CUI JIA WANG jiajia zhang HUIHAI ZHAO MENGYAN LI HUA WANG QUANMING ZOU HAO ZENG National Engineering Research Center of Immunological Products Department of Microbiology and Biochemical PharmacyCollege of PharmacyArmy Medical UniversityChongqing400038China Department of Clinical Laboratory The 980th Hospital of PLA Joint Logistics Support Force(Bethune International Peace Hospital)Shijiazhuang050082China

Objective:Candida albicans is a common fungal pathogen that triggers complex host defense mechanisms,including coordinated innate and adaptive immune responses,to neutralize invading fungi *** the immune microenvironment has the potential to inform the development of therapeutic strategies for fungal ***:The study analyzed individual immune cell profiles in peripheral blood mononuclear cells from Candida albicans-infected mice and healthy control mice using single-cell transcriptomics,fluorescence quantitative PCR,and Western *** investigated intergroup differences in the dynamics of immune cell subpopulation infiltration,pathway enrichment,and differentiation during Candida albicans ***:Our findings indicate that infiltration of CD4^(+)naive cells,regulatory T(Treg)cells,and Microtubules(MT)-associated cells increased after infection,along with impaired T cell ***,CD4^(+)T cells and plasma cells were enhanced after infection,suggesting that antibody production is dependent on T *** addition,we screened 6 hub genes,transcription factor forkhead box protein 3(Foxp3),cytotoxic T-lymphocyte associated protein 4(CTLA4),Interleukin 2 Receptor Subunit Beta(Il2rb),Cd28,C-C Motif Chemokine Ligand 5(Ccl5),and Cd27 for alterations associated with CD4^(+)T cell ***:These results provide a comprehensive immunological landscape of the mechanisms of Candida albicans infection and greatly advance our understanding of adaptive immunity in fungal infections.

关键词： Candida albicans Single-cell transcriptomics Immune microenvironment Fungal infections Hub gene

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Polaron interfacial entropy as a route to high thermoelectric performance in DAE-doped PEDOT:PSS films

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National Science Review 2024年第3期11卷 259-270页

作者： jiajia zhang Caichao Ye Genwang Wei Liang Guo Yuhang Cai Zhi Li Xinzhi Wu Fangyi Sun Qikai Li Yupeng Wang Huan Li Yuchen Li Shuaihua Wang Wei Xu Xuefeng Guo Wenqing zhang Weishu Liu Department of Materials Science and Engineering Southern University of Science and Technology Academy for Advanced Interdisciplinary Studies and Guangdong Provincial Key Laboratory of Computational Science and Material Design Southern University of Science and Technology Department of Mechanical and Energy Engineering Southern University of Science and Technology Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences College of Chemistry and Molecular Engineering National Biomedical Imaging Centre Peking University Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and Technology

Enhancing the thermoelectric transport properties of conductive polymer materials has been a long-term challenge, in spite of the success seen with molecular doping strategies. However, the strong coupling between the thermopower and the electrical conductivity limits thermoelectric performance. Here, we use polaron interfacial occupied entropy engineering to break through this intercoupling for a PEDOT:PSS(poly（3,4-ethylenedioxythiophene）-poly（4-styrenesulfonate）) thin film by using photochromic diarylethene（DAE） dopants coupled with UV-light modulation. With a 10-fold enhancement of the thermopower from 13.5 μV K-1to 135.4 μV K-1and almost unchanged electrical conductivity, the DAE-doped PEDOT:PSS thin film achieved an extremely high power factor of 521.28 μW m-1K-2from an original value of 6.78 μW m-1K-2. The thermopower was positively correlated with the UV-light intensity but decreased with increasing temperature, indicating resonant coupling between the planar closed DAE molecule and PEDOT. Both the experiments and theoretical calculations consistently confirmed the formation of an interface state due to this resonant coupling. Interfacial entropy engineering of polarons could play a critical role in enhancing the thermoelectric performance of the organic film.

关键词： thermoelectric PEDOT: PSS interfacial occupied entropy resonant coupling UV-light modulation

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Digitalization’s Effects on Income Growth and Distribution-Evidence from the CHDES Database

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China Economist 2024年第4期19卷 37-56页

作者： Huang Yanghua zhang jiajia Cai Yuhan zhang Jinshuo School of Applied Economics Renmin University of ChinaBeijingChina

Using the CHDES database,we created the CIDI to comprehensively quantify digital adoption at the individual level and examine digitalization’s impact on individual *** analysis results indicate that increasing the CIDI by one standard deviation(0.13)improves individual income by 5.93 percentage points,which remains true after a series of endogeneity and robustness *** the heterogeneity analysis,we discovered that when digital adoption grows,residents in the countryside and county seats can earn more money through internet business operations and other *** helps to decrease the urban-rural income divide,but it has also pushed those digitally skilled into high-paying sectors,widening the income gaps between *** the mechanism analysis,we developed an income function that takes into account the individual level of digitalization to show that digitalization can boost income by increasing working hours or labor participation and adjusting the portfolio of individual material,human,and social *** this paper,we have expanded the system for measuring the individual levels of digitalization by offering basic data,research methodology,and policy suggestions for the digital economy’s inclusive development.

关键词： Digital economy level of digitalization digital empowerment income function

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习近平人民观的理论渊源、内在逻辑和重大意义

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大连理工大学学报（社会科学版） 2024年第1期45卷 1-8页

作者：张佳佳华东师范大学马克思主义学院上海200241

中国共产党自诞生就把为中国人民谋幸福、为中华民族谋复兴作为党的初心使命。人民是党执政最大的底气,人民的问题是党和国家的根本问题。新时代以来,以习近平同志为核心的党中央持续推进党和人民的事业,不断丰富和发展人民观,这也成为... 详细信息

中国共产党自诞生就把为中国人民谋幸福、为中华民族谋复兴作为党的初心使命。人民是党执政最大的底气,人民的问题是党和国家的根本问题。新时代以来,以习近平同志为核心的党中央持续推进党和人民的事业,不断丰富和发展人民观,这也成为习近平新时代中国特色社会主义思想的重要组成部分。习近平人民观以马克思主义人民观为思想支撑,以中华优秀传统文化中的民本思想为文化积淀,与一百年来中国共产党的人民观既一脉相承又与时俱进。习近平人民观以党的初心和使命为内在动力,以人民立场为深层动因,以人民对美好生活的向往为奋斗目标,以人民至上的原则为实践认识。习近平人民观的发展保障了党的执政生命力,提升了国家抵御风险的能力,推动了世界范围内人类命运共同体的建构。深刻领悟习近平人民观,对全面建设社会主义现代化国家的新征程具有重要意义。

关键词：习近平人民观以人民为中心人类命运共同体

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多元信息获取中的负向态度转变:选择性信息行为的影响

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图书情报工作 2024年第18期68卷 50-58页

作者：张珈茄刘映彤张鹏翼北京大学信息管理系北京100871

[目的/意义]旨在探究多元信息获取背景下的选择性信息行为与态度转变。[方法/过程]采用眼动实验法,向被试提供特定主题的正面文章和负面文章供用户选择和阅读,记录用户的眼动、点击等行为数据,用户完成任务并编写报告后,对被试进行实验... 详细信息

[目的/意义]旨在探究多元信息获取背景下的选择性信息行为与态度转变。[方法/过程]采用眼动实验法,向被试提供特定主题的正面文章和负面文章供用户选择和阅读,记录用户的眼动、点击等行为数据,用户完成任务并编写报告后,对被试进行实验后访谈。[结果/结论]被试在多元信息获取的环境下存在负性偏向,且被试并未意识到自己的负性偏向。大多数被试表现出负向的态度转变,而先验态度偏正向的人,负向的态度转变更为突出。被试在阅读正面和负面信息时关注的材料类型的差异性,对态度转变产生了影响。研究结果有助于加强对多元信息获取环境下的选择性信息行为和负向态度转变的理解,也有助于新闻推荐系统的改进和优化。

关键词：选择性信息行为态度转变确认偏差负性偏差

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风险指引型高温气冷堆SSC安全分级研究

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核动力工程 2024年第3期45卷 193-198页

作者：倪曼赵军钱鸿涛张佳佳宫宇肖军生态环境部核与辐射安全中心北京100082 清华大学北京100084

风险指引安全分级是以概率安全分析(PSA)为基础,对传统的确定论安全分级进行优化,从而改善核电厂安全分级的管理要求,以进一步提升核电厂的安全性和经济性。本文在风险指引安全分级的基础上,提出了高温气冷堆的安全分级流程,并以蒸汽发... 详细信息

风险指引安全分级是以概率安全分析(PSA)为基础,对传统的确定论安全分级进行优化,从而改善核电厂安全分级的管理要求,以进一步提升核电厂的安全性和经济性。本文在风险指引安全分级的基础上,提出了高温气冷堆的安全分级流程,并以蒸汽发生器(SG)事故排放系统为例进行了风险指引安全分级的实例研究。结果表明,安全级的SG电磁排放阀可划分为安全相关但低风险重要等级,说明该系统的安全分级还有优化的空间,可为后续核电厂的构筑物、系统和部件(SSC)安全分级工作提供参考。

关键词：风险指引高温气冷堆概率安全分析(PSA) 构筑物、系统和部件(SSC)

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人口老龄化背景下银发经济发展的内在机理与优化路径探析

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老龄化研究 2024年第2期11卷 325-331页

作者：张佳佳南京林业大学马克思主义学院江苏南京

伴随着我国人口老龄化程度的持续加深,“银发经济”作为一种新的经济形态,正逐渐成为推动社会发展的新引擎。本文在深入剖析人口老龄化背景下银发经济运行的内在机理,即合理把握和发挥人口老龄化带来的庞大消费群体和数字经济内驱动力... 详细信息

伴随着我国人口老龄化程度的持续加深,“银发经济”作为一种新的经济形态,正逐渐成为推动社会发展的新引擎。本文在深入剖析人口老龄化背景下银发经济运行的内在机理,即合理把握和发挥人口老龄化带来的庞大消费群体和数字经济内驱动力作用的基础上,强调应着力破解产业供给端发展不平衡、政府政策和监管缺乏力度、市场规范化程度低、老年群体数字化失能仍然存在等现实困境,通过掌握市场运行规律、健全制度政策体系、跨越数字鸿沟障碍等方面优化银发经济高质量发展的路径,以期对应对人口老龄化挑战、挖掘银发经济潜力。

关键词：人口老龄化银发经济数字经济数字鸿沟

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