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Enhancing Evolutionary Algorithms With Pattern Mining for Sparse Large-Scale Multi-Objective Optimization Problems

IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1786-1801页

作者： Sheng Qi Rui Wang Tao zhang Weixiong Huang Fan Yu Ling Wang College of Systems Engineering National University of Defense TechnologyChangsha 410073China College of Systems Engineering National University of Defense TechnologyChangsha 410073and also with the Xiangjiang LaboratoryChangsha 410205China College of Transportation and Engineering Central South UniversityChangsha 410073China Department of Automation Tsinghua UniversityBeijing 100084China

Sparse large-scale multi-objective optimization problems(SLMOPs)are common in science and ***,the large-scale problem represents the high dimensionality of the decision space,requiring algorithms to traverse vast expanse with limited computational ***,in the context of sparse,most variables in Pareto optimal solutions are zero,making it difficult for algorithms to identify non-zero variables *** paper is dedicated to addressing the challenges posed by *** start,we introduce innovative objective functions customized to mine maximum and minimum candidate *** substantial enhancement dramatically improves the efficacy of frequent pattern *** this way,selecting candidate sets is no longer based on the quantity of nonzero variables they contain but on a higher proportion of nonzero variables within specific ***,we unveil a novel approach to association rule mining,which delves into the intricate relationships between non-zero *** novel methodology aids in identifying sparse distributions that can potentially expedite reductions in the objective function *** extensively tested our algorithm across eight benchmark problems and four real-world *** results demonstrate that our approach achieves competitive solutions across various challenges.

关键词： Evolutionary algorithms pattern mining sparse large-scale multi-objective problems(SLMOPs) sparse large-scale optimization.

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A Two-Layer Encoding Learning Swarm Optimizer Based on Frequent Itemsets for Sparse Large-Scale Multi-Objective Optimization

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1342-1357页

作者： Sheng Qi Rui Wang Tao zhang Xu Yang Ruiqing Sun Ling Wang College of Systems Engineering National University of Defense TechnologyChangsha 410073China Xiangjiang Laboratory Changsha 410205China College of Computer National University of Defense TechnologyChangsha 410073China Department of Automation Tsinghua UniversityBeijing 100084China IEEE

Traditional large-scale multi-objective optimization algorithms(LSMOEAs)encounter difficulties when dealing with sparse large-scale multi-objective optimization problems(SLM-OPs)where most decision variables are *** a result,many algorithms use a two-layer encoding approach to optimize binary variable Mask and real variable Dec ***,existing optimizers often focus on locating non-zero variable posi-tions to optimize the binary variables ***,approxi-mating the sparse distribution of real Pareto optimal solutions does not necessarily mean that the objective function is *** data mining,it is common to mine frequent itemsets appear-ing together in a dataset to reveal the correlation between *** by this,we propose a novel two-layer encoding learning swarm optimizer based on frequent itemsets(TELSO)to address these *** mined the frequent terms of multiple particles with better target values to find mask combinations that can obtain better objective values for fast ***-mental results on five real-world problems and eight benchmark sets demonstrate that TELSO outperforms existing state-of-the-art sparse large-scale multi-objective evolutionary algorithms(SLMOEAs)in terms of performance and convergence speed.

关键词： Evolutionary algorithms learning swarm optimiza-tion sparse large-scale optimization sparse large-scale multi-objec-tive problems two-layer encoding.

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Residual levels and health risk assessment of trace metals in Chinese resident diet

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Journal of Environmental Sciences 2024年第2期136卷 451-459页

作者： Yubing Dai Shuai Sun Rong Cao Haijun zhang Jiping Chen Ningbo Geng CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Shenyang Pharmaceutical University Shenyang 110016China University of Chinese Academy of Sciences Beijing 100049China

Large-scale metal contamination across the food web is an intractable problem due to increasing pollutant emissions,atmospheric transport,and dry and wet deposition of *** present study focus on several trace metals that are rarely studied but have special toxicity,including tin(Sn),antimony(Sb),gold(Au),hafnium(Hf),palladium(Pd),platinum(Pt),ruthenium(Ru),tellurium(Te)and iridium(Ir).We investigated trace metals residues and distribution characteristics,and further evaluated the potential health risks from major daily food intakes in 33 cities in ***,Sb,Ir,Hf,and Au were frequently detected in food samples with the concentrations ranged from ND(not detected)to 24.78μg/kg ww(wet weight).Eggs exhibited the highest residual level of all detected metals(13.70±14.70μg/kg ww in sum),while the lowest concentrations were observed in vegetables(0.53±0.17μg/kg ww in sum).Sn accounting for more than 50%of the total trace metals concentration in both terrestrial and aquatic animal origin *** terrestrial plant origin foods,Sn and Ir were the most abundant *** and Au were the most abundant elements in egg *** addition,Sb and Ir showed a clear trophic dilution effect in terrestrial environments,while in aquatic ecosystems,Sn,Hf,and Au exhibited obvious trophic amplification *** calculated average estimated daily intake(EDI)via food consumption in five regions of China was 0.09μg/(kg·day),implying the health risk of aforementioned elements was acceptable.

关键词： Trace metals Accumulation characteristics Dietary exposure Estimated daily intake(EDI)

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Rice bran oil rescues cognitive decline in D-galactose-induced aging mice by inhibiting Aβ accumulation and Tau hyperphosphorylation induced oxidative stress and neuroinflammation

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Food Science and Human Wellness 2024年

作者： Yadan zhang Diya Xu Xiaoyu zhang Wenhua Zhou Lin zhang Qinlu Lin College of Food Science and Engineering， National Engineering Research Center of Rice and Byproduct Deep Processing， Hunan Key Laboratory of Processed Food for Special Medical Purpose， Central South University of Forestry and Technology

Alzheimer's disease (AD) is a neurodegenerative disorder associated with brain aging， and the accumulation of amyloid-beta (Aβ) and hyperphosphorylated Tau proteins are key pathological features. Currently， drugs for the treatment of AD are mainly single-targeted， but the complex pathogenesis of AD makes it difficult to achieve the desired results. Therefore， the development of multitargeted therapies is crucial for future interventions. Rice bran oil (RBO) has been recognized as an edible oil with several health benefits， but its effects on AD caused by brain aging remain underexplored. In this study， the effects of RBO on memory dysfunction in D-galactose (D-gal) mice and its molecular mechanisms were investigated via in vivo and in silico methods from the perspective of AD pathologies. Our results suggested that compounds in RBO could modulate the activities of β-site amyloid precursor protein cleaving enzyme 1 (BACE1)， mitogen-activated protein kinase 3 (MAPK3)， matrix metalloproteinase 3 (MMP3)， and intercellular adhesion molecule 1 (ICAM1)， leading to inhibition of Aβ accumulation and Tau protein hyper-phosphorylation. Moreover， RBO reduced Aβ-induced oxidative stress by inhibiting the activity of mouse double minute 2 homolog (MDM2) and cyclic adenosine monophosphate response element binding protein binding protein (CREBBP)， and attenuated neuroinflammation by inhibiting the activity of nitric oxide synthase 2 (NOS2) and reducing Aβ accumulation and Tau protein hyperphosphorylation. Additionally， α-linolenic acid in RBO exhibited inhibitory effects on D-gal-induced apoptosis in PC12 cells through modulation of NOS2， MDM2， ICAM1， and phospho-extracellular signal-regulated kinase 1/2 (p-ERK1/2). Similarly， stigmastanol inhibited apoptosis in D-gal-induced PC12 cells through the regulation of NOS2. Thus， RBO can be considered as a potential functional food to attenuate AD owing to its multicomponent and multitarget effects.

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Limited Sea Surface Temperature Cooling Due to the Barrier Layer Promoting Super Typhoon Mangkhut(2018)

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Advances in Atmospheric Sciences 2024年第11期41卷 2156-2172页

作者： Huipeng WANG Jiagen LI Junqiang SONG Liang SUN Fu LIU Han zhang Kaijun REN Huizan WANG Chunming WANG Jinrong zhang Hongze LENG College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230000China State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

This study investigates the impact of the salinity barrier layer(BL)on the upper ocean response to Super Typhoon Mangkhut(2018)in the western North *** the passage of Mangkhut,a noticeable increase(~0.6 psu)in sea surface salinity and a weak decrease(<1℃)in sea surface temperature(SST)were observed on the right side of the typhoon ***-induced SST change can be divided into the three stages,corresponding to the variations in BL thickness and SST before,during,and after the passage of *** the pre-typhoon stage,SST slightly warmed due to the entrainment of BL warm water,which suppressed the cooling induced by surface heat fluxes and horizontal *** the forced stage,SST cooling was controlled by entrainment,and the preexisting BL reduced the total cooling by 0.89℃ d-1,thus significantly weakening the overall SST cooling induced by *** the relaxation stage,the SST cooling was primarily caused by the *** results indicate that a preexisting BL can limit typhoon-induced SST cooling by suppressing the entrainment of cold thermocline water,which contributed to Mangkhut becoming the strongest typhoon in 2018.

关键词： sea surface cooling mixed-layer depth barrier layer typhoon

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Development and Application of a Power Law Constitutive Model for Eddy Current Dampers

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2403-2419页

作者： Longteng Liang Zhouquan Feng Hongyi zhang Zhengqing Chen Changzhao Qian School of Civil Engineering and Architecture Xiamen University of TechnologyXiamen361024China Hunan Provincial Key Laboratory ofWind and Bridge Engineering Hunan UniversityChangsha410082China Fujian Provincial Key Laboratory ofWind Disaster and Engineering Xiamen University of TechnologyXiamen361024China State Key Laboratory of Bridge Engineering Safety and Resilience Hunan UniversityChangsha410082China

Eddy current dampers (ECDs) have emerged as highly desirable solutions for vibration control due to theirexceptional damping performance and durability. However, the existing constitutive models present challenges tothe widespread implementation of ECD technology, and there is limited availability of finite element analysis (FEA)software capable of accurately modeling the behavior of ECDs. This study addresses these issues by developing anewconstitutivemodel that is both easily understandable and user-friendly for FEAsoftware. By utilizing numericalresults obtained from electromagnetic FEA, a novel power law constitutive model is proposed to capture thenonlinear behavior of ECDs. The effectiveness of the power law constitutive model is validated throughmechanicalproperty tests and numerical seismic analysis. Furthermore, a detailed description of the application process ofthe power law constitutive model in ANSYS FEA software is provided. To facilitate the preliminary design ofECDs, an analytical derivation of energy dissipation and parameter optimization for ECDs under harmonicmotionis performed. The results demonstrate that the power law constitutive model serves as a viable alternative forconducting dynamic analysis using FEA and optimizing parameters for ECDs.

关键词： Eddy current damper constitutive model finite element analysis vibration control power law constitutive model

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SEI/dead Li-turning capacity loss for high-performance anode-free solid-state lithium batteries

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Journal of Energy Chemistry 2024年第9期96卷 145-152页

作者： Qianwen Yin Tianyu Li Hongzhang zhang Guiming Zhong Xiaofei Yang Xianfeng Li Division of Energy Storage Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Long-Duration and Large-Scale Energy Storage Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Laboratory of Advanced Spectro-Electrochemistry and Lithium-Ion Batteries Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Anode-free solid-state lithium metal batteries(AF-SSLBs)have the potential to deliver higher energy density and improved safety beyond lithium-metal ***,the unclear mechanism for the fast capacity decay in AF-SSLBs,either determined by dead Li or solid electrolyte interface(SEI),limits the proposal of effective strategies to prolong cycling *** clarify the underlying mechanism,herein,the evolution of SEI and dead Li is quantitatively analyzed by a solid-state nuclear magnetic resonance(ss-NMR)technology in a typical LiPF6-based polymer *** results show that the initial capacity loss is attributed to the formation of SEI,while the dead Li dominates the following capacity loss and the growth rate is 0.141 mA h cm^(−2)cycle−*** reduce the active Li loss,the combination of inorganic-rich SEI and self-healing electrostatic shield effect is proposed to improve the reversibility of Li deposition/dissolution behavior,which reduces the capacity loss rate for the initial SEI and following dead Li generation by 2.3 and 20.1 folds,*** a result,the initial Coulombic efficiency(ICE)and stable CE increase by 15.1%and 15.3%in Li-Cu cells,which guides the rational design of high-performance AF-SSLBs.

关键词： Solid-state lithium batteries Solid-state NMR Anode-free SEI Dead Li

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Numerical Simulation on Radon Retardation Behavior of Covering Floats in Radon-Containing Water

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Biomedical and Environmental Sciences 2024年第4期37卷 406-417页

作者： LIU Shu Yuan zhang Li YE Yong Jun DING Ku Ke National Institute for Radiological Protection Chinese Center for Disease Control and PreventionBeijing 100088China Office for Public Health Management Chinese Center for Disease Control and PreventionBeijing 102206China Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy University of South ChinaHengyang 421001HunanChina

Objective This study aimed to efficiently reduce the release of radon from water bodies to protect the *** Based on the sizes of the experimental setup and modular float,computational fluid dynamics(CFD)was used to assess the impact of the area coverage rate,immersion depth,diffusion coefficient,and radon transfer velocity at the gas–liquid interface on radon migration and exhalation of radon-containing *** on the numerical simulation results,an estimation model for the radon retardation rate was *** effectiveness of the CFD simulation was evaluated by comparing the experimental and simulated variation values of the radon retardation rate with the coverage area *** The effect of radon transfer velocity on radon retardation in water bodies was minor and insignificant according to the appropriate value;therefore,an estimation model of the radon retardation rate of the coverage of a radon-containing water body was constructed using the synergistic impacts of three factors:area coverage rate,immersion depth,and diffusion *** deviation between the experimental and simulated results was<4.3%.Conclusion Based on the numerical simulation conditions,an estimation model of the radon retardation rate of covering floats in water bodies under the synergistic effect of multiple factors was obtained,which provides a reference for designing covering floats for radon retardation in radoncontaining water.

关键词： Radon-containing water Radon retardation rate CFD Coverage experiment Optimized design

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Hydroxysafflor Yellow A Promotes HaCaT Cell Proliferation and Migration by Regulating HBEGF/EGFR and PI3K/AKT Pathways and Circ_0084443

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Chinese Journal of Integrative Medicine 2024年第3期30卷 213-221页

作者： zhang Yue XIAO Yan-wei MA Jing-xin WANG Ao-xue Department of Dermatology the Second Hospital of Dalian Medical UniversityDalianLiaoning Province116021China Department of Cell Biology Dalian Medical UniversityDalianLiaoning Province116044China

Objective:To investigate the effect and possible mechanism of hydroxysafflor yellow A(HSYA) on human immortalized keratinocyte cell proliferation and ***:HaCaT cells were treated with *** proliferation was detected by the cell counting kit-8 assay,and cell migration was measured using wound healing assay and Transwell migration *** mRNA and protein expression levels of heparin-binding epidermal growth factor(EGF)-like growth factor(HBEGF),EGF receptor(EGFR),phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),mammalian target of rapamycin(mTOR),and hypoxia-inducible factor-1α(HIF-1α) were detected by quantitative real-time polymerase chain reaction(qRT-PCR) and Western blot,***_0084443-overexpressing HaCaT cells and empty plasmid HaCaT cells were constructed using the lentiviral stable transfection and treated with *** expression of circ_0084443 was detected by ***:HSYA(800 μmol/L) significantly promoted HaCaT cell proliferation and migration(P0.05).Conclusion:HSYA played an accelerative role in HaCaT cell proliferation and migration,which may be attributable to activating HBEGF/EGFR and PI3K/AKT signaling pathways,and had a particular inhibitory effect on the keratinocyte negative

关键词： hydroxysafflor yellow A circ_0084443 heparin-binding epidermal growth factor-like growth factor/epidermal growth factor receptor phosphatidylinositol 3-kinase/protein kinase B

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STING-mediated IL-6 Inhibits OATP1B1 Expression via the TCF4 Signaling Pathway in Cholestasis

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Journal of Clinical and Translational Hepatology 2024年第8期12卷 701-712页

作者： Yan Guo Hongjia zhang Nan Zhao Ying Peng Dongya Shen Yubin Chen Xiaoxun zhang Can-E Tang Jin Chai Department of Endocrinology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Gastroenterology Institute of Digestive Diseases of PLACholestatic Liver Diseases Center and Center for Metabolic Associated Fatty Liver DiseaseThe First Affiliated Hospital(Southwest Hospital)to Third Military Medical University(Army Medical University)ChongqingChina Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Cardiac Surgery Xiangya HospitalCentral South UniversityChangshaHunanChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunanChina

Background and Aims Organic anion-transporting polypeptides(OATPs)play a crucial role in the transport of bile acids and *** our previous study,interleukin 6(IL-6)reduced OATP1B3 levels in cholestatic ***,it remains unclear whether IL-6 inhibits OATP1B1 expression in cholestatic *** study aimed to investigate whether IL-6 can inhibit OATP1B1 expression and explore the underlying *** The effect of stimulator of interferon genes(STING)signaling on inflammatory factors was investigated in a cholestatic mouse model using RT-qPCR and enzyme-linked immunosorbent *** assess the impact of inflammatory factors on OATP1B1 expression in hepatocellular carcinoma,we analyzed OATP1B1 expression by RT-qPCR and Western Blot after treating PLC/PRF/5 cells with TNF-α,IL-1β,and *** elucidate the mechanism by which IL-6 inhibits OATP1B1 expression,we examined the expression of the OATP1B1 regulator TCF4 in PLC/PRF/5 and HepG2 cells using RT-qPCR and Western *** interaction mechanism betweenβ-catenin/TCF4 and OATP1B1 was investigated by knocking downβ-catenin/TCF4 through siRNA *** The STING inhibitor decreased inflammatory factor levels in the cholestatic mouse model,with IL-6 exhibiting the most potent inhibitory effect on ***-6 downregulatedβ-catenin/TCF4,leading to decreased OATP1B1 ***-downβ-catenin/TCF4 counteracted theβ-catenin/TCF4-mediated repression of *** STING-mediated IL-6 up-regulation may inhibit OATP1B1,leading to reduced transport of bile acids and bilirubin by *** may contribute to altered pharmacokinetics in patients with diseases associated with increased IL-6 production.

关键词： Inflammation Bile acid Bilirubin Cholestasis STING IL-6 β-catenin TCF4

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