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geographical Agglomeration of Chinese Manufacturing Industries

中国人口·资源与环境：英文版 2007年第2期5卷 3-11页

作者： zhang hua 1, 2..zheng wei3.1. institute of geographical sciences and natural resources research, Chinese academy of sciences, beijing 100101, china 2. Graduate School of the Chinese academy of sciences, beijing 100039, china 3. School of Geography, beijing Normal University, beijing 100875, china institute of geographical sciences and natural resources research Chinese Academy of Sciences Beijing 100101 China Graduate School of the Chinese academy of sciences Beijing 100039 China School of Geography Beijing Normal University Beijing 100875 China

Based on the plant level data from the First National Census of Basic Units, the Second National Census of Basic Units, and the First National Economic Census of china, this paper ex- amines the geographical agglomeration of Chinese manufacturing industries at a more disaggregated level both by industrial classi-fication and spatial unit analysis. Applying the agglomeration index proposed by Maurel and Sedillot, studies show that the most agglomerated industries are resource-intensive, and capital and technology intensive while industries demanding localized inputs or serving localized markets or favored by local governments are fairly dispersed. The more disaggregated industries are more spa- tially agglomerated. At the finer spatial scale, industries are more dispersed. Results indicate that within-county spillovers are stronger than nearby-county spillovers, and within-prefecture spillovers are stronger than nearby prefecture spillovers. Local- ized spillovers are still quite substantial at a range beyond that of counties. Comparing the agglomeration index of Chinese manu- facturing industries in 1996, 2001 and 2004, agglomeration seems to be a general tendency. Results also indicate that some industries have experienced remarkable changes in their levels of agglom- eration in the period 1996–2004.

关键词： industrial agglomeration manufacturing industries the MS index

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Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： Feng Li Yuan Yang hua Yue Shuang Wang Xiao zhang wei wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

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Quantitative estimation of the shrub canopy LAI from atmosphere-corrected HJ-1 CCD data in Mu Us Sandland

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Science china Earth sciences 2010年第S1期53卷 26-33页

作者： CHEN wei1,2,CAO ChunXiang1,HE QiSheng1,2,GUO huaDong3,zhang Hao1,2,LI RenQiang4,zheng Sheng1,2,XU Min1,2,GAO MengXu1,2,ZHAO Jian1,2,LI Sha1,NI XiLiang1,2,JIA HuiCong1,JI wei1,TIAN Rong1,2,LIU Cheng1,2,ZHAO YuXing5 & LI JingLu6 1 State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the institute of Remote Sensing Applications of Chinese academy of sciences and beijing Normal University,beijing 100101,china 2 Graduate University of Chinese academy of sciences,beijing 100049,china 3 Center for Earth Observation and Digital Earth,Chinese academy of sciences,beijing 100190,china 4 china Key Laboratory of Ecological Network Observation and Modeling,institute of geographical sciences and natural resources research,Chinese academy of sciences,beijing 100101,china 5 Ordos Forestry Sand Control Science institute,Dongsheng 017000,china 6 Inner Mongolia Biomass Thermoelectricity Limited Company,Wushen 017300,china State Key Laboratory of Remote Sensing Science Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University Beijing China Graduate University of Chinese academy of sciences Beijing China Center for Earth Observation and Digital Earth Chinese Academy of Sciences Beijing China china Key Laboratory of Ecological Network Observation and Modeling Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences Beijing China Ordos Forestry Sand Control Science institute Dongsheng China Inner Mongolia Biomass Thermoelectricity Limited Company Wushen China

The leaf area index(LAI) is an important ecological parameter that characterizes the interface between vegetation canopy and the *** addition,it is used by most process-oriented ecosystem *** paper investigates the potential of HJ-1 CCD data combined with linear spectral unmixing and an inverted geometric-optical model for the retrieval of the shrub LAI in Wushen Banner of Inner Mongolia in the Mu Us ***(Moderate Resolution Atmospheric Radiance and Transmittance Model) was used for atmospheric *** was extracted using the threshold of the normalized difference vegetation index,with which water bodies and farmland were separated,in combination with a vegetation map of the People's Republic of china(1:1000000).Using the geometric-optical model,we derive the per-pixel reflectance as a simple linear combination of two components,namely sunlit background and *** fraction of sunlit background is related to the shrub *** the support of HJ-1 CCD data,we employ linear spectral unmixing to obtain the fraction of sunlit background in an atmospherically corrected HJ *** addition,we use the measured shrub canopy structural parameters for shrub communities to invert the geometric-optical model and retrieve the pixel-based shrub *** total,18 sample plots collected in Wushen Banner of Inner Mongolia are used for *** results of the shrub LAI show good agreement with R2 of 0.817 and a root-mean-squared error of 0.173.

关键词： shrub leaf area index inversion HJ-1 data geometric-optical model MODTRAN Mu Us Sandland

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Species recognition and the divergences in the chemical and ultrasonic signals between two coexisting Rattus species

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Current Zoology 2024年第4期70卷 531-538页

作者： wei-Chao Wang Zhi-Ming Li Yi Chen Jin-hua zhang Jian-Xu zhang Yao-hua zhang The State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAs Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina

The ability to recognize and differentiate between conspecifics and heterospecifics as well as their signals is critical for the coexistence of closely related *** the genus Rattus,species are morphologically similar and multiple species often ***,we investigated the interspecific recognition and signal differentiation of two sympatric rat species,the brown rat(Rattus norvegicus,RN)and the Asian house rat(Rattus tanezumi,RT).In a two-way choice test,both RN and RT females showed a preference for conspecific male rats to heterospecific *** females showed a significant preference for accessible urine of males of same species to those of other species,but not for the inaccessi-ble *** the other hand,there were significant differences in the structural characteristics of the ultrasonic vocalization emitted by males of these two rat *** dodecyl sulphate-polyacrylamide gel electrophoresis(SDS-PAGE)and isoelectric focusing electrophoresis unveiled that major urinary proteins(MUPs)in voided urine were more highly expressed in RN males versus RT *** interspecific dif-ferences of urinary volatile compounds were also *** conclusion,female rats had the ability to distinguish between males of either species.

关键词： Asian house rats brown rats closely related species pheromones ultrasonic vocalization.

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Health risks and sources of trace elements and black carbon in PM_(2.5)from 2019 to 2021 in beijing

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Journal of Environmental sciences 2024年第8期142卷 69-82页

作者： Chenjie hua wei Ma Feixue zheng Yusheng zhang Jiali Xie Li Ma Boying Song Chao Yan Hongyan Li Zhen Liu Qian Liu Markku Kulmala Yongchun Liu Aerosol and Haze Laboratory Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China institute for Atmospheric and Earth System research Faculty of ScienceUniversity of HelsinkiHelsinki 00014Finland School of Environment and Safety Taiyuan University of Science and TechnologyTaiyuan 030024China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

A comprehensive health risk assessment of PM_(2.5)is meaningful to understand the current status and directions regarding further improving air quality from the perspective of human *** this study,we evaluated the health risks of PM_(2.5)as well as highly toxic inorganic components,including heavy metals(HMs)and black carbon(BC)based on longterm observations in beijing from 2019 to *** results showed that the relative risks of chronic obstructive pulmonary disease,lung cancer,acute lower respiratory tract infection,ischemic heart disease,and stroke decreased by 4.07%-9.30%in 2020 and 2.12%-6.70%in2021 compared with ***,they were still at high levels ranging from 1.26 to 1.77,in particular,stroke showed the highest value in *** had the highest hazard quotient(HQ,from 2.18 to 2.56)for adults from 2019 to 2021,while Ni,Cr,Pb,As,and BC showed high carcinogenic risks(CR>1.0×10^(-6))for *** HQ values of Mn and As and the CR values of Pb and As showed constant or slight upwards trends during our observations,which is in contrast to the downward trends of other HMs and PM_(2.5).Mn,Cr,and BC are crucial toxicants in PM_(2.5).A significant shrink of southern region sourcesof HMs and BCshrank suggests the increased importance of local ***,dust,and biomass burning are the major contributors to the non-carcinogenic risks,while traffic emissions and industry are the dominant contributors to the carcinogenic risks in beijing.

关键词： PM_(2.5) Heavy metals Black carbon Health risk Source apportionment

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Revisiting the island of hexadecapoledeformation nuclei in the A≈150 mass region:focusing on the model application to nuclear shapes and masses

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Communications in Theoretical Physics 2024年第2期76卷 74-88页

作者： Xiao-Yang wei hua-Lei Wang Zhen-Zhen zhang Min-Liang Liu School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Key Laboratory of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Based on the potential-energy-surface calculation,the impact of different deformation degrees of freedom on a single-particle structure and binding energies in nuclei around^(152)Nd,located on one of the hexadecapole-deformation islands,is analyzed in a multi-dimensional deformation *** energy maps,curves and tables are presented to indicate nuclear *** calculated equilibrium deformations and binding energies with different potential parameters are compared with experimental data and other *** is found that the inclusion of the hexadecapole deformations,especially the axial one,can improve the theoretical description of both nuclear shapes and *** addition,our calculated potential-energy curve shows that a critical deformation-point,β_(2)≈0.4,exists—the triaxial(hexadecapole)deformation effect can be neglectable but the hexadecapole(triaxial)one plays an important role before(after)such a critical point.

关键词： hexadecapole deformation binding energy potential-energy-surface calculation nuclear property

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The RNA-binding domain of DCL3 is required for long-distance RNAi signaling

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aBIOTECH 2024年第1期5卷 17-28页

作者： Jie Li Bo-Sen zhang hua-wei Wu Cheng-Lan Liu Hui-Shan Guo Jian-hua Zhao State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of the Chinese Academy of SciencesBeijing 100049China Qilu Zhongke academy of Modern Microbiology Technology Jinan 250022China

Small RNA(sRNA)-mediated RNA silencing(also known as RNA interference,or RNAi)is a conserved mechanism in eukaryotes that includes RNA degradation,DNA methylation,heterochromatin formation and protein translation *** plants,sRNAs can move either cell-to-cell or systemically,thereby acting as mobile silencing signals to trigger noncell autonomous ***,whether and what proteins are also involved in noncell autonomous silencing have not been *** this study,we utilized a previously reported inducible RNAi plant,PDSi,which can induce systemic silencing of the endogenous PDS gene,and we demonstrated that DCL3 is involved in systemic PDS silencing through its RNA binding *** confirmed that the C-terminus of DCL3,including the predicted RNA-binding domain,is capable of binding short *** affecting RNA binding,but not processing activity,reduced systemic PDS silencing,indicating that DCL3 binding to RNAs is required for the induction of systemic *** mosaic virus infection assays showed that the RNA-binding activity of DCL3 is required for antiviral RNAi in systemically noninoculated *** findings demonstrate that DCL3 acts as a signaling agent involved in noncell autonomous silencing and an antiviral effect in addition to its previously known function in the generation of 24-nucleotide sRNAs.

关键词： RNAi signaling DCL3 RBD RNAs Cucumber mosaic virus

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Scale effects of leaf area index inversion based on environmental and disaster monitoring satellite data

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Science china Earth sciences 2010年第S1期53卷 92-98页

作者： zhang Hao1,LI XiaoWen1,2,CAO ChunXiang1,YANG hua2,GAO MengXu1,3,zheng Sheng1,3,XU Min1,3,XIE DongHui2,JIA HuiCong1,JI {3.1,ZHAO Jian1,3,CHEN {3.1,3 & NI XiLiang1,3.1 State Key Laboratory of Remote Sensing Science,Jointly Sponsored by institute of Remote Sensing Applications,Chinese academy of sciences and beijing Normal University,beijing 100101,china 2 State Key Laboratory of Remote Sensing Science,Jointly Sponsored by beijing Normal University and institute of Remote Sensing Applications of Chinese academy of sciences,beijing 100875,china 3 Graduate University of Chinese academy of sciences,beijing 100049,china State Key Laboratory of Remote Sensing Science Jointly Sponsored by Institute of Remote Sensing Applications Chinese Academy of Sciences and Beijing Normal University Beijing China State Key Laboratory of Remote Sensing Science Jointly Sponsored by Beijing Normal University and Institute of Remote Sensing Applications of Chinese Academy of Sciences Beijing China Graduate University of Chinese academy of sciences Beijing China

The spatial distribution of sub-pixel components has an impact on retrieval accuracy,and should be accounted for when inverting a three-dimensional adiative transfer model to retrieve leaf area index(LAI).To investigate this effect,we constructed three realistic scenarios with the same LAI values and other properties,except that the simulated plants had different *** implemented the radiosity method to subsequently produce synthetic bidirectional reflectance factor(BRF) datasets based upon these simulated *** inversion was conducted using these data,which showed that spatial distribution affects retrieval *** inversion was also conducted for LAI based on charge-coupled device(CCD) data from the Environment and Disaster Monitor Satellite(HJ-1),which depicted both forest and drought-resistant crop land *** showed that heterogeneity in coarse-resolution remote sensing data is the main error source in LAI *** spatial distribution of global fractal dimension index,which can be used to describe the area of sub-pixel components and their spatial distribution modes,shows good consistency with the coarse resolution LAI inversion error.

关键词： HJ-1 leaf area index scale effect spatial distribution

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Observation of spectral lines in the exceptional GRB 221009A

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Science china(Physics,Mechanics & Astronomy) 2024年第8期67卷 187-206页

作者： Yan-Qiu zhang Shao-Lin Xiong Ji-Rong Mao Shuang-Nan zhang Wang-Chen Xue Chao zheng Jia-Cong Liu Zhen zhang Xi-Lu Wang Ming-Yu Ge Shu-Xu Yi Li-Ming Song zheng-hua An Ce Cai Xin-Qiao Li Wen-Xi Peng Wen-Jun Tan Chen-wei Wang Xiang-Yang Wen Yue Wang Shuo Xiao Fan zhang Peng zhang Shi-Jie zheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese academy of sciences Beijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100012China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China College of Physics and Hebei Key Laboratory of Photophysics research and Application Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China College of Electronic and Information Engineering Tongji UniversityShanghai 201804China

As the brightest gamma-ray burst ever observed,GRB 221009A provided a precious opportunity to explore spectral line *** this article,we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GECAM-C and Fermi/GBM data to search for emission and absorption *** the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems,and identified prominent emission lines in multiple time *** central energy of the Gaussian emission line evolves from about 37 to 6 MeV,with a nearly constant ratio(about 10%)between the line width and central ***,we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of–1 and–2,*** suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 ke V *** find that a standard high latitude emission scenario cannot fully interpret the observation,thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the *** this scenario,we can use the emission line to directly,for the first time,measure the bulk Lorentz factor of the jet(Γ)and reveal its time evolution(i.e.,Γ~t^(-1))during the prompt ***,we find that the flux of the annihilation line in the co-moving frame keeps *** discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.

关键词： GRB GRB 221009A emission line

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Detector performance of the Gamma-ray Transient Monitor onboard DRO-A satellite

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Science china(Physics,Mechanics & Astronomy) 2024年第11期67卷 75-90页

作者： Pei-Yi Feng zheng-hua An Da-Li zhang Chen-wei Wang Chao zheng Sheng Yang Shao-Lin Xiong Jia-Cong Liu Xin-Qiao Li Ke Gong Xiao-Jing Liu Min Gao Xiang-Yang Wen Ya-Qing Liu Xiao-Yun Zhao Fan zhang Xi-Lei Sun Hong Lu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese academy of sciences Beijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

The Gamma-ray Transient Monitor(GTM) is an all-sky monitor onboard the Distant Retrograde Orbit-A(DRO-A) satellite with the scientific objective of detecting gamma-ray transients ranging from 20 ke V to 1 MeV. The GTM was equipped with five Gamma-ray Transient Probe(GTP) detector modules utilizing a NaI(Tl) scintillator coupled with a SiPM array. To reduce the SiPM noise, GTP uses a dedicated dual-channel coincident readout design. In this work, we first studied the impact of different coincidence times on the detection efficiency and ultimately selected a 0.5 μs time coincidence window for offline data processing. To test the performance of the GTPs and validate the Monte-Carlo-simulated energy response, we conducted comprehensive ground calibration tests using the Hard X-ray Calibration Facility(HXCF) and radioactive sources, including the energy response, detection efficiency, spatial response, bias-voltage response, and temperature dependence. We extensively present the ground calibration results and validate the design and mass model of the GTP detector, thus providing the foundation for in-flight observations and scientific data analysis.

关键词： NaI(Tl)detector energy response ground calibration gamma-ray detector DRO-A satellite

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