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geographical Agglomeration of chinese Manufacturing Industries

中国人口·资源与环境：英文版 2007年第2期5卷 3-11页

作者： zhang hua 1, 2. zheng wei3.1. institute of geographical sciences and natural resources research,{2., Beijing 100101, china 2. Graduate School of the{2., Beijing 100039, china 3. School of Geography, Beijing Normal University, Beijing 100875, china institute of geographical {2. and natural resources research Chinese Academy of Sciences Beijing 100101 China Graduate School of the chinese academy of sciences Beijing 100039 China School of Geography Beijing Normal University Beijing 100875 China

Based on the plant level data from the First National Census of Basic Units, the Second National Census of Basic Units, and the First National Economic Census of china, this paper ex- amines the geographical agglomeration of {2. manufacturing industries at a more disaggregated level both by industrial classi-fication and spatial unit analysis. Applying the agglomeration index proposed by Maurel and Sedillot, studies show that the most agglomerated industries are resource-intensive, and capital and technology intensive while industries demanding localized inputs or serving localized markets or favored by local governments are fairly dispersed. The more disaggregated industries are more spa- tially agglomerated. At the finer spatial scale, industries are more dispersed. Results indicate that within-county spillovers are stronger than nearby-county spillovers, and within-prefecture spillovers are stronger than nearby prefecture spillovers. Local- ized spillovers are still quite substantial at a range beyond that of counties. Comparing the agglomeration index of {2. manu- facturing industries in 1996, 2.01 and 2.04, agglomeration seems to be a general tendency. Results also indicate that some industries have experienced remarkable changes in their levels of agglom- eration in the period 1996–2.04.

关键词： industrial agglomeration manufacturing industries the MS index

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Integrated multi-omics analysis reveals liver metabolic reprogramming by fish iridovirus and antiviral function of alpha-linolenic acid

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Zoological research 2024年第3期45卷 520-534页

作者： Lin Liu Ya zhang Meng-Di Yuan Dong-Miao Xiao wei-{2. Xu Qi zheng Qi-wei Qin You-{2. {2.ng Xiao-Hong {2.ng College of Marine sciences South China Agricultural UniversityGuangdong Laboratory for Lingnan Modern AgricultureGuangzhouGuangdong 510642China Nansha-South china Agricultural University Fishery research {2. GuangzhouGuangdong 511464China Southern Marine Science and Engineering Guangdong Laboratory ZhuhaiGuangdong 519082China

Iridovirus poses a substantial threat to global aquaculture due to its high mortality rate;however,the molecular mechanisms underpinning its pathogenesis are not well ***,a multi-omics approach was applied to groupers infected with Singapore grouper iridovirus(SGIV),focusing on the roles of key *** showed that SGIV induced obvious histopathological damage and changes in metabolic enzymes within the ***,SGIV significantly reduced the contents of lipid droplets,triglycerides,cholesterol,and *** analysis indicated that the altered metabolites were enriched in 19 pathways,with a notable down-regulation of lipid metabolites such as glycerophosphates and alpha-linolenic acid(ALA),consistent with disturbed lipid homeostasis in the *** of transcriptomic and metabolomic data revealed that the top enriched pathways were related to cell growth and death and nucleotide,carbohydrate,amino acid,and lipid metabolism,supporting the conclusion that SGIV infection induced liver metabolic *** integrative transcriptomic and proteomic analysis indicated that SGIV infection activated crucial molecular events in a phagosome-immune depression-metabolism dysregulation-necrosis signaling *** note,integrative multi-omics analysis demonstrated the consumption of ALA and linoleic acid(LA)metabolites,and the accumulation of L-glutamic acid(GA),accompanied by alterations in immune,inflammation,and cell death-related *** experimental data showed that ALA,but not GA,suppressed SGIV replication by activating antioxidant and anti-inflammatory responses in the ***,these findings provide a comprehensive resource for understanding host response dynamics during fish iridovirus infection and highlight the antiviral potential of ALA in the prevention and treatment of iridoviral diseases.

关键词： Iridovirus Liver damage Metabolic reprogramming SGIV Alpha-linolenic acid Antiinflammatory

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***2.regulates plant height by affecting the main inflorescence length and first effective branch height in Brassica napus L.

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The Crop Journal 2024年第4期12卷 1102-1111页

作者： Chengke Pang Jun Yu Liang zhang Min Tang Hongfang Liu Ying Cai Feng Chen Jiefu zhang {2. hua Xiaodong Wang Ming zheng Oil Crops research institute of the {2. academy of Agricultural sciences Key Laboratory of Biology and Genetic Improvement of Oil CropsMinistry of Agriculture and Rural AffairsWuhan 430062HubeiChina Key Laboratory of Cotton and Rapeseed Ministry of Agriculture and Rural AffairsKey Laboratory of Jiangsu Province for AgrobiologyInstitute of Industrial CropsJiangsu Academy of Agricultural SciencesNanjing 210014JiangsuChina National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina

Rapeseed(Brassica napus L.)is one of the main oil crops in the world,and increasing its yield is of great significance for ensuring the safety of edible ***,improving rapeseed plant architecture is an effective way to increase rapeseed yield with higher planting ***,the regulatory mechanism of rapeseed plant architecture is poorly *** this study,a dwarf rapeseed mutant dwarf08(df08)is obtained by ethyl methane sulfonate(EMS)-*** decrease in plant height of df08 is mainly caused by the reduction in main inflorescence length and first effective branch height and controlled by a single semi-dominant *** hybrid plants(F1)show a semi-dwarf *** map-based cloning and transgenic assay,we confirm that the nonsynonymous single nucleotide variant(SNV)(C to T)in ***2.which is homologous with Arabidopsis(Arabidopsis thaliana)BIN2.is responsible for the dwarfism of ***2.interacts with BnaBZR1/BES1 and involves in brassinosteroids(BRs)signal *** to Leucine substitution in 2.4(P2.4L)enhances the protein stability of ***2.D,disrupts BRs signal transduction and affects the expression of genes regulating cell division,leading to dwarfism of *** study provides a new insight for the mechanism of rapeseed plant height regulation and creates an elite germplasm that can be used for genetic improvement of rapeseed architecture.

关键词： Brassica napus Plant height Brassinosteroids BIN2

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Quantitative estimation of the shrub canopy LAI from atmosphere-corrected HJ-1 CCD data in Mu Us Sandland

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Science china Earth sciences 2010年第S1期53卷 26-33页

作者： CHEN wei1,2,CAO ChunXiang1,HE QiSheng1,2,GUO huaDong3,zhang Hao1,2,LI RenQiang4,zheng Sheng1,2,XU Min1,2,GAO MengXu1,2,ZHAO Jian1,2,LI Sha1,NI XiLiang1,2,JIA HuiCong1,JI wei1,TIAN Rong1,2,LIU Cheng1,2,ZHAO YuXing5 & LI JingLu6 1 State Key Laboratory of Remote Sensing Science,Jointly Sponsored by the institute of Remote Sensing Applications of chinese academy of sciences and Beijing Normal University,Beijing 100101,china 2 Graduate University of chinese academy of sciences,Beijing 100049,china 3 Center for Earth Observation and Digital Earth,chinese academy of sciences,Beijing 100190,china 4 china Key Laboratory of Ecological Network Observation and Modeling,institute of geographical sciences and natural resources research,chinese academy of sciences,Beijing 100101,china 5 Ordos Forestry Sand Control Science institute,Dongsheng 017000,china 6 Inner Mongolia Biomass Thermoelectricity Limited Company,Wushen 017300,china 1. State Key Laboratory of Remote Sensing Science Jointly Sponsored by the Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University Beijing 100101 China 2. Graduate University of chinese academy of sciences Beijing 100049 China 3. Center for Earth Observation and Digital Earth Chinese Academy of Sciences Beijing 100190 China 4. china Key Laboratory of Ecological Network Observation and Modeling Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China 5. Ordos Forestry Sand Control Science institute Dongsheng 017000 China 6. Inner Mongolia Biomass Thermoelectricity Limited Company Wushen 017300 China

The leaf area index(LAI) is an important ecological parameter that characterizes the interface between vegetation canopy and the *** addition,it is used by most process-oriented ecosystem *** paper investigates the potential of HJ-1 CCD data combined with linear spectral unmixing and an inverted geometric-optical model for the retrieval of the shrub LAI in Wushen Banner of Inner Mongolia in the Mu Us ***(Moderate Resolution Atmospheric Radiance and Transmittance Model) was used for atmospheric *** was extracted using the threshold of the normalized difference vegetation index,with which water bodies and farmland were separated,in combination with a vegetation map of the People's Republic of china(1:1000000).Using the geometric-optical model,we derive the per-pixel reflectance as a simple linear combination of two components,namely sunlit background and *** fraction of sunlit background is related to the shrub *** the support of HJ-1 CCD data,we employ linear spectral unmixing to obtain the fraction of sunlit background in an atmospherically corrected HJ *** addition,we use the measured shrub canopy structural parameters for shrub communities to invert the geometric-optical model and retrieve the pixel-based shrub *** total,18 sample plots collected in Wushen Banner of Inner Mongolia are used for *** results of the shrub LAI show good agreement with R2.of 0.817 and a root-mean-squared error of 0.173.

关键词： shrub leaf area index inversion HJ-1 data geometric-optical model MODTRAN Mu Us Sandland

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Hydrogen peroxide sulfenylates and inhibits the photorespiratory enzyme PGLP1 to modulate plant thermotolerance

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Plant Communications 2024年第6期5卷 139-153页

作者： zheng-wei Fu Feng Ding Bing-Lei {2. Wen-Cheng Liu Zi-Hong huang Shi-Hang Fan Yu-Rui Feng Ying-Tang Lu wei hua Key Laboratory of Biology and Genetic Improvement of Oil Crops Ministry of Agriculture and Rural AffairsOil Crops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062China State Key Laboratory of Hybrid Rice College of Life SciencesWuhan UniversityWuhan 430072China School of Landscape and Ecological Engineering Hebei University of EngineeringHandan 056038China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China Hubei Hongshan Laboratory Wuhan 430070China

Climate change is resulting in more frequent and rapidly changing temperatures at both extremes that severely affect the growth and production of plants,particularly *** stress caused by high temperatures is one of the most damaging factors for ***,the role of hydrogen peroxide(H_(2.O_(2.)in modulating plant thermotolerance is largely unknown,and the regulation of photorespiration essential for C3 species remains to be fully ***,we report that heat stress promotes H2.2.accumulation in chloroplasts and that H2.2.stimulates sulfenylation of the chloroplast-localized photorespiratory enzyme 2.phosphoglycolate phosphatase 1(PGLP1)at cysteine 86,inhibiting its activity and promoting the accumulation of the toxic metabolite *** also demonstrate that PGLP1 has a positive function in plant thermotolerance,as PGLP1 antisense lines have greater heat sensitivity and PGLP1-overexpressing plants have higher heat-stress tolerance than the wild ***,our results demonstrate that heat-induced H2.2.in chloroplasts sulfenylates and inhibits PGLP1 to modulate plant ***,targeting CATALASE2.to chloroplasts can largely prevent the heatinduced overaccumulation of H2.2.and the sulfenylation of PGLP1,thus conferring thermotolerance without a plant growth *** findings reveal that heat-induced H2.2.in chloroplasts is important for heat-caused plant damage.

关键词： heat stress photorespiration hydrogen peroxide PGLP1 2.phosphoglycolate

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Health risks and sources of trace elements and black carbon in PM_(2.5)from 2.19 to 2.2. in Beijing

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Journal of Environmental sciences 2024年第8期142卷 69-82页

作者： Chenjie hua wei Ma Feixue {2. Yusheng zhang Jiali Xie Li Ma Boying Song Chao Yan Hongyan Li Zhen Liu Qian Liu Markku Kulmala Yongchun Liu Aerosol and Haze Laboratory Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China institute for Atmospheric and Earth System research Faculty of ScienceUniversity of HelsinkiHelsinki 00014Finland School of Environment and Safety Taiyuan University of Science and TechnologyTaiyuan 030024China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

A comprehensive health risk assessment of PM_(2.5)is meaningful to understand the current status and directions regarding further improving air quality from the perspective of human *** this study,we evaluated the health risks of PM_(2.5)as well as highly toxic inorganic components,including heavy metals(HMs)and black carbon(BC)based on longterm observations in Beijing from 2.19 to *** results showed that the relative risks of chronic obstructive pulmonary disease,lung cancer,acute lower respiratory tract infection,ischemic heart disease,and stroke decreased by 4.07%-9.30%in 2.2. and 2.12.-6.70%in2.2. compared with ***,they were still at high levels ranging from 1.2. to 1.77,in particular,stroke showed the highest value in *** had the highest hazard quotient(HQ,from 2.18 to 2.56)for adults from 2.19 to 2.2.,while Ni,Cr,Pb,As,and BC showed high carcinogenic risks(CR>1.0×10^(-6))for *** HQ values of Mn and As and the CR values of Pb and As showed constant or slight upwards trends during our observations,which is in contrast to the downward trends of other HMs and PM_(2.5).Mn,Cr,and BC are crucial toxicants in PM_(2.5).A significant shrink of southern region sourcesof HMs and BCshrank suggests the increased importance of local ***,dust,and biomass burning are the major contributors to the non-carcinogenic risks,while traffic emissions and industry are the dominant contributors to the carcinogenic risks in Beijing.

关键词： PM_(2.5) Heavy metals Black carbon Health risk Source apportionment

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Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

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Military Medical research 2024年第4期11卷 500-520页

作者： Kun zhang Meng-Xia zhang Xiao-Xiang Meng Jing Zhu Jia-Jun Wang Yi-Fan He Ye-{2. Li Si-Cong Zhao Zhe-Min Shi Li-Na zheng Tao Han wei Hong Department of Histology and Embryology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Department of Hepatology and Gastroenterology Tianjin Union Medical CenterTianjin Medical UniversityTianjin Union Medical Center Affiliated to Nankai UniversityTianjin 300000China

Background:G-protein coupled receptors(GPCRs)are recognized as attractive targets for drug ***,it remains poorly understood how GPCRs,except for a few chemokine receptors,regulate the progression of liver ***,we aimed to reveal the role of GPR65,a proton-sensing receptor,in liver fibrosis and to elucidate the underlying ***:The expression level of GPR65 was evaluated in both human and mouse fibrotic ***,Gpr65-deficient mice were treated with either bile duct ligation(BDL)for 2. d or carbon tetrachloride(CCl4)for 8 weeks to investigate the role of GPR65 in liver fibrosis.A combination of experimental approaches,including Western blotting,quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR),and enzyme-linked immunosorbent assay(ELISA),confocal microscopy and rescue studies,were used to explore the underlying mechanisms of GPR65’s action in liver ***,the therapeutic potential of GPR65 inhibitor in the development of liver fibrosis was ***:We found that hepatic macrophage(HM)-enriched GPR65 was upregulated in both human and mouse fibrotic ***,knockout of Gpr65 significantly alleviated BDL-and CCl4-induced liver inflammation,injury and fibrosis in vivo,and mouse bone marrow transplantation(BMT)experiments further demonstrated that the protective effect of Gpr65knockout is primarily mediated by bone marrow-derived macrophages(BMMs).Additionally,in vitro data demonstrated that Gpr65 silencing and GPR65 antagonist inhibited,while GPR65 overexpression and application of GPR65 endogenous and exogenous agonists enhanced the expression and release of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and transforming growth factor-β(TGF-β),all of which subsequently promoted the activation of hepatic stellate cells(HSCs)and the damage of hepatocytes(HCs).Mechanistically,GPR65 overexpression,the acidic pH and GPR65 exogenous agonist induced up-regulation of

关键词： GPR65 Hepatic fibrosis Hepatic macrophages Inflammation c-Jun N-terminal kinase Nuclear factorκB

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Observation of spectral lines in the exceptional GRB 2.1009A

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Science china(Physics,Mechanics & Astronomy) 2024年第8期67卷 187-206页

作者： Yan-Qiu zhang Shao-Lin Xiong Ji-Rong Mao Shuang-Nan zhang Wang-Chen Xue Chao zheng Jia-Cong Liu Zhen zhang Xi-Lu Wang Ming-Yu Ge Shu-Xu Yi Li-Ming Song zheng-hua An Ce Cai Xin-Qiao Li Wen-Xi Peng Wen-Jun Tan Chen-wei Wang Xiang-Yang Wen Yue Wang Shuo Xiao Fan zhang Peng zhang Shi-Jie zheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Beijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100012China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China College of Physics and Hebei Key Laboratory of Photophysics research and Application Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China College of Electronic and Information Engineering Tongji UniversityShanghai 201804China

As the brightest gamma-ray burst ever observed,GRB 2.1009A provided a precious opportunity to explore spectral line *** this article,we performed a comprehensive spectroscopy analysis of GRB 2.1009A jointly with GECAM-C and Fermi/GBM data to search for emission and absorption *** the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems,and identified prominent emission lines in multiple time *** central energy of the Gaussian emission line evolves from about 37 to 6 MeV,with a nearly constant ratio(about 10%)between the line width and central ***,we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of–1 and–2.*** suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 ke V *** find that a standard high latitude emission scenario cannot fully interpret the observation,thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the *** this scenario,we can use the emission line to directly,for the first time,measure the bulk Lorentz factor of the jet(Γ)and reveal its time evolution(i.e.,Γ~t^(-1))during the prompt ***,we find that the flux of the annihilation line in the co-moving frame keeps *** discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.

关键词： GRB GRB 2.1009A emission line

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Scale effects of leaf area index inversion based on environmental and disaster monitoring satellite data

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Science china Earth sciences 2010年第S1期53卷 92-98页

作者： zhang Hao1,LI XiaoWen1,2.CAO ChunXiang1,YANG hua2.GAO MengXu1,3,{2. Sheng1,3,XU Min1,3,XIE DongHui2.JIA HuiCong1,JI {3.1,ZHAO Jian1,3,CHEN {3.1,3 & NI XiLiang1,3.1 State Key Laboratory of Remote Sensing Science,Jointly Sponsored by institute of Remote Sensing Applications,chinese academy of sciences and Beijing Normal University,Beijing 100101,china 2.State Key Laboratory of Remote Sensing Science,Jointly Sponsored by Beijing Normal University and institute of Remote Sensing Applications of chinese academy of sciences,Beijing 100875,china 3 Graduate University of chinese academy of sciences,Beijing 100049,china 1. State Key Laboratory of Remote Sensing Science Jointly Sponsored by Institute of Remote Sensing Applications Chinese Academy of Sciences and Beijing Normal University Beijing 100101 China2. State Key Laboratory of Remote Sensing Science Jointly Sponsored by Beijing Normal University and Institute of Remote Sensing Applications of Chinese Academy of Sciences Beijing 100875 China3. Graduate University of Chinese Academy of Sciences Beijing 100049 China

The spatial distribution of sub-pixel components has an impact on retrieval accuracy,and should be accounted for when inverting a three-dimensional adiative transfer model to retrieve leaf area index(LAI).To investigate this effect,we constructed three realistic scenarios with the same LAI values and other properties,except that the simulated plants had different *** implemented the radiosity method to subsequently produce synthetic bidirectional reflectance factor(BRF) datasets based upon these simulated *** inversion was conducted using these data,which showed that spatial distribution affects retrieval *** inversion was also conducted for LAI based on charge-coupled device(CCD) data from the Environment and Disaster Monitor Satellite(HJ-1),which depicted both forest and drought-resistant crop land *** showed that heterogeneity in coarse-resolution remote sensing data is the main error source in LAI *** spatial distribution of global fractal dimension index,which can be used to describe the area of sub-pixel components and their spatial distribution modes,shows good consistency with the coarse resolution LAI inversion error.

关键词： HJ-1 leaf area index scale effect spatial distribution

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Detector performance of the Gamma-ray Transient Monitor onboard DRO-A satellite

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Science china(Physics,Mechanics & Astronomy) 2024年第11期67卷 75-90页

作者： Pei-Yi Feng zheng-hua An Da-Li {2. Chen-wei Wang Chao zheng Sheng Yang Shao-Lin Xiong Jia-Cong Liu Xin-Qiao Li Ke Gong Xiao-Jing Liu Min Gao Xiang-Yang Wen Ya-Qing Liu Xiao-Yun Zhao Fan {2. Xi-Lei Sun Hong Lu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Beijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

The Gamma-ray Transient Monitor(GTM) is an all-sky monitor onboard the Distant Retrograde Orbit-A(DRO-A) satellite with the scientific objective of detecting gamma-ray transients ranging from 2. ke V to 1 MeV. The GTM was equipped with five Gamma-ray Transient Probe(GTP) detector modules utilizing a NaI(Tl) scintillator coupled with a SiPM array. To reduce the SiPM noise, GTP uses a dedicated dual-channel coincident readout design. In this work, we first studied the impact of different coincidence times on the detection efficiency and ultimately selected a 0.5 μs time coincidence window for offline data processing. To test the performance of the GTPs and validate the Monte-Carlo-simulated energy response, we conducted comprehensive ground calibration tests using the Hard X-ray Calibration Facility(HXCF) and radioactive sources, including the energy response, detection efficiency, spatial response, bias-voltage response, and temperature dependence. We extensively present the ground calibration results and validate the design and mass model of the GTP detector, thus providing the foundation for in-flight observations and scientific data analysis.

关键词： NaI(Tl)detector energy response ground calibration gamma-ray detector DRO-A satellite

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