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关节灌洗术联合心理护理对TMJOA患者的影响

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中国城乡企业卫生 2024年第6期39卷 101-105页

作者：崔静张智玲天津市口腔医院南开大学口腔医院颌面头颈外科天津300041

目的探讨颞下颌关节灌洗术联合心理护理对颞下颌关节骨关节炎(TMJOA)患者临床效果、生活质量水平及心理状况的影响。方法选取2020年1—12月于天津市口腔医院就诊治疗的TMJOA患者200例。将患者随机分为研究组和对照组各100例。研究组采... 详细信息

目的探讨颞下颌关节灌洗术联合心理护理对颞下颌关节骨关节炎(TMJOA)患者临床效果、生活质量水平及心理状况的影响。方法选取2020年1—12月于天津市口腔医院就诊治疗的TMJOA患者200例。将患者随机分为研究组和对照组各100例。研究组采用颞下颌关节灌洗术联合心理护理,对照组仅采用颞下颌关节灌洗术。比较两组患者干预前后最大张口度、疼痛评分、生活质量评分及心理状况评分。结果干预前,两组患者最大开口情况和疼痛评分比较差异无统计学意义(P>0.05);干预后3个月及6个月,两组患者最大开口情况和疼痛评分均优于干预前,且研究组优于对照组,差异均有统计学意义(P0.05);干预后3个月及6个月,两组患者OHIP-14量表评分均低于干预前,且研究组低于对照组,差异均有统计学意义(P0.05);干预后3个月及6个月,两组患者DASS-21量表评分均低于干预前,且研究组低于对照组,差异均有统计学意义(P<0.05)。结论颞下颌关节灌洗术联合心理护理与单纯颞下颌关节灌洗术均对TMJOA有一定临床疗效,其中颞下颌关节灌洗术联合心理护理治疗方式对改善患者生活质量水平及心理状况效果更佳。

关键词：颞下颌关节骨关节炎颞下颌关节灌洗术心理护理

颅脑手术患者术后发生手术部位感染危险因素的Meta分析

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实用心脑肺血管病杂志 2024年第6期32卷 90-97,102页

作者：梁新慧张珊张腊婷胡梦依贾瑶刘芳姜雪陕西中医药大学护理学院陕西省咸阳市712046 空军军医大学第二附属医院神经外科陕西省西安市710038 中国人民解放军空军军医大学护理系陕西省西安市710032

目的系统评价颅脑手术患者术后发生手术部位感染的危险因素。方法计算机检索PubMed、Embase、Cochrane Library、Web of Science、中国生物医学文献数据库、中国知网、万方数据知识服务平台、维普网中关于颅脑手术患者术后发生手术部位... 详细信息

目的系统评价颅脑手术患者术后发生手术部位感染的危险因素。方法计算机检索PubMed、Embase、Cochrane Library、Web of Science、中国生物医学文献数据库、中国知网、万方数据知识服务平台、维普网中关于颅脑手术患者术后发生手术部位感染危险因素的研究。检索时限为建库至2023年10月。提取纳入文献的资料,采用RevMan 5.3和Stata 15.0软件进行Meta分析。结果共纳入41篇文献,共60673例颅脑手术患者。Meta分析结果显示,颅脑手术患者术后手术部位感染发生率为8.4%〔95%CI(6.8%~10.1%)〕。术前住院时间>3 d〔OR=2.96,95%CI(1.68~5.22),P2 h〔OR=3.40,95%CI(2.07~5.58),PⅡ级〔OR=3.75,95%CI(1.40~10.04),P3 h〔OR=2.60,95%CI(1.61~4.21),P4 h〔OR=2.26,95%CI(1.41~3.62),P2个〔OR=3.82,95%CI(1.60~9.14),P3 d〔OR=2.43,95%CI(1.44~4.09),P4 d〔OR=1.97,95%CI(1.34~2.89),P3 d、合并糖尿病、备皮时间>2 h、ASA分级>Ⅱ级、二次手术、急诊手术、手术持续时间延长、手术持续时间>3 h、手术持续时间>4 h、污染切口、手术切口数量>2个、硬脑膜切开、术中输血、术中植入物、脑脊液漏、脑室外引流、留置引流管时间、留置引流管时间>3 d、留置引流管>4 d是颅脑手术患者术后发生手术部位感染的危险因素。

关键词：神经外科手术外科伤口感染危险因素 Meta分析

Synthesis and characterization of carbazole-based dendrimers as bipolar host materials for green phosphorescent organic light emitting diodes

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Chinese Chemical Letters 2016年第3期27卷 441-446页

作者： Ting zhang Dong-Qing Xu Jun-Ming Chen Ping zhang Xu-Chun Wang School of Chemistry and Material Engineering Anhui Science and Technology University Center of Analysis and Measurement Anhui Science and Technology University

A group of novel, carbazole-based dendrimers comprised of the electron-accepting dibenzothiophene core and the electron-donating oligo-carbazole dendrons, namely G1 SF and G2 SF, are synthesized utilizing the Ullmann C–N coupling reaction. The dendrimers are designed in such a way to show good solubility in common organic solvents, excellent thermochemical stability with decomposition temperatures（Td） up to430 8C, and high HOMO levels in a range from 5.45 e V to 5.37 e V. Results of density functional theory calculations（DFT） indicate G2 SF has an almost complete separation of HOMO and LUMO levels at the holeand electron-transporting moieties; while G1 SF exhibits only partial separation of the HOMO and LUMO levels possibly due to intramolecular charge transfer. Green phosphorescent OLEDs were fabricated by the spin coating method with the dendrimers as hosts and traditional green iridium phosphor as doped emitter. Under ambient conditions, a maximum luminance efficiency（hl） of 19.83 cd A^-1and a maximum external quantum efficiency of 5.85% are achieved for G1 SF, and 15.50 cd A ^-1and 4.57% for G2 SF.

关键词： OLEDs Bipolar host materials Dendrimer Carbazole Dibenzothiophene

Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins

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Chinese Journal of Natural Medicines 2015年第9期13卷 660-666页

作者： zhang Shou-De SHAN Lei LI Wei LI Hong-Lin zhang Wei-Dong Shanghai Key Laboratory of New Drug Design State Key Laboratory of Bioreactor Engineering School of Pharmacy East China University of Science and Technology School of Pharmacy Second Military Medical University Qinghai Academy of Agriculture and Forestry Science

The biflavonoid isochamaejasmin is mainly distributed in the root of Stellera chamaejasme L.(Thymelaeaceae) that is used in traditional Chinese medicine(TCM) to treat tumors, tuberculosis, and psoriasis. Herein, isochamaejasmin was found to show similar bioactivity against Bcl-2 family proteins to the reference Bcl-2 ligand(–)-gossypol through 3D similarity search. It selectively bound to Bcl-xL and Mcl-1 with Ki values being 1.93 ± 0.13 μmol·L-1 and 9.98 ± 0.21 μmol·L-1, respectively. In addition, isochamaejasmin showed slight growth inhibitory activity against hl-60 with IC50 value being 50.40 ± 1.21 μmol·L-1 and moderate growth inhibitory activity against K562 cells with IC50 value being 24.51 ± 1.62 μmol·L-1. Furthermore, isochamaejasmin induced apoptosis of K562 cells by increasing the intracellular expression levels of proteins of the cleavage of caspase-9, caspase-3, and PARP which involved in the Bcl-2-induced apoptosis pathway. These results indicated that isochamaejasmin induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S. chamaejasme L..

关键词： Stellera chamaejasme L. Isochamaejasmin Bcl-2 3D Similarity search (–)-Gossypol Apoptosis

通过金属离子刺激调节金属有机骨架结构用于光催化CO_(2)还原

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无机化学学报 2024年第1期40卷 209-220页

作者：路新钱建磊葛发源李浩天郑和根张传磊安庆师范大学化学化工学院光电磁功能材料安徽省重点实验室安庆246133 南京大学化学化工学院配位化学国家重点实验室南京210023

通过自组装得到一种具有适中配位键强度和适度骨架柔性的二维Cd基金属有机骨架(MOF){[Cd(hl)(BPY)_(0.5)(H_(2)O)]·2H_(2)O}_(n)(1),其中H_(3)L=4,4′,4″-(亚硝基三(亚甲基))三苯甲酸,(BPY=4,4′-联吡啶)。由于其独特的结构特征,在金... 详细信息

通过自组装得到一种具有适中配位键强度和适度骨架柔性的二维Cd基金属有机骨架(MOF){[Cd(hl)(BPY)_(0.5)(H_(2)O)]·2H_(2)O}_(n)(1),其中H_(3)L=4,4′,4″-(亚硝基三(亚甲基))三苯甲酸,(BPY=4,4′-联吡啶)。由于其独特的结构特征,在金属离子(Zn^(2+)/Ni^(2+)/Co^(2+))刺激下,1逐渐转变成相应金属离子主导的MOF结构2、3和4。在此过程中,随着金属离子Cd^(2+)→Zn^(2+)、Cd^(2+)→Ni^(2+)和Cd^(2+)→Co^(2+)的交换,1通道中自由的Cd^(2+)和L^(3-)与MOF的骨架进行融合,导致通道空间的扩大,发生次级构筑单元(SBU)的转变,进而形成可调节的骨架。光催化二氧化碳还原结果表明,由离子交换所得到的新结构在催化效率上并没有很大改观,但在产物选择性上却有极大地提升(其中配合物3展示出100%的CO选择性)。

关键词：金属有机骨架离子刺激结构转换光催化二氧化碳还原

Deciphering and engineering high-light tolerant cyanobacteria for efficient photosynthetic cell factories

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Chinese Journal of Chemical Engineering 2021年第2期34卷 82-91页

作者： Yaru Xie Lei Chen Tao Sun Weiwen zhang Laboratory of Synthetic Microbiology School of Chemical Engineering&TechnologyTianjin UniversityTianjin 300072China Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering Ministry of Education of ChinaTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072China Center for Biosafety Research and Strategy Tianjin UniversityTianjin 300072China Law School Tianjin UniversityTianjin 300072China

Development and utilization of“liquid sunshine”could be one of key solutions to deal with the issues of fossil fuel depletion and increasing carbon *** are the only prokaryotes capable of performing oxygenic photosynthesis,and their activity accounts for~25%of the total carbon fixation on *** importantly,besides their traditional roles as primary producers,cyanobacteria could be modified as“photosynthetic cell factories”to produce renewable fuels and chemicals directly from CO_(2) driven by solar energy,with the aid of cutting-edging synthetic biology *** their large-scale biotechnological application in the future,many challenges still need to be properly addressed,among which is cyanobacterial cell factories inevitably suffer from high light(hl)stress during large-scale outdoor cultivation,resulting in photodamage and even cell death,limiting their *** this review,we critically summarized recent progress on deciphering molecular mechanisms to hl and developing hl-tolerant chassis in cyanobacteria,aiming at facilitating construction of hlresistant chassis and promote the future application of the large-scale outdoor cultivation of cyanobacterial cell ***,the future directions on cyanobacterial chassis engineering were discussed.

关键词： High-light Stress Chassis Cell factories Cyanobacteria

Magnetocaloric effect and slow magnetic relaxation behavior in binuclear rare earth based RE_(2)(L)_(2)(DMF)4(RE=Gd,Tb,and Dy) complexes

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Journal of Rare Earths 2022年第6期40卷 916-923,I0003页

作者： Zhenqian zhang Yuwei Wu Haifeng Wang Lingwei Li Key Laboratory of Novel Materials for Sensor of Zhejiang Province Institute of Advanced Magnetic MaterialsHangzhou Dianzi UniversityHangzhou 310012China State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi'an 710072China Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern UniversityShenyang 110819China

Three binuclear rare earth based complexes combining RE ions with semirigid tricarboxylic ligand(H_(3)L).namely,[RE_(2)(L)_(2)(DMF)_(4)][RE=Gd,Tb,and Dy;H_(3)L=5-((4-Carboxybenzyl)oxy)isophthalic acid;DMF=N,N-dimethylformamide]complexes,were fabricated success *** RE_(2)(L)_(2)(DMF)_(4) co mplexe s consist of two central RE ions with the same coordination environment which were connected by two tridentate bridging carboxylic groups and two syn-syn bidentate bridging carboxylic groups originating from the L^(3-)ligands to form the{RE_(2)}dimeric unit,and thus provides the basis for further constructing a dense three-dimensional(3 D)network ***,the present RE_(2)(L)_(2)(DMF)_(4) complexes can be described by a topology diagram with the topology point symbol of{4^(2)·6}_(2){4^(4)·6^(2)·8^(7)·10^(2)}.Weak antiferromagnetic(AFM)coupling between the adjacent RE ions for all the present complexes was found according to the magnetic *** observed significant cryogenic magnetocaloric effect(MCE)with the maximum magnetic entropy change-ΔS_(M)^(max) to be 26.3 J/(kg·K)withΔH=7 T in Gd_(2)(L)_(2)(DMF)_(4) complex makes it competitive for the cryogenic magnetic ***,the slow magnetic relaxation behavior at 0.2 T dc field with an obvious large U_(eff)/k=45(4)K and τ_(0)=6.5(2)×10^(-10)s was confirmed in Dy_(2)(L)_(2)(DMF)_(4)*** work not only provides an effective strategy for obtaining molecular materials with high MCE,but also confirms that tricarboxylate ligands are the ideal choice for constructing stable high dimensional geometric structures.

关键词： Magnetocaloric effect Rare earth based complex Magnetic properties Slow magnetic relaxation bahavior

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基于稳健统计量的Morris因子筛选方法

运筹与管理 2024年第6期33卷 93-99页

作者：谢恩马义中刘丽君张凤霞南京理工大学经济管理学院江苏南京210094

Morris方法因其高效且与模型无关的特性,被广泛应用于输入因子数目较大或计算模型运行成本较高的因子筛选研究中。然而,传统的Morris方法基于数据无异常值的假设,难以应对数据中存在异常值情形的因子筛选问题。因此,本文采用稳健统计量... 详细信息

Morris方法因其高效且与模型无关的特性,被广泛应用于输入因子数目较大或计算模型运行成本较高的因子筛选研究中。然而,传统的Morris方法基于数据无异常值的假设,难以应对数据中存在异常值情形的因子筛选问题。因此,本文采用稳健统计量度量因子效应来改进传统的Morris方法,有效的解决了模型响应中存在异常值时的因子筛选问题。本文首先引入稳健统计量并简单分析其性质;然后,采用稳健的位置和尺度统计量替代均值和标准差改进传统的Morris方法,使得因子筛选结果不受异常值影响;最后,引入两个常用的测试函数和一个实际案例,验证所提方法的有效性和适用性。试验结果表明,本文所提方法具有广泛的适用性,不管模型响应中是否存在异常值都能有效进行因子筛选,且比传统的Morris方法具有更高的效率。

关键词： Morris方法基本效应因子筛选稳健统计量异常值

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耳穴疗法对尿失禁防治效果的Meta分析

军事护理 2024年第9期41卷 104-107页

作者：张颖吴思远朱柯平侯思佳王薇浙江大学医学院附属第一医院护理部浙江杭州310003

目的探讨耳穴疗法对尿失禁的防治效果。方法检索国知网、PubMed、Web of Science等数据库中耳穴疗法防治尿失禁的相关文献,检索时限自建库至2024年7月11日。结果纳入14项研究,共1196例患者。结果显示,耳穴疗法在临床有效率、尿失禁发生... 详细信息

目的探讨耳穴疗法对尿失禁的防治效果。方法检索国知网、PubMed、Web of Science等数据库中耳穴疗法防治尿失禁的相关文献,检索时限自建库至2024年7月11日。结果纳入14项研究,共1196例患者。结果显示,耳穴疗法在临床有效率、尿失禁发生率、生活质量、漏尿次数、漏尿量和尿失禁持续时间的临床效果优于对照组(均P0.05)。结论耳穴疗法应用于尿失禁患者能够增强其临床疗效,减少漏尿次数和漏尿量,改善患者生活质量。

关键词：耳穴疗法耳穴贴压尿失禁系统评价 Meta分析