检索结果-南通市图书馆

基于胸痛数据库构建急诊急性高危胸痛患者急性心肌梗死的无创诊断模型及临床意义

在线全文

学校读者我要写书评

暂无评论

中国医师进修杂志 2024年第8期47卷 673-679页

作者：王琰王喜云张东勤师猛济宁医学院附属医院急诊科济宁272029

目的基于胸痛数据库构建急诊急性高危胸痛患者急性心肌梗死(AMI)的无创诊断模型,并分析其临床意义。方法回顾性选取2020年1月至2022年10月济宁医学院附属医院收治的467例急性高危胸痛患者,根据是否发生AMI分为AMI组(317例)、非AMI组(150... 详细信息

目的基于胸痛数据库构建急诊急性高危胸痛患者急性心肌梗死(AMI)的无创诊断模型,并分析其临床意义。方法回顾性选取2020年1月至2022年10月济宁医学院附属医院收治的467例急性高危胸痛患者,根据是否发生AMI分为AMI组(317例)、非AMI组(150例),比较两组临床资料,采用Lasso回归和Logistic回归分析发生AMI的危险因素,采用R语言建立诊断模型,采用一致性指数(C-index)评价模型的预测能力,采用校准曲线和决策分析曲线(DCA)对所建立模型进行外部验证和评价。结果单因素分析结果显示,AMI组冠心病患者比例、呼吸频率、肌红蛋白、肌酸激酶同工酶-MB(CK-MB)、心肌肌钙蛋白I(cTnI)、D-二聚体、N末端B型利钠肽前体、C反应蛋白、纤维蛋白原、乳酸、ST段抬高患者比例、室壁运动异常患者比例高于非AMI组[51.10%(162/317)比21.33%(32/150)、(19.25±2.44)次/min比(16.30±2.15)次/min、(270.03±26.59)μg/L比(71.44±19.85)μg/L、(30.51±8.22)μg/L比(3.22±0.88)μg/L、(4.51±1.38)μg/L比(0.04±0.01)μg/L、(1.69±0.51)mg/L比(0.32±0.09)mg/L、(2085.66±561.24)ng/L比(964.39±257.40)ng/L、(13.98±4.52)mg/L比(7.11±2.26)mg/L、(4.07±0.83)g/L比(2.95±0.78)g/L、(2.20±0.49)mmol/L比(1.36±0.35)mmol/L、80.76%(256/317)比16.67%(25/150)、95.27%(302/317)比17.33%(26/150)],血小板计数、活化部分凝血活酶时间、凝血酶原时间、左室射血分数低于非AMI组[(168.97±29.66)×10^(9)/L比(230.58±30.57)×10^(9)/L、(30.25±4.59)s比(33.59±4.16)s、(11.82±0.74)s比(13.25±1.02)s、(47.25±5.33)%比(58.49±5.07)%],差异均有统计学意义(P<0.05)。Lasso回归分析选出7个预测变量,分别为冠心病、肌红蛋白、CK-MB、cTnI、D-二聚体、ST段抬高、室壁运动异常;多因素Logistic回归分析结果显示,冠心病、肌红蛋白、CK-MB、cTnI、D-二聚体、ST段抬高、室壁运动异常是发生AMI的独立危险因素(P<0.05),经Hosmer-Lemeshow拟合优度检验显示拟合良好(χ^(2)=2.56,df=9,P=0.860);运用R语言绘制AMI的无创诊断模型,其C-index为0.945,提示预测能力良好;校准曲线分析显示,诊断模型校准度为0.918,提示模型与实际观测结果有较好的一致性;绘制DCA显示诊断AMI的列线图模型具有明显的正向净收益,临床效用良好。结论冠心病、肌红蛋白、CK-MB、cTnI、D-二聚体、ST段抬高、室壁运动异常可作为急诊急性高危胸痛患者AMI的无创诊断标志物,基于以上因素所构建的诊断模型预测性能良好。

关键词：胸痛心肌梗死无创诊断模型基本数据数据库

在线全文

学校读者我要写书评

暂无评论

中国运动训练理论的历史演进与逻辑解析

上海体育大学学报 2024年第9期48卷 1-11,70页

作者：金成平余银胡海旭高平杨成波张冬琴贾昊哲石磊武汉理工大学体育学院湖北武汉430070 山东体育学院运动监控大数据中心山东日照276826 武汉体育学院运动训练学院湖北武汉430079 南京体育学院运动训练学院江苏南京210014 成都体育学院运动训练学院四川成都610041 北京体育大学竞技体育学院北京100084 首都体育学院武术与表演学院北京100191

采用文献资料、专家访谈、个案分析、历史追踪等方法,回溯新中国成立以来中国运动训练理论的发展轨迹,探讨中国运动训练理论的发展历程、建设成就、演进逻辑、现实问题。发现:中国运动训练理论历经3个历史发展阶段,通过实践界、理论界... 详细信息

采用文献资料、专家访谈、个案分析、历史追踪等方法,回溯新中国成立以来中国运动训练理论的发展轨迹,探讨中国运动训练理论的发展历程、建设成就、演进逻辑、现实问题。发现:中国运动训练理论历经3个历史发展阶段,通过实践界、理论界和科技界几代人的共同努力和单学科纵深发展、多学科融合发展、跨学科合作发展路径,已经构建了系统知识体系、创新学科体系和实践指导体系;通过重视历史经验的传承性、发展性和自觉性,强化指导实践的学理性、创新性和系统性,遵循理论演进的导向性、规律性和协同性等多种逻辑,实现了中国运动训练理论的科学升级和守正创新。

关键词：运动训练理论知识体系学科体系指导体系代表性成果

维普期刊数据库博看期刊

微生物菌肥替代部分化肥对花椰菜产量、品质及土壤微生物的影响

在线全文

学校读者我要写书评

暂无评论

浙江农业学报 2024年第3期36卷 589-599页

作者：侯栋李亚莉岳宏忠张东琴姚拓黄书超杨海兴甘肃省农业科学院蔬菜研究所甘肃兰州730070 甘肃农业大学草业学院草业生态系统教育部重点实验室甘肃兰州730070 甘肃农业大学园艺学院甘肃兰州730070 甘肃省榆中县农业技术推广中心甘肃榆中730070

于2018—2020年在甘肃省兰州市榆中县开展连续3 a的定点试验,监测微生物菌肥替代部分化肥对花椰菜产量、品质及土壤环境的影响。试验共设3个处理:A,全量化肥(当地常用化肥施用量,100%化肥);B,菌肥(60 kg·hm^(-2))+当地常用化肥施用量的... 详细信息

于2018—2020年在甘肃省兰州市榆中县开展连续3 a的定点试验,监测微生物菌肥替代部分化肥对花椰菜产量、品质及土壤环境的影响。试验共设3个处理:A,全量化肥(当地常用化肥施用量,100%化肥);B,菌肥(60 kg·hm^(-2))+当地常用化肥施用量的60%;C,菌肥(120 kg·hm^(-2))+当地常用化肥施用量的40%。结果表明:在2018年和2020年,B处理的产量分别达到了32.41、33.61 t·hm^(-2),较同年的A处理分别显著(P<0.05)高出7.7%和2.1%;但在2019年,A处理的产量显著高于其他处理。与A处理相比,B、C处理在2019年的V C含量分别显著提高了72.2%和94.3%;B处理的花椰菜花球在2020年的硝酸盐含量显著降低了7.0%。经过3 a试验,与A处理相比,B、C处理的土壤蔗糖酶活性和有效磷含量显著升高;C处理的土壤速效钾含量显著下降,而全磷含量显著升高。较全量化肥而言,施用微生物菌肥不仅增加了有益微生物,如浮霉菌门(Planctomycetota)、放线菌门(Actinobacteria)、厚壁菌门(Firmicutes)和被孢霉属(Mortierella)等的相对丰度,而且降低了病原菌,如油壶菌属(Olpidium)和小壶菌属(Spizellomyces)的相对丰度,降幅分别为2.98%~42.97%、80.69%~85.31%。综上所述,用适量的微生物菌肥替代部分化肥有助于提高土壤质量,平衡微生物区系,改善高原种植区花椰菜的品质,在本试验条件下,以B处理的效果最佳。

关键词：花椰菜微生物菌肥土壤微生物土壤理化性质

A hybrid RNA-protein biosensor for high-throughput screening of adenosylcobalamin biosynthesis

在线全文

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2024年第3期9卷 513-521页

作者： Xia Yang Huiying Wang dongqin Ding Huan Fang Huina Dong Dawei zhang College of Biological and Pharmaceutical Sciences China Three Gorges UniversityYichangHubei443002China Tianjin Institute of Industrial Biotechnology Chinese Academy of SciencesTianjin300308China Key Laboratory of Engineering Biology for Low-Carbon Manufacturing Tianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjin300308China University of Chinese Academy of Sciences Beijing100049China

Genetically encoded circuits have been successfully utilized to assess and characterize target variants with desirable traits from large mutant *** is an essential coenzyme that is required in many intracellular physiological reactions and is widely used in the pharmaceutical and food ***-throughput screening techniques capable of detecting adenosylcobalamin productivity and selecting superior adenosylcobalamin biosynthesis strains are critical for the creation of an effective microbial cell factory for the production of adenosylcobalamin at an industrial *** this study,we developed an RNA-protein hybrid biosensor whose input part was an endogenous RNA riboswitch to specifically respond to adenosylcobalamin,the inverter part was an orthogonal transcriptional repressor to obtain signal inversion,and the output part was a fluorescent protein to be easily *** hybrid biosensor could specifically and positively correlate adenosylcobalamin concentrations to green fluorescent protein expression levels in *** study also improved the operating concentration and dynamic range of the hybrid biosensor by systematic *** individual cell harboring the hybrid biosensor presented over 20-fold higher fluorescence intensity than the negative ***,using such a biosensor combined with fluorescence-activated cell sorting,we established a high-throughput screening platform for screening adenosylcobalamin *** study demonstrates that this platform has significant potential to quickly isolate high-productive strains to meet industrial demand and that the framework is acceptable for various metabolites.

关键词： Adenosylcobalamin Genetically encoded biosensor Riboswitch Transcriptional repressor High-throughput screening

Time for a change:Rethinking the global renewable energy transition from the Sustainable Development Goals and the Paris Climate Agreement

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Innovation 2024年第1期5卷 13-14页

作者： Guanglei Yang Donglan Zha dongqin Cao Guoxing zhang School of Management Lanzhou UniversityLanzhou 730000China College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China School of Economics Lanzhou UniversityLanzhou 730000China

The concept of energy transition was initially proposed by the German Academy of Sciences in 1980,advocating for the abandonment of nuclear power and oil in response to the energy *** that time,insufficient attention was given to the energy *** 1980 to 1992,the global economy experienced significant growth,with the gross domestic product doubling from 11.34 trillion dollars to 25.41 trillion dollars(data from the World Bank).

关键词： Sustainable dollar transition

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

人类独特表型遗传基础的研究进展

科学通报 2017年第13期62卷 1324-1332页

作者：罗鑫张栋秦宿兵中国科学院昆明动物研究所遗传资源与进化国家重点实验室昆明650223 中国科学院大学昆明生命科学学院昆明650223

大约500万年前人类(Homo sapiens)和黑猩猩(Pan troglodytes)分歧之后,人类在进化过程中逐渐形成了很多独特的表型.什么样的遗传变异造就了如此独特的人类呢?近10年来,通过比较人类和其他非人灵长类的基因组序列,研究者已经发现了许多... 详细信息

大约500万年前人类(Homo sapiens)和黑猩猩(Pan troglodytes)分歧之后,人类在进化过程中逐渐形成了很多独特的表型.什么样的遗传变异造就了如此独特的人类呢?近10年来,通过比较人类和其他非人灵长类的基因组序列,研究者已经发现了许多基因组区域在人类中受到自然选择而发生了人类特异的遗传改变,包括基因编码区的改变、基因表达调控的改变、基因的丢失和基因的重复等.这些不同水平的遗传改变在进化过程中通过自然选择的作用在人群中固定下来,对人类独特表型的产生有着重要贡献.本文将从这4个遗传层面介绍人类特异表型与遗传变异的关系.另外,文中也介绍了利用基因编辑技术建立人源化的诱导多能干细胞及转基因动物模型研究人类特异突变和表型的关系,以及新的测序方法在筛选群体中天然突变个体中的应用.

关键词：人类独特表型编码基因基因表达调控基因丢失基因重复

Effects of Acupoint Exercise on Anxiety, Depression and Sleep Quality of Hemodialysis Patients

在线全文

学校读者我要写书评

暂无评论

World Journal of Integrated Traditional and Western Medicine 2018年第4期4卷 56-60页

作者： zhang dongqin Yang Dan Pan Xiuli Blood Purification Room The Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology

OBJECTIVE: To explore the influence of acupoint exercise on anxiety, depression and sleep quality in hemodialysis patients, aiming to provide scientific basis for clinical diagnosis and treatment. METHODS: A total of 78 hemodialysis patients who were treated in our hospital from May 2015 to May 2018 were selected as subjects. All patients were divided into two groups according to the random number table method. Among them, 40 patients in the observation group were given acupoint operation intervention, and 38 patients in the control group were given routine care. The anxiety level(HAMA), depression level(HAMD), hopeful sleep quality(PSQI) level, and quality of life(SF-36) levels were compared between the two groups. RESULTS: The HAMA and HAMD scores of the two groups were not significantly different before intervention. However, the scores of HAMA and HAMD in the observation group were lower than those in the control group. The scores of the PSQI scale were higher than those in the control group, indicating that the sleeping quality of the observation group was better. And the SF-36 score was higher in the observation group than that of the control group, and the difference was statistically significant. CONCLUSION: Acupoint exercise plays an important role in improving anxiety and depression and quality of sleep in hemodialysis patients. It can effectively improve the quality of life of hemodialysis patients, and can be applied clinically to improve its therapeutic effect.

关键词： Acupoint exercise Hemodialysis Anxiety and depression Sleep quality Quality of life

Meiotic nuclear divisions 1 suppresses the proliferation and invasion of pancreatic cancer cells via regulating H2A.X variant histone

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2024年第1期48卷 111-122页

作者： dongqin WANG YAN SHI ZHIQIANG WANG JING zhang LUYAO WANG HONGYU MA SHUHUA SHI XIAOFU LIAN HUA HUANG XIAOJING WANG CHAOQUN LIAN Anhui Province Key Laboratory of Clinical and Preclinical Research in Respiratory Disease Molecular Diagnosis CenterThe Department of Pulmonary Critical Care MedicineFirst Affiliated Hospital of Bengbu Medical CollegeBengbu233030China Department of Genetics School of Life SciencesBengbu Medical CollegeBengbu233000China Department of Clinical Medicine Bengbu Medical CollegeBengbu233030China Research Center of Clinical Laboratory Science Bengbu Medical CollegeBengbu233030China

Introduction:Among all malignant tumors of the digestive system,pancreatic carcinoma exhibits the highest mortality ***,prevention and effective treatment are urgent issues that need to be ***:The study focused on meiotic nuclear divisions 1(MND1),integrating data from the Gene Expression Profiling Interactive Analysis(GEPIA)database with prognostic survival ***,experiments at cellular level were employed to demonstrate the effect of MND1 on the proliferation and migration of *** small-molecule inhibitor of MND1 was used to suppress the migration of PC cells by knocking down MND1 using small interfering RNA(siRNA)in Patu-8988 and Panc1 cell ***:The results of Cell Counting Kit-8 indicated that the suppression of MND1 resulted in a decrease in cell *** healing and Transwell assays revealed that MND1 knockdown reduced cell migration and *** cytometry revealed that inhibiting MND1 hindered the cell ***,MND1 could stimulate the proliferation,migration,and invasion of Patu-8988 and Panc1 cells by increasing the expression of ***,MND1 had a positive effect on H2AFX expression in PC *** MND1 expression suggests the low overall survival rate of individuals diagnosed with ***:These findings suggest that MND1 has the potential to be a gene with the ability to accurately diagnose and treat PC.

关键词： Pancreatic carcinoma MND1 H2AFX Cell cycle

基于“互联网+”的大学物理实验教学创新模式实践

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

无线互联科技 2018年第15期15卷 99-100页

作者：张东芹上海市公用事业学校上海200030

互联网的迅速发展给教育教学带来了新的发展机遇,应用"互联网+"是教育教学改革的必然趋势,文章根据笔者进行多学科融合,通过促进学生认知能力的培养,强化实验意识,促进学生探究能力的培养。主要阐述在互联网下物理实验的教学模式创新,... 详细信息

互联网的迅速发展给教育教学带来了新的发展机遇,应用"互联网+"是教育教学改革的必然趋势,文章根据笔者进行多学科融合,通过促进学生认知能力的培养,强化实验意识,促进学生探究能力的培养。主要阐述在互联网下物理实验的教学模式创新,以及互联网在大学物理实验教学中实践,带动高校大学生的学习和学术气氛,培养大学生创新精神,促进大学物理和大学物理实验的课程建设和教学改革。

关键词：互联网大学物理实验创新实践