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Progress of Pharmaceutical Continuous Crystallization

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Engineering 2017年第3期3卷 354-364页

作者： dejiang zhang Shijie Xu Shichao Du Jingkang Wang Junbo Gong School of Chemical Engineering and Technology State Key Laboratory of Chemical Engineering Tianjin University Tianjin 300072. China Collaborative Innovation Center of Chemical Science and Chemical Engineering Tianjin University Tianjin 300072 China

Crystallization is an important unit operation in the pharmaceutical industry. At present, most pharmaceutical crystallization processes are performed in batches. However, due to product variability from batch to batch and to the low productivity of batch crystallization, continuous crystallization is gaining increasing attention. In the past few years, progress has been made to allow the products of continuous crystallization to meet different requirements. This review summarizes the progress in pharmaceutical continuous crystallization from a product engineering perspective. The advantages and disadvantages of different types of continuous crystallization are compared, with the main difference between the two main types of crystallizers being their difference in residence time distribution. Approaches that use continuous crystallization to meet different quality requirements are summarized. Continuous crystallization has advantages in terms of size and morphology control. However, it also has the problem of a process yield that may be lower than that of a batch process, especially in the production of chirality crystals. Finally, different control strategies are compared.

关键词： Continuous crystallization Pharmaceutical MSMPR Tubular crystallizer Control strategy

The Crystallization Process in Petrochemical Industry

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China Petroleum Processing & Petrochemical Technology 2021年第2期23卷 1-10页

作者： zhang dejiang Fan Yingqi Xie Li Ding Huidian Wang Hao SINOPEC Research Institute of Petroleum Processing Beijing 100083

Crystallization is a widely used product refining *** the characteristics of the crystallization process in the petrochemical industry is helpful to selecting and designing new crystallization *** review briefly introduces the characteristics of the crystallization process,summarizes the crystallization processes applied in petrochemical industry,and discusses some points for crystallization process *** in the petrochemical process is mainly used in the purification of polymer monomers and is often a unit operation in the whole refining *** a reasonable crystallization process requires consideration of process safety,feasibility,and economy from an overall perspective.

关键词： crystallization petrochemical process design purification monomer

Amorphous and humidity caking: A review

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Chinese Journal of Chemical Engineering 2019年第6期27卷 1429-1438页

作者： Mingyang Chen dejiang zhang Weibing Dong Zhilong Luo Chao Kang Haichao Li Gang Wang Junbo Gong School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China College of Chemistry and Chemical Engineering QingHai Nationalities UniversityXining 810007China Xi'an Modern Chemistry Research Institute Xi'an 710000China Key Laboratory Modern Drug Delivery and High Efficiency in Tianjin University Tianjin 300072China The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin Tianjin 300072China

Caking of products is a common and undesired phenomenon in food, chemical, pharmaceutical, and fertilizer industries which leads to extra cost and irregular quality. In general, caking processes could be identified as amorphous caking or humidity caking. In this review, history of studying caking, formation, methods, and prospects of these two caking processes are summarized and discussed. The relevant studies from the 1920 s to today are mentioned briefly. According to the different properties(i.e. hygrocapacity, hygrosensitivity, mechanical properties, and diffusion behavior) of amorphous powders and crystals, the conditions and mechanisms of amorphous and humidity caking are discussed. It is summarized that glass transition, moisture sorption, quantitative methods characterizing caking, accelerated caking tests, and simulation of caking behaviors are the main aspects that should be studied for a caking process. The methods for these five aspects are reviewed. Potential research points are proposed including caking of mixed particles, caking with phase transition or polymorph transition,non-homogenous caking, and simulation of caking.

关键词： Agglomeration Particle Powder technology Amorphous caking Humidity caking

Research Progress in Refining Process for Production of Caprolactam by Beckman Rearrangement Reaction

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China Petroleum Processing & Petrochemical Technology 2019年第2期21卷 10-18页

作者： Wang Hao zhang dejiang Fan Yingqi Xie Li Luo Yibin Zong Baoning SINOPEC Research Institute of Petroleum Processing

Caprolactam, which is mainly produced via the Beckmann rearrangement reaction, is an important chemical material. The strict specifications of caprolactam products make the refining process of caprolactam extremely important. According to the different rearrangement process, the refining process of caprolactam is also different. The main refining sequence of liquid phase rearrangement products includes extraction, ion exchange, hydrogenation, and distillation. The refining process of gas phase rearrangement products is conducted mainly through distillation, crystallization, and hydrogenation. In this paper, the research progress of caprolactam refining technology will be summarized according to different rearrangement reaction processes, which will provide a reference for the selection of appropriate caprolactam refining process.

关键词： caprolactam Beckman rearrangement refining oximation

Cooperate,Develop and Create a Future Together

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China Today 2004年第8期53卷 11-14页

作者： zhang dejiang Secretary of the CPC Guangdong Provincial Committee.

NEW technolo-gy, particularly information technology is a global trend that has given impetus to economic development, but levels of development vary according to the conditions in different countries and regions.

关键词：广东地方经济泛珠江三角洲区域经济合作

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试论地方工科院校的定位

高等工程教育研究 2007年第1期55卷 110-113页

作者：张德江华中科技大学教育科学研究院

研究地方高校如何根据社会需求和本校实际进行定位,是十分重要的课题。本文对地方工科院校定位问题进行了分析,对地方工科院校如何定位进行了探讨和研究,并提出了有关政策建议。

关键词：地方工科院校定位政策建议

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新建院校合格评估需要把握的关键要素

高教发展与评估 2011年第1期27卷 16-21,117页

作者：张德江长春工业大学校长办公室吉林长春130012

针对新建院校教学工作合格评估,以教学条件基本达标、教学管理基本规范、教学质量基本保证为必备要素,以新的人才培养目标、培养方案和新专业为特殊要素,以人才培养模式为主线,以注重内涵建设为引导,提出在合格评估中应把握的关键要素,... 详细信息

针对新建院校教学工作合格评估,以教学条件基本达标、教学管理基本规范、教学质量基本保证为必备要素,以新的人才培养目标、培养方案和新专业为特殊要素,以人才培养模式为主线,以注重内涵建设为引导,提出在合格评估中应把握的关键要素,为参评院校的评建工作提供参考。

关键词：新建院校合格评估评建工作

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对创业教育的认识与实践

中国高教研究 2006年第5期 10-11,14页

作者：张德江华中科技大学教育科学研究院

首先对与创业教育有关的若干概念,包括创业教育与就业教育、创新教育与创造教育、创业教育与创新教育、创业教育与学科教育进行了探析;然后对创业教育中应把握的几个问题,包括创业教育重在哪个层面,实现创业的条件和时机等等进行了讨论... 详细信息

首先对与创业教育有关的若干概念,包括创业教育与就业教育、创新教育与创造教育、创业教育与创新教育、创业教育与学科教育进行了探析;然后对创业教育中应把握的几个问题,包括创业教育重在哪个层面,实现创业的条件和时机等等进行了讨论;最后介绍了长春工业大学开展创业教育的实践探索。

关键词：创业教育就业教育创新教育创造教育创业品质长春工业大学大学生就业形势

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基于小波变换技术的发动机异响故障诊断

机械工程学报 2009年第6期45卷 239-245页

作者：臧玉萍张德江王维正中国科学院长春光学精密机械与物理研究所长春130033 中国科学院研究生院北京100039 长春工业大学人文信息学院长春130122 长春工业大学电气与电子工程学院长春130012

针对发动机异响故障信号呈非平稳时变特征并伴随有强烈的背景噪声,提出一种基于小波细节系数自相关性分析的分层阈值降噪法,该方法对信号进行离散小波变换,将信号分解为近似系数和细节系数,求出各层细节系数的自相关序列,根据序列是否... 详细信息

针对发动机异响故障信号呈非平稳时变特征并伴随有强烈的背景噪声,提出一种基于小波细节系数自相关性分析的分层阈值降噪法,该方法对信号进行离散小波变换,将信号分解为近似系数和细节系数,求出各层细节系数的自相关序列,根据序列是否呈白噪声自相关特性确定该层阈值。信号经过分层阈值降噪后,再进行连续小波变换,画出时频图,结合时域特征和频域特征确定故障类别。试验研究首先以模拟的信号模型为例,再针对实际的活塞敲缸响和曲轴轴承响两种常见异响故障进行比较分析,结果表明,分层阈值降噪法可以提高信噪比,恢复较高频率的有用信号,小波时频图可以清晰地呈现故障信号的时域和频域特征,为诊断提供一种切实可行的策略。

关键词：小波变换发动机异响故障自相关序列分层阈值时频图