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基于网络药理学和分子对接技术探讨参芪扶正注射液治疗慢性阻塞性肺疾病的潜在药理学机制

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Journal of Chinese Pharmaceutical Sciences 2024年第4期33卷 339-351页

作者：刘芳琳张春娟沈秋跃周昔程赵越富冯峰刘芳海盐县人民医院药剂科浙江海盐314300 海盐县人民医院呼吸与危重症医学科浙江海盐314300 陆军军医大学西南医院药学部重庆400038

参芪扶正注射液(SFI)是一种由黄芪(黄芪,HQ)和党参(党参,DS)组成的传统中药注射液,我们通过网络药理学和分子对接分析研究了SFI治疗慢性阻塞性肺病(COPD)的潜在机制和分子靶点。首先,我们在多个数据库中检索和筛选了SFI的潜在生物活性... 详细信息

参芪扶正注射液(SFI)是一种由黄芪(黄芪,HQ)和党参(党参,DS)组成的传统中药注射液,我们通过网络药理学和分子对接分析研究了SFI治疗慢性阻塞性肺病(COPD)的潜在机制和分子靶点。首先,我们在多个数据库中检索和筛选了SFI的潜在生物活性化合物和相应的COPD相关靶基因。随后,使用Cytoscape 3.9.1和STRING分析并构建了蛋白质-蛋白质相互作用(PPI)网络,以获得关键靶基因。随后,为了确定与SFI相关的潜在信号通路,研究人员进行了GO和KEGG富集研究,并进行了分子对接分析以验证结果。通过网络药理学分析,共获得65种活性成分(DS35种,HQ 30种)和233个关键靶点。其中,前五大生物活性成分(槲皮素、芹菜素、大豆异黄酮、山柰酚和木犀草素)和前五大靶点(TP53、AKT1、EP300、MAPK1和JUN)在分子对接分析中表现出良好的亲和力和稳定的结合力,结合能≤–5.0kcal/mol。这些研究结果表明,SFI可通过多种化合物和多种途径对慢性阻塞性肺病发挥治疗作用。此外,本研究还为SFI作为慢性阻塞性肺疾病的辅助治疗药物进一步应用于临床提供了药理学依据和参考。

关键词：参芪扶正注射液 COPD 网络药理学分子对接

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复方新诺明致高血钾不良反应的药学管理

实用药物与临床 2024年第6期27卷 435-438页

作者：张春娟赵蕊周昔程海盐县人民医院药剂科浙江嘉兴314300 浙江大学医学院附属邵逸夫医院药学部浙江杭州310000

目的为复方新诺明(Sulfamethoxazole/trimethoprim,SMZ-TMP)致高血钾不良反应(Adverse drug reaction,ADR)的药学管理提供参考。方法回顾性分析临床药师参与的1例重症肺孢子菌肺炎(Pneumocystis jiroveci pneumonia,PJP)患者使用SMZ-TMP后出现高钾血症的诊疗过程,对该ADR进行了相关性分析和SMZ-TMP致高血钾ADR风险因素和管理措施探讨。结果该患者在使用SMZ-TMP后血钾呈上升趋势,第6天达峰值5.78 mmol/L,经钙剂、胰岛素、降钾树脂以及连续肾脏替代治疗后,高钾血症得到有效缓解,Naranjo’s评分5分,二者很可能相关。高剂量SMZ-TMP以及合并使用损害肾钾排泄的药物使高钾血症风险增加。结论SMZ-TMP在使用过程中可能发生高血钾,合并使用泼尼松的患者,需提高警惕;在治疗过程中(前2~4 d)应及时监测血钾,确定易感患者,避免发生严重ADR;若患者不能耐受SMZ-TMP时,建议可选择伯氨喹+克林霉素或喷他脒或阿托伐醌替代治疗。

关键词：复方新诺明高血钾不良反应风险因素

Masked Autoencoders as Single Object Tracking Learners

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Computers, Materials & Continua 2024年第7期80卷 1105-1122页

作者： chunjuan Bo XinChen Junxing zhang School of Information and Communication Engineering Dalian Minzu UniversityDalian116600China School of Information and Communication Engineering Dalian University of TechnologyDalian116024China

Significant advancements have beenwitnessed in visual tracking applications leveragingViT in recent years,mainly due to the formidablemodeling capabilities of Vision Transformer(ViT).However,the strong performance of such trackers heavily relies on ViT models pretrained for long periods,limitingmore flexible model designs for tracking *** address this issue,we propose an efficient unsupervised ViT pretraining method for the tracking task based on masked autoencoders,called *** pretraining,we employ two shared-parameter ViTs,serving as the appearance encoder and motion encoder,*** appearance encoder encodes randomly masked image data,while the motion encoder encodes randomly masked pairs of video ***,an appearance decoder and a motion decoder separately reconstruct the original image data and video frame data at the pixel *** this way,ViT learns to understand both the appearance of images and the motion between video frames *** results demonstrate that ViT-Base and ViT-Large models,pretrained with TrackMAE and combined with a simple tracking head,achieve state-of-the-art(SOTA)performance without additional ***,compared to the currently popular MAE pretraining methods,TrackMAE consumes only 1/5 of the training time,which will facilitate the customization of diverse models for *** instance,we additionally customize a lightweight ViT-XS,which achieves SOTA efficient tracking performance.

关键词： Visual object tracking vision transformer masked autoencoder visual representation learning

Disulfiram thermosensitive in-situ gel based on solid dispersion for cataract

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Asian Journal of Pharmaceutical Sciences 2018年第6期13卷 527-535页

作者： chunjuan zhang Tonghua Xu Donglei zhang Wei He Siling Wang Tongying Jiang Shenyang Pharmaceutical University He University

To improve the corneal permeability and water-solubility of disulfiram(DSF), which is an ocular drug for cataract, P188 was selected as a matrix to prepare solid dispersion of DSF(DSF SD) by hot melt method. The DSF SD was characterized by DSC, XRD, and IR, and the results suggested that DSF was amorphous in DSF SD. The DSF SD was added to borate buffer solution(BBS) contained 20% poloxamer P407 and 1.2% poloxamer P188 to form in-situ gel. In vitro and in vivo experiments revealed that DSF SD combined with in-situ gel(DSF SD/in-situ gel) increased the residence time and the amount of DSF penetrated through the corneal. The pharmacodynamics studies exhibited DSF SD/in-situ gel delayed the development of selenium-induced cataract at some content. These results investigated that DSF SD/in-situ gel as a drug delivery system can improve DSF ocular permeability.

关键词： Disulfiram Solid dispersion In-situ gel Permeability Anti-cataract

Experimental investigation and modeling of flotation column for treatment of oily wastewater

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International Journal of Mining Science and Technology 2013年第5期23卷 665-668页

作者： Ran Jincai Liu Jiongtian zhang chunjuan Wang Dengyue Li Xiaobing National Engineering Research Center of Coal Preparation and Purifcation China University of Mining & Technology

A unique cyclonic static microbubble flotation column was developed for oily wastewater *** separation effciency was found to be highly dependent on gas holdup and bubble size *** changing the circulation pressure,gas flow rate,frother concentration,the effect of operation parameters on gas holdup and oil removal effciency were attained.A mathematical modeling between the kinetic constant and the gas holdup was established for oily water separation *** results show that higher gas holdup and smaller microbubble sizes are benefcial to improve oil removal effciency.

关键词： Oily wastewater Separation Floatation column Modeling

Adsorption of oil from waste water by coal:characteristics and mechanism

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Mining Science and Technology 2010年第5期20卷 778-781页

作者： LI Xiaobing,zhang chunjuan,LIU Jiongtian School of Chemical Engineering and Technology,China University of Mining & Technology,Xuzhou 221116,China School of Chemical Engineering and Technology China University of Mining&Technology Xuzhou 221116 China

The work described here was focused on exploring the potential application of coal to purification of oily waste *** was added to oily waste water as an adsorbent and then removed through a flotation *** allowed economical and highly efficient separation of oil from the waste *** absorption time,coal type,coal particle size distribution,pH value and oil concentration were *** results indicate that oil absorption by a coal increases for a period of 1.5 h and then gradually tends toward an equilibrium *** appears that the absorption capacity of anthracite is more than that of lean coal or lignite,given the same coal particle size *** absorption capacity of a coarse coal fraction is less than that of finer coal,given the same of coal *** absorption capacity of anthracite decreases slightly as the pH increases from 4 to *** adsorption of oil on anthracite follows the Freundlich isothermal adsorption law:given initial oil concentrations of 160.5 or 1023.6 mg/L the absorption capacity was 23.8 or 840.0 mg/*** absorption mechanism consists of two kinds of absorption,a physical process assisted by a chemical one.

关键词： oily wastewater waste water separation coal oil adsorption mechanism

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人工智能对基层医院医疗发展的制约因素分析

中国农村卫生事业管理 2024年第7期44卷 522-526页

作者：张春娟马小董周昔程浦国明邬梅珍海盐县人民医院浙江嘉兴314300

目的了解潜在的人工智能(Artificial intelligence, AI)偏倚如何影响基层卫生医疗结果,以及如何识别和减轻医疗结果不平等现象,推进基层医疗发展。方法结合基层医疗现状,全面调研AI算法模型全生命周期(Whole lifetime, WLT)中的偏倚... 详细信息

目的了解潜在的人工智能(Artificial intelligence, AI)偏倚如何影响基层卫生医疗结果,以及如何识别和减轻医疗结果不平等现象,推进基层医疗发展。方法结合基层医疗现状,全面调研AI算法模型全生命周期(Whole lifetime, WLT)中的偏倚以及影响基层医疗发展的制约因素,并提出相应的解决对策思考。结果 AI可能从研究方向提出、数据采集、变量选择、设计开发到临床实施的WLT制约基层医院医疗发展。医院管理者可采取相应的对策,包括加强自身学习、顶层指导,加强院内病历质量考核,加强基层医院信息化建设,加强数据监管、质控和标准化,制定人才培养引进政策等,减轻不平等现象,实现AI赋能基层医疗水平提升的目的。结论 AI算法模型在其WLT中的偏倚是不容忽视的,解决偏倚对于促进基层医院医疗决策的公平性至关重要。在公共卫生领域,AI对医疗结果公平伦理挑战的监管框架尚未得到充分解决,需要进一步关注。

关键词：人工智能机器学习全生命周期基层医院医疗结果公平制约因素解决对策

Identification and fine mapping of qSW2 for leaf slow wilting in soybean

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The Crop Journal 2024年第1期12卷 244-251页

作者： Shengyou Li Changling Wang chunjuan Yan Xugang Sun Lijun zhang Yongqiang Cao Wenbin Wang Shuhong Song Institute of Crop Research Liaoning Academy of Agricultural SciencesShenyang 110161LiaoningChina

Drought is one of the abiotic stresses limiting the production of soybean(Glycine max).Elucidation of the genetic and molecular basis of the slow-wilting(SW)trait of this crop offers the prospect of its genetic improvement.A panel of 188 accessions and a set of recombinant inbred lines produced from a cross between cultivars Liaodou 14 and Liaodou 21 were used to identify quantitative-trait loci(QTL)associated with *** were genotyped by Specific-locus amplified fragment sequencing and seedling leaf wilting was assessed under three water-stress treatments.A genome-wide association study identified 26 SW-associated single-nucleotide polymorphisms(SNPs),including three located in a 248-kb linkage-disequilibrium(LD)block on chromosome *** mapping revealed a major-effect QTL,qSW2,associated with all three treatments and adjacent to the LD *** mapping in a BC_(2)F_(3) population derived from a backcross between Liaodou 21 and R26 confined qSW2 to a 60-kb *** expression and sequence variation analysis identified the gene Glyma.02 g218100,encoding an auxin transcription factor,as a candidate gene for *** results will contribute significantly to improving drought-resistant soybean cultivars by providing genetic information and resources.

关键词： Drought GWAS Linkage mapping Slow wilting Soybean(Glycine max)

百年中国歌剧研究的成就与启示——以文献整理与经典诠释为核心

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戏剧（中央戏剧学院学报） 2022年第5期 25-36页

作者：张春娟上海师范大学音乐学院

20世纪是一个中国歌剧诞生、发展与繁荣的时代,从20年代儿童歌舞剧的诞生,到40、50年代中国新歌剧的夺目绽放,再到70、80年代间中国歌剧的再次焕发生机,造就了中国歌剧在20世纪的生成与发展史。本文以新文化、新中国、新时期、新世纪为... 详细信息

20世纪是一个中国歌剧诞生、发展与繁荣的时代,从20年代儿童歌舞剧的诞生,到40、50年代中国新歌剧的夺目绽放,再到70、80年代间中国歌剧的再次焕发生机,造就了中国歌剧在20世纪的生成与发展史。本文以新文化、新中国、新时期、新世纪为四大关键节点,简要回顾近百年中国歌剧研究的演变历程,并就文献整理与经典诠释两大板块对歌剧百年研究的主要成就加以简要总结,以期从中获得有益的思考与启示。

关键词：中国歌剧研究文献整理经典诠释