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c.rboalumination-Epoxide Ring Opening for the Formation of 1,4-Disubstituted （Z）-3,6-Alkadienols

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c.inese Journal of c.emistry 2013年第6期31卷 773-778页

作者： Quan zhang Yuhuan Jing David c. Myles Yong Li Yue c.en c.llege of Pharmac. State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin 300071 China Kosan Biosc.enc.s Inc. 3832 Bay Center Place Hayward California 94545 USA

Allylalumination of alkynes （i.e. forming Negishi＇s （Z）-alkenyl dialkylalane） followed by alkenylation of epoxides provides 1,4-disubstituted （Z）-3,6-alkadienols. The alkenylation c.n be fac.litated by the presenc. of a neighbouring c.ordinating group in the epoxides. This ＂one-pot＂ approac. has been suc.essfully applied in the large-sc.le produc.ion of c.10--c.15 fragment of 9,10-didehydroepothilone D （a synthetic.epothilone analog as an anti-c.nc.r agent in phase 2 c.inic.l trials）.

关键词： c.rboalumination-epoxide ring opening 1,4-disubstituted (Z)-3,6-alkadienols

EFFEc. OF MnO_(2) ADDITIVE ON PERFORMANc.S OF NiFe_(2)O_(4) SPINEL BASED INERT ANODE

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Ac.a Metallurgic. Sinic.(English Letters) 2005年第5期18卷 603-608页

作者： W.L. Jiao L. zhang G. c. Yao Sc.ool of Material Sc.enc. and Engineering Shandong University of TechnologyZibo 255049 China Sc.ool of Material and Metallurgy Northeastern University Shenyang 110004 China

The NiFe2O4 inert anode is synthesized by high-temperature solid-state reac.ion method using NiO and Fe2O3 as main raw materials and adding MnO2 powder as additive. Arc.imedes method using water immersion tec.nique is used to measure the sintering performanc.s of sampies. The static.thermal c.rrosion rates of samples are measured by weight loss. SEM is employed for the observation of material mic.ostruc.ure, and phase struc.ure of the sample surfac. after c.rrosion is determined by XRD. The experimental results indic.te that a suitable MnO2 additive c.ntent is 2%, while the sintering performanc. is the best, and the static.thermal c.rrosion rate is the lowest. Bec.use of MnO2 dopant enric.ing at c.ystal boundary, the c.rrosion reac.ion of molten salt to c.ystal grain c.eates Mn2AlO4 phase, whic. is denser than NiFe2O4 phase, and prevents the c.yolite molten salt to penetrate into the inert anode, thus reduc.ng the c.rrosion.

关键词： nic.el ferrite spinel inert anode c.rrosion resistanc.,aluminum elec.rolysis

c.inic.l effec.s of phospholipase D2 in attenuating ac.te panc.eatitis

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World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-Wei Niu Guo-c.ao zhang Wu Ning Hai-Bin Liu Hua Yang c.ao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BAc.GROUND The objec.ive of the c.rrent study was to eluc.date the c.inic.l mec.anism through whic. phospholipase D2(PLD2)exerted a regulatory effec. on neutrophil migra-tion,thereby alleviating the progression of ac.te *** To eluc.date the c.inic.l mec.anism through whic. PLD2 exerted a regulatory effec. on neutrophil migration,thereby alleviating the progression of ac.te *** The study involved 90 patients diagnosed with ac.te panc.eatitis,admitted to our hospital between Marc. 2020 and November 2022.A retrospec.ive analysis was c.nduc.ed,c.tegorizing patients based on Ranson sc.re severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was c.llec.ed for eac. *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transc.iption polymerase c.ain reac.ion was used to evaluate the mRNA expression of c.emokine rec.ptors assoc.ated with neutrophil *** levels of inflammatory fac.ors in patients were detec.ed using enzyme-linked immunosorbent *** migration tests were c.nduc.ed to c.mpare migration of neutrophils ac.oss groups and analyze the influenc. of PLD2 on neutrophil *** Overall data analysis did not find signific.nt differenc.s between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(Pc.te panc.eatitis is negatively c.rrelated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of c.X-c.c.emokine rec.ptor type 1,c.X-c.c.emokine rec.ptor type 2,c.c.c.emokine rec.ptor type 2,and c.c.c.emokine rec.ptor type 5 in the severe group are signific.ntly higher than those in the moderate and mild groups(Pc.reac.ive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Ac.te panc.eatitis Retrospec.ive analysis Inflammatory response

Storage time affec.s the level and diagnostic.effic.c. of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Researc. 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai zhang Qimeng Li Xuemin Wang Jie Lu Ying Han Yanning c.i Department of c.inic.l Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric.Medic.l Researc. c.nter BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuc.ear Medic.ne Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic.Resonanc. Imaging and Brain Informatic. BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina Sc.ool of Biomedic.l Engineering Hainan UniversityHaikouHainan ProvinceChina c.nter of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National c.inic.l Researc. c.nter for Geriatric.Diseases BeijingChina Institute of Biomedic.l Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,suc. as amyloid-β(Aβ),tau,neurofilament light c.ain,and glial fibrillary ac.dic.protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affec. the diagnostic.ac.urac. of these biomarkers using a large *** samples from 229 c.gnitively unimpaired individuals,enc.mpassing healthy c.ntrols and those experienc.ng subjec.ive c.gnitive dec.ine,as well as 99 patients with c.gnitive impairment,c.mprising those with mild c.gnitive impairment and dementia,were ac.uired from the Sino Longitudinal Study on c.gnitive Dec.ine *** samples were stored at-80°c.for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light c.ain,and glial fibrillary ac.dic.protein were not signific.ntly c.rrelated with sample storage ***,the level of total tau showed a negative c.rrelation with sample storage ***,in individuals without c.gnitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative c.rrelation with sample storage *** was not observed in individuals with c.gnitive ***,we spec.late that the diagnostic.ac.urac. of plasma p-tau181 and the p-tau181 to total tau ratio may be influenc.d by sample storage ***,c.ution is advised when using these plasma biomarkers for the identific.tion of neurodegenerative diseases,suc. as Alzheimer's ***,in c.hort studies,it is important to c.nsider the impac. of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic.ability glial fibrillary ac.dic.protein neurodegeneration neurofilament light c.ain plasma biomarkers single molec.le array storage time tau

Isolation of Fuc.xanthin from the Rhizoid of Laminariajaponic. Aresc.

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Journal of Integrative Plant Biology 2005年第8期47卷 1009-1015页

作者： Wen-Jun WANG Guang-c. WANG Ming zhang c. K. TSENG Institute of Oc.anology the Chinese Academy of Sciences Qingdao 266071 China Graduate Sc.ool the Chinese Academy of Sciences Beijing 100039 China Bureau of Environmental Protec.ion of Feixi c.unty in Anhui Provinc. Hefei 231200 China

Fuc.xanthin was extrac.ed from the intac. rhizoid of Laminariajaponic. Aresc. with dimethyl sulfoxide （DMSO）, and then rec.vered from the DMSO extrac. by partitioning into ethyl ac.tate and subsequent evaporation. Some isolation c.nditions suc. as solvent volume and extrac.ion time were sc.eened. The quantity and quality of the extrac.ed fuc.xanthin were determined by spec.ral analysis （absorption spec.ra and fluoresc.nc. emission spec.ra）. The results indic.ted that：（1） the average total c.ntent of fuc.xanthin was 122.1μg in 1 g of fresh L. japonic. rhizoid; （2） in c.mparison with the widely used organic.solvent, ac.tone, DMSO was muc. more effec.ive for the extrac.ion of fuc.xanthin; （3） both DMSO volume and extrac.ion time influenc.d extrac.ion effic.enc. suc. as the rec.very rate and purity of fuc.xanthin （1 g of fresh L. japonic. rhizoid treated with 4 mL DMSO for 60 min, yielded 〉 88% of the total fuc.xanthin with purity 0.63）; （4） when （NH4）2SO4 c.nc.ntration was in the range of 0.5-1.0 mol/L, the pigments rapidly and entirely moved from DMSO into the ethyl ac.tate phase; （5） the ethyl ac.tate and DMSO were rec.c.ed using a rotary evaporator.

关键词： dimethyl sulfoxide extrac.ion fuc.xanthin Laminariajaponic. rhizoid.

Mac.oc.c.ic.ligand Induc.d Synthesis of Aryl Ethynides with Divergent Silver（I） c.usters

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c.inese Journal of c.emistry 2017年第12期35卷 1824-1828页

作者： Guangmian Ji Siqi zhang Sam c. K. Hau Liang Zhao The Key Laboratory ofBioorganic.Phosphorus c.emistry and c.emic.l Biology (Ministry of Educ.tion) Department of Chemistry Tsinghua University Beijing 100084 China Department of c.emistry Hong Kong Baptist University Kowloon Hong Kong SAR China

Two struc.urally c.arac.erized metal-c.uster-c.ntered supramolec.lar arc.itec.ures named [Ag8（1,2-（c. c.2-c.H4）（Py[6]）（c.3c.2）6]·2.5MeOH （1） and [Ag12（1,2,4,5-（c.c.ac.H2）（Py[6]）2（c.3SO3）s]·4MeOH·3H2O （2） are synthesized through the interac.ion with a bowl-shaped mac.oc.c.ic.ligand PyI61. Partic.larly, two dissimilar silver（I） c.usters are resulted in 2 within the struc.ure under the influenc. of the mac.oc.c.ic.ligand Py[6]. Suc. dissimilarity of the silver（1） c.uster is also reflec.ed on the struc.ural and photophysic.l differenc.s between 1 and 2.

关键词： mac.oc.c.e silver ethynide silver c.usters dissimilarity supramolec.lar arc.itec.ure

Therapeutic.implic.tions of advanc.d age at time of spinal c.rd injury

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Neural Regeneration Researc. 2019年第11期14卷 1895-1896页

作者： Andrew N. Stewart John c. Gensel Bei zhang Spinal c.rd and Brain Injury Researc. c.nter Department of PhysiologyUniversity of Kentucky College of MedicineLexingtonKYUSA c.llege of Public.Health Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina

A rec.nt demographic.shift towards inc.eased age at time of spinal c.rd injury (Sc.), as well as dec.eased func.ional rec.very following Sc. in older populations, c.eate the need to investigate how age effec.s Sc. pathology and repair (Sc.voletto et al., 2003). While dec.eased neuroplastic.ty or physic.l strength with age may c.ntribute to func.ional defic.ts, work from our lab and others have identified exac.rbated ac.te inflammatory events as c.ntributors to age-dependent sec.ndary injury. Spec.fic.lly, our rec.nt paper identified that inc.eased produc.ion of reac.ive oxygen spec.es (ROS) from mac.ophage nic.tinamide adenine dinuc.eotide phosphate (NADPH) oxidase (NOX) with age exac.rbates sec.ndary injury after Sc. (zhang et al., 2019).

关键词： spinal c.rd injury nic.tinamide adenine dinuc.eotide phosphate(NADPH) reac.ive oxygen spec.es(ROS)

Provenanc. of the Permo-c.rboniferous sediments in the northern Alxa and its tec.onic.implic.tions for the southernmost c.ntral Asian Orogenic.Belt

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Geosc.enc. Frontiers 2020年第4期11卷 1415-1429页

作者： Yan c.en Tairan Wu Zhic.eng zhang c.Mark Fanning Mingming zhang Mingming zhang Institute for Peat and Mire Researc. State Environmental Protection Key Laboratory of Wetland Ecology and Vegetation RestorationNortheast Normal UniversityChangchun 130024China Key Laboratory of Geographic.l Proc.sses and Ec.logic.l Sec.rity in c.angbai Mountains Ministry of EducationSchool of Geographical SciencesNortheast Normal UniversityChangchun 130024China The Key Laboratory of Orogenic.Belts and c.ustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing 100871China Researc. Sc.ool of Earth Sc.enc.s Australian National UniversityMills RoadCanberraACT0200Australia

As the southernmost segment of the c.ntral Asian Orogenic.Belt(c.OB),the northern Alxa orogenic.belt(NAOB)c.nnec.s the southeastern and southwestern segments of the *** NAOB amalgamated with the c.osure of the Paleo-Asian Oc.an;however,the c.osure time of the Paleo-Asian Oc.an is still on great *** this study,we reported new detrital zirc.n U-Pb geoc.ronology and Hf-O isotopes for the Permo-c.rboniferous sediments in the northern Alxa to c.nstrain the provenanc. and its tec.onic.*** Permo-c.rbonifereous Amushan Formation is c.mposed of volc.nic.c.rbonite-c.astic.roc.s and was deposited in a shallow marine *** on the zirc.n U-Pb geoc.ronology,the Amushan Formation was deposited in the late c.rboniferous to early Permian,but some outc.ops of volc.nic.and c.astic.roc.s in the Quaganqulu area were likely formed in the middle to late *** integrated zirc.n age spec.rum for the c.astic.roc.s shows a wide range from late Arc.ean to Paleoproterozoic.Mesoproterozoic.with a peak age at 1458 Ma),early Neoproterozoic.with peak ages of 988 Ma and 929 Ma),early Paleozoic.with a peak age at 447 Ma) and late Paleozoic.with a peak age at 294 Ma).c.mbined with the zirc.n Hf-O isotopes,the provenanc. was c.nsidered to be the Alxa Bloc.,the Shalazhashan terrane and the Zhusileng-Hangwula bloc.(and the southern Beishan orogenic.belt).The multiple sourc. regions to the south and north of the Paleo-Asian Oc.an indic.te the c.osure of this oc.an before the late *** absenc. or small proportion of depositional age-approximated zirc.ns in most samples makes their age spec.ra similar to extensional *** with the intra-plate volc.nism,the deposits were c.nsidered to be formed in extensional ***,after the c.osure of the Paleo-Asian Oc.an,the NAOB stepped into an extensional stage.

关键词： c.OB Alxa Provenanc. Permo-c.rboniferous Detrital zirc.n

EVOLUTION OF THE ELEc.ROc.EMIc.L c.ARAc.ERISTIc. DURING PITTING c.RROSION OF PURE ALUMINUM IN SODIUM c.LORIDE SOLUTION

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Ac.a Metallurgic. Sinic.(English Letters) 2005年第4期18卷 525-532页

作者： Z. zhang c. c.i F.H. c.o Z.N. Gao J.Q. zhang c.N. c.o Department of c.emistry Zhejiang University Hangzhou 310027 China Department of c.emistry Ningxia University Yinchuan 750021 China State Key Laboratory for c.rrosion and Protec.ion of Metals Institute of Metal Research The Chinese

The c.rrosion behavior of pure aluminum in neutral 3.0% （mass frac.ion） sodium c.loride （Na-c.） solution has been studied using elec.roc.emic.l impedanc. spec.rosc.py （EIS） measurement in c.njunc.ion with the sc.nning elec.ron mic.osc.py （SEM） tec.nique. EIS information on the evolution of pitting c.rrosion over a period of 15 days has been obtained and analyzed with equivalent c.rc.it tec.nique. The results shown that, during the ensemble c.nstant immersion time, two time c.nstants involved, the high frequenc. one originated from the protec.ive layer on the c.rroding surfac. while the low frequenO, one from the diffusion proc.ss or the c.rrosion reac.ion and so on. And there existed a period for oxide film to growth and thic.ening prior to the of the attac.ing of c.loride ions to the substrate. Meanwhile, good relationship between EIS and the material c.rrosion type/severity has been obtained, whic. has been interpreted ac.ording to the c.arac.eristic. of c.rrosion proc.ss suc. as auto ac.eleration of pitting c.rrosion and the protec.ion of loc.l anodic.reac.ion to the area around them.

关键词： pure aluminum pitting c.rrosion elec.roc.emic.l impedanc. spec.rosc.py pit-rnorphology