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Systematic identification of wheat spike developmental regulators by integrated multiomics, transcriptional network, GWAS, and genetic analyses

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Molecular Plant 2024年第3期17卷 438-459页

作者： Xuelei Lin Yongxin Xu Dongzhi Wang Yiman Yang Xiaoyu zhang Xiaomin Bie Lixuan Gui Zhongxu Chen Yiliang Ding Long Mao Xueyong zhang Fei Lu Xiansheng zhang Cristobal Uauyo Xiangdong Fu Jun Xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Nanjing Agricultural University NanjingJiangsu 210095China Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTaianShandong 271018China Department of Life Science Tcuni Inc.ChengduSichuan 610000China John Innes Centre Norwich Research ParkNorwich NR47UHUK institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) Institute of Genetics and Developmental BiologyCASBeijing 100101China

The spike architecture of wheat plays a crucial role in determining grain number,making it a key trait for optimization in wheat breeding *** this study,we used a multi-omic approach to analyze the transcriptome and epigenome profiles of the young spike at eight developmental stages,revealing co-ordinated changes in chromatin accessibility and H3K27me3 abundance during the flowering *** constructed a core transcriptional regulatory network(TRN)that drives wheat spike formation and experimentally validated a multi-layer regulatorymodule involving TaSPL15,TaAGLG1,and *** integrating the TRN with genome-wide association studies,we identified 227 transcription factors,including 42 with known functions and 185 with unknown *** investigation of 61 novel transcription factors using multiple homozygous mutant lines revealed 36 transcription factors that regulate spike architecture or flowering time,such as TaMYC2-A1,TaMYB30-A1,and *** particular interest,TaMYB30-A1,downstream of and repressed by WFzP,was found to regulate fertile spikelet ***,the excellent haplotype of TaMYB30-A1,which contains a C allele at the WFzP binding site,was enriched during wheat breeding improvement in china,leading to improved agronomic ***,we constructed a free and open access Wheat Spike Multi-Omic Database(http://39.***.48.156:8800/#/).Our study identifies novel and high-confidence regulators and offers an effective strategy for dissecting the genetic basis of wheat spike development,with practical value forwheat breeding.

关键词： wheat spike development epigenome TRN TaMYB30-A1 breeding selection

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Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

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Journal of Pharmaceutical Analysis 2024年第5期14卷 722-732页

作者： Shi-Qi Wang Xun Zhao Li-Jun zhang Yue-Mei Zhao Lei Chen Jin-Lin zhang Bao-Cheng Wang Sheng Tang Tom Yuan Yaozuo Yuan Mei zhang Hian Kee Lee Hai-Wei Shi Jiangsu institute for Food and Drug control Nanjing210019China School of Pharmacy China Pharmaceutical UniversityNanjing211112China School of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia commission Beijing100061China Nanjing Well Pharmaceutical Group co. Ltd.Nanjing210018China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA Department of Chemistry National University of SingaporeSingapore117543Singapore

Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual *** similar structures and polarities of PS20 components make accurate separation,identification,and quantification *** this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple *** separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD *** polysorbate compound database and library were expanded over 7-time compared to the commercial *** method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process ***-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different *** method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to ***-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.

关键词： Polysorbate 20 component Database Discrimination Degradation

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The Effects of Thickness and Location of PCMon the Building’s Passive Temperature-control–A Numerical Study

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Energy Engineering 2024年第3期121卷 681-702页

作者： Zhengrong Shi JieRen Tao zhang Yanming Shen college of Energy and Mechanical Engineering Shanghai University of Electric PowerShanghai201306China Research and Development Center Heatmate New Energy Technology Co.Ltd.Shanghai200090China Shanghai Non-Carbon Energy conversion and Utilization institute Shanghai Jiao Tong UniversityShanghai200240China

Building energy consumption and building carbon emissions both account for more than 20%of their total national values in *** employing phase change material(PCM)for passive temperature control shows a promising prospect in meeting the comfort demand and reducing energy consumption ***,there is a lack of more detailed research on the interaction between the location and thickness of PCM and indoor natural convection,as well as indoor temperature *** this study,the numerical model of a passive temperature-controlled building integrating the developed PCM module is established with the help of *** which,the actual weather condition of beijing city is set as the boundary conditions and the indoor natural convection is simulated with the consideration of radiation *** effects of PCM’s thickness and location on the internal temperature field are analyzed and *** results show that the room could maintain within the human comfort temperature range with the longest ratio of 94.10%and the shortest ratio of 51.04%as integrating *** comparison,the value is only 26.70%without *** room’s maximum temperature fluctuation can also be improved;it could be lowered by 64.4%compared to the normal *** the quantity of PCM is sufficient,further increasing the PCM amount results in a temperature fluctuation reduction of less than 0.1°C and does not increase the comfort *** PCM on the wall induces an apparent variation in indoor temperature along the vertical ***,placing PCM on the roof can lead to a heat transfer rate difference of up to seven *** optimal placement of PCM depends on the difference between the environmental and phase change *** the difference is positive,placing PCM on the roof is more effective;conversely,the opposite *** to the results over the entire cycle,PCM application on vertical walls yields better *** significant diffe

关键词： Phase change materials passive temperature regulation numerical simulation temperature field

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Superconducting single-photon detector with a speed of 5 GHz and a photon number resolution of 61

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Photonics Research 2024年第6期12卷 1328-1333页

作者： TIANZHU zhang JIA HUANG XINGYU zhang CHaoMENG DING HUIQIN YU YOU XIao CHaoLIN LV XIaoYU LIU ZHEN WANG LIXING YOU XIaoMING XIE Hao LI Shanghai Key Laboratory of Superconductor Integrated Circuit Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Photon Technology(Zhejiang)co. Ltd.Jiaxing 314100China

Rapid detection and discrimination of single photons are pivotal in various applications,such as deep-space laser co.munication,high-rate quantum key distribution,and optical quantum ***,conventional single-photon detectors(SPDs),including semiconducting and recently developed superconducting detectors,have limited detection speed and photon number resolution(PNR),which pose significant challenges in practical *** this paper,we present an efficient,fast SPD with good PNR,which has 64 paralleled,sandwiched superconducting nanowires fabricated on a distributed Bragg *** detector is operated in a compact Gifford–McMahon cryocooler that supports 64 electrical channels and has a minimum working temperature of 2.3 *** combined detector system shows a functional nanowire yield of 61/64,a system detection efficiency of 90%at 1550 nm,and a maximum count rate of 5.2 ***,it has a maximum PNR of 61,corresponding to the operating *** SPD signifies a substantial improvement in quantum detector technology,with potential applications in deep-space laser co.munication,high-speed quantum co.munication,and fundamental quantum optics experiments.

关键词： co.munication photon quantum

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Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application

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Acta Pharmaceutica Sinica B 2024年第2期14卷 623-634页

作者： Jiacheng Xiong Rongrong Cui Zhaojun Li Wei zhang Runze zhang Zunyun Fu Xiaohong Liu Zhenghao Li Kaixian Chen Mingyue Zheng Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China college of computer and Information Engineering Dezhou UniversityDezhou 253023China AI Department Suzhou Alphama Biotechnology Co.Ltd.Suzhou 215000China Shanghai institute for Advanced Immunochemical Studies and School of Life Science and TechnologyShanghaiTech UniversityShanghai 200031China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Aldehyde oxidase(aoX)is a molybdoenzyme that is primarily expressed in the liver and is involved in the metabolism of drugs and other ***-mediated metabolism can result in unexpected outcomes,such as the production of toxic metabolites and high metabolic clearance,which can lead to the clinical failure of novel therapeutic *** models can assist medicinal chemists in rapidly evaluating the aoX metabolic risk of compounds during the early phases of drug discovery and provide valuable clues for manipulating aoX-mediated metabolism *** this study,we developed a novel graph neural network called aoMP for predicting aoX-mediated *** integrated the tasks of metabolic substrate/non-substrate classification and metabolic site prediction,while utilizing transfer learning from 13C nuclear magnetic resonance data to enhance its performance on both *** significantly outperformed the benchmark methods in both cross-validation and external *** aoMP,we systematically assessed the aoX-mediated metabolism of common fragments in kinase inhibitors and successfully identified four new scaffolds with aoX metabolism liability,which were validated through in vitro ***,for the convenience of the community,we established the first online service for aoX metabolism prediction based on aoMP,which is freely available at https://***.

关键词： Drugmetabolism Aldehyde oxidase Transferlearning Graph neural network Kinase inhibitor

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Observation of spectral lines in the exceptional GRB 221009A

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Science china(Physics,Mechanics & Astronomy) 2024年第8期67卷 187-206页

作者： Yan-Qiu zhang Shao-Lin Xiong Ji-Rong Mao Shuang-Nan zhang Wang-Chen Xue Chao Zheng Jia-cong Liu Zhen zhang Xi-Lu Wang Ming-Yu Ge Shu-Xu Yi Li-Ming Song Zheng-Hua An Ce Cai Xin-Qiao Li Wen-Xi Peng Wen-Jun Tan Chen-Wei Wang Xiang-Yang Wen Yue Wang Shuo Xiao Fan zhang Peng zhang Shi-Jie Zheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100012China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China college of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China college of Electronic and Information Engineering Tongji UniversityShanghai 201804China

As the brightest gamma-ray burst ever observed,GRB 221009A provided a precious opportunity to explore spectral line *** this article,we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GECAM-C and Fermi/GBM data to search for emission and absorption *** the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems,and identified prominent emission lines in multiple time *** central energy of the Gaussian emission line evolves from about 37 to 6 MeV,with a nearly constant ratio(about 10%)between the line width and central ***,we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of–1 and–2,*** suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 ke V *** find that a standard high latitude emission scenario cannot fully interpret the observation,thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the *** this scenario,we can use the emission line to directly,for the first time,measure the bulk Lorentz factor of the jet(Γ)and reveal its time evolution(i.e.,Γ~t^(-1))during the prompt ***,we find that the flux of the annihilation line in the co-moving frame keeps *** discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.

关键词： GRB GRB 221009A emission line

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Phase relationship of complex multi-component system in chromate cleaner production

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Progress in Natural Science:Materials International 2007年第7期17卷 845-850页

作者： Ge Xinlei~1 Wang Xidong~(1,3**) Zheng Shili~2 zhang Mei~1 zhang Yi~2 (1.Department of Physical Chemistry,University of Science and Technology beijing,beijing 100083,china 2.institute of Process Engineering,Chinese Academy of Sciences,beijing 100080,china 3.college of Engineering,Peking University,beijing 100871,china) Department of Physical Chemistry University of Science and Technology Beijing Beijing 100083 China college of Engineering Peking University Beijing 100871 China institute of Process Engineering Chinese Academy of Sciences Beijing 100080 China

The phase relationships of the complex multi-component systems in the liquid-phase oxidization and separation process related with the chromate cleaner production are investigated theoretically and *** phase diagram of main system Fe- Cr2O4-KOH-O2of oxidization process and the relationship of its standard Gibbs free energy change with temperature are calculated.A se- ries of phase diagrams of the separation process at different temperatures,such as K（Na）OH-K（Na）2CrO4-H2O,KOH-KAlO2-H2O, K（Na）OH-K（Na）2co3-H2O,K（Na）OH-K（Na）Hco3-H2O and K（Na）Hco3-K（Na）2CrO4-H2O have also been *** ex- periments are carried out to verify the calculated *** results showed that the sub-molten salt media are suitable for the oxidization and separation processes;FeCr2O4can be oxidized across a wide range of temperature;K（Na）2CrO4can be separated from K（Na）AlO2system at appropriate temperature and proper concentration;the crystallization of carbonate is easier than that of K（Na）2CrO4.

关键词： chromite chromate system thermodynamics calculation phase diagram

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Double enzyme mimetic activities of multifunctional Ag nanoparticle-decorated co_(3)V_(2)O_(8)hollow hexagonal prismatic pencils for application in colorimetric sensors and disinfection

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Nano Materials Science 2024年第2期6卷 244-255页

作者： Ying Gao Peng Ju Yu zhang Yuxin zhang Xiaofan Zhai Jizhou Duan Baorong Hou Key Laboratory of Marine Environmental corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesQingdao266071PR China Key Laboratory of Marine Eco-Environmental Science and Technology Marine Bioresource and Environment Research CenterFirst Institute of OceanographyMinistry of Natural ResourcesQingdao266061PR China University of Chinese Academy of Sciences Beijing100049PR China Open Studio for Marine corrosion and Protection Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266071PR China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao266071PR China college of Materials Science and Engineering Chongqing UniversityChongqing400044China

Since the catalytic activity of most nanozymes is still far lower than the corresponding natural enzymes,there is urgent need to discover novel highly efficient enzyme-like *** this work,co_(3)V_(2)O_(8)with hollow hexagonal prismatic pencil structures were prepared as novel artificial enzyme *** were then decorated by photo-depositing Ag nanoparticles(Ag NPs)on the surface to further improve its catalytic *** Ag NPs decorated co_(3)V_(2)O_(8)(ACVPs)showed both excellent oxidase-and peroxidase-like catalytic *** can oxidize the colorless 3,3’,5,5’-tetramethylbenzidine rapidly to induce a blue *** enhanced enzyme mimetic activities can be attributed to the surface plasma resonance(SPR)effect of Ag NPs as well as the synergistic catalytic effect between Ag NPs and co_(3)V_(2)O_(8),accelerating electron transfer and promoting the catalytic *** were applied in constructing a colorimetric sensor,validating the occurrence of the Fenton reaction,and disinfection,presenting favorable catalytic *** enzyme-like catalytic mechanism was studied,indicating the chief role of⋅O_(2)-radicals in the catalytic *** work not only discovers a novel functional material with double enzyme mimetic activity but also provides a new insight into exploiting artificial enzyme mimics with highly efficient catalytic ability.

关键词： co_(3)V_(2)O_(8) Ag NPs Enzyme mimetic colorimetric sensor Disinfection

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combined Promoting Effects of Specific Organic Functional Groups and Alumina Surface Characteristics for the Design of a Highly Efficient NiMo/Al_(2)O_(3) Hydrodesulfurization Catalyst

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china Petroleum Processing & Petrochemical Technology 2024年第1期26卷 1-11页

作者： Li Huifeng Li Mingfeng zhang Le Wang Wei Nie Hong National Energy R&D Center of Petroleum Refining Technology SINOPEC Research Institute of Petroleum Processing Co.Ltd.Beijing 100083China

To prepare a highly efficient NiMo/Al_(2)O_(3) hydrodesulfurization catalyst,the combined effects of specific organic functional groups and alumina surface characteristics were ***,the correlation between the surface characteristics of four different alumina and the existing Mo species states was *** was found that the Mo equilibrium adsorption capacity can be used as a specific descriptor to quantitatively evaluate the changes in surface characteristics of different alumina.A lower Mo equilibrium adsorption capacity for alumina means weaker metal-support interaction and the loaded Mo species are easier to transform into ***,the Mo-O-Al bonds still exist at the metal-support *** introduction of cationic surfactant hecadecyl trimethyl ammonium bromide(CTAB)can further improve Mo species dispersion through electrostatic attraction with Mo anions and interaction of its alkyl chain with the alumina surface;meanwhile,the introduction of ethylenediamine tetraacetic acid(EDTA)can complex with Ni ions to enhance the Ni-promoting effect on ***,the NiMo catalyst designed using alumina with lower Mo equilibrium adsorption capacity and the simultaneous addition of EDTA and CTAB exhibits the highest hydrodesulfurization activity for 4,6-dimethyl dibenzothiophene because of its proper metal-support interaction and more well-dispersed Ni-Mo-S active phases.

关键词： alumina Mo equilibrium adsorption capacity organic functional groups metal-support interaction hydrodesulfurization

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Surrogate-assisted differential evolution using manifold learning-based sampling for highdimensional expensive constrained optimization problems

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Chinese Journal of Aeronautics 2024年第7期37卷 252-270页

作者： Teng LONG Nianhui YE Rong CHEN Renhe SHI Baoshou zhang School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Dynamics and control of Flight Vehicle of Ministry of Education Beijing 100081China china Academy of Launch Vehicle Technology Beijing 100076China

To address the challenges of high-dimensional constrained optimization problems with expensive simulation models,a Surrogate-Assisted Differential Evolution using Manifold Learning-based Sampling(SADE-MLS)is *** SADE-MLS,differential evolution operators are executed to generate numerous high-dimensional candidate *** alleviate the curse of dimensionality,a Manifold Learning-based Sampling(MLS)mechanism is developed to explore the high-dimensional design space *** MLS,the intrinsic dimensionality of the candidate points is determined by a maximum likelihood ***,the candidate points are mapped into a low-dimensional space using the dimensionality reduction technique,which can avoid significant information loss during dimensionality ***,Kriging surrogates are constructed in the low-dimensional space to predict the responses of the mapped candidate *** candidate points with high constrained expected improvement values are selected for global ***,the local search process assisted by radial basis function and differential evolution is performed to exploit the design space *** numerical benchmarks are tested to compare SADE-MLS with other ***,SADE-MLS is successfully applied to a solid rocket motor multidisciplinary optimization problem and a re-entry vehicle aerodynamic optimization problem,with the total impulse and lift to drag ratio being increased by 32.7%and 35.5%,*** optimization results demonstrate the practicality and effectiveness of the proposed method in real engineering practices.

关键词： Surrogate-assisted differential evolution Dimensionality reduction Solid rocket motor Re-entry vehicle Expensive constrained optimization

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