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A genetic variant study of bortezomib-induced peripheral neuropathy in Chinese multiple myeloma patients

Oncology Research 2024年第5期32卷 955-963页

作者： yan zhang HEyanG zhang JING WANG XIN WEI YI QU FENG XU LIJUN zhang Department of Hematology The First Affiliated Hospital of China Medical UniversityShenyang110001China

Background:Bortezomib results in peripheral neuropathy(PN)in approximately 50%of patients,during multiple myeloma(MM)treatment,a complication known as Bortezomib-induced peripheral neuropathy(BIPN).The drug response varies among *** factor may play an important role in ***:A nextgeneration sequencing(NGS)panel containing 1659 targets from 233 genes was used to identify risk variants for developing BIPN in 204 MM patients who received bortezomib *** expression of MTHFR and ALDH1A1 in 62 peripheral blood samples was detected by real-time quantitative PCR(RT-qPCR).Serum homocysteine(Hcy)levels were detected in 40 samples by chemiluminescent microparticle immunoassay(CMIA).Results:Compared with the non-BIPN group(n=89),a total of 8 significantly associated single nucleotide polymorphisms(SNPs)were identified in the BIPN group(n=115):MTHFR(rs1801131,rs1801133,rs17421511),EPHX1(rs1051740),MME(rs2016848),ALDH1A1(rs6151031),HTR7(rs1935349)and CYP2A6(rs8192720).The mRNA expression level of MTHFR in newly diagnosed patients with peripheral neuritis after treatment(NP group)was lower than that of newly diagnosed patients without peripheral neuritis after treatment(NnP group)(1.70±0.77 vs.2.81±0.97,p=0.009).Serum Hcy levels were significantly higher in BIPN group than in non-BIPN group(11.66±1.79μmol/L vs.8.52±3.29μmol/L,p=0.016)and healthy controls(11.66±1.79μmol/L vs.8.55±2.13μmol/L,p≤0.001).Conclusion:CYP2A6,EPHX1,MTHFR,ALDH1A1,HTR7,MME and BIPN are linked in Chinese MM *** is more likely to occur in patients with lower MTHFR mRNA expression,which might result in higher serum Hcy levels.

关键词： Multiple Myeloma Peripheral neuropathy Bortezomib Bortezomib-induced peripheral neuropathy Next-generation sequencing MTHFR Serum Hcy

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Photocatalytic Site-Selective Cascade Radical Addition of Biaryl Ynones for the Construction of Spiro-and Fused Carbon Rings

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Chinese Journal of Chemistry 2024年第14期42卷 1599-1605页

作者： Kairui Liu Chunhang Zhao Liji Gu Xiang Li Jiali yan Siqi Lao Weiwei Huan yan zhang Key Laboratory of the Ministry of Education for Advanced Catalysis Materials and Drug Discovery&Innovation CenterCollege of Chemistry and Materials ScienceZhejiang Normal UniversityJinhuaZhejiang321004 China Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass College of Chemistry and Materials EngineeringZhejiang A&F UniversityHangzhouZhejiang311300 China

Functionalized free radical addition/cyclization reactions represent an efficient way for introducing new functionality or coupling fragments to *** are good regional selectivity radical acceptors in organic synthesis,and many of bio-relevant cyclic compounds could be easily obtained by direct radical cyclization ***,we report a photocatalytic cascade radical addition of biaryl ynones,for the divergent synthesis of privileged carbon ***,further transformation of the multi-functional group product into a variety of other derivatives demonstrates the synthetic value of this developed method.

关键词： Ynones Photocatalysis Cascade cyclization Alkoxycarbonyl radical Dearomatization Biaryls Regioselectivity Radical reactions

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SCREEN:predicting single-cell gene expression perturbation responses via optimal transport

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Frontiers of Computer Science 2024年第3期18卷 255-257页

作者： Haixin WANG Yunhan WANG Qun JIANG yan zhang Shengquan CHEN Cadre Medical Department The 1st Clinical CenterChinese PLA General HospitalBeijing 100853China School of Statistics Renmin University of ChinaBeijing 100872China Ministry of Education Key Laboratory of Bioinformatics Bioinformatics Division of BNRISTDepartment of AutomationTsinghua UniversityBeijing 100084China School of Mathematical Sciences and LPMC Nankai UniversityTianjin 300071China

1 Introduction Recent advances in single-cell RNA sequencing(scRNA-seq)have enabled the study of how individual cells respond to various external perturbations such as drug stimulation at gene expression level[1].Precisely inferring perturbation responses allows us to explore how and why individual tumor cells evade cancer treatment,greatly advancing personalized medicine research and deepening our understanding of biological mechanisms[2].However,considering the high costs of sequencing and the complexity of obtaining perturbed samples,utilizing computational methods to predict cellular responses to perturbations holds great potential[2].

关键词： stimulation perturbation deepening

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Gastric cancer secreted miR 214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells

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Oncology Research 2024年第3期32卷 489-502页

作者： WEIXUE WANG TONGTONG WANG yan zhang TING DENG HAIyanG zhang YI BA Department of GI Medical Oncology Tanjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerTianjin Key Iaboratory of Digestive CancerKey Laboratory of Cancer Prevention and TherapyTianjin300060China

Diferent from necrosis,apoptosis,autophagy and other forms of cell death,ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated ftty acids under the action of iron divalent or lipoxygenase,leading to cell *** is currently used in the third line standard treatment of advanced gastric cancer,targeting the anti-angiogenesis ***,Apatinib mediated ferroptosis in vascular endothelial cells has not been reported *** exosomes can be taken up into target cells to regulate tumor development,but the mechanism related to vascular endothelial cell ferroptosis has not yet been ***,we show that exosomes secreted by gastric cancer cells carry miR-214.3p into vascular endothelial cells and directdy target zinc finger protein A20 to negatively regulate ACSL4,a key enzyme of lipid peroxidation during frroptosis thereby inhibiting ferroptosis in vascular endothelial cells and reducing the eficiency of *** conclusion,inhibition of miR-214-3p can increase the sensitivity of vascular endothelial cells to Apatinib,thereby promoting the antiangiogenic efect of Apatinib,suggesting a potential combination therapy for advanced gastric cancer.

关键词： Cellular ferroptosis Exosome Tyrosine kinase inhibitor Gastrointestinal tumors miRNA

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Application and progress of artificial intelligence technology in the segmentation of hyperreflective foci in OCT images for ophthalmic disease research

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1138-1143页

作者： Jia-Ning Ying Hu Li yan-yan zhang Wen-Die Li Quan-Yong Yi Ningbo Eye Hospital Wenzhou Medical UniversityNingbo 315042Zhejiang ProvinceChina Health Science Center Ningbo UniversityNingbo 315211Zhejiang ProvinceChina

With the advancement of retinal imaging,hyperreflective foci(HRF)on optical coherence tomography(OCT)images have gained significant attention as potential biological biomarkers for retinal ***,these biomarkers,represented by HRF,present pose challenges in terms of localization,quantification,and require substantial time and *** recent years,the progress and utilization of artificial intelligence(AI)have provided powerful tools for the analysis of biological *** technology enables use machine learning(ML),deep learning(DL)and other technologies to precise characterization of changes in biological biomarkers during disease progression and facilitates quantitative *** on ophthalmic images,AI has significant implications for early screening,diagnostic grading,treatment efficacy evaluation,treatment recommendations,and prognosis development in common ophthalmic ***,it will help reduce the reliance of the healthcare system on human labor,which has the potential to simplify and expedite clinical trials,enhance the reliability and professionalism of disease management,and improve the prediction of adverse *** article offers a comprehensive review of the application of AI in combination with HRF on OCT images in ophthalmic diseases including age-related macular degeneration(AMD),diabetic macular edema(DME),retinal vein occlusion(RVO)and other retinal diseases and presents prospects for their utilization.

关键词： artificial intelligence deep learning hyperreflective foci image analysis

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Full-Stokes metasurface polarimetry requiring only a single measurement

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Photonics Research 2024年第3期12卷 514-521页

作者： CHENGLONG ZHENG HUI LI JINGYU LIU MENGGUANG WANG HUAPING ZANG yan zhang JIANQUAN YAO Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Key Laboratory of Opto-Electronics Information Technology(Tianjin University) Ministry of EducationSchool of Precision Instruments and Opto-Electronics EngineeringTianjin UniversityTianjin 300072China Beijing Key Laboratory for Metamaterials and Devices Key Laboratory of Terahertz OptoelectronicsMinistry of Educationand Beijing Advanced Innovation Center for Imaging TechnologyDepartment of PhysicsCapital Normal UniversityBeijing 100048China State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China

Polarization is crucial in various fields such as imaging,sensing,and substance detection.A compact,fast,and accurate polarization detection device is vital for these ***,we demonstrate a multifocus metalens for terahertz polarization detection that requires only a single measurement to obtain complete polarization parameters and reconstruct the polarization state of the incident *** individual subarrays of this metalens convert each of the six polarized components into the same polarization,which in turn links the Stokes parameters to these six *** incident linear polarizations and elliptical polarizations are characterized by Stokes parameters and polarization *** and experimental results show that the scheme can accurately detect the incident polarization with a single *** proposed metasurface polarimetry may find applications in the fields of real-time terahertz detection and integrated optics.

关键词： field incident polar

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Strain engineering of Pt-based electrocatalysts for oxygen reaction reduction

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Frontiers in Energy 2024年第2期18卷 241-262页

作者： Zeyu WANG yanru LIU Shun CHEN Yun ZHENG Xiaogang FU yan zhang Wanglei WANG State Key Laboratory of Solidification Processing Atomic Control and Catalysis Engineering LaboratorySchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyDepartment of Dental MaterialsSchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China Institute of New Energy Materials and Engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Key Laboratory of Marine Chemistry Theory and Technology(Ministry of Education) College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao 266100China

Proton exchange membrane fuel cells(PEMFCs)are playing irreplaceable roles in the construction of the future sustainable energy ***,the insufficient performance of platinum(Pt)-based electrocatalysts for oxygen reduction reaction(ORR)hinders the overall efficiency of *** the surface strain of catalysts is considered an effective way to tune their electronic structures and therefore optimize catalytic *** this paper,insights into strain engineering for improving Pt-based catalysts toward ORR are elaborated in ***,recent advances in understanding the strain effects on ORR catalysts are comprehensively ***,strain engineering methodologies for adjusting Ptbased catalysts are comprehensively ***,further information on the various challenges and potential prospects for strain modulation of Pt-based catalysts is provided.

关键词： strain engineering Pt-based catalysts oxygen reduction reaction(ORR) catalytic performance proton exchange membrane fuel cells(PEMFCs)

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Photochemical Production of Methyl Halides with Guaiacol as the Precursor

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Journal of Ocean University of China 2024年第5期23卷 1275-1286页

作者： yanG Fan zhang yan WU Guanyu HE Zhen yanG Guipeng Frontiers Science Center for Deep Ocean Multispheres and Earth System Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education Ocean University of China Laboratory for Marine Ecology and Environmental Science Qingdao Marine Science and Technology Center Institute of Marine Chemistry Ocean University of China

Methyl halides are crucial trace greenhouse gases in the atmosphere, playing a significant role in global climate change and the atmospheric environment. This study investigated the photochemical production of methyl halides in an artificial seawater system using guaiacol as a precursor through laboratory simulation experiments. The influences of various environmental factors, including illumination time, radiation wavebands, illumination intensity, concentrations of guaiacol and halide ions（X-）, Fe3+, salinity, dissolved oxygen（DO）, and pH value on the photochemical production of methyl halides were examined. We demonstrated that increased illumination intensity and duration promote the photochemical production of methyl halides, with a notable enhancement under UV-B radiation. Guaiacol and halide ions were identified as key precursors, and their high concentrations facilitated the formation of methyl halides. Additionally, different types of halide ions exhibited a competitive relationship in producing methyl halides. The study found that an increase in pH inhibited the photochemical formation of CH3I due to the reaction between OH-and ·CH3. Dissolved oxygen was found to inhibit the photochemical formation of CH3I while promoting the formation of CH3Cl. Conversely, an appropriate concentration of Fe3+enhanced the photochemical production of methyl halides. Field observations indicated a high photochemical production of methyl halides in the natural waters near Qingdao's coastal area, likely due to the high concentration of dissolved organic matter（DOM）, which supports photochemical reactions. Furthermore, the photochemical production of methyl halides in natural seawater was significantly higher than in dark conditions, underscoring the importance of illumination in promoting these photochemical processes in seawater.

关键词： dissolved organic matter guaiacol methyl halides photochemical production

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A study on the temperature sensitivity of NMR porosity in porous media based on the intensity of magnetization Dedicated to the special issue “Magnetic Resonance in Porous Media”

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Magnetic Resonance Letters 2024年第1期4卷 28-39页

作者： Lu zhang Lizhi Xiao Wensheng Wu Guangzhi Liao yan zhang Sihui Luo Xinglong Lei National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China College of Geophysics China University of PetroleumBeijing102249China PetroChina Huabei Oilfield Company China National Petroleum CorporationRenqiu062552China

The measurement of nuclear magnetic resonance(NMR)porosity is affected by *** considering the impact of NMR logging tools,this phenomenon is mainly caused by variations in magnetization intensity of the measured system due to temperature fluctuations and difference between the temperature of the porous medium and calibration *** this study,the effect of temperature was explained based on the thermodynamic theory,and the rules of NMR porosity responses to temperature changes were identified through core physics *** addition,a method for correcting the influence of temperature on NMR porosity measurement was proposed,and the possible factors that may affect its application were also discussed.

关键词： NMR porosity Temperature Porous media Intensity of magnetization

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Microstructure Features and the Macroscopic Acoustic Behavior of Gassy Silt in the Yellow River Delta

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Journal of Ocean University of China 2024年第2期23卷 371-382页

作者： LIU Tao GUO Zhenqi zhang yan WU Chen LIU Lele DENG Shenggui Laboratory for Marine Geology Pilot National Laboratory for Marine Science and TechnologyQingdao 266061China Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of ChinaQingdao 266100China College of Civil Engineering Anhui Jianzhu UniversityHefei 230601China The Key Laboratory of Gas Hydrate Ministry of Natural ResourcesQingdao Institute of Marine GeologyQingdao 266071China College of Marine Geosciences Key Laboratory of Submarine Geosciences and ProspectingOcean University of ChinaQingdao 266100China

The morphological changes in isolated bubbles in gassy silt play a critical role in the microscopic structures between soil particles and bubbles and macroscopic physical *** on X-ray CT scanning experiments under various vertical loads(four levels),self-designed acoustic macro experiments,and a series of formula revisions to the macro-air-bearing silt sound-velocity prediction model,this paper discusses the macro-and micro-scale features of gassy silts from the Yellow River *** samples consisted of different proportions of silt from the Yellow River Delta and porous media,and they were used to form two types of aerosol silts with initial gas contents of 4.23%and 7.67%.The results show that the air bubble content and external load considerably affect the microstructural parameters and acoustic behavior of gassy silt in the Yellow River *** macroscopic sound velocity showed a linear positive correlation with vertical load and relation to microstructural parameters in varying manners and *** on the traditional Biot-Stoll acoustic model,the gas-phase medium coefficient was introduced for the proper calculation and prediction of the sound velocity of air-bearing *** errors of the overall prediction varied between 5.6%and 9.6%.

关键词： gassy silt vertical load microstructure parameters bubble vibration Biot-Stoll acoustic model

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