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Infection with SARS-CoV-2 can cause pancreatic impairment

Signal Transduction and Targeted Therapy 2024年第5期9卷 2143-2160页

作者： Wei deng Linlin Bao Zhiqi Song Ling zhang Pin Yu Yanfeng Xu Jue Wang Wenjie Zhao Xiuqin zhang Yunlin Han Yanhong Li Jiangning Liu Qi Lv Xujian Liang Fengdi Li Feifei Qi Ran deng Siyuan Wang Yibai Xiong Ruiping Xiao Hongyang Wang chuan Qin NHC Key Laboratory of Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China Institute of Molecular Medicine College of Future TechnologyPeking UniversityBeijing 100871China Beijing Key Laboratory of Cardiometabolic Molecular Medicine Peking UniversityBeijing 100871China State Key Laboratory of Biomembrane and Membrane Biotechnology Peking-Tsinghua Center for Life SciencesBeijing 100871China Chinese Academy of Engineering Eastern Hepatobiliary Surgery Hospital225 Changhai RoadYangpu DistrictShanghai 200438China International Co-operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteSecond Military Medical UniversityShanghai 200438PR China National Laboratory for Oncogenes and Related Genes Cancer Institute of Shanghai Jiao Tong UniversityShanghai 200441PR China Changping National laboratory(CPNL) Beijing 102206China State Key Laboratory of Respiratory Health and Multimorbidity National Health Commission of the People’s Republic of ChinaBeijingPR China

Evidence suggests associations between COVId-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of ***,we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SARS-CoV-2 infected non-human primates(NHPs)models and 121 vaccinated and infected NHPs from 2020 to 2023 and COVId-19 ***-label immunofluorescence revealed direct infection of both exocrine and endocrine pancreatic cells by the virus in NHPs and *** and limited phenotypic and histopathological changes were observed in adult *** proteomics and metabolomics results indicated metabolic disorders,mainly enriched in insulin resistance pathways,in infected adult NHPs,along with elevated fasting C-peptide and C-peptide/glucose ratio ***,in elder COVId-19 NHPs,SARS-CoV-2 infection causes loss of beta(β)cells and lower expressed-insulin in situ characterized by islet amyloidosis and necrosis,activation ofα-SMA and aggravated fibrosis consisting of lower collagen in serum,an increase of pancreatic inflammation and stress markers,ICAM-1 and G3BP1,along with more severe glycometabolic *** contrast,vaccination maintained glucose homeostasis by activating insulin receptorαand insulin receptorβ.Overall,the cumulative risk of diabetes post-COVId-19 is closely tied to age,suggesting more attention should be paid to blood sugar management in elderly COVId-19 patients.

关键词： infected elevated homeostasis

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Graphene-loaded nickel−vanadium bimetal oxides as hydrogen pumps to boost solid-state hydrogen storage kinetic performance of magnesium hydride

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2645-2657页

作者： dong-qiang GAO Fu-ying WU Zhi zhang Zi-chuan LU Ren ZHOU Hu ZHAO Liu-ting zhang School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China Instrumental Analysis Center Jiangsu University of Science and TechnologyZhenjiang 212003China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

To modify the thermodynamics and kinetic performance of magnesium hydride(MgH_(2))for solid-state hydrogen storage,Ni_(3)V_(2)O_(8)-rGO(rGO represents reduced graphene oxide)and Ni_(3)V_(2)O_(8)nanocomposites were prepared by hydrothermal and subsequent heat *** beginning hydrogen desorption temperature of 7 wt.%Ni_(3)V_(2)O_(8)-rGO modified MgH_(2)was reduced to 208℃,while the additive-free MgH_(2)and 7 wt.%Ni_(3)V_(2)O_(8)doped MgH_(2)appeared to discharge hydrogen at 340 and 226℃,respectively.A charging capacity of about 4.7 wt.%H_(2)for MgH_(2)+7 wt.%Ni_(3)V_(2)O_(8)-rGO was achieved at 125℃ in 10 min,while the dehydrogenated MgH_(2)took 60 min to absorb only 4.6 wt.%H_(2)at 215℃.The microstructure analysis confirmed that the in-situ generated Mg_(2)Ni/Mg_(2)N_(i)H_(4) and metallic V contributed significantly to the enhanced performance of MgH_(2).In addition,the presence of rGO in the MgH_(2)+7 wt.%Ni_(3)V_(2)O_(8)-rGO composite reduced particle aggregation tendency of Mg/MgH_(2),leading to improving the cyclic stability of MgH_(2)during 20 cycles.

关键词： hydrogen storage properties MgH_(2) graphene-loaded Ni−V bimetal oxides catalytic mechanism

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河北省乡村振兴水平评价及空间差异研究

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中国农业资源与区划 2024年第3期45卷 187-195页

作者：宋川张宁河北开放大学河北农业大学

[目的]对2010—2020年河北省及其各区域乡村振兴水平进行测度，并针对区域差异展开解析，以期为该区域农业绿色发展提供科学参考。[方法]文章构建河北省乡村振兴评价指标体系，然后基于2010—2020年的面板数据，综合运用熵权法、均权法... 详细信息

[目的]对2010—2020年河北省及其各区域乡村振兴水平进行测度，并针对区域差异展开解析，以期为该区域农业绿色发展提供科学参考。[方法]文章构建河北省乡村振兴评价指标体系，然后基于2010—2020年的面板数据，综合运用熵权法、均权法、加权综合评价指数法对河北省及其区域乡村振兴水平进行测度，同时选取变异系数和锡尔指数对区域差异进行测度和分解。[结果]（1）河北省乡村振兴发展水平及产业兴旺、生态宜居、乡风文明、治理有效、生活富裕5个子系统均呈现稳步逐年上升趋势，其中，乡风文明、治理有效两子系统水平偏低，产业兴旺和生态宜居水平相对较高，变化趋势以生态宜居增长最快，生活富裕增长缓慢，产业兴旺波动性较大。（2）河北省各区域乡村振兴水平和变化趋势差异较大。邯郸和唐山发展水平最高，沧州和承德相对较低，邯郸、保定、石家庄、张家口和承德5市水平提升较快，衡水变化最小，其他地区提升速度相对缓慢。（3）冀东、冀南地区的乡村振兴水平区域差异性较小，冀中、冀北区域差异相对较大，冀北和四大区域间差异是造成全省差异性的主要原因。[结论]河北省乡村振兴发展水平整体呈现逐年递增趋势，但增幅有限；地区发展不平衡，地区发展水平差距大，中心城市规模小，乡村之间、地区之间要素流动的成本高，难以对乡村造成有效辐射，农业产业基础薄弱，公共服务设施不足等诸多乡村振兴的短板依然存在。未来应继续加强推进缩小区域间差异，尤其是冀北和冀中地区内部乡村振兴发展不平衡问题较严重。

关键词：乡村振兴指标体系水平测度区域差异

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禀赋效应与风险承载力对宅基地退出意愿的影响——基于江苏省6754份调查问卷的实证分析

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资源科学 2024年第1期46卷 218-231页

作者：韩述郭贯成张传南京农业大学公共管理学院南京210095 南京农业大学中国资源环境与发展研究院南京210095

【目的】统筹禀赋效应与风险承载力的基础上剖析农户行为逻辑,对于盘活闲置宅基地、保障农民资产权益、深化宅基地改革具有重要意义。【方法】本文基于江苏省6754户农户微观数据,构建禀赋效应、风险承载力与宅基地退出意愿的理论框架,... 详细信息

【目的】统筹禀赋效应与风险承载力的基础上剖析农户行为逻辑,对于盘活闲置宅基地、保障农民资产权益、深化宅基地改革具有重要意义。【方法】本文基于江苏省6754户农户微观数据,构建禀赋效应、风险承载力与宅基地退出意愿的理论框架,通过中介效应模型探究禀赋效应在风险承载力对宅基地退出意愿影响中的中介传递,采用门槛模型检验风险承载力对宅基地退出意愿的双门槛效应,并探究在不同风险承载力门槛内禀赋效应中介作用的差异。【结果】(1)禀赋效应通过主体依恋、客体依赖与不确定感知3条路径对宅基地退出意愿有显著的负向影响;(2)风险承载力对宅基地退出意愿的影响有双门槛效应。风险承载力介于两门槛值间时,对宅基地退出意愿的影响为正,过低或过高时,对宅基地退出意愿的影响均为负。(3)禀赋效应是风险承载力影响宅基地退出意愿的中介变量。其中,中介效应从大到小的顺序为宅基地不可替代性、心理所有权与不确定感知;(4)在风险承载力从低到高的积累过程中,禀赋效应的中介效应经历了完全中介、部分中介和不中介的演变,表明随着风险承载力的积累,禀赋效应的中介作用被逐渐削弱。【结论】政府应明确风险承载力适中的农户群体,健全宅基地退出动员与示范机制,提高农户政策认知水平,完善农户风险承载力保障机制,促进宅基地退出向以人为本转变。

关键词：禀赋效应风险承载力宅基地退出意愿中介效应门槛效应江苏省

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Assessing environmental impact:Micro-energy network optimization in a Chinese industrial park

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Chinese Journal of Population,Resources and Environment 2024年第1期22卷 68-73页

作者： Guanzhun Cao chuan Feng Tong Li Hongjuan zhang Xiaoyao Guo Wen Li Yanshuang Jia Leping Chen Yuan Xu Qingsong Wang Guifang Chen Xueliang Yuan China Tobacco Shandong Industrial Co. Ltd.Jinan 250104China Shandong Academy of Environmental Sciences Jinan 250109China Shandong Electrical Engineering&Equipment Group Co. Ltd.Jinan 250001China School of Energy and Power Engineering Shandong UniversityJinan 250061China

Micro-energy systems contribute significantly to environmental improvement by reducing dependence on power grids through the utilization of multiple renewable energy *** study quantified the environmental impact of a micro-energy network system in an industrial park through a life cycle assessment using the operation of the micro-energy network over a year as the functional unit and“cradle-to-gate”as the system *** on the baseline scenario,a natural gas generator set was added to replace central heating,and the light pipes were expanded to constitute the optimized *** results showed that the key impact categories for both scenarios were global warming,fine particulate matter formation,human carcinogenic toxicity,and human non-carcinogenic *** overall environmental impact of the optimized scenario was reduced by 68%compared to the baseline scenario.A sensitivity analysis of the key factors showed that electricity from the power grid was the key impact factor in both scenarios,followed by central heating and natural ***,to reduce the environmental impact of network systems,it is necessary to further optimize the grid power *** research approach can be used to optimize micro-energy networks and evaluate the environmental impact of different energy systems.

关键词： Micro-energy network Life cycle assessment Optimal operation Environmental impact

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Small-molecule agents for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 905-952页

作者： Fang Wang Kai Fu Yujue Wang Can Pan Xueping Wang Zeyu Liu chuan Yang Ying Zheng Xiaopeng Li Yu Lu Kenneth Kin Wah To Chenglai Xia Jianye zhang Zhi Shi Zeping Hu Min Huang Liwu Fu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Esophageal Cancer InstituteGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Pharmaceutical Sciences Tsinghua-Peking Center for Life SciencesBeijing Frontier Research Center for Biological StructureTsinghua UniversityBeijing 100084China State Key Laboratory of drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China department of Cell Biology&Institute of Biomedicine National Engineering Research Center of Genetic MedicineMOE Key Laboratory of Tumor Molecular BiologyGuangdong Provincial Key Laboratory of Bioengineering MedicineCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China School of Pharmacy The Chinese University of Hong KongHong Kong 999077China Affiliated Foshan Maternity and Child Healthcare Hospital Southern Medical UniversityFoshan 528000China

Cancer immunotherapy,exemplified by the remarkable clinical benefits of the immune checkpoint blockade and chimeric antigen receptor T-cell therapy,is revolutionizing cancer *** induce long-term tumor regression and overall survival benefit in many types of *** the advances in our knowledge about the tumor immune microenvironment,remarkable progress has been made in the development of small-molecule drugs for *** molecules targeting PRR-associated pathways,immune checkpoints,oncogenic signaling,metabolic pathways,cytokine/chemokine signaling,and immune-related kinases have been extensively *** of smallmolecule immunotherapeutic drugs and their combinations with other antitumor modalities are under active clinical investigations to overcome immune tolerance and circumvent immune checkpoint inhibitor ***,we review the latest development of small-molecule agents for cancer immunotherapy by targeting defined pathways and highlighting their progress in recent clinical investigations.

关键词： Cancer immunotherapy Small-molecule agents Immune checkpoints Oncogenic signaling Metabolic pathways Cytokine/chemokine signaling Antitumor immunity Tumor immune microenvironment

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基于系统思维的高中化学“化学反应与电能”项目式教学——基于系统结构优化的视角理解原电池原理

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化学教育（中英文） 2024年第11期45卷 60-67页

作者：张传贵河南省淮阳中学河南淮阳466700

通过“化学反应与电能”项目式教学的开展,学生能了解原电池结构与功能的关系,进一步完善原电池的结构模型,在此基础上引导学生以铜-锌原电池的结构优化为起点,依据实验现象推断其结构缺陷,提出优化方案。通过液接电势的消除、盐桥向隔... 详细信息

通过“化学反应与电能”项目式教学的开展,学生能了解原电池结构与功能的关系,进一步完善原电池的结构模型,在此基础上引导学生以铜-锌原电池的结构优化为起点,依据实验现象推断其结构缺陷,提出优化方案。通过液接电势的消除、盐桥向隔膜的演变等后续结构优化方案的创设训练,学生能明确新型电池的优化思路、建立电池设计的思维模型,从而加深对原电池原理的理解、培养运用系统方法解决实际问题的创新思维能力。

关键词：系统结构系统功能优化原电池原理

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斯大林民族定义在中国的九十年(1929-2019)--兼论马克思主义民族定义的中国化

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中南民族大学学报（人文社会科学版） 2024年第1期44卷 62-70,183页

作者：周传斌张丽兰州大学西北少数民族研究中心/历史文化学院甘肃兰州730020

民族定义是马克思主义民族理论与民族政策研究领域的核心内容之一。作为马克思主义经典作家,斯大林的“民族”(нация/nation)定义对我国的民族理论与民族政策产生了不容忽视的影响。通过回顾斯大林民族定义自1929年传入中国之后,... 详细信息

民族定义是马克思主义民族理论与民族政策研究领域的核心内容之一。作为马克思主义经典作家,斯大林的“民族”(нация/nation)定义对我国的民族理论与民族政策产生了不容忽视的影响。通过回顾斯大林民族定义自1929年传入中国之后,随着时代的变迁而发生的不同影响,以及我国学术界围绕这一问题在不同时期展开的争论,从而展现马克思主义民族定义中国化的历程。随着中国特色社会主义新时代的开启,我国的马克思主义民族理论取得了创新性发展,对民族定义的理解也发生了相应的转变。

关键词：斯大林民族定义中国化马克思主义民族理论

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New HⅠObservations Toward the NGC 5055 Galaxy Group with FAST

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Research in Astronomy and Astrophysics 2024年第7期24卷 249-256页

作者： Xiao-Lan Liu Ming Zhu Jin-Long Xu Peng Jiang chuan-Peng zhang Nai-Ping Yu Jun-Jie Wang Yan-Bin Yang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 550000China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China GEPI Observatoire de ParisUniversite PSLCNRSPlace Jules Janssen92195 MeudonFrance

We report a new high-sensitivity HⅠmapping observation of the NGC 5055 galaxy group over an area of 1°.5×0°.75 with the Five-hundred-meter Aperture Spherical radio Telescope(FAST).Our observation reveals that the warped HⅠdisk of NGC 5055 is more extended than what was previously observed by WSRT,out to239(61.7 kpc).The total HⅠmass of NGC 5055 is determined to be~1.1×10^(10)M_Θ.We identified three HⅠclouds with HⅠmasses of the order of~10^(7)M_Θat the southeastern edge of the HⅠdisk,as well as a candidate high-velocity cloud with an HⅠmass of(1.2±0.5)×10^(6)M_Θto the north of NGC *** HⅠcontent of UGCA337 is robustly detected for the first time by the FAST *** has a narrow HⅠlinewidth of W_(50)=17.4±3.8 km s^(-1)with a total HⅠmass of(3.5±0.3)×10^(6)M_Θ.Comparing the gas content and g-r color of UGCA 337 with typical low-mass dwarf galaxies,UGCA 337 appears relatively gas-poor despite its blue *** suggests that UGCA 337 may have undergone gas stripping in the *** also analyzed the possible origin of the diffuse HⅠclouds located at the outskirts of NGC 5055,and speculate that they might be the remnant features of a merger event in the past.

关键词： galaxies evolution-galaxies structure-galaxies individual(NGC 5055)-galaxies kinematics and dynamics-galaxies interactions

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Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes

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Science China(Life Sciences) 2024年第8期67卷 1697-1714页

作者： Huan Wu Yanman zhang Yuqian Li Shuya Sun Jintao zhang Qingsong Xie Yue dong Shushu Zhou Xuan Sha Kuokuo Li Jinyi Chen Xin zhang Yang Gao Qunshan Shen Guanxiong Wang Xiaomin Zha Zongliu duan dongdong Tang chuan Xu Hao Geng Mingrong Lv Yuping Xu Ping Zhou Zhaolian Wei Rong Hua Yunxia Cao Mingxi Liu Xiaojin He Reproductive Medicine Center Department of Obstetrics and GynecologyThe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China State Key Laboratory of Reproductive Medicine and Offspring Health Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 210029China State Key Laboratory of Reproductive Medicine and Offspring Health The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou School of Clinical MedicineNanjing Medical UniversityNanjing 211166China Reproductive Medicine Center Department of Obstetrics and GynecologyShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China State Key Laboratory of Reproductive Medicine and Offspring Health Clinical Center of Reproductive MedicineThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University) Hefei 230032China Key Laboratory of Population Health Across Life Cycle(Anhui Medical University) Ministry of Education of the People’s Republic of ChinaHefei 230032China Anhui Province Key Laboratory of Reproductive Health and Genetics Hefei 230032China Biopreservation and Artificial Organs Anhui Provincial Engineering Research CenterAnhui Medical UniversityHefei 230032China

The complexities of energy transfer mechanisms in the flagella of mammalian sperm flagella have been intensively investigated and demonstrate significant diversity across *** shuttles,particularly adenylate kinase(AK)and creatine kinase(CK),are pivotal in the efficient transfer of intracellular ATP,showing distinct tissue-and ***,the expression profiles of AK and CK were investigated in mice and found to fall into four subgroups,of which Subgroup III AKs were observed to be unique to the male reproductive system and conserved across *** AK8 and AK9 were found to be indispensable to male reproduction after analysis of an infertile male *** mouse models showed that AK8 and AK9 were central to promoting sperm *** combined with mass spectrometry revealed that AK8 and AK9 interact with the radial spoke(RS)of the *** of various human and mouse sperm samples with substructural damage,including the presence of multiple RS subunits,showed that the head of radial spoke 3 acts as an adapter for AK9 in the flagellar *** an ATP probe together with metabolomic analysis,it was found that AK8 and AK9 cooperatively regulated ATP transfer in the axoneme,and were concentrated at sites associated with energy consumption in the *** findings indicate a novel function for RS beyond its structural role,namely,the regulation of ATP *** conclusion,the results expand the functional spectrum of AK proteins and suggest a fresh model regarding ATP transfer within mammalian flagella.

关键词： adenylate kinase Subgroup III AKs AK8 AK9 male infertility ATP transfer radial spoke

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