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八正散联合左氧氟沙星治疗女性下尿路感染患者临床疗效

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西部医学 2024年第9期36卷 1365-1370页

作者：李昭融吕莹张妍琪天津中医药大学第二附属医院天津300150 天津北辰双福门诊部天津300150 重庆医科大学研究生院重庆400016

目的观察八正散联合左氧氟沙星治疗女性下尿路感染患者的临床疗效,并探究其作用机制。方法以天津中医药大学第二附属医院收治的141例女性下尿路感染患者作为研究对象,采用随机对照法分为八正散组、联合组和对照组,每组各47例。对照组给... 详细信息

目的观察八正散联合左氧氟沙星治疗女性下尿路感染患者的临床疗效,并探究其作用机制。方法以天津中医药大学第二附属医院收治的141例女性下尿路感染患者作为研究对象,采用随机对照法分为八正散组、联合组和对照组,每组各47例。对照组给予左氧氟沙星治疗,八正散组予八正散治疗,联合组予八正散联合左氧氟沙星治疗,3组患者均治疗2周。观察比较患者治疗前后尿频、尿急、尿道灼热刺痛、尿黄赤症状的中医证候积分、尿白细胞计数、尿细菌培养、血清降钙素原(PCT)、C-反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)炎症因子水平及临床疗效和不良反应情况。结果八正散组和联合组患者治疗后中医证候积分、尿白细胞计数、尿培养转阴率、PCT、CRP、IL-6、TNF-α等炎症因子水平较治疗前均有明显改善(P<0.01);与对照组相比,八正散组、联合组患者尿频、尿急、尿道灼热刺痛、尿黄赤等症状改善效果更佳显著(P<0.05),尿白细胞计数显著减少,PCT、CRP、IL-6、TNF-α等炎症因子水平均明显下降,联合组患者尿培养转阴率升高(均P<0.05);与八正散组相比,联合组尿白细胞计数下降显著(P<0.05)。八正散组、联合组、对照组患者总有效率分别为85.11%、93.62%和76.60%,与对照组相比,联合组的有效率较高(P<0.05)。3组患者均出现1例不良反应。结论八正散联合左氧氟沙星治疗女性下尿路感染患者疗效显著,可有效改善患者尿频、尿急、尿道灼热刺痛、尿黄赤等临床症状,降低尿白细胞计数,提高尿培养转阴率,作用机制与减轻炎症反应密切相关,且联合使用优于单独使用。

关键词：八正散左氧氟沙星下尿路感染湿热下注证

护理硕士研究生对高级实践护士的认知与期望现状及影响因素分析

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齐鲁护理杂志 2024年第7期30卷 9-13页

作者：刘晓莅张彦奇徐梅山东大学护理与康复学院山东济南250012 山东第一医科大学附属省立医院济南市市中区人民医院

目的:了解护理硕士研究生对高级实践护士(APN)的期望和认知现状,分析其影响因素。方法:于2023年10月~11月,采用便利抽样法,以设有护理硕士学位点的6所高等院校的全日制在读护理硕士研究生为研究对象,采用自行编制的“护理硕士研究生对AP... 详细信息

目的:了解护理硕士研究生对高级实践护士(APN)的期望和认知现状,分析其影响因素。方法:于2023年10月~11月,采用便利抽样法,以设有护理硕士学位点的6所高等院校的全日制在读护理硕士研究生为研究对象,采用自行编制的“护理硕士研究生对APN角色的期望与认知调查问卷”进行问卷调查,并分析其影响因素。结果:共有294名全日制在读护理硕士研究生参与本研究,其中期望APN的工作形式为负责整体管理、不具体分管床位者占比47.96%;期望其在科室的权力与护士长相同者占比55.78%;期望通过APN基地脱产培训完成认证考核者占比56.12%。在认知方面,护理硕士研究生对APN的认知总分为(44.06±8.67)分,其中角色定位维度得分最低;多元线性回归分析显示,认知水平的影响因素包括未来从事临床护理的家庭支持情况、所在高校开设高级护理实践相关课程的情况、研究生导师类型、硕士学位类型,共可解释回归方程32.4%的变异量。结论:护理硕士研究生在对APN的角色期望表现出临床实践逃避意愿,倾向于从事管理工作;对APN的认知处于中等水平,应注重从提升护理硕士研究生从事临床护理的家庭支持、改善高校开设高级护理实践相关课程的情况、关注不同导师类型及学位类型的护理硕士研究生的培养差异等方面提升其对APN的认知水平和树立积极的临床实践价值观,推动APN在我国的发展。

关键词：高级实践护士研究生期望认知影响因素

Stochastic Unit Commitment with High-Penetration Offshore Wind Power Generation in Typhoon Scenarios

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 535-546页

作者： yanqi Liu Dundun Liu Hongcai zhang State Key Laboratory of Internet of Things for Smart City and Department of Electrical and Computer Engineering University of MacaoMacao 999078China University of Macao Zhuhai UM Science and Technology Research Institute ZhuhaiChina

To tackle the energy crisis and climate change,wind farms are being heavily invested in across the *** China's coastal areas,there are abundant wind resources and numerous offshore wind farms are being *** secure operation of these wind farms may suffer from typhoons,and researchers have studied power system operation and resilience enhancement in typhoon ***,the intricate movement of a typhoon makes it challenging to evaluate its spatial-temporal *** published papers only consider predefined typhoon trajectories neglecting *** address this challenge,this study proposes a stochastic unit commitment model that incorporates high-penetration offshore wind power generation in typhoon *** adopts a data-driven method to describe the uncertainties of typhoon trajectories and considers the realistic anti-typhoon mode in offshore wind farms.A two-stage stochastic unit commitment model is designed to enhance power system resilience in typhoon *** formulate the model into a mixed-integer linear programming problem and then solve it based on the computationally-efficient progressive hedging algorithm(PHA).Finally,numerical experiments validate the effectiveness of the proposed method.

关键词： Unit commitment two-stage stochastic programming offshore wind farm typhoon

IL-17F、IL-36β及CGRP1与中重度斑块型银屑病患者阿达木单抗治疗有效应答的相关性

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辽宁医学杂志 2024年第3期38卷 65-67页

作者：任雪飞张艳奇孙晓圆安阳市第三人民医院河南安阳455000

目的分析IL-17F、IL-36β及CGRP1与中重度斑块型银屑病患者阿达木单抗治疗有效应答的相关性。方法经安阳市第三人民医院伦理学会批准选择医院2020年8月1日至2022年8月1日收治的中重度斑块型银屑病患者68例。使用阿达木单抗治疗,在治疗... 详细信息

目的分析IL-17F、IL-36β及CGRP1与中重度斑块型银屑病患者阿达木单抗治疗有效应答的相关性。方法经安阳市第三人民医院伦理学会批准选择医院2020年8月1日至2022年8月1日收治的中重度斑块型银屑病患者68例。使用阿达木单抗治疗,在治疗前后检测IL-17F、IL-36β及CGRP1水平,并随访评定有效应答,分析其相关性,收集其不良反应。结果治疗前中度患者IL-17F、IL-36β及CGRP1水平低于重度患者(P<0.05)。治疗后中度患者IL-17F、IL-36β及CGRP1水平低于重度患者(P<0.05)。有效应答患者为50例,未应答患者18例。其中未应答患者后IL-17F、IL-36β、CGRP1水平在治疗前后明显高于有效应答患者(P<0.05)。IL-17F、IL-36β、CGRP1水平影响患者有效应答。其水平越高,有效应答率越低,呈负相关(P<0.05)。本次治疗出现了瘙痒(2例)、疼痛(1例)、感染(1例)、红肿(2例)不良反应。结论IL-17F、IL-36β及CGRP1水平影响中重度斑块型银屑病患者阿达木单抗治疗有效应答,其水平越高,有效应答率越低,建议在治疗前密切关注。

关键词： IL-17F IL-36β CGRP1 中重度斑块型银屑病阿达木单抗有效应答相关性

Effects of Gas Flow Field on Clogging Phenomenon in Close-Coupled Vortical Loop Slit Gas Atomization

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Transactions of Nanjing University of Aeronautics and Astronautics 2021年第6期38卷 1003-1019页

作者： zhang Min zhang Zhaoming zhang yanqi LU Yuanjing LU Lin College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China Shanghai Research Institute of Materials Shanghai 200437P.R.China

In order to study the basic characteristics of gas flow field in the atomizing chamber near the nozzle outlet of the vortical loop slit atomizer and its influence mechanism on clogging phenomenon,the computational fluid dynamics(CFD)software Fluent is used to conduct a numerical simulation of the gas flow field in the atomizing chamber near the nozzle outlet of this atomizer under different annular slit widths,different atomization gas pressures and different protrusion lengths of the melt delivery tube. The results show that under atomization gas pressure p=4.5 MPa,the greater the annular slit width D,the lower the static temperature near the central hole outlet at the front end of the melt delivery tube,and the smaller the aspirating pressure at the front end of the melt delivery tube. These features can effectively prevent the occurrence of the clogging phenomenon of metallic melt. Under an annular slit width of D=1.2 mm,when the atomization gas pressure satisfies 1 MPa ≤ p ≤ 2 MPa and increases gradually,the aspirating pressure at the front end of the melt delivery tube will decline rapidly. This can prevent the clogging phenomenon of metallic melt. However,when the atomization gas pressure p >2 MPa,the greater the atomization gas pressure,the lower the static temperature near the central hole outlet at the front end of the melt delivery tube,and the greater the aspirating pressure at the front end of the melt delivery tube. Hence,the effect of preventing the solidification-induced clogging phenomenon of metallic melt is restricted. When atomization gas pressure is p =4.5 MPa and annular slit width is D=1.2 mm,the greater the protrusion length H of the melt delivery tube,and the smaller the aspirating pressure at its front end. The static temperature near the central hole that can be observed in its front end is approximate to effectively prevent the occurrence of clogging phenomenon of metallic melt. However,because of the small aspirating pressure,the metallic

关键词： vortical loop slit atomizer annular slit width atomization gas pressure melt delivery tube protrusion length gas flow field numerical simulation

Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior

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Chinese Science Bulletin 2012年第27期57卷 3631-3638页

作者： LI LinLin zhang yanqi HAO NanJing CHEN Dong TANG FangQiong Laboratory of Controllable Preparation and Application of Nanomaterials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Silica nanorattle with hollow and mesoporous structure has been proven to be an excellent drug ***,how to control the drug release from silica nanorattle is still a *** this study,we designed two methods,in-situ polymerization method and water in oil in water(W/O/W) double emulsion method,to coat a nanosized poly(lactic-co-glycolic acid)(PLGA) layer onto the surface of silica nanorattle for controlling the drug release *** antitumor drug docetaxel was loaded into the PLGA coated silica nanorattle(PLGA@SN).The drug release profile,cellular uptake and cytotoxicity on human liver cancer HepG2 cells were evaluated to prove that the PLGA layer plays an effective role in tuning the drug delivery.

关键词： PLGA 抗癌药物二氧化硅释放行为控制 HepG2细胞制备包覆

Research on Optimal Configuration of Energy Storage in Wind-Solar Microgrid Considering Real-Time Electricity Price

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Energy Engineering 2023年第7期120卷 1637-1654页

作者： Zhenzhen zhang Qingquan Lv Long Zhao Qiang Zhou Pengfei Gao yanqi zhang Yimin Li Electric Power Research Institute State Grid Gansu Electric Power CompanyLanzhou730070China School of New Energy and Power Engineering Lanzhou Jiaotong UniversityLanzhou730000China

Capacity allocation and energy management strategies for energy storage are critical to the safety and economical operation of *** this paper,an improved energymanagement strategy based on real-time electricity price combined with state of charge is proposed to optimize the economic operation of wind and solar microgrids,and the optimal allocation of energy storage capacity is carried out by using this ***,the structure and model of microgrid are analyzed,and the outputmodel of wind power,photovoltaic and energy storage is ***,considering the interactive power cost between the microgrid and the main grid and the charge-discharge penalty cost of energy storage,an optimization objective function is established,and an improved energy management strategy is proposed on this ***,a physicalmodel is built inMATLAB/Simulink for simulation verification,and the energy management strategy is compared and analyzed on sunny and rainy *** initial configuration cost function of energy storage is added to optimize the allocation of energy storage *** simulation results show that the improved energy management strategy can make the battery charge-discharge response to real-time electricity price and state of charge better than the traditional strategy on sunny or rainy days,reduce the interactive power cost between the microgrid system and the power *** analyzing the change of energy storage power with cost,we obtain the best energy storage capacity and energy storage power.

关键词： Energy storage optimization real-time electricity price state of charge energy management strategy interactive power

Existence and implications of hop-17(21)-enes in the lower Cretaceous of the Saihantala Sag, Erlian Basin, China

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Petroleum Science 2012年第2期9卷 154-160页

作者： Luo Qingyong Yu Shijun Liu Yan zhang yanqi Han Hui Qi Lin Zhong Ningning State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing 102249China Jiangxi Division of Geological Prospecting Center SinomaShang-raoJiangxi 334000China

C31- to C35-hop-17（21）-enes are identified by gas chromatography-mass spectrometry （GC-MS） analysis to exist as double isomers in most samples of the Aershan Formation and members 1 and 2 of the Tenggeer Formation from well SH3. Comprehensive organic geochemistry and organic petrology study indicates that algae and bacteria are the main biological source of lower Cretaceous sediments in the Saihantala Sag, and this is in accordance with the existence of hop-17（21）-enes. The similar distributions of hop-17（21）-enes and hopanes of these samples indicate that hop-17（21）-enes were transformed into hopanes through hydrogenation during diagenesis processes. The existence of hop-17（21）-enes means that not only the formation of organic matter is related to an anoxic environment and a biological source of algae and bacteria, but also hop-17（21）-enes are direct indicators of hydrocarbon rock at an immature to low-maturity stage. High hydrocarbon conversion ratio, algae and bacteria source and a high abundance of organic matter suggest that the Saihantala Sag has the potential to generate immature to low-maturity oil, which may be of great significance for oil exploration in the Erlian Basin.

关键词： Biomarkers hop-17(21)-ene biological source immature oil Erlian Basin

Mitochondrial targeting sequence of magnetoreceptor MagR:More than just targeting

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