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Multicenter clinical efficacy observation of integrated Traditional Chinese Medicine-Western Medicine treatment in acute onset period of pulmonary heart disease

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Journal of Traditional Chinese Medicine 2016年第3期36卷 283-290页

作者： Lu Yun Jin Wei zhang Hong zhang xiaoyun Department of Emergency The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine Department of Encephalopathy Meishan Municipal Hospital of Traditional Chinese Medicine

OBJECTIVE: To evaluate the efficacy of integrated Traditional Chinese Medicine-Western Medicine(TCM-WM) in the treatment of acute onset pulmonary heart disease(PHD).METHODS: A total of 240 patients met the inclusion criteria and were enrolled. These inpatients were divided into group A(treatment group) and B(control group) in order of admission according to the principles of randomization and control. The research was performed simultaneously in three hospitals. Two groups were given basic treatment that included: controlled oxygen therapy, active and effective anti-infection, maintaining airway patency,correcting O_2 deficiency and CO_2 retention, correcting acid-base imbalance and electrolyte disturbance, reducing pulmonary hypertension and treating right heart failure, nutritional support and treatment of complications. Group A was given basic treatment and integrated Traditional Chinese Medi-cine(TCM) differentiating therapy; group B was given basic therapy and a placebo that was similar in appearance and taste to TCM medicinal broth of pharmaceutical preparations, provided by Yibin Pharmaceutical Company(Yibin, China, Wuliangye Group).RESULTS: The mortality in the treatment group decreased by 4.98% compared with the control group. The treatment group reported improved ventilation, corrected hypoxemia, improved nutritional status and promoted digestive functions. It also significantly improved the patient's self-life skills, improved the patient's quality of life and could shorten the length of hospital ***: Comprehensive integrated TCMWM treatment showed good clinical efficacy toward the acute onset period of PHD patients.

关键词： integrated Traditional Chinese Medicine and Western Medicine Pulmonary heart disease Treatment outcome Multicenter study

An Ensemble Colorization Method

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Chinese Journal of Electronics 2014年第3期23卷 489-493页

作者： LI Lingzhi ZOU Beiji zhang xiaoyun School of Information Science and Engineering Central South University Mobile-Health Key Lab. Attached to Education Ministry and China Mobile

Colorization is a well established problem concerning recovering the potential colors of monochrome images. In the past decade several highly effective computer-assisted methods have been proposed for solving the colorization problem, among which two methods achieved the state-of-the-art performance. The two methods are totally different, and each of them has its advantages and disadvantages. We propose an ensemble method unifying the two state-of-the-art methods to better exploit their advantages. Empirical results demonstrate the superiority of our ensemble method over using each of the two methods alone.

关键词： Colorization Matrix recovery Low-rank matrix

绝经后骨质疏松症动物模型研究现状及趋势的文献计量可视化分析

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中国组织工程研究 2025年第14期29卷 3070-3080页

作者：章晓云李坤健莫坚柴源黄有荣广西中医药大学附属瑞康医院骨科广西壮族自治区南宁市530011 广西中医药大学广西壮族自治区南宁市530001

背景:近年来,绝经后骨质疏松症受到社会的广泛关注,随着动物模型研究的逐渐深入,动物模型已然成为现代中医药研究的重要手段以及实验基础,因此了解动物模型的研究现状、热点及发展趋势尤为重要。目的:分析国内外绝经后骨质疏松症动物模... 详细信息

背景:近年来,绝经后骨质疏松症受到社会的广泛关注,随着动物模型研究的逐渐深入,动物模型已然成为现代中医药研究的重要手段以及实验基础,因此了解动物模型的研究现状、热点及发展趋势尤为重要。目的:分析国内外绝经后骨质疏松症动物模型的研究现状、热点及发展趋势,为后续研究提供一定的理论基础及参考依据。方法:以“主题词=绝经后骨质疏松AND主题词=鼠+兔+犬+猪+羊+猴+鱼+实验动物+动物实验”为检索式,对1999-01-01/2023-10-01在中国知网、万方数据库中的文章进行主题词检索;同时以“TS=(Postmenopausal osteoporosis)AND TS=(mouse OR mice OR rat OR rabbit OR dog OR swine OR pig OR sheep OR monkey OR fish or flies OR“laboratory animal”OR“experiment animal”)”为检索式,对1999-01-01/2023-10-01在Web of Science核心合集数据库中的文章进行主题词检索。应用Citespace软件对文献作者、机构、国家、关键词以及文献共被引量进行可视化分析。结果与结论:①分析后筛选中国知网及万方数据库共纳入1238篇文献,Web of Science核心合集数据库共纳入3419篇文献。自1999年来,该领域发文量总体呈上升趋势,研究中心性最高的是美国,发文量最高的是中国,研究中心性最高的机构为美国加利福尼亚大学。②去除与文章主题直接相关的关键词,综合共现频率及中心性,“生物力学”“左归丸”“阿仑膦酸盐”“乳腺癌”“生化指标”处于该研究领域较为核心的地位。③通过文献共被引分析,被引频次前10位的文献中有5篇文献与绝经后骨质疏松症治疗措施与临床疗效有关。④综合关键词与共被引文献分析显示,探究成骨细胞的形成以及骨形成的机制、代谢组学的作用机制、中药复方的治疗、信号通路、甲状旁腺激素治疗及硬骨素抗体治疗等方面是当下的研究热点也是未来的研究趋势。

关键词：绝经后骨质疏松症动物模型文献计量学可视化分析 CiteSpace 成骨分化代谢组学中药复方研究热点

中药生物碱类成分防治膝骨关节炎的作用与机制

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中国组织工程研究 2025年第11期29卷 2368-2376页

作者：沈栩钰罗承诺章晓云江周影柴源广西中医药大学广西壮族自治区南宁市530011 广西中医药大学附属瑞康医院广西壮族自治区南宁市530011

背景:目前现代医疗手段治疗膝骨关节炎仍具有一定局限性,中药生物碱类成分可通过多种作用机制有效防治膝骨关节炎。目的:对中药生物碱类成分防治膝骨关节炎的作用机制进行综述,为临床开发治疗膝骨关节炎的药物提供科学依据。方法:查阅... 详细信息

背景:目前现代医疗手段治疗膝骨关节炎仍具有一定局限性,中药生物碱类成分可通过多种作用机制有效防治膝骨关节炎。目的:对中药生物碱类成分防治膝骨关节炎的作用机制进行综述,为临床开发治疗膝骨关节炎的药物提供科学依据。方法:查阅中国知网、万方、Pub Med、Web of Science和Google Scholar数据库从建库至2024年5月发表的相关文献,中文检索词为“膝骨关节炎,骨关节炎,破骨细胞,软骨细胞,生物碱”,英文检索词为“knee osteoarthritis,osteoarthritis,osteoclast,chondrocyte,alkaloids”,排除陈旧及无参考意义的文献,最终纳入68篇文献进行综述。结果与结论:虽然中药治疗膝骨关节炎的历史悠久,但仅有少量的天然化合物处于抗膝骨关节炎的临床前研究阶段,生物碱类成分对于防治膝骨关节炎具有较大潜能,其中苦参碱、氧化苦参碱、青藤碱、甜菜碱等已被证实可通过调控多条信号通路抑制炎症反应、抗氧化反应、抑制软骨细胞凋亡、促进软骨细胞增殖、抑制破骨细胞形成与分化等延缓膝骨关节炎的进展。

关键词：膝骨关节炎中药生物碱类信号通路破骨细胞软骨细胞细胞自噬

Neuropeptide Y receptors in a protozoa Stylonychia mytilus

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Chinese Science Bulletin 1998年第6期43卷 494-497页

作者： Xiaoyang He xiaoyun zhang Yunhong Zhen Shenzhen Univ Life Sci Lab Shenzhen 518060 Peoples R China Shenzhen Univ Inst Appl Nucl Technol Shenzhen 518060 Peoples R China

Radio ligand binding assays(RLBA) were used to study neuropeptide Y (NPY) receptors in a protozoa Stylonychia mytilus. The experimental results showed that 2-3×10+3/mL Stylonychia cells incubated in Pringsheim solution which contained 3H-NPY could specifically bind 3H-NPY and concomitantly present saturable characteristic. This suggested that Stylonychia possessed some specific binding sites for NPY. Scatchard transformations of binding assay for the NPY receptors at 25℃ are compatible with the specific activity of 42.47 fmol/10+3 cells and the binding equilibrium constant of 0.113 nmol/L. The data of 125I-NPY binding assay to the membrane protein extract of Stylonychia indicated that there was a significant difference between the amount of total bound and nonspecific bound of 125I-NPY. This result indicated that NPY receptors were probably localized mainly on the cell membrane.

关键词： Stylonychia NPY receptor radio ligand binding assay(RLBA).

ACTIVATION AND DEPRESSION OF CALCITE IN CALCIUM MINERALS FLOTATION

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中国有色金属学会会刊：英文版 1999年第2期9卷 170-173页

作者： Tian, Xueda zhang, xiaoyun Li, Longfeng Wang, Dianzuo Xiangtang Univ Xiangtang China

１ＩＮＴＲＯＤＵＣＴＩＯＮＳｃｈｅｅｌｉｔｅｏｒｅｓａｌｗａｙｓｃｏｎｔａｉｎｆｌｕｏｒｉｔｅａｎｄｃａｌｃｉｔｅ．Ｗｈｅｎｔｈｅｈｅａｄｇｒａｄｅｏｆｆｌｕｏｒｉｔｅｉｓｕｐｔｏ１５％ＣａＦ２，ｔｈｅｆｌｕｏｒｉｔ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＳｃｈｅｅｌｉｔｅｏｒｅｓａｌｗａｙｓｃｏｎｔａｉｎｆｌｕｏｒｉｔｅａｎｄｃａｌｃｉｔｅ．Ｗｈｅｎｔｈｅｈｅａｄｇｒａｄｅｏｆｆｌｕｏｒｉｔｅｉｓｕｐｔｏ１５％ＣａＦ２，ｔｈｅｆｌｕｏｒｉｔｅｉｓｏｆｅｃｏｎｏｍｉｃｖａｌｕ...

关键词： flotationcalcitescheelitefluorite

ROOM TEMPERATURE CLEANER FLOTATION TECHNIQUE FOR SCHEELITE ROUGH CONCENTRATE

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中国有色金属学会会刊：英文版 1997年第2期7卷 21-25页

作者： Tian, Xueda zhang, xiaoyun Li, Longfeng Wang, Dianzuo Xiangtan Univ Xiangtan China

ＲＯＯＭＴＥＭＰＥＲＡＴＵＲＥＣＬＥＡＮＥＲＦＬＯＴＡＴＩＯＮＴＥＣＨＮＩＱＵＥＦＯＲＳＣＨＥＥＬＩＴＥＲＯＵＧＨＣＯＮＣＥＮＴＲＡＴＥ①ＴｉａｎＸｕｅｄａＣｈｅｍｉｓｔｒｙ＆ＣｈｅｍｉｃａｌＥｎｇｉｎｅｒｉｎｇＣｏ... 详细信息

ＲＯＯＭＴＥＭＰＥＲＡＴＵＲＥＣＬＥＡＮＥＲＦＬＯＴＡＴＩＯＮＴＥＣＨＮＩＱＵＥＦＯＲＳＣＨＥＥＬＩＴＥＲＯＵＧＨＣＯＮＣＥＮＴＲＡＴＥ①ＴｉａｎＸｕｅｄａＣｈｅｍｉｓｔｒｙ＆ＣｈｅｍｉｃａｌＥｎｇｉｎｅｒｉｎｇＣｏｌｅｇｅ，ＸｉａｎｇｔａｎＵｎｉｖ...

关键词： scheelite flotation technique depressant

Three Major Functions of China's Consumption Tax: Effect Evaluation and Policy Adjustment

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当代财经 2015年第S1期 35-45页

作者： JIA Kang zhang xiaoyun Research Institute of Fiscal Science Ministry of Finance

In most developed countries the function of consu mption tax is mainly reflected in the organization of tax revenue, the regulation of consumption structure, and more distinctly in the correction of externalities through raising the prices of taxable consumer goods. This empirical analysis shows that in recent years, although China has made some adjustments to the items and rates of consumption tax, the overall effect of the consumption tax is still limited. Therefore, further adjustment and reform of the consumption tax policy must be carried out to achieve four objectives. The first is to strengthen the three functions of consumption tax and expand the proportion of consumption tax in GDP. The second is to give full play to the externality correction function of the consumption tax by expanding,integrating and adding more items to the consumption tax. The third is to give reasonable play to the income regulation function of consumption tax with clear a target and full regulation. The fourth is to make a reasonable division between central and local taxes, so as to match optimized institutional reforms.

关键词： consumption tax function evaluation revenue function distribution function external compensation function

Influence of magnetic field on nitric oxide and neuropeptide Y in rat adrenal gland

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Chinese Science Bulletin 2001年第23期46卷 1969-1971,2027-2028页

作者： Zhenguo Luo Qingguo Han xiaoyun zhang Shenzhen Univ Dept Biotechnol Shenzhen 518060 Peoples R China

We have investigated the effects of magnetic fields on nitric acid (NO) and neuropeptide Y (NPY) on adrenal glands of the rat using NO nitric acid reductase-spec-trophotometry and histochemistry techniques. We found that all cellular layers of the adrenal cortex, including zona glomerulosa, zona fasciculata and zona reticularis were stained by NADPH-d, and some chromaffin cells of the medulla were positive for NPY. Furthermore, magnetic fields increased NO so strongly that high NO levels could be maintained for several hours, as well as some neuroganglion cells in medulla that were double-stained for NPY and NADPH-d. Our data showed that the magnetic field can regulate endocrine and neuroendocrine directly by some action on parenchyma cells, or indirectly by action to NO-ergic, NPY-ergic neurons in the adrenal gland.

关键词： magnetic field adrenal gland nitric oxide neuropeptide Y nitric acid reductase-spectrophotometry immunocytochemistry rat.