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Multidimensional coupled structure-activity relationship models for replacement of sf_(6)

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High Voltage 2024年第2期9卷 484-494页

作者： Mi zhang Hua Hou Baoshan Wang College of Chemistry and Molecular Sciences Wuhan UniversityWuhanChina

Computational screening of single gases to replace sf_(6)for electrical insulation has been challenged by the difficulty in combining various mutually exclusive properties especially for dielectric performance with liquefaction and environmental *** reveal the inherent correlations between dielectric strength(Er),boiling point(Tb),and global warming potential(GWP)of dielectric materials,a coupled structure-activity relationship(CSAR)model has been proposed for the first *** means of the generic descriptors,as deduced from the electrostatic potentials,and the specific descriptors,as introduced from the respective microscopic mechanisms,the complex interdependence between Er,Tb,and GWP of the insulation gases is quantitatively characterised by the 3-D coupling *** coupling mechanism for the right balance of properties is uncovered in terms of the first-principle *** CSAR model outperforms the previous SAR models in predicting Er,Tb,and GWP simultaneously in a self-consistent *** importantly,the concept of CSAR could be extended readily to any multidimensional macroscopic *** replacement compounds have been identified tentatively to be the promising candidates to replace sf_(6)using the CSAR model.

关键词： properties. dielectric insulation

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自主运动对颈源性头痛复发的预防和治疗作用

中国组织工程研究与临床康复 2007年第39期11卷 8012-8014页

作者：韦凤爱蒋娟张树芳广西中医学院附属瑞康医院骨颈胸科广西壮族自治区南宁市530011

目的:观察自主运动对颈源性头痛的影响。方法:选择本科2000-08/2005-08颈源性头痛患者,纳入标准:①按诊断标准确诊为颈源性头痛。②年龄19～68岁。③愿意接受自主运动训练。排除标准:①合并心脑血管、肝、肾、造血系统严重原发性疾病或... 详细信息

目的:观察自主运动对颈源性头痛的影响。方法:选择本科2000-08/2005-08颈源性头痛患者,纳入标准:①按诊断标准确诊为颈源性头痛。②年龄19～68岁。③愿意接受自主运动训练。排除标准:①合并心脑血管、肝、肾、造血系统严重原发性疾病或精神病患者。②合并有脊柱炎症性疾病、椎旁肿瘤及结核疾病。③未按规定治疗或资料不全者。纳入152例患者,随机分为实验组、对照组,每组76例。实验组采用牵引、手法、中药内服外敷加每天2次自主运动训练。对照组为单纯牵引、手法、中药内服外敷。疗效评定标准:有效:症状和阳性体征改善,双侧上肢肌电图由明显神经损害好转为一般损害。结果:实验组总有效率97%,对照组有效率82%,差异有显著性意义(P<0.01)。结论:自主运动训练疗法指导患者进行康复训练,对颈源性头痛有预防和治疗作用。

关键词：自主运动颈性眩晕防治

Single electron capture with simultaneous ionization in 120 keV He2+ on Ar collision

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Single electron capture with simultaneous ionization in 120 ...

Insulation Design Rule for a Spacer in sf_(6)/N_(2)-filled DC Gas Insulated Apparatus

第七届存储粒子原子物理合作组织国际会议

作者： RT zhang 1 2 X.Ma 1 sf zhang 1 1 Institute of Modern Physics Chinese Academy of Sciences Lanzhou 73000 2 Graduate University of Chinese Academy of Sciences Beijing 100190

＜正＞Reaction microscope is a very effective tool to investigate ion-atom collision *** electrons and recoils can be monitored within 4πsolid *** performed an experiment of 120 keV He 2+ on Ar at the Institute of Modern Physics,CAS,utilizing the reaction microscope,electrons and recoils induced from transfer ionization are measured and *** results show that the ionized electrons are mainly emitted in forward direction in the scattering plane,

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 727-735页

作者： Hongyang Zhou Guoming Ma Meng zhang Cong Wang Youping Tu Chengrong Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources and the Beijing Key Laboratory of High Voltage and EMC North China Electric Power UniversityBeijing 102206China

A recurring challenge of a DC sf_(6)/N_(2)-filled GIS/GIL apparatus is the charge accumulation at DC *** conventional design rules and knowledge of AC spacers may not be applicable for this new type of apparatus.A novel design rule is proposed considering the effect of accumulated charge on the threshold of electric field strength being resistant to the superposed voltage.A surface charge accumulation simulation model is introduced,and the key parameters in the simulation model are *** addition,an experimental platform for a 100 kV spacer flashover test is *** flashover tests under superimposed voltage with opposing polarities are carried out,and the withstanding voltage of the spacer is ***,based on the proposed model,the threshold of the surface electric field strength(tangential component)on the DC spacer in sf_(6)/N_(2) mixed gases is *** a reliable insulation design of a DC GIS/GIL apparatus filled with 0.7 MPa sf_(6)/N_(2),the threshold of surface electric field strength on the DC spacer is 12 kV/*** insulation design rule can be referenced in the design of a high-voltage DC sf_(6)/N_(2)-filled GIS/GIL apparatus.

关键词： Charge accumulation DC spacer flashover voltage sf_(6)/N_(2) threshold of surface electric field strength

Charge Accumulation Characteristics of sf6-Epoxy Interface Under Negative Repetitive Nanosecond Pulses

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1808-1815页

作者： Shaocong Wu Geng Chen Yuming Shao Hao Xu Xuanning zhang Yanyu Liang Youping Tu State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources and the Beijing Key Laboratory of High Voltage and EMC North China Electric Power UniversityBeijing 102206China

Repetitve nanosecond impulses in gas-insulated metal-enclosed switchgear (GIS) are likely to trigger inside flashover. Interface charges on the spacer in GIS are considered one of the main factors damaging insulation performance and may be induced by overvoltage. For good understanding of insulation failures, accumulation characteristics of charges between sf6 and epoxy spacers under repetitive nanosecond impulses are investigated. It can be found under nanosecond impulses, the charge source in gas volume contributes to interface charge accumulation predominantly. Interface charges will be promoted by impulse number and amplitude. Accumulation processes are analyzed based on runaway electrons mechanism. When impulse amplitude exceeds a threshold value, discharge in the gas volume turns to a runaway mode. A runaway electron leads to the interface charge accumulation. Affected by motion of the runaway electrons, the potential peak gradually moves close to the grounded electrode when impulse amplitude is raised. Meanwhile, increasing impulse number can enhance surface potential. Surface potential will reach saturation eventually. However, memory effect of the repetitive impulse discharge makes the half-peak width of the surface potential at the interface change little. Design of GIS gas-solid insulations can refer to this research.

关键词： GIS interface charge repetitive nano-second pulse sf6

Analysis of sf6 decomposed products by fibre-enhanced Raman spectroscopy for gas-insulated switchgear diagnosis

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High Voltage 2024年第1期9卷 206-216页

作者： Jianxin Wang Weigen Chen Pinyi Wang Fu Wan Zhixian zhang Shoufei Gao Yingying Wang School of Electrical Engineering Chongqing UniversityChongqingChina State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqingChina Institute of Photonics Technology Jinan UniversityGuangzhouChina

Sulphur hexafluoride(sf6)decomposed products analysis is highly critical in the earlystage fault diagnosis of gas-insulated switchgear(GIS).Spectrum technology outperforms traditional methods on non-invasiveness,no sample preparation,and no ***,the authors present an improved fibre-enhanced Raman spectroscopy(FERS)as a comprehensive analytical tool to detect a suite of sf_(6)decomposed products(SO_(2)F_(2),SOF_(2),SO_(2),H_(2)S,CF_(4),OCS,CO_(2),and CO).The FERS approach is combined with two iris diaphragms for spatial filtering and a rear-end reflector for additional Raman signal *** of detection down to 1×10^(−6)–8×10^(−6)are achieved for different sf6 decompositions,and quantification of an undefined multigas,sampled from an 800 kV GIS in service,is realised utilising sf6 as the internal standard gas and with a maximum error of 5.5%.The GIS is diagnosed according to the results and confirmed by an on-site *** authors foresee that this technique will provide a route for trace gas analysis in the power industry.

关键词： sf6 diagnosis fibre

Investigation on Degradation Path of sf_(6)in Packed-bed Plasma:Effect of Plasma-generated Radicals

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1231-1241页

作者： Zhaolun Cui Chang Zhou Amin Jafarzadeh Xiaoxing zhang Peng Gao Licheng Li Yanpeng Hao School of Electric Power Engineering South China University of TechnologyGuangzhou 510630China School of Electrical and Electronic Engineering Hubei University of TechnologyWuhan 430068China Research group PLASMANT Department of ChemistryUniversity of AntwerpUniversiteitsplein 1BE-2610 Wilrijk-AntwerpBelgium CSEE

sf_(6)degradation mechanism in non-thermal plasma(NTP)systems is not fully understood due to the formation of a complex physico-chemical reaction network,especially when reactive gases and packing materials are *** this work,we conduct a combined experimental and theoretical study to unravel the sf_(6)degradation path in a-Al_(2)O_(3)packed plasma in the presence of H_(2)O or O_(2).Our experimental results show that both H_(2)O and O_(2)have a synergetic effect with-Al_(2)O_(3)packing on promoting sf_(6)degradation,leading to higher stable gas yields than typical spark or corona discharges.H_(2)O or O_(2)addition promotes SO_(2)or SO_(2)F_(2)selectivity,*** functional theory(DFT)calculations reveal that SO_(2)generation corresponding with the highest activation barrier is the most critical step toward sf_(6)*** like H and O generated from H_(2)O or O_(2)discharge can significantly promote the degradation process via Eley-Rideal mechanism,affecting key reactions of stable product generation,advancing degradation *** results of this work could provide insights on further understanding sf_(6)degradation mechanism especially in packed-bed plasma systems.

关键词： Degradation mechanism packed-bed plasma radicals sf_(6)

Safety, immunogenicity and protective effectiveness of heterologous boost with a recombinant COVID-19 vaccine (sf9 cells) in adult recipients of inactivated vaccines

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1165-1173页

作者： Wenxin Luo Jiadi Gan Zhu Luo Shuangqing Li Zhoufeng Wang Jiaxuan Wu Huohuo zhang Jinghong Xian Ruixin Cheng Xiumei Tang Yi Liu Ling Yang Qianqian Mou Xue zhang Yi Chen Weiwen Wang Yantong Wang Lin Bai Xuan Wei Rui zhang Lan Yang Yaxin Chen Li Yang Yalun Li Dan Liu Weimin Li Lei Chen Department of Pulmonary and Critical Care Medicine West China HospitalSichuan UniversityChengduChina Institute of Respiratory Health Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengduChina Precision Medicine Center Precision Medicine Key Laboratory of Sichuan ProvinceWest China HospitalSichuan UniversityChengduChina State Key Laboratory of Respiratory Health and Multimorbidity West China HospitalChengduChina Institute of Respiratory Health and Multimorbidity West China HospitalSichuan UniversityChengduChina Clinical Trial Center West China HospitalSichuan UniversityChengduChina General Practice Medical Center West China HospitalSichuan UniversityChengduChina Fangcao Community Health Service Center of Chengdu High-tech Zone ChengduChina The Research Units of West China Chinese Academy of Medical SciencesWest China HospitalChengduChina West China School of Nursing Sichuan UniversityChengduChina Department of Infection Control West China HospitalSichuan UniversityChengduChina Department of Pathology West China HospitalSichuan UniversityChengduChina Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology West China HospitalSichuan UniversityChengduChina

Vaccines have proven effective in protecting populations against COVID-19,including the recombinant COVID-19 vaccine(sf9 cells),the first approved recombinant protein vaccine in *** this positive-controlled trial with 85 adult participants(sf9 cells group:n=44;CoronaVac group:n=41),we evaluated the safety,immunogenicity,and protective effectiveness of a heterologous boost with the sf9 cells vaccine in adults who had been vaccinated with the inactivated vaccine,and found a post-booster adverse events rate of 20.45%in the sf9 cells group and 31.71%in the CoronaVac group(p=0.279),within 28 days after booster *** group reported any severe adverse *** the sf9 cells vaccine booster,the geometric mean titer(GMT)of binding antibodies to the receptor-binding domain of prototype SARS-CoV-2 on day 28 post-booster was significantly higher than that induced by the CoronaVac vaccine booster(100,683.37 vs.9,451.69,p sf9 cells group,GMTs of neutralizing antibodies against pseudo SARS-CoV-2 viruses(prototype and diverse variants of concern[VOCs])increased by 22.23–75.93 folds from baseline to day 28 post-booster,while the CoronaVac group showed increases of only 3.29–10.70 ***,neutralizing antibodies against live SARS-CoV-2 viruses(prototype and diverse VOCs)increased by 68.18–192.67 folds on day 14 post-booster compared with the baseline level,significantly greater than the CoronaVac group(19.67–37.67 folds).A more robust Th1 cellular response was observed with the sf9 cells booster on day 14 post-booster(mean IFN-γ+spot-forming cells per 2×105 peripheral blood mononuclear cells:26.66 vs.13.59).Protective effectiveness against symptomatic COVID-19 was approximately twice as high in the sf9 cells group compared to the CoronaVac group(68.18%vs.36.59%,p=0.004).Our study findings support the high protective effectiveness of heterologous boosting with the recombinant COVID-19 vaccine(sf9 cells)against symptomatic COVID-19 of dive

关键词： protective vaccine boost

PACS gene family-related neurological diseases: limited genotypes and diverse phenotypes

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World Journal of Pediatrics 2024年第1期20卷 82-91页

作者： Han zhang Kai Gao Shuang Wang Yue-Hua zhang Zhi-Xian Yang Ye Wu Yu-Wu Jiang Department of Pediatrics Peking University First Hospital.No.1 Xi'an Men StreetWest DistrictBeijing 100034China Bejing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases BeijingChina Children Epilepsy Center Peking University First HospitalBeijingChina Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijingChina

Background The PACS gene family has been demonstrated to be related to intracellular vesicular *** phenotypic manifestations caused by the pathogenic variants of PACS include epilepsy,intellectual disability/developmental delay,and malformations,such as facial *** We identified seven new cases with pathogenic or likely pathogenic PACS variants using next-generation *** information obtained from these patients was analyzed along with that obtained from previously reported *** With the inclusion of the newly diagnosed cases in this study,103 cases with PACS gene family-related neurological diseases were reported,of which 43 were PACS2-related cases and the remaining were PACSI-related *** patients had seizures,which have been reported to be effectively controlled by several types of anti-seizure medications(ASMs).The most efficacious and frequently prescribed ASMs included sodium valproate(43.3%,13/30),oxcarbazepine/carbamazepine(26.7%,8/30),and levetiracetam(20%,6/30).Almost all patients had intellectual disability/developmental *** most common pathogenic missense variants were PACSI ***203Trp and PACS2 *** addition,we report a patient carrying a likely pathogenic copy number variation(CNV)(de novo heterozygous deletion of chr14:105821380-106107443,286 kilobase,destroyed part of the furin-binding region domain and the protein structure after it)with more severe and refractory late-onset *** The clinical phenotypes of the different PACS heterozygous missense variants were *** pathogenic variant sites of PACSI and PACS2 were quite limited but located in different regions.A CNV destroying part of the PACS2 gene might also be *** findings may provide an important clue for further functional studies on the pathogenic mechanism of neurological disorders related to the PACS gene family.

关键词： Developmental delay Epilepsy Intellectual disability PACSI PACS2