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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： yi zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li zhang Zheng Gang zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

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The method of variation on parameters for integration of a generalized Birkhoffian system

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Acta Mechanica Sinica 2011年第6期27卷 1059-1064页

作者： yi zhang College of Civil Engineering Suzhou University of Science and Technology 215011 Suzhou China

This paper focuses on studying the integration method of a generalized Birkhoffian *** method of variation on parameters for the dynamical equations of a generalized Birkhoffian system is *** procedure for solving the problem can be divided into two steps：the first step,a system of auxiliary equations is constructed and its general solution is given;the second step,the parameters are varied,and the solution of the problem is obtained by using the properties of generalized canonical *** method of variation on parameters for the generalized Birkhoffian system is of universal significance,and we take a nonholonomic system and a nonconservative system as examples to illustrate the application of the results of this paper.

关键词： Birkhoffian system Method of integration Variation on parameter. Nonholonomic constraint. Nonconservative system

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Informational uncertainties of risk assessment about accidents of chemicals

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Journal of Environmental Sciences 2001年第1期13卷 69-74页

作者： zhang yi-xian Suzhou Institute of Urban Construction and Environmental Protection Suzhou 215011China

An analysis system of informational uncertainties for accidental risk assessment of chemicals is introduced. Statistical test methods and fuzzy sets method can do the quantitative analysis of the input parameters. The uncerainties of the model can be used by quantitative compared method for the leakage accidents of chemicals. The estimation of the leaking time is important for discussing accidental source term. The uncertain analyses of the release accident for pipeline gas (CO) liquid chlorine and liquid propane gas (LPG) have been discussed.

关键词： uncertainty risk assessment accident chemicals pipeline gas liquid chlorine LPG

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The Method of Variation of Parameters for Solving a Dynamical System of Relative Motion

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Chinese Physics Letters 2011年第10期28卷 146-149页

作者： zhang yi College of Civil Engineering Suzhou University of Science and TechnologySuzhou 215011

The integration method of a dynamical system of relative motion is studied,and the method of variation of parameters for the dynamical equations of relative motion is ***,the dynamic equations of relative motion are brought into the frame of generalized Birkhoffian systems and are expressed in the contravariant algebraic ***,an auxiliary system is constructed and its complete solution is ***,the variation of parameters is given,and a complete solution of the problem is obtained by taking advantage of the properties of generalized canonical *** example is given to illustrate the application of the results.

关键词： form dynamical system

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Numerical Study of the High-Frequency Wave Loads and Ringing Response of A Bottom-Hinged Vertical Cylinder in Focused Waves

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China Ocean Engineering 2020年第4期34卷 513-525页

作者： zhang yi TENG Bin State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

This paper presents a numerical study on the high-frequency wave loads and ringing response of offshore wind turbine foundations exposed to moderately steep transient water *** wave groups are generated by the technique of frequency-focusing,and the numerical simulation of focused waves is based on the NewWave model and a Fourier time-stepping *** proposed model is validated by comparison with the published laboratory *** respect of both the wave elevations and the underlying water particle kinematics,the numerical results are in excellent agreement with the experimental ***,the local evolution of power spectra and the transfer of energy into higher frequencies can be clearly *** the generalized FNV theory and Rainey’s model are applied respectively to calculate the nonlinear wave loads on a bottom-hinged vertical cylinder in focused *** ringing response excited by the nonlinear high-frequency wave loads is found in the numerical simulation when frequency ratios(natural frequency of the structure to peak frequency of wave spectra)are equal to 3–*** amplification factor of ringing response is also investigated for different dynamic properties(natural frequency and damping ratio)of the structure.

关键词： high-frequency wave loads ringing response focused wave vertical cylinder

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Effect of Aspect on Climate Variation in Mountain Ranges of Shennongjia Massif, Central China

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Chinese Geographical Science 2018年第1期28卷 74-85页

作者： zhang yi School of Earth Sciences China University of Geosciences The College of Urban & Environmental Sciences Central China Normal University

The aim of this study was to better understand the mechanisms of regional climate variation in mountain ranges with contrasting aspects as mediated by changes in global climate. It may help predict trends of vegetation variations in native ecosystems in natural reserves. As measures of climate response, temperature and precipitation data from the north, east, and south-facing mountain ranges of Shennongjia Massif in the coldest and hottest months(January and July), different seasons(spring, summer, autumn, and winter) and each year were analyzed from a long-term dataset(1960 to 2003) to tested variations characteristics, temporal and spatial quantitative relationships of climates. The results showed that the average seasonal temperatures and precipitation in the north, east, and south aspects of the mountain ranges changed at different rates. The average seasonal temperatures change rate ranges in the north, east, and south-facing mountain ranges were from –0.0210℃/yr to 0.0143℃/yr, –0.0166℃/yr to 0.0311℃/yr, and –0.0290 ℃/yr to 0.0084℃/yr, respectively, and seasonal precipitation variation magnitude were from –1.4940 mm/yr to 0.6217 mm/yr, –1.6833 mm/yr to 2.6182 mm/yr, and –0.8567 mm/yr to 1.4077 mm/yr, respectively. The climates variation trend among the three mountain ranges were different in magnitude and direction, showing a complicated change of the climates in mountain ranges and some inconsistency with general trends in global climate change. The climate variations were significantly different and positively correlated cross mountain ranges, revealing that aspects significantly affected on climate variations and these variations resulted from a larger air circulation system, which were sensitive to global climate change. We conclude that location and terrain of aspect are the main factors affecting differences in climate variation among the mountain ranges with contrasting aspects.

关键词： regional climate variation slope aspect Shennongjia Massif One-way ANOVA global climate change

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Symmetries and Two Types of Non-Noether Conservation Laws of Birkhoffian System with Unilateral Constraints

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Communications in Theoretical Physics 2006年第2期45卷 239-244页

作者： zhang yi Department of Civil Engineering University of Science and Technology of Suzhou Suzhou 215011 China

The symmetries and non-Noether conservation laws of Birkhoffian system with unilateral constraints are studied. The differential equations of motion of the system are established, and the criterions of Noether symmetry, Lie symmetry and Mei symmetry of the system are given. Two types of new conservation laws, called the Hojman conservation law and the Mei conservation law respectively, are obtained, and the intrinsic relations among the symmetries and the new conservation laws are researched. At the end of the paper, an example is given to illustrate the application of the results.

关键词： analytical mechanics unilateral constraint Birkhoffian system symmetry conservation law

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Neighbor Library-Aware Graph Neural Network for Third Party Library Recommendation

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Tsinghua Science and Technology 2023年第4期28卷 769-785页

作者： ying Jin yi zhang yiwen zhang School of Artificial Intelligence and Big Data Hefei UniversityHefei 230601China School of Computer Science and Technology Anhui UniversityHefei 230601China

Modern software development has moved toward agile growth and rapid delivery,where developers must meet the changing needs of users *** such a situation,plug-and-play Third-Party Libraries(TPLs)introduce a considerable amount of convenience to ***,selecting the exact candidate that meets the project requirements from the countless TPLs is challenging for *** works have considered setting up a personalized recommender system to suggest TPLs for ***,these approaches rarely consider the complex relationships between applications and TPLs,and are unsatisfactory in accuracy,training speed,and convergence *** this paper,we propose a new end-to-end recommendation model called Neighbor Library-Aware Graph Neural Network(NLA-GNN).Unlike previous works,we only initialize one type of node embedding,and construct and update all types of node representations using Graph Neural Networks(GNN).We use a simplified graph convolution operation to alternate the information propagation process to increase the training efficiency and eliminate the heterogeneity of the app-library bipartite graph,thus efficiently modeling the complex high-order relationships between the app and the *** experiments on large-scale real-world datasets demonstrate that NLA-GNN achieves consistent and remarkable improvements over state-of-the-art baselines for TPL recommendation tasks.

关键词： Third-Party Library(TPL) TPL recommendation Graph Neural Network(GNN) bipartite graph

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Integrating Factors and Conservation Laws of Generalized Birkhoff System Dynamics in Event Space

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Communications in Theoretical Physics 2009年第6期51卷 1078-1082页

作者： zhang yi College of Civil Engineering Suzhou University of Science and Technology Suzhou 215011 China

In this paper, the conservation laws of generalized Birkhoff system in event space are studied by using the method of integrating factors. Firstly, the generalized Pfaff-Birkhoff principle and the generalized Birkhoff equations are established, and the definition of the integrating factors for the system is given. Secondly, based on the concept of integrating factors, the conservation theorems and their inverse for the generalized Birkhoff system in the event space are presented in detail, and the relation between the conservation laws and the integrating factors of the system is obtained and the generalized Killing equations for the determination of the integrating factors are given. Finally, an example is given to illustrate the application of the results.

关键词： generalized Birkhoff system dynamics conservation law event space integrating tactor

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A Review on Deterministic Lateral Displacement for Particle Separation and Detection

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Nano-Micro Letters 2019年第4期11卷 353-385页

作者： Thoriq Salafi yi zhang Yong zhang NUS Graduate School for Integrative Sciences and Engineering National University of SingaporeSingapore 119077Singapore Department of Biomedical Engineering National University of SingaporeSingapore 117583Singapore

The separation and detection of particles in suspension are essential for a wide spectrum of applications including medical *** this field,microfluidic deterministic lateral displacement(DLD)holds a promise due to the ability of continuous separation of particles by size,shape,deformability,and electrical properties with high *** is a passive microfluidic separation technique that has been widely implemented for various bioparticle separations from blood cells to *** techniques have been previously reviewed in *** then,the field has matured as several physics of DLD have been updated,new phenomena have been discovered,and various designs have been presented to achieve a higher separation performance and ***,some recent progress has shown new clinical applications and ability to use the DLD arrays as a platform for biomolecules *** review provides a thorough discussion on the recent progress in DLD with the topics based on the fundamental studies on DLD models and applications for particle separation and ***,current challenges and potential solutions of DLD are also *** believe that a comprehensive understanding on DLD techniques could significantly contribute toward the advancements in the field for various *** particular,the rapid,low-cost,and high-throughput particle separation and detection with DLD have a tremendous impact for point-of-care diagnostics.

关键词： Microfluidic Deterministic lateral displacement Particle separation Particle detection

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