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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu yan zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Peficitinib suppresses diffuse-type tenosynovial giant cell tumor by targeting TYK2 and JAK/STAT signaling

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Science China Life Sciences 2025年

作者： Shan Lu Chenxi Cao Wenjia zhang Jiayi Li Jingli yang Zisheng Huang Zhijun Wu Baitao Liu Hongjie Huang Haijun Wang Yongjian Wang Dingge Liu Zhihua zhang Kaiping Liu Gang yang Xi Gong Hui Dai Yingjia Li Erdan Dong Xin zhang yan zhang Haihe Laboratory of Cell Ecosystem Institute of Cardiovascular Diseases The First Affiliated Hospital of Dalian Medical University Institute of Cardiovascular Sciences School of Basic Medical Sciences Peking University Health Science Center Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalState Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Sports Medicine Peking University Third Hospital Institute of Sports Medicine of Peking University Beijing Key Laboratory of Sports Injuries Engineering Research Center of Sports Trauma Treatment Technology and Devices Ministry of Education State Key Laboratory of Membrane Biology Institute of Molecular Medicine College of Future Technology Peking University Peking University Health Science Centre Peking University Department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology Peking University Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases Chinese Academy of Medical Sciences

Diffuse-type tenosynovial giant cell tumor(dTGCT) is a destructive but rare benign proliferative synovial neoplasm. Although surgery is currently the main treatment modality for dTGCT, the recurrence risk is up to 50%. Therefore, there is a great need for effective drugs against dTGCT with minor side effects. The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling plays a central role in rheumatoid arthritis(RA), a disease with similar characteristics as dTGCT, but its function in dTGCT remains *** fibroblast-like synoviocytes(FLS) and macrophages were isolated from 10 synovial tissue samples from dTGCT patients for the screening and validation of the five clinically approved JAK inhibitors to treat RA against dTGCT. Cell viability, cell death, inflammation and the activity of the JAK family members of cultured dTGCT FLS(both 2-D and 3-D) and macrophages were investigated for the efficacy of the JAK inhibitors. Here, we found that similar to RA, JAK/STAT signaling was markedly activated in the dTGCT synovium. Of the 5 JAK inhibitors, peficitinib was shown to have the most potency in addressing some of the pathological responses of dTGCT FLS and *** potency of peficitinib was much higher than pexidartinib, which is the only FDA-approved drug for dTGCT. Mechanistically, peficitinib inhibited tyrosine kinase 2(TYK2), a JAK family member necessary for the pathological progression of dTGCT FLS and macrophages. In summary, we not only revealed JAK/STAT(especially TYK2) signaling as the major mechanism underlying dTGCT, but also identified peficitinib as a promising drug against dTGCT.

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密度对谷物混合颗粒分层影响的分析

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农机化研究 2025年第4期47卷 35-41,49页

作者：张妍王子谦张延胡欣宇赵湛江苏大学农业工程学院江苏镇江212013

采用离散元模拟了垂直振动下具有相同尺寸、不同密度的谷物混合颗粒分层过程,结果表明:小密度颗粒倾向于向上运动形成单一颗粒层,而大密度颗粒与部分小密度颗粒停留在单一颗粒层下,组成混合状态。为此,提出相应评价指标,定量描述混合物... 详细信息

采用离散元模拟了垂直振动下具有相同尺寸、不同密度的谷物混合颗粒分层过程,结果表明:小密度颗粒倾向于向上运动形成单一颗粒层,而大密度颗粒与部分小密度颗粒停留在单一颗粒层下,组成混合状态。为此,提出相应评价指标,定量描述混合物分层程度,并讨论了混合颗粒密度比对分层速度的影响。结合混合物分层中空隙填充及动能理论,分析了密度影响分层机理,结果表明:在不同密度谷物混合颗粒分层过程中,随密度比增加小密度颗粒组成的单一颗粒层厚度增加并趋于饱和;混合层占总层数比率随密度比增加而减少并趋于稳定;颗粒分层速度随着密度比增加而增加,当密度比大于10时密度比对分层速度影响减弱;在混合物分层过程中,大密度颗粒较为活跃,且动能大于小密度颗粒的动能。

关键词：谷物颗粒分层密度数值模拟离散元法

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装配式建筑梁柱节点疲劳损伤检测方法研究

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山东理工大学学报（自然科学版） 2025年第1期39卷 35-40页

作者：张延滁州职业技术学院建筑工程学院安徽滁州239000

常规的装配式建筑梁柱节点疲劳损伤检测主要采用梁柱图像分析实现,忽略了节点内部损伤的影响,导致检测结果相对变化量系数与实际系数的差值较大。本文对装配式建筑梁柱节点疲劳损伤检测方法进行了研究,于装配式建筑梁柱周围布置测点对... 详细信息

常规的装配式建筑梁柱节点疲劳损伤检测主要采用梁柱图像分析实现,忽略了节点内部损伤的影响,导致检测结果相对变化量系数与实际系数的差值较大。本文对装配式建筑梁柱节点疲劳损伤检测方法进行了研究,于装配式建筑梁柱周围布置测点对梁柱节点的应变状态进行分析;根据分析结果,结合梁柱内部能量耗散值,计算节点疲劳损伤能量系数;将该系数作为节点应变能密度因子分析节点轴向力,由此得出检测的梁柱节点疲劳损伤值。实验结果表明,所提方法应用后梁柱节点疲劳损伤检测结果表现出的相对变化量系数差值较小,检测结果准确率较高,满足了装配式建筑梁柱安全运维工作的现实需求。

关键词：梁柱节点装配式建筑疲劳损伤检测梁柱损伤检测方法

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数字化赋能市域产教联合体建设研究——基于整体性治理理论的视角

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教育与职业 2025年第1期 14-22页

作者：李雨健张燕梁卿天津职业技术师范大学衢州职业技术学院衢州职业技术学院职业教育研究所

从整体性治理理论来看，市域产教联合体建设存在治理主体、资源要素和组织形态的“碎片化”问题，分别表现为：信息共享融通不足，互动沟通亟待加强；资源共建共享不足，资源整合需要加强；治理机制有待完善，协同治理有待提升。基于整... 详细信息

从整体性治理理论来看，市域产教联合体建设存在治理主体、资源要素和组织形态的“碎片化”问题，分别表现为：信息共享融通不足，互动沟通亟待加强；资源共建共享不足，资源整合需要加强；治理机制有待完善，协同治理有待提升。基于整体性治理理论，数字生产力作为一种新质生产力可以破解以上问题，数字技术的连接能力可以赋能信息畅通，数字技术的整合能力可以赋能资源共享，数字技术的去中心化可以赋能组织治理。基于市域产教联合体建设的实际需要，数字化赋能市域产教联合体建设可采取的举措包括：搭建产教信息联动网络，助力人才培养；夯实产教资源共享载体，服务产业发展；完善内部数字治理体系，提升发展效能。

关键词：市域产教联合体整体性治理数字技术新质生产力

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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-yan zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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基于卡尔加里-剑桥指南的沙龙培训模式提升全科规培医师医患沟通技能的对照研究

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中国全科医学 2025年第1期28卷 71-76页

作者：彭涛邹川曾欣张焱沈静四川省成都市第五人民医院全科医学科 611130

背景医患沟通技能是全科医生的核心岗位胜任力之一,高水平的医患沟通能力是创建和谐医患关系的基石,有助于提高患者就医获得感和满意度。而我国全科医生沟通能力普遍偏低,有待探索出一种适应我国国情、满足我国全科医生沟通需求的医患... 详细信息

背景医患沟通技能是全科医生的核心岗位胜任力之一,高水平的医患沟通能力是创建和谐医患关系的基石,有助于提高患者就医获得感和满意度。而我国全科医生沟通能力普遍偏低,有待探索出一种适应我国国情、满足我国全科医生沟通需求的医患沟通培训模式来提高其医患沟通能力。目的探索基于卡尔加里-剑桥指南的沙龙培训模式在全科规培医师医患沟通技能培训中的应用效果,为构建适合我国国情的医患沟通培训体系提供参考依据。方法选取成都市第五人民医院2019—2020年度全科规培医师40名作为研究对象,按照随机数字表法分为沙龙组和对照组,每组20名,其中沙龙组使用基于卡尔加里-剑桥指南的沙龙培训模式进行医患沟通培训,对照组设置为空白对照,培训前、培训后1周分别对两组学员采用标准化病人(SP)模式进行接诊,使用医患沟通评价量表(SEGUE量表)进行现场观察评分,比较两组学员的医患沟通培训效果。结果最终纳入28名,其中沙龙组15名,对照组13名,培训后沙龙组规培医师SEGUE量表评分从(11.80±4.36)分提高至(18.07±4.11)分,对照组规培医师SEGUE量表评分从(12.15±4.63)分提高至(14.46±3.71)分。沙龙组培训后的SEGUE量表评分与培训前的比较,差异有统计学意义(t=3.250,P<0.001);对照组培训后的SEGUE量表评分与培训前比较,差异无统计学意义(t=2.582,P=0.624);培训后对SEGUE量表中的25个项目进行分析,沙龙组与对照组SEGUE量表评分比较,差异有统计学意义(P<0.05)。沙龙组以下5个项目结果优于对照组,准备阶段中的“建立个人信任关系”(93.3%比7.7%)、“保护患者的隐私/尊重患者选择权”(53.3%比15.4%);理解患者阶段中的“认同患者为疾病所付出的努力、改变及其遇到的困难”(33.3%比23.1%)、“表达关心,使患者感到温暖/树立信心”(100.0%比69.2%);结束问诊阶段中的“询问患者是否还有其他的问题需要探讨”(66.7%比23.1%)。结论基于卡尔加里-剑桥指南的沙龙培训模式对全科规培医师进行医患沟通技能培训可增强学员主动参加培训的兴趣和积极性,对于医患沟通能力的提升具有较好的培训效果,值得借鉴和推广。

关键词：全科医学全科医师规范化培训医患沟通沟通培训卡尔加里-剑桥指南

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面向工业物联网的策略隐藏属性基加密方案

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现代电子技术 2025年第1期48卷 90-96页

作者：尹建标张言史培中古春生江苏理工学院计算机工程学院江苏常州213001

针对工业物联网中的生产和监管数据易泄露与数据获取中断的问题,提出支持策略隐藏的属性基加密方案。将属性信息分为属性名和属性值进行方案构造,属性值在构造过程中并未暴露并且上传到云服务器的访问策略仅由属性名构成,工业物联网设... 详细信息

针对工业物联网中的生产和监管数据易泄露与数据获取中断的问题,提出支持策略隐藏的属性基加密方案。将属性信息分为属性名和属性值进行方案构造,属性值在构造过程中并未暴露并且上传到云服务器的访问策略仅由属性名构成,工业物联网设备在获取生产信息时不会完整的访问策略,防止了不法分子对设备信息盗取进而导致访问策略及生产信息的泄露。同时,授权多个半可信云服务器,当某个半可信云服务器不能正常工作时可快速根据服务器密钥更新用户私钥,使得其他半可信云服务器接替其工作,保证物联网设备读取数据的连续性。此外,引入属性认证,在撤销过程中无需重更新密文,适用于产生大量数据的物联网环境的撤销。经过安全性分析和性能分析,该方案能抵抗选择明文攻击,且系统初始化、用户密钥生成、加密、解密都具有较高的运行效率。

关键词：工业物联网数据安全策略隐藏单点故障属性认证属性撤销

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Development and prospect of near-infrared spectroscopy-assisted schizophrenia diagnosis based on bibliometrics

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World Journal of Psychiatry 2025年第1期15卷 7-11页

作者： yan zhang Hao-Yu Xing Juan yan Administration Office Lishui Second People’s HospitalLishui 323060Zhejiang ProvinceChina Department of Medical Engineering The Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhou 310013Zhejiang ProvinceChina Quality Control Office The Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhou 310013Zhejiang ProvinceChina

In this editorial,we comment on the recent article by Fei et al exploring the field of near-infrared spectroscopy(NIRS)research in schizophrenia from a bibliometrics *** recent years,NIRS has shown unique advantages in the auxiliary diagnosis of schizophrenia,and the introduction of bibliometrics has provided a macro perspective for research in this *** the opportunities brought about by these technological developments,remaining challenges require multidi-sciplinary approach to devise a reliable and accurate diagnosis system for ***,NIRS-assisted technology is expected to contribute to the division of methods for early intervention and treatment of schizophrenia.

关键词： Bibliometrics Schizophrenia Near-infrared spectroscopy Diagnostic technique Data analysis

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Numerical Investigation on Characteristics of Supercritical CO_(2)Heat Transfer in Vertical Circular Tubes with Circumferentially Half-Side Heating

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Journal of Thermal Science 2024年第5期33卷 1744-1756页

作者： zhang yan zhang Xinyi yan Chenshuai WU Wenhua GAO Erman School of Energy and Power Engineering Northeast Electric Power UniversityJilin 132012China

The design of heat exchangers in the advanced supercritical power conversion system cannot be separated from the study of heat transfer ***-side heating mode is often encountered for solar receiver and supercritical ***,the characteristics of supercritical CO_(2)(sCO_(2))convection heat transfer in vertical tubes with circumferentially half-side heating was numerically investigated through the SST k-ωturbulent model which matches well with the experimental ***,heat transfer between sCO_(2)upflow and downflow was *** to film boiling heat transfer at subcritical pressure,numerical results were processed according to the supercritical pseudo-phase transition hypothesis,with liquid-like phase in the tube core region and vapor-like film in the region near the heated tube *** structure of two layers was demarcated by pseudo-critical temperature T_(pc).Therefore,sCO_(2)heat transfer was assessed according to double thermal resistances caused by vapor-like film near the wall and core liquid-like *** findings suggest that wall temperature for upflow is higher than that for downflow,which is attributed to larger thermal resistance in the fluid domain for upflow than that for *** difference guarantees the excellent heat transfer performance for downflow than *** is also further concluded that the formation of vapor-like film near the wall due to pseudo-phase transition plays a key role in dominating wall temperature and inducing heat transfer deterioration in half-side heating *** present contribution is significant to the design of supercritical heat exchanger under half-side heating mode.

关键词： supercritical CO_(2) pseudo-phase transition half-side heating thermal resistance flow direction

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