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Peficitinib suppresses diffuse-type tenosynovial giant cell tumor by targeting TYK2 and JAK/STAT signaling

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Science China Life Sciences 2025年

作者： Shan Lu Chenxi Cao wenjia zhang Jiayi Li Jingli Yang Zisheng Huang Zhijun Wu Baitao Liu Hongjie Huang Haijun Wang Yongjian Wang Dingge Liu Zhihua zhang Kaiping Liu Gang Yang Xi Gong Hui Dai Yingjia Li Erdan Dong Xin zhang Yan zhang Haihe Laboratory of Cell Ecosystem Institute of Cardiovascular Diseases The First Affiliated Hospital of Dalian Medical University Institute of Cardiovascular Sciences School of Basic Medical Sciences Peking University Health Science Center Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalState Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Sports Medicine Peking University Third Hospital Institute of Sports Medicine of Peking University Beijing Key Laboratory of Sports Injuries Engineering Research Center of Sports Trauma Treatment Technology and Devices Ministry of Education State Key Laboratory of Membrane Biology Institute of Molecular Medicine College of Future Technology Peking University Peking University Health Science Centre Peking University Department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology Peking University Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases Chinese Academy of Medical Sciences

Diffuse-type tenosynovial giant cell tumor(dTGCT) is a destructive but rare benign proliferative synovial neoplasm. Although surgery is currently the main treatment modality for dTGCT, the recurrence risk is up to 50%. Therefore, there is a great need for effective drugs against dTGCT with minor side effects. The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling plays a central role in rheumatoid arthritis(RA), a disease with similar characteristics as dTGCT, but its function in dTGCT remains *** fibroblast-like synoviocytes(FLS) and macrophages were isolated from 10 synovial tissue samples from dTGCT patients for the screening and validation of the five clinically approved JAK inhibitors to treat RA against dTGCT. Cell viability, cell death, inflammation and the activity of the JAK family members of cultured dTGCT FLS(both 2-D and 3-D) and macrophages were investigated for the efficacy of the JAK inhibitors. Here, we found that similar to RA, JAK/STAT signaling was markedly activated in the dTGCT synovium. Of the 5 JAK inhibitors, peficitinib was shown to have the most potency in addressing some of the pathological responses of dTGCT FLS and *** potency of peficitinib was much higher than pexidartinib, which is the only FDA-approved drug for dTGCT. Mechanistically, peficitinib inhibited tyrosine kinase 2(TYK2), a JAK family member necessary for the pathological progression of dTGCT FLS and macrophages. In summary, we not only revealed JAK/STAT(especially TYK2) signaling as the major mechanism underlying dTGCT, but also identified peficitinib as a promising drug against dTGCT.

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SNR-adaptive deep joint source-channel coding scheme for image semantic transmission with convolutional block attention module

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The Journal of China Universities of Posts and Telecommunications 2024年第1期31卷 1-11页

作者： Yang Yujia Liu Yiming zhang wenjia zhang Zhi State Key Laboratory of Networking and Switch Technology Beijing University of Posts and TelecommunicationsBeijing 100876China

With the development of deep learning(DL),joint source-channel coding(JSCC)solutions for end-to-end transmission have gained a lot of *** deep JSCC schemes support dynamically adjusting the rate according to different channel conditions during transmission,enhancing robustness in dynamic wireless ***,most of the existing adaptive JSCC schemes only consider different channel conditions,ignoring the different feature importance in the image processing and *** uniform compression of different features in the image may result in the compromise of critical image details,particularly in low signal-to-noise ratio(SNR)*** address the above issues,in this paper,a dual attention mechanism is introduced and an SNR-adaptive deep JSCC mechanism with a convolutional block attention module(CBAM)is proposed,in which matrix operations are applied to features in spatial and channel dimensions *** proposed solution concatenates the pooling feature with the SNR level and passes it sequentially through the channel attention network and spatial attention network to obtain the importance evaluation *** show that the proposed solution outperforms other baseline schemes in terms of peak SNR(PSNR)and structural similarity(SSIM),particularly in low SNR scenarios or when dealing with complex image content.

关键词： semantic communication joint source-channel coding image transmission

Specific photoacoustic cavitation through nucleus targeted nanoparticles for high-efficiency tumor therapy

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Nano Research 2020年第3期13卷 719-728页

作者： Yuan Wang Guangle Niu Shaodong Zhai wenjia zhang Da Xing MOE Key Laboratory cf Laser Life Science&Institute of Laser Life Science South China Normal UniversityGuangzhou 510631China College of Biophotonics South China Normal UniversityGuangzhou 510631China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute cf Physics and ChemistryChinese Academy of SciencesBeijing 100190China Department of Pharmacology&Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong Kongt PokfulamHong KongChina

As a new type of cancer treatment,photoacoustic(PA)therapy is based on PA shockwave for rapid,selective and effective killing of cancer *** nucleus has been widely used as a target for tumor therapy,which has obtained a very considerable therapeutic *** situ destruction of tumor cell nucleus by photoacoustic therapy has not been *** this paper,a highly efficient nucleus-targeted photoacoustic theranostic polymer was developed for fluorescence and photoacoustic dual-mode imaging-guided PA *** prepared polymer consists of nucleus targeting TAT peptide(TAT:YGRKKRRQRRR),hydrophilic chain poly(N,N-dimethylacrylamide)(PDMA),and near-infrared(NIR)light absorbing agent(hCyR),which can self-assemble to form nanoparticles of approximately 28 nm(denoted as TAT-PDMA-hCyR NPs).The designed nanoparticles show excellent nucleus targeting and tumor cell death(up to 80%)caused by DNA damage under pulsed laser irradiation compared to non-nucleus target counterpart PDMA-hCyR NPs without TAT peptide in *** expected,the fluorescence and PA dual-mode imaging observed that TAT-PDMA-hCyR NPs were able to passively target and enrich in tumors,providing an experimental basis for in vivo treatment and thus ensuring a significant tumor inhibition rate(about 92%).In conclusion,this study provides a new and practicable method for the development of nucleus-targeting nanoparticles as potential theranostic agent for in vivo cancer imaging and therapy.

关键词： photoacoustic therapy nucleus near-infrared light targeted therapy

N/S codoping modification based on the metal organic frameworkderived carbon to improve the electrochemical performance of different energy storage devices

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Journal of Energy Chemistry 2022年第11期31卷 394-403,I0011页

作者： Ziyi Zhu Xue Li Zhong zhang Qi Meng wenjia zhang Peng Dong Yingjie zhang National and Local Joint Engineering Laboratory for Lithium-ion Batteries and Materials Fabrication Technology Yunnan Provincial Laboratory for Advanced Materials and Batteries ApplicationKunming University of Science and TechnologyKunming 650093YunnanChina Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina School of Applied Sciences and Engineering Fuzhou Institute of TechnologyFuzhou 350118FujianChina

Carbon-based materials have become a research hotspot in the field of energy storage devices in recent years due to their abundant resources,low cost,and environmental ***,the low capacity and poor high rate performance still constitute great *** organic framework-derived carbon has been widely researched because of its high porosity,tunable structure,and good *** this work,N/S codoped hierarchical porous carbon microspheres were prepared by a high-temperature heat treatment and atomic doping process using a zinc-based organic framework as the *** used as a potassium-ion battery anode,it has a high reversible specific capacity(435.7 mAh g^(-1)),good rate performance(133.5 mAh g^(-1)at 10,000 m A g^(-1)),and long-term cycling stability(73.2%capacity retention after the 2500th cycle).The potassium storage mechanism of the derived carbon was explained by various electrochemical analysis methods and microstructure characterization techniques,and the relationship between the structural characteristics and electrochemical properties was *** a supercapacitor,the porous carbon material exhibits a specific capacitance of 307.2 F g^(-1)at a current density of 0.2 A g^(-1)in a KOH aqueous solution and achieves a retention rate of 99.88%after 10,000 *** assembled symmetric supercapacitor device delivers a high energy density of 6.69 Wh kg^(-1),with a corresponding power density of 2500 W kg^(-1).In addition,density functional theory calculations further confirmed that N/S codoping can improve the adsorption capacities of potassium and hydroxyl ions in the derived carbon.

关键词： N/S codoped Carbon microspheres Metal organic frameworks Potassium-ion batteries Supercapacitors

Self-Certificating Root:A Root Zone Security Enhancement Mechanism for DNS

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Computers, Materials & Continua 2020年第4期63卷 521-536页

作者： Wenfeng Liu Yu zhang wenjia zhang Lu Liu Hongli zhang Binxing Fang School of Computer Science and Technology Harbin Institute of TechnologyHarbinChina

As a critical Internet infrastructure,domain name system(DNS)protects the authenticity and integrity of domain resource records with the introduction of security extensions(DNSSEC).DNSSEC builds a single-center and hierarchical resource authentication architecture,which brings management convenience but places the DNS at risk from a single point of *** the root key suffers a leak or misconfiguration,top level domain(TLD)authority cannot independently protect the authenticity of TLD data in the root *** this paper,we propose self-certificating root,a lightweight security enhancement mechanism of root zone compatible with DNS/DNSSEC *** adding the TLD public key and signature of the glue records to the root zone,this mechanism enables the TLD authority to certify the self-submitted data in the root zone and protects the TLD authority from the risk of root key *** mechanism is implemented on an open-source software,namely,Berkeley Internet Name Domain(BIND),and evaluated in terms of performance,compatibility,and *** results show that the proposed mechanism enables the resolver that only supports DNS/DNSSEC to authenticate the root zone TLD data effectively with minimal performance difference.

关键词： Domain name system root zone security single point of failure

20736-node weighted max-cut problem solving by quadrature photonic spatial Ising machine

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Science China(Information Sciences) 2023年第12期66卷 289-290页

作者： Xin YE wenjia zhang Shaomeng WANG Xiaoxuan YANG Zuyuan HE State Key Laboratory of Advanced Optical Communication Systems and Networks Shanghai Jiao Tong University Peng Cheng Laboratory

The max-cut problem is one of the fundamental NP-hard problems in combinatorial optimization, which can describe the practical applications such as data clustering, machine scheduling, and image recognition. This prob...

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Network controllability analysis of awake and asleep conditions in the brain

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第5期24卷 458-462页

作者： Yan HE Zhiqiang YAN wenjia zhang Jie DONG Hao YAN Key Laboratory for Artificial Intelligence and Cognitive Neuroscience of Language Xi'an International Studies UniversityXi'an 710121China Department of Neurosurgery Xijing HosptialAir Force Medical UniversityXi'an 710032China Department of Linguistics Xidian UniversityXi'an 710121China Center for Language and Brain Shenzhen Institute of NeuroscienceShenzhen 518107China

The difference between sleep and wakefulness is critical for human *** takes up one third of our lives and remains one of the most mysterious con-ditions;it plays an important role in memory consoli-dation and health ... 详细信息

关键词： analysis restoration lives

Residents’Self-Build:Local Practice and Local Wisdom Beyond Planning--A Case Study on Renewal and Development in Hanyin Old City,Shaanxi Province

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China City Planning Review 2020年第4期29卷 47-55页

作者： Zhao Xu zhang wenjia Yin Jie School of Urban Planning and Design of Peking University(Shenzhen Graduate School) ShenzhenP.R.China College of Urban and Environmental Sciences Peking UniversityShenzhenP.R.China Urban Planning Society of China

This paper focuses on the phenomenon of residents’self-build structures in the old city of Hanyin County since the 1980 s,and draws the following conclusions:firstly,regarding the local policies formed in the process of local practice beyond planning,i.e.,"neighbors’consent,""cooperative building,"and"building setback at no charge;"secondly,that the legal interpretation of neighboring relations is the legal basis for the rationalization of the policy beyond planning;thirdly,the local government’s selective use of planning tools and its cooperation with residents reflects the local wisdom,which helps to promote urban renewal at a lower cost.

关键词： residents’self-build beyond planning local policy urban renewal Hanyin County

Versatile carbon-based materials from biomass for advanced electrochemical energy storage systems

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eScience 2024年第5期4卷 27-69页

作者： Ziyi Zhu Yongling Men wenjia zhang Wenhao Yang Fei Wang Yanjia zhang Yiyong zhang Xiaoyuan Zeng Jie Xiao Cheng Tang Xue Li Yingjie zhang National and Local Joint Engineering Research Center of Lithium-ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Battery Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093China Instituto de Ciencia de Materiales de Madrid Consejo Superior de Investigaciones CientíficasCampus de CantoblancoMadrid 28049Spain Department of Chemistry and Life Science Yokohama National UniversityYokohama 240-8501Japan Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

The development of new energy storage technology has played a crucial role in advancing the green and low-carbon energy *** has led to significant progress,spanning from fundamental research to its practical application in industry over the past ***,the constrained performance of crucial materials poses a significant challenge,as current electrochemical energy storage systems may struggle to meet the growing market *** recent years,carbon derived from biomass has garnered significant attention because of its customizable physicochemical properties,environmentally friendly nature,and considerable economic *** review aims to provide a comprehensive overview of the production-application chain for biomass-derived *** provides a comprehensive analysis of morphology design,structural regulation,and heteroatom-doping modification,and explores the operational mechanisms in different energy storage ***,considering recent research progress,the potential uses of biomass-derived carbon in alkali metal-ion batteries,lithium–sulfur batteries,and supercapacitors are thoroughly assessed,offering a broader outlook on the emerging energy ***,based on the technical challenges that need to be addressed,potential research directions and development objectives are suggested for achieving large-scale production of biomass-derived carbon in the field of energy storage.

关键词： Biomass-derived carbon Energy storage mechanisms Alkali metal-ion batteries Lithium–sulfur batteries Supercapacitors