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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong Tang Li Jiang Xiong-Ying Ji Feng-Ying zhang ping zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Universal tweakable Even-Mansour cipher and its applications

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Frontiers of Computer Science 2023年第4期17卷 181-192页

作者： ping zhang School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing 210023China

The construction of the tweakable Even-Mansour cipher is in fact the designs of permutations,mask operations,and masking *** information-theoretic security,permutations are usually taken as random *** paper focuses on the mask operations and masking functions to construct a universal tweakable Even-Mansour ***,we describe a formal definition of a universal masking function and provide a universal tweakable Even-Mansour cipher *** the random permutation model,we prove that UTEM is multi-key secure by H-coefficients *** we show some efficient instantiations of the universal masking function to concertize ***,we apply UTEM to an encryption mode TIE(tweak incrementation encryption)and an authenticated encryption mode IAPM(integrity aware parallelizable mode),present two new schemes TIE-plus and IAPM-plus,and prove their *** enriches tweakable blockciphers,brings more research topics,and plays an important role in modes of operation,which will be of great significance.

关键词： tweakable Even-Mansour cipher masking function multi-key security H-coefficients technique encryption authenticated encryption

Remark on the Regularities of Kato's Solutions to Navier-Stokes Equations with Initial Data in L^d(R^d)

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Chinese Annals of Mathematics,Series B 2008年第3期29卷 265-272页

作者： ping zhang Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China

Motivated by the results of J. Y. Chemin in ＂J. Anal. Math., 77, 1999, 27- 50＂ and G. Furioli et al in ＂Revista Mat. Iberoamer., 16, 2002, 605-667＂, the author considers further regularities of the mild solutions to Navier-Stokes equation with initial data uo ∈ L^d（R^d）. In particular, it is proved that if u C ∈（[0, T^＊）; L^d（R^d）） is a mild solution of （NSv）, then u（t,x）- e^vt△uo ∈ L^∞（（0, T）;B2/4^1,∞）~∩L^1 （（0, T）; B2/4^3 ,∞） for any T 〈 T^＊.

关键词： Navier-Stokes equations Kato's solutions Para-differential decomposition

A hybrid subcell-remapping algorithm for staggered multi-material arbitrary Lagrangian-Eulerian methods

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Applied Mathematics and Mechanics(English Edition) 2019年第10期40卷 1487-1508页

作者： Haihua YANG ping zhang Institute of Applied Physics and Computational Mathematics

A new flux-based hybrid subcell-remapping algorithm for staggered multimaterial arbitrary Lagrangian-Eulerian (MMALE) methods is presented. This new method is an effective generalization of the original subcell-remapping method to the multi-material regime (LOUBERE, R. and SHASHKOV,M. A subcell remapping method on staggered polygonal grids for arbitrary-Lagrangian-Eulerian methods. Journal of Computational Physics, 209, 105–138 (2005)). A complete remapping procedure of all fluid quantities is described detailedly in this paper. In the pure material regions, remapping of mass and internal energy is performed by using the original subcell-remapping method. In the regions near the material interfaces, remapping of mass and internal energy is performed with the intersection-based fluxes where intersections are performed between the swept regions and pure material polygons in the Lagrangian mesh, and an approximate approach is then introduced for constructing the subcell mass fluxes. In remapping of the subcell momentum, the mass fluxes are used to construct the momentum fluxes by multiplying a reconstructed velocity in the swept region. The nodal velocity is then conservatively recovered. Some numerical examples simulated in the full MMALE regime and several purely cyclic remapping examples are presented to prove the properties of the remapping method.

关键词： multi-material arbitrary Lagrangian-Eulerian (MMALE) subcell remapping method hybrid remapping method

Phase stability of Ta-W alloys

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Acta Metallurgica Sinica(English Letters) 2010年第3期23卷 215-222页

作者： Xiaobo LI ping zhang College of Civil Engineering and Mechanics Xiangtan University Xiangtan 411105 China Key Laboratory of Materials Design and Preparation Technology of Hunan Province Xiangtan University Xiangtan 411105 China

The characteristic crystal model is applied to the study of phase stability and thermodynamics in substitutional bcc-based Ta-W *** basic principle and method of alloy thermodynamics which is described by the characteristic crystal model is introduced in *** Gibbs energy of various phases including both disordered and ordered phases of the Ta-W system are *** phase diagram of Ta-W alloys is assessed and *** results are in good agreement with experiments and better than that of first principle.

关键词： Ta-W alloys Phase diagram Characteristic crystal model Thermodynamics Phase stability

Precipitation anomaly over the Tibetan Plateau affected by tropical sea-surface temperatures and mid-latitude atmospheric circulation in September

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Science China Earth Sciences 2023年第3期66卷 619-632页

作者： ping zhang Anmin DUAN State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth Science University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China

Tibetan Plateau(TP)precipitation is affected by anomalous circulation systems in both the tropics and mid-latitudes,due to the TP’s unique geographical *** using observational,reanalysis,and CMIP6 model datasets,this study reveals the individual and joint effects of the Indian Ocean Dipole(IOD)and Silk Road pattern(SRP)on the interannual variability of TP precipitation in *** the positive IOD phase,the zonal gradient of the sea-surface temperature anomalies(SSTAs)drives a Gill-type response with an anticyclonic anomaly over the Indian subcontinent and Bay of *** the north,anomalous westerlies induce a shallow trough,and the associated anomalous southwesterlies transport moisture to the southeastern TP,resulting in surplus precipitation ***,the westerly jet disturbances over the North Atlantic excite an SRP-like pattern,resulting in a baroclinic structure in northern India with the upper(lower)tropospheric anomalous anticyclone(cyclone)over west-central Asia(northern India).The anomalous southwesterlies to the east of the low-level cyclone transport abundant moisture to the southeastern TP,which results in increased precipitation *** joint effects of IOD and SRP can explain nearly 52%of the TP precipitation anomaly,exceeding the contribution of IOD(19%)and SRP(27%)*** results highlight the necessity of considering the joint effects of drivers in the tropics and mid-latitudes,providing a basis for more accurate simulations and predictions of TP precipitation.

关键词： Tibetan Plateau precipitation Interannual variability Indian Ocean Dipole Silk Road pattern

Special issue on 5G wireless communication systems and technologies

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Frontiers of Information Technology & Electronic Engineering 2017年第6期18卷 751-752页

作者： ping zhang Beijing University of Posts and Telecommunications Beijing 100876China

The explosive growth of data traffic due to ubiquitous smart devices has accelerated the evolution of mobile communication from 4G to 5G. To achieve an extremely high performance, 5G mobile communication system is facing challenges in the design of new network architectures, new radio access techniques, and new transmission waveforms. Motivated by this observation, FITEE organizes this special issue on 5G Wireless Communication Systems and Technologies, to advance the studies of this field.

关键词： explosive extremely traffic ubiquitous challenges smart challenging maximization throughput carefully

Special Blocks of Finite Groups

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Acta Mathematica Sinica,English Series 2016年第1期32卷 115-123页

作者： Ji ping zhang Beijing International Center for Mathematical Research Lmam School of Mathematical SciencesPeking University

We first determine in this paper the structure of the generalized Fitting subgroup F＊（G） of the finite groups G all of whose defect groups （of blocks） are conjugate under the automorphism group Aut（G） to either a Sylow p-subgroup or a fixed p-subgroup of G. Then we prove that if a finite group L acts transitively on the set of its proper Sylow p-intersections, then either L/Op（L） has a T.I. Sylow p-subgroup or p = 2 and the normal closure of a Sylow 2-subgroup of L/O2（L） is 2-nilpotent with completely descripted structure. This solves a long-open problem. We also obtain some generalizations of the classic results by Isaacs and Passman on half-transitivity.

关键词： Finite groups representations blocks defect groups

The Hadamard Theorem and Borel-Carathéodory Theorem on Riemann Surfaces

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Acta Mathematica Sinica,English Series 2006年第3期22卷 945-950页

作者： Hui ping zhang School of Information Renmin University of China

In this paper, we first define a kind of pseudo-distance function and annulus domain on Riemann surfaces, then prove the Hadamard Theorem and the Borel-Carathéodory Theorem on any Riemann surfaces.

关键词： (Sub)harmonic functions Pseudo-distance function Annulus domain Analytic function