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Rare Metals 2024年第3期43卷 1309-1315页

作者： Long-Hua Ding Ya-Wen Wang Qiu-Wen li li-li zhang Ai-Zhu Wang Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China HCA Florida Healthcare Westside/Northwest Hospital Internal Medicine PlantationFL33324USA

In this study,an electrochemical impedimetric sensor was established for imidacloprid(IMI)detection based on WO_(3)/MoS_(2)and molecular imprinted polymer(MIP)*** layer was prepared on electrode surface by electropolymerization of o-phenylenediamine(o-PD)in the presence of IMI template,which ensured the specific rec-ognization toward IMI.

关键词： electrochemical polymer polymerization

女性情感激活了我的乡土记忆--乔叶、张莉对谈

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小说评论 2024年第2期 120-126页

作者：乔叶张莉北京市作家协会北京师范大学

打开自己,进入新的乡村生活张莉:我们还是从《宝水》的写作说起吧。宝水村这个名字是怎么想起来的?这个词太好了,记得你第一次给我打电话说这个小说的时候,我直觉“宝水”是一个很好的书名,别有文学气象。就应该用这个名字,不应该仅是... 详细信息

打开自己,进入新的乡村生活张莉:我们还是从《宝水》的写作说起吧。宝水村这个名字是怎么想起来的?这个词太好了,记得你第一次给我打电话说这个小说的时候,我直觉“宝水”是一个很好的书名,别有文学气象。就应该用这个名字,不应该仅是村名。

关键词：乡土记忆张莉乔叶宝水情感激活打电话书名

Expanding catalytic promiscuity of a bifunctional terpene synthase through a single mutation-induced change in hydrogen-bond network within the catalytic pocket

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Synthetic and Systems Biotechnology 2024年第2期9卷 380-387页

作者： Xinye Wang Yiyi Huang Weiyan zhang Kangjie Lv Xiaoying li Zhixin Wang li zhang Tom Hsiang lixin zhang liming Ouyang Xueting liu State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237China Department of Chemistry Boston UniversityBostonMAUSA School of Environmental Sciences University of Guelph50 Stone Road EastGuelphOntarioN1G 2W1Canada

Fungal bifunctional terpene synthases(BFTSs)catalyze the formation of numerous di-/sester-/tri-terpenes ***,the mechanism in controlling the cyclization pattern of terpene scaffolds is rarely deciphered for further application of tuning the catalytic promiscuity of terpene synthases for expanding the chemical *** this study,we expanded the catalytic promiscuity of Fusarium oxysporum fusoxypene synthase(FoFS)by a single mutation at L89,leading to the production of three new *** computational analysis revealed that the reconstitution of the hydrogen-bond(H-bond)network of second-shell residues around the active site of FoFS influences the orientation of the aromatic residue W69 within the first-shell catalytic ***,the dynamic orientation of W69 alters the carbocation transport,leading to the production of diverse ring system *** findings enhance our knowledge on understanding the molecular mechanisms,which could be applied on protein engineering terpene synthases on regulating the terpene skeletons.

关键词： Bifunctional terpene synthase Sesterterpene Carbocation transportation Density functional theory calculations Molecular dynamics simulations

Novel method for the recognition of Jinnan cattle action using bottleneck attention enhanced two-stream neural network

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 203-210页

作者： Wangli Hao Meng Han Kai zhang li zhang Wangbao Hao Fuzhong li Zhenyu liu School of Software Shanxi Agricultural UniversityJinzhong 030801ShanxiChina Yuncheng National Jinnan Cattle Genetic Resources and Gene Protection Center Yongji 044500ShanxiChina Yongji Puzhou Old City Beimenwai Cattle Farm Yongji 044500ShanxiChina College of Engineering Shanxi Agricultural UniversityJinzhong 030801ShanxiChina

Effective and accurate action recognition is essential to the intelligent breeding of the Jinnan ***,there are still several challenges in the current Jinnan cattle action *** methods are based on manual characteristics and low recognition *** study is aimed at the efficient and accurate development of Jinnan cattle action recognition methods to overcome existing problems and support intelligent *** acquired data from the previous methods contain a lot of noise,which will cause individual cattle to have excessive behaviors due to *** the high labor costs,low efficiency,and low model accuracy of the above approaches,this study developed a bottleneck attention-enhanced two-stream(BATS)Jinnan cattle action recognition *** primarily comprises a Spatial Stream Subnetwork,a Temporal Stream Subnetwork,and a Bottleneck Attention *** can capture the spatial-channel dependencies in RGB and optical flow two branches respectively,so as to extract richer and more robust ***,the decision of the two branches can be fused to gain improved cattle action recognition *** with the traditional methods,the model proposed in this study has achieved state-of-the-art recognition performance,and the accuracy of motion recognition was 96.53%,which was 4.60%higher than other *** method significantly improves the efficiency and accuracy of behavior recognition and provides an important research foundation and direction for the development of higher-level behavior analysis models in the future development of smart animal husbandry.

关键词： Jinnan cattle action recognition bottleneck attention two-stream neural network

Microfluidics-derived microfibers in flexible bioelectronics

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Materials Futures 2024年第3期3卷 54-70页

作者： Chaoyu Yang Xingyu Hou li zhang Department of Mechanical and Automation Engineering The Chinese University of Hong KongShatinN.T.Hong Kong Special Administrative Region of China 999077People’s Republic of China

Flexible electronics have attracted extensive attention across a wide range of fields due to their potential for preventive medicine and early disease ***-based textiles,encountered in everyday life,have emerged as promising platforms with integrated sensing *** technology has been recognized as a promising avenue for the development of flexible conductive microfibers and has made significant *** this review,we provide a comprehensive overview of the state-of-the-art advancements in microfiber-based flexible electronics fabricated using microfluidic ***,the fundamental strategies of the microfluidic fabrication of conductive microfibers with different structures and morphologies are ***,attention is then directed towards the diverse applications of these microfibers in ***,we offer a forwardlooking perspective on the future challenges about microfluidic-derived microfibers in flexible bioelectronics.

关键词： microfluidics conductive microfibers sensing flexible bioelectronics

BrrTCP4b interacts with BrrTTG1 to suppress the development of trichomes in Brassica rapa var. rapa

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Plant Diversity 2024年第3期46卷 416-420页

作者： Cheng li li zhang Hefan li Yuanwen Duan Xuemei Wen Yongping Yang Xudong Sun The Germplasm Bank of Wild Species Yunnan Key Laboratory of Crop Wild Relatives OmicsInstitute of Tibetan Plateau Research at KunmingKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences BeijingChina Tibet Plateau Institute of Biology Lhasa 850001TibetChina

The number of trichomes significantly increased in CRISPR/Cas9-edited BrrTCP4b turnip(Brassica rapa ***)***,the underlying molecular mechanism remains to be *** this study,we performed the Y2H screen using BrrTCP4b as the bait,which unveiled an interaction between BrrTCP4b and BrrTTG1,a pivotal WD40-repeat protein transcription factor in the MYB-bHLH-WD40(MBW)*** physical interaction was further validated through bimolecular luciferase complementation and ***,it was found that the interaction between BrrTCP4b and BrrTTG1 could inhibit the activity of MBW complex,resulting in decreased expression of BrrGL2,a positive regulator of trichomes *** contrast,AtTCP4 is known to regulate trichomes development by interacting with AtGL3 in Arabidopsis ***,this study revealed that BrrTCP4b is involved in trichome development by interacting with BrrTTG1 in turnip,indicating a divergence from the mechanisms observed in model plant *** findings contribute to our understanding of the regulatory mechanisms governing trichome development in the non-model plants turnip.

关键词： TCP transcription factor MBW complex Trichome development Turnip

Highly selective photocatalytic oxidation of methane to methyl hydroperoxide

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Nano Research 2024年第4期17卷 2473-2480页

作者： Chunling Bo li zhang Xiaolong liu Huaiqiu Chang Yingxue Sun Xinyi zhang Ting Tan lingyu Piao National Center for Nanoscience and Technology Beijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China

Partial oxidation of methane into primary oxidation products with high value remains a *** this work,photocatalytic oxidation of methane(CH_(4))with high methyl hydroperoxide(CH_(3)OOH)selectivity is achieved using pure titanium oxide(TiO_(2))without any cocatalyst at room temperature and atmospheric *** CH_(3)OOH production rate can reach up to 2050±88μmol·g^(-1)·h^(-1) at pH≈7.0 with 100%selectivity in the liquid *** stable reaction cycle can reach more than 30 *** low-cost system achieves superior CH_(4) conversion activity and selectivity compared with similar *** energy of hydrogen peroxide(H_(2)O_(2))to adsorbed hydroperoxyl radical(^(*)OOH)has a significantly lower reaction energy than conversion to adsorbed hydroxyl radical(*OH)on the(210)surface of the TiO_(2).The^(*)OOH preferentially combines with methyl radical(·CH_(3))to form the most energetically favorable CH_(3)*** mild oxidative environment of this system prevents the reduction of CH_(3)OOH to CH_(3)OH or over-oxidation of CH_(4),which ensures the final CH_(3)OOH with high selectivity and *** work provided a low-cost but highly efficient method to achieve partial oxidation with superior selectivity,i.e.,to convert CH_(4) into high-value chemicals.

关键词： photocatalytic methane oxidation methyl hydroperoxide titanium oxide

Nicotinamide adenine dinucleotide treatment confers resistance to neonatal ischemia and hypoxia:effects on neurobehavioral phenotypes

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Neural Regeneration Research 2024年第12期19卷 2760-2772页

作者： Xiaowen Xu Xinxin Wang li zhang Yiming Jin lili li Meifang Jin lianyong li Hong Ni Division of Brain Science Institute of Pediatric ResearchChildren’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Pediatric Orthopedics Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Neonatal hypoxic-ischemic brain injury is the main cause of hypoxic-ischemic encephalopathy and cerebral ***,there are few effective clinical treatments for neonatal hypoxic-ischemic brain ***,we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide,which can protect against hypoxic injury in adulthood,in a mouse model of neonatal hypoxic-ischemic brain *** this study,nicotinamide adenine dinucleotide(5 mg/kg)was intraperitoneally administered 30 minutes befo re surgery and every 24 hours *** results showed that nicotinamide adenine dinucleotide treatment improved body weight,brain structure,adenosine triphosphate levels,oxidative damage,neurobehavioral test outcomes,and seizure threshold in experimental *** mass tag proteomics revealed that numerous proteins were altered after nicotinamide adenine dinucleotide treatment in hypoxic-ischemic brain injury *** reaction monitoring and western blotting confirmed changes in the expression levels of proteins including serine(or cysteine)peptidase inhibitor,clade A,member 3N,fibronectin 1,5'-nucleotidase,cytosolic IA,microtubule associated protein 2,and complexin *** analyses showed that nicotinamide adenine dinucleotide ameliorated hypoxic-ischemic injury through inflammation-related signaling pathways(e.g.,nuclear factor-kappa B,mitogen-activated protein kinase,and phosphatidylinositol 3 kinase/protein kinase B).These findings suggest that nicotinamide adenine dinucleotide treatment can improve neurobehavioral phenotypes in hypoxic-ischemic brain injury mice through inflammation-related pathways.

关键词： brain injury cerebral palsy hypoxia hypoxic-ischemic brain injury inflammation neuroprotection nicotinamide adenine dinucleotide neonate nicotinamide adenine dinucleotide proteomics

Multiscale spatiotemporal meteorological drought prediction:A deep learning approach

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Advances in Climate Change Research 2024年第2期15卷 211-221页

作者： Jia-li zhang Xiao-Meng HUANG Yu-Ze SUN Department of Earth System Science Ministry of Education Key Laboratory for Earth System ModellingInstitute for Global Change StudiesTsinghua UniversityBeijing 100084China

Reliable monitoring and thorough spatiotemporal prediction of meteorological drought are crucial for early warning and decision-making regarding drought-related *** utilisation of multiscale methods is effective for a comprehensive evaluation of drought occurrence and progression,given the complex nature of meteorological ***,the nonlinear spatiotemporal features of meteorological droughts,influenced by various climatological,physical and environmental factors,pose significant challenges to integrated prediction that considers multiple indicators and time *** address these constraints,we introduce an innovative deep learning framework based on the shifted window transformer,designed for executing spatiotemporal prediction of meteorological drought across multiple *** formulate four prediction indicators using the standardized precipitation index and the standard precipitation evaporation index as core methods for drought definition using the ERA5 reanalysis *** indicators span time scales of approximately 30 d and one ***-term indicators capture more anomalous variations,whereas long-term indicators attain comparatively higher accuracy in predicting future *** focus on the East Asian region,notable for its diverse climate conditions and intricate terrains,to validate the model's efficacy in addressing the complexities of nonlinear spatiotemporal *** model's performance is evaluated from diverse spatiotemporal viewpoints,and practical application values are analysed by representative drought *** results substantiate the effectiveness of our proposed model in providing accurate multiscale predictions and capturing the spatiotemporal evolution characteristics of *** of the four drought indicators accurately delineates specific facets of the meteorological drought ***,three representative drought events,namely flash drought,sustained drought and severe drought,

关键词： Meteorological drought Spatiotemporal prediction Multiscale Swim transformer Deep learning

Advances of nanoparticles in transmucosal drug delivery

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Nano Research 2024年第4期17卷 2874-2885页

作者： li zhang Changwei Yang Yingxiang Song Tao Sheng Junyan li Jicheng Yu Xiaohong Wu Xiao Ye Geriatric Medicine Center Department of EndocrinologyZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China liangzhu Laboratory Zhejiang University Medical CenterHangzhou 311121China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Key Laboratory for Diagnosis and Treatment of Endocrine Gland Diseases of Zhejiang Province Hangzhou 310014China

Transmucosal drug administration represents a potential strategy for enhancing treatment efficacy and reducing side effects by avoiding the first-pass effect into the systemic circulation and delivering therapeutics directly to the target disease ***,many challenges still remain in its clinical application,including low drug availability and limited retention time in the *** burgeoning advancement of nanotechnologies offers great potential to overcome the above limitations,leveraging their distinct advantages of high drug-loading capacity and strong *** this review,the latest developments of nanoparticles(NPs)in transmucosal drug delivery as well as their clinical applications are discussed.

关键词： nanoparticles(NPs) transmucosal drug delivery mucosal barriers biomaterials