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Inflammation induced-endothelial cells release angiogenesis associated-microRNAs into circulation by microparticles

Chinese Medical Journal 2014年第12期127卷 2212-2217页

作者： zhang jing ren jingyi chen hong geng qiang Department of Cardiology Peking University Peoples HospitalBeijing 100044China

Background Endothelial cells derived microRNAs can be detected in plasma and serum and there is evidence that inflammatory disease states may affect the levels of circulating ***,there is no direct proof that inflammation induces endothelial cells to release microRNAs into *** study aimed to explore whether inflammation could induce endothelial cells to release microRNAs into circulation and to investigate whether these released microRNAs derived from endothelial cells were transported in *** Microparticles were isolated from human atherosclerotic plaques with an active inflammatory phenotype and normal vascular *** cytometry and real-time PCR were used to detect the levels of microparticles and *** umbilical vein endothelial cells （HUVEC） was treated with tumour necrosis factor α （TNF-α,10 ng/ml） for 24 hours,and then HUVEC and the culture medium were respectively *** By comparing microparticles isolated from human atherosclerotic plaques with an active inflammatory phenotype （n=9） and those from normal vascular tissues （n-9）,we found levels of annexin V＋ microparticles and annexin V＋ CD144＋ microparticles were significantly increased in plaques and angiogenesis associated microRNAs （106b,25,92a and 21） were also significantly increased in microparticles from *** exposure to TNF-α at a concentration of 10 ng/ml （TNF-α group,n=3） or DMEM （control group,n=3） for 24 hours,counts of microparticles and expressions of microRNAs 106b,25,92a and 21 in microparticles isolated from medium significantly ***,there were no differences in the intracellular levels of microRNAs 25,92a or 21 isolated from HUVEC between TNF-α group and control group,while microRNA 106b decreased in TNF-α *** Inflammation could induce endothelial cells to release angiogenesis associated microRNAs into circulation,causing higher levels of circulating endothelial cells derived microRNAs

关键词： microRNAs atherosclerosis inflammation microparticle

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XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： Qiu-Zhong Pan jing-jing Zhao Liang Liu Dong-Sheng zhang Li-Ping Wang Wen-Wei Hu De-Sheng Weng Xiang Xu Yi-Zhuo Li Yan Tang Wei-hong zhang Jie-Yao Li Xiao Zheng Qi-jing Wang Yong-qiang Li Tong Xiang Li Zhou Shuang-Ning Yang chen Wu Rong-Xing Huang Jia He Wei-Jiao Du Lu-Jun chen Yue-Na Wu Bin Xu Qiong Shen Yi zhang jing-Ting Jiang Xiu-Bao ren Jian-Chuan Xia State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China Jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China Institute for Cell Therapy of Soochow University ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains *** phase 3 trial(***:NCT03950154)assessed the efficacy and adverse events(AEs)of the combination of PD-1 blockade-activated DC-CIK(PD1-T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of 202 participants were enrolled and randomly assigned in a 1:1 ratio to receive either first-line XELOX plus bevacizumab(the control group,n=102)or the same regimen plus autologous PD1-T cell immunotherapy(the immunotherapy group,n=100)every 21 days for up to 6 cycles,followed by maintenance treatment with capecitabine and *** main endpoint of the trial was progression-free survival(PFS).The median follow-up was 19.5 *** PFS was 14.8 months(95%CI,11.6-18.0)for the immunotherapy group compared with 9.9 months(8.0-11.8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and 25.6 months(95%CI,18.3-32.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in 20.0%of patients in the immunotherapy group and 23.5%in the control groups,with no toxicity-associated deaths *** addition of PD1-T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

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Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： qiang Li Li‑Jiao Wang Xiang‑Biao Qiu jing‑Wen Li Wei Xu Tao Li Ze‑Bin Lin Chang‑Jun Ning Yong‑Hao chen Rui‑Rui Fan Kang Sun jing‑Yu Tang Rong zhang Han‑Tao jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping chen Zhen chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑cheng He Yang hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu Guang‑Yuan Luan Bin‑Bin Qi Jie ren Zhi‑Zhou ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu Guo‑Hui zhang Lin‑Hao zhang Mo‑Han zhang Qi‑Wei zhang Xian‑Peng zhang Yu‑Liang zhang Yue zhang Zhi‑Yong zhang Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

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10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： qiang Li Li‑Jiao Wang jing‑Yu Tang Xiang‑Biao Qiu Zhen chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan Wei Xu Tao Li Su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing Feng Rong zhang Xiao‑Yang Sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping chen Yong‑Hao chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑cheng He Yang hong Yi‑Wei Hu Han‑Xiong Huang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Gong Li Xiao Li Yang Li Jie Liu Rong Liu Shu‑Bin Liu Yi‑Na Liu Guang‑Yuan Luan Jie ren Zhi‑Zhou ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑cheng Wang Peng‑cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui zhang Hang‑Chang zhang Lin‑Hao zhang Qi‑Wei zhang Xian‑Peng zhang Yu‑Liang zhang Yue zhang Zhi‑Yong zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

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Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao chen jing-Yu Tang Rui-Rui Fan qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang chen Yi-Wei Yang Rong Liu Han Yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping chen Zhen chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-cheng He Yang hong Yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang Ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie ren Zhi-Zhou ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui zhang Lin-Hao zhang Mo-Han zhang Qi-Wei zhang Xian-Peng zhang Yu-Liang zhang Yue zhang Zhi-Yong zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

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Measurement of the neutron total cross section of^(9)Be at the Back-n white neutron source of CSNS

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Chinese Physics C 2024年第8期48卷 140-152页

作者： Jiangbo Bai jingyu Tang Liqun Shi Yonghao chen Han Yi Jie Bao Yu Bao Ping Cao Haolei chen Zhen chen Zengqi Cui Ruirui Fan Changqing Feng Keqing Gao Xiaolong Gao MinHao Gu Changcai Han Guozhu He Yongcheng He Yang hong Yiwei Hu Hanxiong Huang Xiru Huang Haoyu Jiang Wei Jiang Zhijie Jiang Hantao jing Ling Kang Bo Li Chao Li Jiawen Li qiang Li Xiao Li Yang Li Jie Liu Shubin Liu Ze Long Guangyuan Luan Changjun Ning Mengchen Niu Binbin Qi Jie ren Xichao Ruan Zhaohui Song Kang Sun Zhijia Sun Zhixin Tan Xinyi Tang Binbin Tian Lijiao Wang Pengcheng Wang Zhaohui Wang Xiaoguang Wu Xuan Wu Likun Xie Xiaoyun Yang Li Yu Tao Yu Yongji Yu Guohui zhang Linhao zhang Qiwei zhang Xianpeng zhang Yuliang zhang Zhiyong zhang Luping Zhou Zhihao Zhou Kejun Zhu Institute of Modern Physics Fudan UniversityShanghai 200433China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Sate Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

The neutron total cross section data of^(9)Be are essential in the nuclear structure model research of light nuclei and nuclear power *** neutron total cross section of^(9)Be in the 0.3 eV−120 MeV energy region has been measured using time-of-flight and transmission methods with the Neutron Total Cross Sectional Spectrometer(NTOX)based on the multi-cell fast fission chamber at the China Spallation Neutron Source(CSNS)-Back-n white neutron source(Back-n).The fission count-neutron energy distributions of ^(235)U and ^(238)U without samples and with Be samples with three thicknesses were measured in the double-bunch operation mode for a beam power of 100 *** Bayesian method was used to eliminate the influence of the double-bunch problem on neutron measurement in the energy region above 10 *** neutron total cross section of^(9)Be results was consistent with ENDF/B-VIII.0 evaluation library data in the 0.3 eV−20 MeV energy *** the energy ranges of 0.3 eV to 10 keV and 0.01 to 20 MeV,the deviations between our results and the evaluation results of ENDF/B-VIII.0 were within 2.5%and 15%,*** the resonance energy region,the measured resonance energies in our experiment were 0.63,0.82,and 2.8 MeV,*** results showed that the total cross section uncertainties of three Be samples were within 2.2%in the energy region below 1 *** total cross section uncertainty of 30 mm Be from ^(235)U was the smallest and less than 5%in the energy region of 0.3 eV−120 *** results of this experiment can provide technical support for further data analysis and related nuclear data evaluation.

关键词： ^(9)Be neutron total cross section CSNS Back-n time-of-flight method transmission method multi-cell fast fission chamber

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燃烧源氨排放对灰霾期间北京大气铵的重要贡献

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Science Bulletin 2024年第7期69卷 978-987页

作者：吴礼彬王芃张强任红 Zongbo Shi 胡伟陈静谢巧蓉李林杰越思瑶韦莲芳宋琳琳张永根王子涵陈爽韦琬王小曼章炎麟孔少飞葛宝珠杨婷方运霆任露洁邓君俊孙业乐王自发张宏亮胡建林刘丛强 Roy M.Harrison Qi Ying 傅平青 Institute of Surface-Earth System Science School of Earth System ScienceTianjin UniversityTianjin 300072China Department of Atmospheric and Oceanic Sciences Fudan UniversityShanghai 200438China IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health Fudan UniversityShanghai 200438China Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing 100084China Air Environmental Modeling and Pollution Controlling Key Laboratory of Sichuan Higher Education Institute Chengdu University of Information TechnologyChengdu 610225China Division of Environmental Health&Risk Management School of GeographyEarth&Environmental SciencesUniversity of BirminghamBirmingham B152TTUK School of Environmental Science and Engineering Tianjin UniversityTianjin 300072China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110164China Yale-NUIST Center on Atmospheric Environment International Joint Laboratory on Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjing 210044China Department of Atmospheric Sciences School of Environmental Studies and Department of Environmental Science and TechnologySchool of Environmental StudiesChina University of GeosciencesWuhan 430074China Department of Environmental Science and Engineering Fudan UniversityShanghai 200438China Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlNanjing University of Information Science and TechnologyNanjing 210044China Department of Environmental Sciences/Center of Excellence in Environmental Studies King Abdulaziz UniversityJeddah 21589Saudi Arabia Zachr

Aerosol ammonium(NH_(4)^(+)),mainly produced from the reactions of ammonia(NH_(3))with acids in the atmosphere,has significant impacts on air pollution,radiative forcing,and human *** the source and formation mechanism of NH_(4)^(+)can provide scientific insights into air quality ***,the sources of NH_(3)in urban areas are not well understood,and few studies focus on NH_(3)/NH_(4)^(+)at different heights within the atmospheric boundary layer,which hinders a comprehensive understanding of aerosol NH_(4)^(+).In this study,we perform both field observation and modeling studies(the Community Multiscale Air Quality,CMAQ)to investigate regional NH_(3)emission sources and vertically resolved NH_(4)^(+)formation mechanisms during the winter in *** stable nitrogen isotope analyses and CMAQ model suggest that combustion-related NH_(3)emissions,including fossil fuel sources,NH_(3)slip,and biomass burning,are important sources of aerosol NH_(4)^(+)with more than 60%contribution occurring on heavily polluted *** contrast,volatilization-related NH_(3)sources(livestock breeding,N-fertilizer application,and human waste)are dominant on clean ***-related NH_(3)is mostly local from Beijing,and biomass burning is likely an important NH_(3)source(~15%–20%)that was previously *** effective control strategies such as the two-product(e.g.,reducing both SO_(2)and NH_(3))control policy should be considered to improve air quality.

关键词： Particulate ammonium Nitrogen isotope PM2.5 The Community Multiscale Air Quality(CMAQ) Control policy

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酸枣仁的化学成分、药理作用和临床应用研究进展

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药学前沿 2024年第9期28卷 98-108页

作者：曲彤耿飞飞李宁鲁文静任慧崔小敏胡静梁超陈志永张红陕西省中医药研究院西安710003 陕西中医药大学药学院陕西咸阳712046

酸枣仁主要含有皂苷类、黄酮类、生物碱类、脂肪酸类等成分,具有镇静催眠、抗焦虑、抗抑郁、保护神经、保护心脑血管、保肝、抗氧化等多种活性,广泛应用于医药、食品、保健食品等领域。本文通过查阅文献,系统整理归纳了酸枣仁的化学成... 详细信息

酸枣仁主要含有皂苷类、黄酮类、生物碱类、脂肪酸类等成分,具有镇静催眠、抗焦虑、抗抑郁、保护神经、保护心脑血管、保肝、抗氧化等多种活性,广泛应用于医药、食品、保健食品等领域。本文通过查阅文献,系统整理归纳了酸枣仁的化学成分、药理作用及临床应用,以期为酸枣仁资源的可持续开发和合理使用提供理论指导。

关键词：酸枣仁化学成分药理作用临床研究皂苷黄酮生物碱脂肪酸

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新冠病毒感染"乙类甲管"期间定点医院集束化院感防控体系的建设体会

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中华危重病急救医学 2024年第2期36卷 195-201页

作者：杨万杰刘先夺王西墨徐卫国张磊傅强杨积明钱静张富玉田丽张文龙张宇陈征邵世峰王湘耿莉任怡王莹史丽霞万振谢祎刘媛媛于维莉韩晶刘莉朱欢于自江刘宏阳王士梅天津市海河医院天津300350 天津市呼吸疾病研究所天津300350 天津市卫生健康委员会天津300070 天津市第三中心医院天津300170 天津市天津医院天津300211 天津中医药研究院天津300020 天津市第四中心医院天津300140 天津市第二人民医院天津300192 天津市第二人民医院感染管理科天津300192 天津市第三中心医院感染管理科天津300170 天津市第三中心医院护理部天津300170 天津市海河医院感染管理科天津300350 天津市第一中心医院感染管理处天津300192 天津市海河医院护理部天津300350 天津市第一中心医院护理部天津300192 天津市海河医院医务科天津300350 天津市海河医院信息科天津300350 天津市海河医院科教科天津300350 天津市海河医院公共卫生科天津300350 天津市人民医院医务处天津300121 天津市急救中心急救三科天津300011

波及全球的新型冠状病毒感染(新冠病毒感染)疫情持续3年,对人类生命健康和经济活动造成了严重影响。中国的疫情防控经历了应急性超常规防控阶段、应急常态化防控阶段和应急常态化向"乙类乙管"常态化过渡转段阶段,取得了疫情防控重大决... 详细信息

波及全球的新型冠状病毒感染(新冠病毒感染)疫情持续3年,对人类生命健康和经济活动造成了严重影响。中国的疫情防控经历了应急性超常规防控阶段、应急常态化防控阶段和应急常态化向"乙类乙管"常态化过渡转段阶段,取得了疫情防控重大决定性胜利。天津市新冠病毒感染救治定点医院在疫情防控的各阶段均圆满完任务,积累了宝贵经验。本文总结定点医院"乙类甲管"期间院感防控(感控)体系建设经验,概括为集束化"3、2、1"感控体系,即外、中、内"三环",绿、橙、红"三区",前、中、后"三事";"两天预净化"和"双点长制";"一个模块"化管理。应急情况下,可采用简化版的集束化感控体系,其特点为:一是强调"集束化",即关键措施的整体效能,避免任何短板的发生。二是强调感控理念的转变,使感控最大化地为医疗服务提供安全保障。三是强调流程的优化,防控措施既要全面和重点突出,又要防止过度;利用最少的资源,达到最佳的感控效果。四是强调对感控工作的质量控制,关注流程的重要性,提倡"制度瘦身,流程增肥"的理念。五是强调未来的发展寄希望于人工智能,以期最大程度地提高防控质量和效率。六是强化持续的培训和再培训,利用包括人工智能在内的多样化的培训方法,确保感染控制的政策和程序清晰易懂、易于遵循,并建立实施评估和反馈机制,使医务人员随时保持应急状态。

关键词：新冠病毒感染乙类甲管集束化防控体系

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A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

引用

National Science Review 2021年第8期8卷 147-157页

作者： Li zhang Lei Cao Xing-Su Gao Bin-Yang Zheng Yong-qiang Deng jing-Xin Li Rui Feng Qian Bian Xi-Ling Guo Nan Wang hong-Ying Qiu Lei Wang Zhen Cui Qing Ye geng chen Kui-Kui Lu Yin chen Yu-Tao chen hong-Xing Pan Jiaping Yu Wenrong Yao Bao-Li Zhu Jianping chen Yong Liu cheng-Feng Qin Xiangxi Wang Feng-Cai Zhu National Health Commission of the People’s Republic of China Key Laboratory of Enteric Pathogenic Microbiology (Jiangsu Provincial Center for Disease Control and Prevention) Center for Global Health School of Public HealthNanjing Medical University CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of Sciences Guangzhou Regenerative Medicine and Health Guangdong Laboratory Jiangsu Rec-biotechnology Co.Ltd State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology

Mutations and transient conformational movements of the receptor binding domain(RBD) that make neutralizing epitopes momentarily unavailable present immune escape routes for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). To mitigate viral escape, we developed a cocktail of neutralizing antibodies(NAbs) targeting epitopes located on different domains of spike(S) protein. Screening of a library of monoclonal antibodies generated from peripheral blood mononuclear cells of COVID-19 convalescent patients yielded potent NAbs, targeting the N-terminal domain(NTD) and RBD domain of S, effective at n M concentrations. Remarkably, a combination of RBD-targeting NAbs and NTD-binding NAbs, FC05, enhanced the neutralization potency in cell-based assays and an animal model. Results of competitive surface plasmon resonance assays and cryo-electron microscopy(cryo-EM) structures of antigen-binding fragments bound to S unveil determinants of immunogenicity. Combinations of immunogens, identified in the NTD and RBD of S, when immunized in rabbits and macaques, elicited potent protective immune responses against SARS-CoV-2. More importantly, two immunizations of this combination of NTD and RBD immunogens provided complete protection in macaques against a SARS-CoV-2 challenge, without observable antibody-dependent enhancement of infection. These results provide a proof of concept for neutralization-based immunogen design targeting SARS-CoV-2 NTD and RBD.

关键词： SARS-CoV-2 neutralizing antibodies vaccine development structure-based immunogen design

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