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健康中国:“体医结合”至“体医融合”的模式初探

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福建体育科技 2017年第6期36卷 1-3,10页

作者：张鲲杨丽娜张嘉旭陕西师范大学体育学院陕西西安710119

健康中国战略的推行,将体医融合推向了热潮,加快推进体医融合势在必行。运用文献资料、逻辑分析等方法阐释了我国"体医结合"现状,剖析了健康中国视角下"体医融合"的内涵及特征,并分别从"技术融合""资源融合""话语权融合"三方面着手,探... 详细信息

健康中国战略的推行,将体医融合推向了热潮,加快推进体医融合势在必行。运用文献资料、逻辑分析等方法阐释了我国"体医结合"现状,剖析了健康中国视角下"体医融合"的内涵及特征,并分别从"技术融合""资源融合""话语权融合"三方面着手,探索体医融合的发展模式。目前体医结合向体医融合的发展存在思想观念、管理体制、政策资金等障碍,提出:转变思想观念、创新管理体制、加强政策扶持、加大资金投入等建议,为"体医融合"良性发展提供有力保障。

关键词：健康中国体医结合体医融合模式

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基于深度强化学习的无地图移动机器人导航

控制与决策 2024年第3期39卷 985-993页

作者：户高铭蔡克卫王芳康玉伟张家旭金兆一林远山大连海洋大学信息工程学院辽宁大连116023 大连海洋大学设施渔业教育部重点实验室辽宁大连116023 辽宁省海洋信息技术重点实验室辽宁大连116023 大连民族大学机电工程学院辽宁大连116023

针对传统导航方法对地图精度依赖和动态复杂场景适应差问题,提出一种基于课程学习的深度强化学习无地图自主导航算法.为了克服智能体稀疏奖励情况下学习困难的问题,借鉴课程学习思想,提出一种基于能力圈课程引导的深度强化学习训练方法... 详细信息

针对传统导航方法对地图精度依赖和动态复杂场景适应差问题,提出一种基于课程学习的深度强化学习无地图自主导航算法.为了克服智能体稀疏奖励情况下学习困难的问题,借鉴课程学习思想,提出一种基于能力圈课程引导的深度强化学习训练方法.此外,为了更好地利用机器人当前的碰撞信息辅助机器人做动作决策,引入碰撞概率的概念,将机器人当前感知到的障碍物信息以一种高层语义的形式进行表示,并将其作为导航策略输入的一部分编码至机器人当前观测中,以简化观测到动作的映射,进一步降低学习的难度.实验结果表明,所提出的课程引导训练和碰撞概率可令导航策略收敛速度明显加快,习得的导航策略在空间更大的场景成功率到达90%以上,行驶耗时减少53.5%73.1%,可为非结构化未知环境下的无人化作业提供可靠导航.

关键词：移动机器人自主导航无地图导航深度强化学习课程学习

双电磁铁比例方向阀零位位置控制死区补偿方法研究

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机电工程 2019年第3期36卷 262-266页

作者：张佳旭俞亚新翁之旦金波郭强浙江理工大学机械与自动控制学院浙江杭州310018 宁波华液机器制造有限公司浙江宁波315153 浙江大学机械工程学院浙江杭州310027

针对双电磁铁驱动并带有阀心位置传感器的比例方向阀位置控制在零位存在死区的问题,运用Simulink对阀心位置控制系统进行了建模,对零位死区的形成原因进行了研究。通过仿真,对形成零位死区的各个影响因素对死区时间的影响程度进行了分析... 详细信息

针对双电磁铁驱动并带有阀心位置传感器的比例方向阀位置控制在零位存在死区的问题,运用Simulink对阀心位置控制系统进行了建模,对零位死区的形成原因进行了研究。通过仿真,对形成零位死区的各个影响因素对死区时间的影响程度进行了分析;基于不同的影响因素,提出了零位电流阶跃与衰减式位置指令跳跃的补偿策略;比较了该控制策略与其他控制方法对阀心位置的控制性能,最后通过实验进行了验证。研究结果表明:采用该位置控制补偿策略可以有效地消除由于系统非线性和时变性所带来的比例方向阀的零位位置控制死区,改善了阀心位置的响应波形。

关键词：零位位置死区位置补偿电流阶跃比例方向阀阀心

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

网格因素对水陆两栖飞机着水性能计算结果的影响

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船海工程 2021年第4期50卷 10-13页

作者：胡奇王明振吴彬张家旭黄淼中国特种飞行器研究所高速水动力航空科技重点实验室湖北荆门448035

为了准确预报水陆两栖飞机着水性能,采用有限体积法和重叠网格技术,根据网格划分特点,分析第一层网格节点高度、船体表面网格尺寸及重叠网格大小等网格因素对水陆两栖飞机着水性能计算结果的影响,将不同网格划分方法得到的垂向加速度、... 详细信息

为了准确预报水陆两栖飞机着水性能,采用有限体积法和重叠网格技术,根据网格划分特点,分析第一层网格节点高度、船体表面网格尺寸及重叠网格大小等网格因素对水陆两栖飞机着水性能计算结果的影响,将不同网格划分方法得到的垂向加速度、姿态角与模型试验结果进行对比,得出精度较好的着水仿真计算的网格参数。

关键词：水陆两栖飞机着水性能重叠网格网格因素

Deciphering Water Oxidation Catalysts: The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： An, Li Li, jianyi Sun, Yuanmiao Zhu, jiamin Seow, Justin Zhu Yeow zhang, Hong zhang, Nan Xi, Pinxian xu, Zhichuan J. Yan, Chun-Hua Lanzhou Univ Frontiers Sci Ctr Rare Isotopes Key Lab Nonferrous Met Chem & Resources Utilizat G State Key Lab Appl Organ ChemColl Chem & Chem Eng Lanzhou 730000 Peoples R China Nanyang Technol Univ Sch Mat Sci & Engn Singapore 639798 Singapore Chinese Acad Sci Fac Mat Sci & Energy Engn Shenzhen Inst Adv Technol Inst Technol Carbon Neutral Shenzhen 518055 Peoples R China Yunnan Univ Natl Ctr Int Res Photoelect & Energy Mat Electron Microscopy Ctr Sch Mat & EnergyKey Lab Electromagnet Mat & Devic Kunming 650091 Peoples R China Baotou Res Inst Rare Earths State Key Lab Baiyunobo Rare Earth Resource Res & Baotou 014030 Peoples R China Peking Univ Beijing Natl Lab Mol Sci State Key Lab Rare Earth Mat Chem & Applicat PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Chem Beijing 100871 Peoples R China

Demonstrate that the key factor to determine the activity of reconstructed surfaces is the surface chemistry, instead of reconstruction degree using the popular perovskite LaNi1-xFexO3 oxides as model *** content can influence both the surface reconstruction degree, the activation degree, and the activity of reconstructed *** oxygen evolution reaction activity of reconstructed catalysts is primarily governed by the chemistry of the reconstructed surface species. Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution reaction. The surface reconstruction has been widely observed in perovskite catalysts, and the reconstruction degree has been often correlated with the activity enhancement. Here, a systematic study on the roles of Fe substitution in activation of perovskite LaNiO3 is reported. The substituting Fe content influences both current change tendency and surface reconstruction degree. LaNi0.9Fe0.1O3 is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi1-xFexO3 (x = 0.00, 0.10, 0.25, 0.50, 0.75, 1.00) series. The reconstructed LaNi0.9Fe0.1O3 shows a higher intrinsic activity than most reported NiFe-based catalysts. Besides, density functional theory calculations reveal that Fe substitution can lower the O 2p level, which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term stability. Furthermore, it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction degree. The effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface reconstruction. This finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

Application of Continuous Compaction Technology in the Quality Control and Acceptance of High-Speed Railway Subgrade

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Journal of Southwest jiaotong University(English Edition) 2010年第3期18卷 196-200页

作者：张家玲徐光辉蔡英 MOE Key Laboratory of High-Speed Railway Engineering Southwest Jiaotong University

On the basis of the theory of continuous compaction technology, we put forward the vibratory compaction value （VCV） index measured by a roller compactor, in order to evaluate the quality of continuously compacted subgrade. The relationships between the VCV index and the currently used indexes K30, Evd, Ev1 and Ev2, were explored by analyzing the experimental data collected from two test sections on the Beijing - Shanghai High-Speed Railway. The result shows that the VCV index has a linear relationship with the currently used indexes.

关键词： Continuous compaction control technology Compaction quality Vibratory compaction value Control and accoptanc~

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未知参数最大权条件及其在天体测量中的应用

天文学报 1984年第1期 82-85页

作者：张挥徐家岩中国科学院陕西天文台

本文论证了最小二乘法中未知参数最大权条件并给出应用于天体测量中确定最佳观测条件的简化方法的实例。

关键词：最大值天体测量天文技术基本方程最小二乘法最小二乘算法计算方法未知参数

Advances in the Development of Gradient Scaffolds Made of Nano-Micromaterials for Musculoskeletal Tissue Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-46页

作者： Fang, Lei Lin, Xiaoqi xu, Ruian Liu, Lu zhang, Yu Tian, Feng Li, jiao jiao xue, jiajia Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Beijing 100029 Peoples R China Univ Technol Sydney Fac Engn & IT Sch Biomed Engn Sydney NSW 2007 Australia

This review highlights the gradient variations in the structural composition of musculoskeletal tissues and comprehensively examines recent progress in the fabrication and application of biomimetic gradient scaffolds for musculoskeletal *** challenges and prospects of gradient scaffolds for clinical application are discussed. The intricate hierarchical structure of musculoskeletal tissues, including bone and interface tissues, necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered substitutes. This has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic outcomes. Building on the anatomical characteristics of bone and interfacial tissues, this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues, specifically focusing on methods used to construct compositional and structural gradients within the scaffolds. The latest applications of gradient scaffolds for the regeneration of bone, osteochondral, and tendon-to-bone interfaces are presented. Furthermore, the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed, as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration