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Unexpected/contrary behavior of aerosol mass concentration in response to the individual components'concentration reduction in Kitakyushu,Japan

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Journal of Environmental Sciences 2024年第1期135卷 630-639页

作者： xi zhang Takuya Murakami Jinhe Wang Masahide Aikawa Faculty of Environmental Engineering The University of Kitakyushu1-1HibikinoWakamatsuKitakyushuFukuoka 808-0135Japan Resources and Environment Innovation Research Institute School of Municipal and Environmental EngineeringShandong Jianzhu UniversityJinan 250101China

In the suburbs of Kitakyushu,Japan,the inorganic aerosol mass concentration(IAM)was about 32.7μg/m^(3),with the aerosol pH of *** study the thermodynamics of aerosol when its individual components'concentration is reduced,sensitive tests were performed using the ISORROPIAⅡmodel,in which the seven control species—TNaCl,TNH_(4)^(+),TSO_(4)^(2-),TNO_(3)^(-),TMg^(2+),TK^(+),and TCa^(2+)—were taken into *** and inorganic aerosol pH after reducing TNaCl,TNO_(3)^(-),TMg^(2+),TK^(+),and TCa^(2+)responded linearly(0%≤concentration reduction ratio(CRR)≤100%,with the exception of 100%in TNaCl);the nonlinear variations of these two parameters could be observed by controlling TNH_(4)^(+)and TSO_(4)^(2-).Unexpected aerosol behavior occurred at 100%reduction of TNaCl,which was caused by the sudden increase of NO_(3)^(-),NH_(4)^(+),and aerosol liquid water content(ALWC);the increase of IAM was also observed after controlling TSO_(4)^(2-)(60%≤CRR≤100%)and TCa^(2+)(0%≤CRR≤100%),which was mainly related to the variation of ALWC driven by the response of CaSO_(4).Multiple regression analysis showed that ALWC was statistically and strongly related to the variations of NO_(3)^(-),Cl-,SO_(4)^(2-),HSO_(4)^(-),HNO_(3),and NH_(3)(P<0.05),with regression coefficients of 1.68,5.23,1.83,2.81,0.34,and 0.57,*** highest coefficient(5.23)was found for Cl^(-),revealing that sea salts significantly influenced particle ***,this study comprehensively investigated aerosol characteristics and inner responses for the reduction of components,which is of great significance for a better understanding of atmospheric chemistry in Kitakyushu,Japan.

关键词： Sensitive tests Reduction Gas-particle conversion process Aerosol liquid water content Sea salts

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Identification of human microRNA-disease association via low-rank approximation-based link propagation and multiple kernel learning

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Frontiers of Computer Science 2024年第2期18卷 217-229页

作者： Yizheng WANG xin zhang ying JU Qing LIU Quan ZOU Yazhou zhang Yijie DING ying zhang Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Yangtze Delta Region Institute(Quzhou) University of Electronic Science and Technology of ChinaQuzhou 324000China Beidahuang Industry Group General Hospital Harbin 150088China School of Informatics Xiamen UniversityXiamen 361005China Department of Anesthesiology Hospital(T.C.M)Affiliated to Southwest Medical UniversityLuzhou 646000China Software Engineering College Zhengzhou University of Light IndustryZhengzhou 450002China

Numerous studies have demonstrated that human microRNAs(miRNAs)and diseases are associated and studies on the microRNA-disease association(MDA)have been *** developed a model using a low-rank approximation-based link propagation algorithm with Hilbert–Schmidt independence criterion-based multiple kernel learning(HSIC-MKL)to solve the problem of the large time commitment and cost of traditional biological experiments involving miRNAs and diseases,and improve the model *** constructed three kernels in miRNA and disease space and conducted kernel fusion using *** propagation uses matrix factorization and matrix approximation to effectively reduce computation and time *** results of the experiment show that the approach we proposed has a good effect,and,in some respects,exceeds what existing models can do.

关键词： human miRNA-disease association multiple kernel learning link propagation miRNA similarity disease similarity

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The Mechanics of Tumor Cells Dictate Malignancy via Cytoskeleton-Mediated APC/Wnt/β-Catenin Signaling

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Research 2024年第2期2023卷 659-673页

作者： xi Chen Zichen Xu Kai Tang Guanshuo Hu Pengyu Du Junfang Wang Cunyu zhang ying xin Keming Li Qiantang zhang Jianjun Hu Zhuxue zhang Mo Yang Guixue Wang Youhua Tan The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen518057China Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular ImplantsBioengineering College of Chongqing UniversityChongqing400030China Research Institute of Smart Ageing The Hong Kong Polytechnic UniversityHong KongChina Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Pathology Guizhou Provincial People's HospitalGuiyangGuizhou550002China

Tumor cells progressively remodel cytoskeletal structures and reduce cellular stiffness during tumor progression,implicating the correlation between cell mechanics and ***,the roles of tumor cell cytoskeleton and the mechanics in tumor progression remain incompletely *** report that softening/stiffening tumor cells by targeting actomyosin promotes/suppresses self-renewal in vitro and tumorigenic potential in ***/strengthening actin cytoskeleton impairs/reinforces the interaction between adenomatous polyposis coli(APC)andβ-catenin,which facilitatesβ-catenin nuclear/cytoplasmic ***β-catenin binds to the promoter of Oct4,which enhances its transcription that is crucial in sustaining self-renewal and *** results demonstrate that the mechanics of tumor cells dictate self-renewal through cytoskeleton-APC-Wnt/β-catenin-Oct4 signaling,which are correlated with tumor differentiation and patient *** study unveils an uncovered regulatory role of cell mechanics in self-renewal and malignancy,and identifies tumor cell mechanics as a hallmark not only for cancer diagnosis but also for mechanotargeting.

关键词： diagnosis skeleton APC

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Genetic Analysis of Two Novel GPI Variants Disrupting H Bonds and Localization Characteristics of 55 Gene Variants Associated with Glucose-6-phosphate Isomerase Deficiency

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Current Medical Science 2024年第2期44卷 426-434页

作者： Bi-xin xi Si-ying LIU Yu-ting XU De-dong zhang Qun HU Ai-guo LIU Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Glucose-6-phosphate isomerase(GPI)deficiency is a rare hereditary nonspherocytic hemolytic anemia caused by GPI gene *** disorder exhibits wide heterogeneity in its clinical manifestations and molecular characteristics,often posing challenges for precise diagnoses using conventional *** this end,this study aimed to identify the novel variants responsible for GPI deficiency in a Chinese ***:The clinical manifestations of the patient were summarized and analyzed for GPI deficiency phenotype *** compound heterozygous variants of the GPI gene,c.174C>A(***58Lys)and c.1538G>T(***513Leu),were identified using whole-exome and Sanger *** AlphaFold program and Chimera software were used to analyze the effects of compound heterozygous variants on GPI ***:By characterizing 53 GPI missense/nonsense variants from previous literature and two novel missense variants identified in this study,we found that most variants were located in exons 3,4,12,and 18,with a few localized in exons 8,9,and *** study identified novel compound heterozygous variants associated with GPI *** pathogenic variants disrupt hydrogen bonds formed by highly conserved GPI amino ***:Early family-based sequencing analyses,especially for patients with congenital anemia,can help increase diagnostic accuracy for GPI deficiency,improve child healthcare,and enable genetic counseling.

关键词： glucose-6-phosphate isomerase deficiency whole-exome sequencing compound heterozygous variants genetic characterization hydrogen bond

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Microscale spherical TiO_(2)powder prepared by hydrolysis of TiCl_(4)solution:Synthesis and kinetics

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Particuology 2024年第1期84卷 60-71页

作者： Peiyi Yan ying zhang Shili Zheng School of Rare Earths University of Science and Technology of ChinaHefei230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341119China Key Laboratory of Green Process and Engineering National Engineering Research Center of Green Recycling for Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing100190China State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization Panzhihua617000China

Hydrolysis of TiCl_(4)solution is capable of preparing microscale TiO_(2)*** research studied the synthesis of microscale spherical TiO_(2)powders and the hydrolysis *** effects of the flow field generated by different agitators and baffles in the crystallizer,the initial free acid concentration,the initial equivalent TiO_(2)concentration,and the temperature on the hydrolysis progress and powder morphology were systematically *** results show that the flow field in a crystallizer can significantly affect the morphology and particle size of the powders,and the axial flow can improve the sphericity of the *** increased free HCl and equivalent TiO_(2)concentrations in the pregnant solution inhibit the forward hydrolysis reaction,prolong the time to reach equilibrium,and reduce the *** appropriate temperature matching the compositions of the pregnant solution is crucial for the powder morphology and *** with sizes ranging from around 5 um-40μm can be tuned under controlled flow field,solution compositions,and temperature *** addition,the Cheng and Wunderlich modified Avrami equation was used for the crystallization kinetic *** effects of the free HCl concentration,equivalent TiO_(2)concentration,and hydrolysis temperature are reflected in the reaction rate constant and active nuclei reduction *** the free HCl and equivalent TiO_(2)concentrations will reduce the reaction rate constant and accelerate the deactivation of the active nuclei,thus increasing the final powder size,while increasing the temperature will lead to the opposite results.

关键词： TiCl_(4) Hydrolysis Microscale TiO_(2) Spherical Kinetics

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“Blocking and rebalance” mechanism-guided design strategies of bimetallic doped 2D a-phosphorus carbide as efficient catalysts for N2 electroreduction

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Journal of Energy Chemistry 2024年第10期97卷 68-78页

作者： Cheng He Jianglong Ma Shen xi Wenxue zhang State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and Engineering Xi'an Jiaotong University School of Materials Science and Engineering Chang'an University

Compared to single atom catalysts（SACs）,the introduction of dual atom catalysts（DACs） has a significantly positive effect on improving the efficiency in the electrocatalytic nitrogen reduction reaction（NRR） which provides an environmental alternative to the Haber-Bosch ***,the research on the mechanism and strategy of designing bimetallic combinations for better performance is still in its early ***,based on "blocking and rebalance" mechanism,45 combinations of bimetallic pair doped α-phosphorus carbide（TMATMB@PC） are investigated as efficient NRR catalysts through density functional theory and machine learning *** a multi-step screening,the combinations of TiV,TiFe,MnMo,and FeW exhibit highly efficient catalytic performance with significantly lower limiting potentials（-0.17,-0.18,-0.14,and-0.30 V,respectively）.Excitingly,the limiting potential for CrMo and CrW combinations is 0 V,which are considered to be extremely suitable for the NRR *** mechanism of "blocking and rebalance" is revealed by the exploration of charge transfer for phosphorus atoms in electron blocking ***,the descriptor φ is proposed with machine learning,which provides design strategies and accurate prediction for finding efficient *** work not only offers promising catalysts TMATMB@PC for NRR process but also provides design strategies by presenting the descriptor φ.

关键词： 2D α-phosphorus carbide DACs Inherent attributes Machine learning Nitrogen reduction reaction

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Gene therapy for monogenic disorders: challenges, strategies, and perspectives

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Journal of Genetics and Genomics 2024年第2期51卷 133-143页

作者： Yi zhang Zhi-ying Wu Department of Medical Genetics and Center for Rare Diseases Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key Laboratory of Medical Neurobiology of Zhejiang Province HangzhouZhejiang 310009China

Monogenic disorders refer to a group of human diseases caused by mutations in single genes. While disease-modifying therapies have offered some relief from symptoms and delayed progression for some monogenic diseases, most of these diseases still lack effective treatments. In recent decades, gene therapy has emerged as a promising therapeutic strategy for genetic disorders. Researchers have developed various gene manipulation tools and gene delivery systems to treat monogenic diseases. Despite this progress, concerns about inefficient delivery, persistent expression, immunogenicity, toxicity, capacity limitation, genomic integration, and limited tissue specificity still need to be addressed. This review gives an overview of commonly used gene therapy and delivery tools, along with the challenges they face and potential strategies to counter them.

关键词： Gene therapy Monogenic diseases Geneediting Genedelivery Challenges

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Effect of Mn Addition and Heat Treatment on the Corrosion Behaviour of Mg-Ag-Mn Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 665-677页

作者： You Lv Yupeng zhang xi Liu Zehua Dong xiaorong Zhou xinxin zhang Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Material Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China Hubei Engineering Research Centre for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan430074China Corrosion and Protection Centre Department of MaterialsThe University of ManchesterManchesterM139PLUK

The high corrosion sensitivity and the potential bio-toxicity of Mg-Ag alloys limit their wide applications for the production of implanted devices. In the present work, Mn is added into the Mg-Ag alloy to optimize its corrosion behaviour. The corrosion behaviour of Mg-Ag-Mn alloys is investigated with the underlying microstructural factors examined. The Mg-Ag alloy with 2 wt% Mn exhibits the highest corrosion resistance after post-casting heat treatment at 440 ℃. The addition of Mn results in α-Mn phase with the incorporation of Fe, which suppresses the cathodic activity of impurity Fe. Further, heat treatment of the cast alloys homogenizes the distribution of Ag and promotes the precipitation of α-Mn phase. The former removes Ag segregations as potential cathodes;the latter promotes a more uniform distribution of cathodes and, therefore, prevents localized corrosion.

关键词： Mg-Ag alloy Mn addition Post-casting heat treatment Cathodic activity Corrosion mechanism

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Characterization of cerebrovascular changes in Alzheimer's disease mice by photoacoustic imaging

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Journal of Innovative Optical Health Sciences 2024年第6期17卷 29-40页

作者： xi Li Zhongyang zhang Hua Shi Feifan Zhou Key Laboratory of Biomedical Engineering of Hainan Province School of Biomedical Engineering Hainan University Sanya 572025P.R.China

The cerebral vasculature plays a significant role in the development of Alzheimer's disease(AD),however,the specific association between them remains *** this paper,based on the benefits of photoacoustic imaging(PAI),including label-free,high-resolution,in vivo imaging of vessels,we investigated the structural changes of cerebral vascular in wild-type(WT)mice and AD mice at different ages,analyzed the characteristics of the vascular in different brain regions,and correlated vascular characteristics with cognitive *** results showed that vascular density and vascular branching index in the cortical and frontal regions of both WT and AD mice decreased with ***,vascular lacunarity increased with age,and the changes in vascular structure were more pronounced in AD *** trend of vascular dysfunction aligns with the worsening cognitive dysfunction as the disease ***,we utilized in vivo PAI to analyze the changes in vascular structure during the progression of AD,elucidating the spatial and temporal correlation with cognitive impairment,which will provide more intuitive data for the study of the correlation between cerebrovascular and the development of AD.

关键词： Photoacoustic imaging Alzheimer's disease cerebrovascular vascular network cognitive impairment.

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A state-of-the-art review of the development of self-healing concrete for resilient infrastructure

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 151-169页

作者： Dong LU xi JIANG Yao zhang Shaowei zhang Guoyang LU Zhen LENG Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China Laboratory of Fire Safety School of Safety Engineering and Emergency ManagementShijiazhuang Tiedao UniversityShijiazhuang 050043China Department of Architecture and Civil Engineering City University of Hong KongHong Kong 999077China

The brittleness of cement composites makes cracks almost inevitable,producing a serious limitation on the lifespan,resilience,and safety of concrete *** address this brittleness,self-healing concrete has been developed for regaining its mechanical and durability properties after becoming cracked,thereby promising sustainable development of concrete *** paper provides a comprehensive review of the latest developments in self-healing *** begins by summarizing the methods used to evaluate the self-healing efficiency of ***,it compares strategies for achieving healing *** then discusses the typical approaches for developing self-healing ***,critical insights are proposed to guide future studies on the development of novel self-healing *** review will be useful for researchers and practitioners interested in the field of self-healing concrete and its potential to improve the durability,resilience,and safety of concrete infrastructure.

关键词： resilient infrastructure sustainable concrete self-healing cracks

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