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FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation

Science China Life Sciences 2025年

作者： Dake Xiao Haowen Ran Lishu Chen Yuanyuan Li Yan Cai Songyang zhang Qinghui Qi Huiran Wu cheng zhang Shuailiang Cao Lanjuan Mi Haohao Huang Ji Qi Qiuying Han Haiqing Tu Huiyan Li Tao Zhou Fangye Li Ailing Li Jianghong Man Nanhu Laboratory National Center of Biomedical Analysis School of Traditional Chinese Medicine Capital Medical University Department of Neurosurgery General Hospital of Central Theater Command of Chinese PLA School of Life and Health Sciences Huzhou College Department of Neurosurgery Beijing Fengtai Hospital Department of Neurosurgery First Medical Center of PLA General Hospital

The infiltration of glioblastoma multiforme(GBM) is predominantly characterized by diffuse spread, contributing significantly to therapy resistance and recurrence of GBM. In this study, we reveal that microtubule deacetylation, mediated through the downregulation of fibronectin type III and SPRY domain-containing 1(FSD1), plays a pivotal role in promoting GBM diffuse infiltration. FSD1 directly interacts with histone deacetylase 6(HDAC6) at its second catalytic domain, thereby impeding its deacetylase activity on α-tubulin and preventing microtubule deacetylation and depolymerization. This inhibitory interaction is disrupted upon phosphorylation of FSD1 at its Ser317 and Ser324 residues by activated CDK5, leading to FSD1 dissociation from microtubules and facilitating HDAC6-mediated α-tubulin deacetylation. Furthermore, increased expression of FSD1 or interference with FSD1 phosphorylation reduces microtubule deacetylation, suppresses invasion of GBM stem cells, and ultimately mitigates tumor infiltration in orthotopic GBM xenografts. Importantly, GBM tissues exhibit diminished levels of FSD1 expression, correlating with microtubule deacetylation and unfavorable clinical outcomes in GBM patients. These findings elucidate the mechanistic involvement of microtubule deacetylation in driving GBM cell invasion and offer potential avenues for managing GBM infiltration.

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When AI meets sustainable 6G

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Science China(Information Sciences) 2025年第1期 4-22页

作者： Xiaohu YOU Yongming HUANG cheng zhang Jiaheng WANG Hao YIN Hequan WU National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories Chinese Academy of Military Science China Information Communication Technologies Group

Sixth-generation(6G) networks are anticipated to achieve transformative advancements, characterized by extreme connectivity, deep integration with artificial intelligence(AI) and sensing, and airground integration. The evolution of 6G exhibits two major trends: ubiquitous intelligence and sustainability. The former aims to embed state-of-the-art AI technology into the 6G network, from the physical layers to applications, while the latter emphasizes reducing energy consumption while enhancing network performance to address environmental concerns. Despite the amazing progress in recent years, AI advancements come with substantial increases in data and computational overhead, posing critical challenges for integrating AI into sustainable 6G networks. First, high energy consumption from large datasets and heavyweight AI models contradicts6G's green goals. Second, the precise collection of large datasets, message delivery latency, and inference delays in AI models pose challenges for real-time tasks in 6G. Third, the uninterpretability and unpredictability of AI models complicate meeting the stringent requirements for controllable transmission in dynamic wireless environments. Addressing these challenges and achieving sustainable 6G with ubiquitous intelligence calls for a revolutionary design of 6G architecture and AI frameworks. To this end, this paper introduces a novel and practical methodology for green, real-time, and controllable 6G native intelligence,starting with knowledge graph(KG) analysis to extract small but critical datasets, followed by the development of distributed lightweight AI models, and the use of digital twins(DTs) to create precise replicas of physical 6G networks. This leads to a pervasive multi-level(PML)-AI framework supported by a task-centric, three-layer 6G architecture. The AI framework operates through non-real-time and real-time cycles, leveraging three key technologies: wireless data KGs for efficient data management,lightweight AI mode

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Mapping impervious surfaces with a hierarchical spectral mixture analysis incorporating endmember spatial distribution

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Geo-Spatial Information Science 2022年第4期25卷 550-567页

作者： Zhenfeng Shao Yuan zhang cheng zhang Xiao Huang Tao cheng State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhanChina Department of Geosciences University of ArkansasFayettevilleARUSA

Impervious surface mapping is essential for urban environmental *** Mixture Analysis(SMA)and its extensions are widely employed in impervious surface estimation from medium-resolution *** SMA,inappropriate endmember combinations and inadequate endmember classes have been recognized as the primary reasons for estimation ***,the spectral-only SMA,without considering urban spatial distribution,fails to consider spectral variability in an adequate *** lack of endmember class diversity and their spatial variations lead to over/*** mitigate these issues,this study integrates a hierarchical strategy and spatially varied endmember spectra to map impervious surface abundance,taking Wuhan and Wuzhou as two study ***,the piecewise convex multiple-model endmember detection algorithm is applied to automatically hierarch-ize images into three regions,and distinct endmember combinations are independently developed in each ***,spatially varied endmember spectra are synthesized through neighboring spectra using the distance-based *** analysis indicates that the proposed method achieves better performance than Hierarchical SMA and Fixed Four-endmembers SMA in terms of MAE,SE,and *** analysis suggests that the hierarch-ical strategy can expand endmember class types and considerably improve the performance for the study areas in general,specifically in less developed ***,we find that spatially varied endmember spectra facilitate the reduction of heterogeneous surface material variations and achieve the improved performance in developed areas.

关键词： Impervious surface Spectral Mixture Analysis(SMA) hierarchical strategy endmember class spatially varied endmember spectra

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Hall Algebras Associated to Complexes of Fixed Size

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Acta Mathematica Sinica,English Series 2022年第5期38卷 907-923页

作者： Hai cheng zhang School of Mathematical Sciences Nanjing Normal UniversityNanjing 210023P.R.China

Let A be a finitary hereditary abelian category with enough *** study the Hall algebra of complexes of fixed size over ***,we first give a relation between Hall algebras of complexes of fixed size and cyclic ***,we characterize the Hall algebra of complexes of fixed size by generators and relations,and relate it to the derived Hall algebra of ***,we give the integration map on the Hall algebra of 2-term complexes over projectives.

关键词： Bridgeland Hall algebra derived Hall algebra complex of fixed size

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Real-time reconfigurable metasurfaces enabling agile terahertz wave front manipulation

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Light(Science & Applications) 2023年第12期12卷 2551-2553页

作者： Huixian Zhou cheng zhang School of Optical and Electronic Information&Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China

Real-time controlled programmable metasurfaces,having an array-of-subarrays architecture under the control of one-bit digital coding sequence,are demonstrated for rapid and precise multifunctional Terahertz wave front... 详细信息

关键词： reconfigurable wave arrays

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Vector NLS solitons interacting with a boundary

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Communications in Theoretical Physics 2021年第4期73卷 45-51页

作者： cheng zhang Da-jun zhang Department of Mathematics Shanghai UniversityShanghai200444China

We construct multi-soliton solutions of the n-component vector nonlinear Schrödinger equation on the half-line subject to two classes of integrable boundary conditions(BCs):the homogeneous Robin BCs and the mixed Neumann/Dirichlet *** construction is based on the so-called dressing the boundary,which generates soliton solutions by preserving the integrable BCs at each step of the Darboux-dressing *** the Robin BCs,examples,including boundary-bound solitons,are explicitly derived;under the mixed Neumann/Dirichlet BCs,the boundary can act as a polarizer that tunes different components of the vector *** of our construction to the inverse scattering transform is also provided.

关键词： polarizer effect solitons on the half-line vector nonlinear Schrödinger equation integrable boundary conditions boundary-bound states

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Effect of Stress Ratio on the Fatigue Crack Propagation Behavior of the Nickel-based GH4169 Alloy

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Acta Metallurgica Sinica(English Letters) 2017年第9期30卷 809-821页

作者： Shen Ye Jian-Guo Gong Xian-cheng zhang Shan-Tung Tu cheng-cheng zhang Key Laboratory of Pressure Systems and Safety Ministry of EducationSchool of Mechanical and Power EngineeringEast China University of Science and TechnologyMeilongRoad 130Xuhui DistrictShanghai 200237People'sRepublic of China AECC Commercial Aircraft Engine Co.LTD ShanghaiEngineering Research Center for Commercial Aircraft EngineShanghai 201108People's Republic of China

The fatigue crack growth behavior of the newly developed GH4169 nickel-based alloy at a maximum stress of 700 MPa and different stress ratios was investigated in the present work employing the specimens with a single micro- notch at a frequency of 129 Hz at room temperature. The results demonstrate a typical three-stage process of fatigue crack propagation processing from the microstructurally small crack （MSC） stage to the physically small crack （PSC） stage, and finally to the long crack stage. The crack growth rate in the MSC stage is relatively high, while the crack growth rate in the PSC stage is relatively low. A linear function of crack-tip reversible plastic zone size was proposed to predict the crack growth rate, indicating an adequate prediction solution.

关键词： Fatigue crack Crack growth rate Stress ratio Nickel-based alloy

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Low-cycle fatigue life prediction of a polycrystalline nickel-base superalloy using crystal plasticity modelling approach

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Journal of Materials Science & Technology 2020年第3期38卷 28-38页

作者： Guang-Jian Yuan Xian-cheng zhang Bo Chen Shan-Tung Tu cheng-cheng zhang Key Laboratory of Pressure Systems and Safety Ministry of EducationSchool of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237China The Institute for Advanced Manufacturing and Engineering Faculty of EngineeringEnvironment and ComputingCoventry UniversityCoventry CV65LZUK AECC Commercial Aircraft Engine Co.LTD Shanghai Engineering Research Center for Commercial Aircraft EngineShanghai 201108China

A crystal plasticity model is developed to predict the cyclic plasticity during the low-cycle fatigue of GH4169 *** plastic slip and energy dissipation as fatigue indicator parameters(FIPs)are used to predict fatigue crack initiation and the fatigue life until *** show that fatigue damage is most likely to initiate at triple points and grain boundaries where severe plastic slip and energy dissipation are *** predicted fatigue life until failure is within the scatter band of factor 2 when compared with experimental data for the total strain amplitudes ranging from 0.8%to 2.4%.Microscopically,the adjacent grain arrangements and their interactions account for the stress *** addition,different sets of grain orientations with the same total grain numbers of 150 were generated using the present *** show that different sets have significant influence on the distribution of stresses between each individual grain at the meso-scale,although little effect is found on the macroscopic length-scale.

关键词： Crystal plasticity Fatigue Finite element Life prediction Micro-mechanics Nickel-base superalloy

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非厄米PT对称多通道光波导体系的调控及动力学

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原子与分子物理学报 2025年第1期42卷 108-117页

作者：孙武叶伏秋张光成吉首大学物理与机电工程学院吉首416000

宇称-时间(PARITY-TIME PT)对称光学波导系统中有关PT对称性的调控主要通过周期性变化的复折射率材料来实现.本文中我们给出了一种对于已耦合的双通道波导体系中额外引入周期调制的中性波导操纵PT对称性的构型,通过高频近似将系统转换... 详细信息

宇称-时间(PARITY-TIME PT)对称光学波导系统中有关PT对称性的调控主要通过周期性变化的复折射率材料来实现.本文中我们给出了一种对于已耦合的双通道波导体系中额外引入周期调制的中性波导操纵PT对称性的构型,通过高频近似将系统转换为重整化参数后的等效未调制系统后,发现可以通过额外引入单频周期调制的光波导去调控体系的PT对称性,并且讨论了周期调制的非厄米三通道波导体系的能谱特性.最后通过解析和数值的方法给出了光在非厄米三通道光学波导中的动力学演化.

关键词： PT对称非厄米三通道波导

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Toxic effects of acetochlor, methamidophos and their combination on nifH gene in soil

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Journal of Environmental Sciences 2007年第7期19卷 864-873页

作者： SU Zhen-cheng zhang Hui-wen LI Xin-yu zhang Qin zhang cheng-gang Key Laboratory of Terrestrial Ecological Process Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China. Graduate School of the Chinese Academy of Sciences Beijing 100039 China

Toxic effects of two agrochemicals on nifH gene in agricultural black soil were investigated using denaturing gradient gel electrophoresis （DGGE） and sequencing approaches in a microcosm experiment. Changes of soil nifH gene diversity and composition were examined following the application of acetochlor, methamidophos and their combination. Acetochlor reduced the nifH gene diversity （both in gene richness and diversity index values） and caused changes in the nifH gene composition. The effects of acetochlor on nifH gene were strengthened as the concentration of acetochlor increased. Cluster analysis of DGGE banding patterns showed that nifH gene composition which had been affected by low concentration of acetochlor （50 mg/kg） recovered firstly. Methamidophos reduced nifH gene richness that except at 4 weeks. The medium concentration of methamidophos （150 mg/kg） caused the most apparent changes in nifH gene diversity at the first week while the high concentration of methamidophos （250 mg/kg） produced prominent effects on nifH gene diversity in the following weeks. Cluster analysis showed that minimal changes of nifH gene composition were found at 1 week and maximal changes at 4 weeks. Toxic effects of acetochlor and methamidophos combination on nifH gene were also apparent. Different nifH genes （bands） responded differently to the impact of agrochemicals： four individual bands were eliminated by the application of the agrochemicals, five bands became predominant by the stimulation of the agrochemicals, and four bands showed strong resistance to the influence of the agrochemicals. Fifteen prominent bands were partially sequenced, yielding 15 different nifH sequences, which were used for phylogenetic reconstructions. All sequences were affiliated with the alpha- and beta-proteobacteria, showing higher similarity to eight different diazotrophic genera.

关键词： agrochemicals acetochlor methamidophos toxic effects nifH gene PCR-DGGE

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