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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li zhang Zheng gang zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

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Tunability of Band Gaps in Two-Dimensional Phononic Crystals with Magnetorheological and Electrorheological Composites

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Acta Mechanica Solida Sinica 2021年第1期34卷 40-52页

作者： gang zhang Yuanwen Gao Key Laboratory of Mechanics on Environment and Disaster in Western China The Ministry of Education of ChinaLanzhou UniversityLanzhou730000China Department of Mechanics and Engineering Science College of Civil Engineering and MechanicsLanzhou UniversityLanzhou730000China

The elastic wave propagation properties of phononic crystals(PnCs)composed of an elastic matrix embedded in magnetorheological and electrorheological elastomers are studied in this *** tunable band gaps and transmission spectra of these materials are calculated using the finite element method and supercell *** variations in the band gap characteristics with changes in the electric/magnetic fields are *** numerical results show that the electric and magnetic fields can be used in combination to adjust the band gaps *** start and stop frequencies of the band gap are obviously affected by the electric field,and the band gap width is regulated more significantly by the magnetic *** widest and highest band gap can be obtained by combined application of the electric and magnetic *** addition,the band gaps can be moved to the low-frequency region by drilling holes in the PnC,which can also open or close new band *** results indicate the possibility of multi-physical field regulation and design optimization of the elastic wave properties of intelligent PnCs.

关键词： Phononic crystal.Band gap Magnetic field Electric field Combined adjustment

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Fast calculation method for mission opportunities in orbital interception and rendezvous problems

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Chinese Journal of Aeronautics 2023年第6期36卷 201-212页

作者： Huidong MA gang zhang Research Center of Satellite Technology Harbin Institute of TechnologyHarbin 150080China

This paper proposes a fast calculation method to solve all mission opportunities for orbital interception and orbital rendezvous under the impulse-magnitude *** from the existing search methods,the proposed method does not need to solve Lambert's problem in the whole *** cases are considered for either departure time or transfer time being free,or both being *** fixed departure time,the feasible windows of transfer time are obtained by solving a single-variable nonlinear equation only of terminal true ***,for fixed interception(or rendezvous)time,the feasible windows of departure time are *** free departure time and free transfer time,all mission opportunities are obtained by using a onedimensional search *** hyperbolic-transfer and the multiple-revolution cases are also *** results show that the proposed method is superior to the typical pork-chop plot method and the two-dimensional launch window method in computational time.

关键词： Mission opportunity Impulse-magnitude constraint Orbital interception Orbital rendezvous Pork-chop plot

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Quantum uncertainty relations of Tsallis relative α entropy coherence based on MUBs

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Communications in Theoretical Physics 2022年第1期74卷 31-39页

作者： Fu-gang zhang School of Mathematics and Information Science Nanchang Hangkong UniversityNanchang 330063China

In this paper,we discuss quantum uncertainty relations of Tsallis relative α entropy coherence for a single qubit system based on three mutually unbiased *** α∈[1/2,1)U(1,2],the upper and lower bounds of sums of coherence are ***,the above results cannot be verified directly for any α∈(0,1/2).Hence,we only consider the special case of α=1/n+1,where n is a positive integer,and we obtain the upper and lower *** comparing the upper and lower bounds,we find that the upper bound is equal to the lower bound for the special α=1/2,and the differences between the upper and the lower bounds will increase as α ***,we discuss the tendency of the sum of coherence,and find that it has the same tendency with respect to the different θ or φ,which is opposite to the uncertainty relations based on the Rényi entropy and Tsallis entropy.

关键词： quantum uncertainty relation Tsallis relativeαentropy of coherence the upper and lower bounds single qubit state MUB

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Tangent-impulse transfer from elliptic orbit to an excess velocity vector

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Chinese Journal of Aeronautics 2014年第3期27卷 577-583页

作者： zhang gang zhang Xiangyu Cao Xibin Research Center of Satellite Technology Harbin Institute of Technology National and Local United Engineering Research Center of Small Satellite Technology

The two-body orbital transfer problem from an elliptic parking orbit to an excess veloc-ity vector with the tangent impulse is studied. The direction of the impulse is constrained to be aligned with the velocity vector, then speed changes are enough to nullify the relative velocity. First, if one tangent impulse is used, the transfer orbit is obtained by solving a single-variable function about the true anomaly of the initial orbit. For the initial circular orbit, the closed-form solution is derived. For the initial elliptic orbit, the discontinuous point is solved, then the initial true anomaly is obtained by a numerical iterative approach; moreover, an alternative method is proposed to avoid the singularity. There is only one solution for one-tangent-impulse escape trajectory. Then, based on the one-tangent-impulse solution, the minimum-energy multi-tangent-impulse escape trajectory is obtained by a numerical optimization algorithm, e.g., the genetic method. Finally, several examples are provided to validate the proposed method. The numerical results show that the minimum-energy multi-tangent-impulse escape trajectory is the same as the one-tangent-impulse trajectory.

关键词： Elliptic orbit Escape trajectory Excess velocity vector Orbital transfer Tangent impulse

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Nanophononic metamaterials induced proximity effect in heat flux regulation

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Frontiers of physics 2024年第2期19卷 149-156页

作者： Jian zhang Haochun zhang gang zhang School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Institute of High Performance Computing Agency for ScienceTechnology and Research(A*STAR)Singapore 138632Singapore

Recent studies have shown that the construction of nanophononic metamaterials can reduce thermal conductivity without affecting electrical properties,making them promising in many fields of application,such as energy conversion and thermal ***,although extensive studies have been carried out on thermal conductivity reduction in nanophononic metamaterials,the local heat flux characteristic is still *** this work,we construct a heat flux regulator which includes a silicon nanofilm with silicon *** regulator has remarkable heat flux regulation ability,and various impacts on the regulation ability are ***,even in the region without nanopillars,the local heat current is still lower than that in pristine silicon nanofilms,reduced by the neighboring nanopillars through the thermal proximity *** combine the analysis of the phonon participation ratio with the intensity of localized phonon modes to provide a clear *** findings not only provide insights into the mechanisms of heat flux regulation by nanophononic metamaterials,but also will open up new research directions to control local heat flux for a broad range of applications,including heat management,thermoelectric energy conversion,thermal cloak,and thermal concentrator.

关键词： nanophononic metamaterials proximity effect

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Thermal conduction across the one-dimensional interface between a MoS2 monolayer and metal electrode

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Nano Research 2016年第8期9卷 2372-2383页

作者： Xiangjun Liu gang zhang Yong-Wei zhang Institute of High Performance Computing A'STAR Singapore 138632 Singapore

The thermal conductance across the one-dimensional （1D） interface between a MoS2 monolayer and Au electrode （edge-contact） has been investigated using molecular dynamics simulations. Although the thermal conductivity of monolayer MoS2 is 2-3 orders of magnitude lower than that of graphene, the covalent bonds formed at the interface enable interfacial thermal conductance （ITC） that is comparable to that of a graphene-metal interface. Each covalent bond at the interface serves as an independent channel for thermal conduction, allowing ITC to be tuned linearly by changing the interfacial bond density （controlling S vacancies）. In addition, different Au surfaces form different bonding configurations, causing large ITC variations. Interestingly, the S vacancies in the central region of MoS2 only slightly affect the ITC, which can be explained by a mismatch of the phonon vibration spectra. Further, at room temperature, ITC is primarily dominated by phonon transport, and electron-phonon coupling plays a negligible role. These results not only shed light on the phonon transport mechanisms across 1D metal-MoS2 interfaces, but also provide guidelines for the design and optimization of such interfaces for thermal management in MoS2-based electronic devices.

关键词： MoS2 interracial thermalconductance thermal management

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Transitions to Equilibrium State in Classical φ4 Lattice

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Communications in Theoretical Physics 2002年第8期38卷 157-162页

作者： WANG Xin-gang zhang Ying HU gang Department of Physics Beijing Normal University Beijing 100875 China The Abdus Salam International Centre for Theoretical Physics (ICTP) P.O. Box 586 34100 Trieste Italy Department of Physics Beijing Normal University Beijing 100875 China

Statistical behavior of a classical φ4 Hamiltonian lattice is investigated from microscopic dynamics. Thelargest Lyapunov exponent and entropies are considered for manifesting chaos and equipartition behaviors of the *** is found, for the first time, that for any large while finite system size there exist two critical couplings for the transitionsto equipartitions, and the scaling behaviors of these lower and upper critical couplings vs. the system size are numericallyobtained.

关键词： Hamiltonian system, measure synchronization, equilibrium, equipartition

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2-Independent Domination in Trees

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Journal of the Operations Research Society of China 2024年第2期12卷 485-494页

作者： gang zhang Baoyindureng Wu College of Mathematics and System Sciences Xinjiang UniversityUrumqi830046XinjiangChina

A subset D■V(G)in a graph G is a dominating set if every vertex in V(G)I D is adjacent to at least one vertex of S.A subset S■V(G)in a graph G is a 2-independent set if△(G[S])<*** 2-independence numberα2(G)is the order of a largest 2-independent set in ***,a subset D■V(G)in a graph G is a 2-independent dominating set if D is both dominating and *** 2-independent domination number i^(2)(G)is the order of a smallest 2-independent dominating set in *** this paper,we characterize all trees T of order n with i^(2)(T)=n/***,we prove that for any tree T of order n≥2,i^(2)(T)≤2/3α2(T),and this bound is sharp.

关键词： Domination Independent domination 2-Independent domination 2-Independence Trees

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General theories and features of interfacial thermal transport

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Chinese Physics B 2018年第3期27卷 1-11页

作者： Hangbo Zhou gang zhang Institute of High Performance Computing A＇STAR Singapore 138632 Singapor

A clear understanding and proper control of interfacial thermal transport is important in nanoscale devices. In this review, we first discuss the theoretical methods to handle the interfacial thermal transport problem, such as the macroscopic model, molecular dynamics, lattice dynamics, and quantum transport theories. Then we discuss various effects that can significantly affect the interfacial thermal transport, such as the formation of chemical bonds at interface, defects, interface roughness, strain, substrates, atomic species, mass ratios, and structural orientations. Then importantly, we analyze the role of inelastic scattering at the interface, and discuss its application in thermal rectifications. Finally, the challenges and promising directions are discussed.

关键词： thermal conductance interfacial thermal conductance nanomaterials

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