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川芎嗪对宫颈癌细胞上皮间质转化和放疗耐药性的影响与机制

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中国临床药理学杂志 2024年第8期40卷 1165-1169页

作者：郭宗梁张彩霞张新悦内蒙古医科大学附属医院妇产科内蒙古自治区呼和浩特010059

目的研究川芎嗪调节Yes相关蛋白(YAP)/转录辅激活因子(TAZ)信号通路对宫颈癌细胞上皮间质转化和放疗耐药性的影响。方法将人宫颈癌细胞株C33A随机分为对照组(不做任何干预处理)、川芎嗪组(1.5 mg·mL^(-1)川芎嗪)、川芎嗪+空载组(1.5... 详细信息

目的研究川芎嗪调节Yes相关蛋白(YAP)/转录辅激活因子(TAZ)信号通路对宫颈癌细胞上皮间质转化和放疗耐药性的影响。方法将人宫颈癌细胞株C33A随机分为对照组(不做任何干预处理)、川芎嗪组(1.5 mg·mL^(-1)川芎嗪)、川芎嗪+空载组(1.5 mg·mL^(-1)川芎嗪+转染空载质粒)、川芎嗪+YAP1过表达组(1.5 mg·mL^(-1)川芎嗪+转染YAP1过表达质粒)。构建人宫颈癌放射线抵抗细胞C33A-RR并随机分为放射抵抗对照组(不做任何干预处理)、放射组(6 Gy射线)、放射+川芎嗪组(6 Gy射线+1.5 mg·mL^(-1)川芎嗪)、放射+川芎嗪+空载组(6 Gy射线+1.5 mg·mL^(-1)川芎嗪+转染空载质粒)、放射+川芎嗪+YAP1过表达组(6 Gy射线+1.5 mg·mL^(-1)川芎嗪+转染YAP1过表达质粒)。用蛋白质印迹法检测蛋白相对表达水平;用细胞划痕和Transwell侵袭实验分别检测细胞迁移和侵袭情况;用细胞计数试剂盒8(CCK-8)检测细胞增殖情况。结果对照组、川芎嗪组、川芎嗪+空载组和川芎嗪+YAP1过表达组的迁移率分别为(84.82±12.16)%、(20.67±4.48)%、(21.22±5.03)%和(76.74±0.15)%, E-cadherin蛋白相对表达水平分别为0.16±0.03、0.70±0.08、0.72±0.13和0.19±0.04,川穹嗪组上述指标与对照组比较,在统计学上差异均有统计学意义(均P<0.05);川芎嗪+YAP1过表达组上述指标与川芎嗪组、川芎嗪+空载组比较,在统计学上差异均有统计学意义(均P<0.05)。放射抵抗对照组、放射组、放射+川芎嗪组、放射+川芎嗪+空载组和放射+川芎嗪+YAP1过表达组YAP1蛋白相对表达水平分别为0.79±0.14、0.88±0.16、0.21±0.03、0.22±0.04和0.82±0.16,细胞的存活率分别为(100.00±0.00)%、(95.78±20.12)%、(40.13±6.07)%、(42.21±6.45)%和(90.12±18.65)%。放射组上述指标与放射抵抗对照组比较,在统计学上差异均有统计学意义(均P<0.05);放射+川芎嗪组、放射+川芎嗪+空载组上述指标与放射组、放射+川芎嗪+YAP1过表达组比较,在统计学上差异均有统计学意义(均P<0.05)。结论川芎嗪可下调YAP/TAZ信号通路蛋白相对表达水平,从而抑制宫颈癌细胞上皮间质转化、迁移和侵袭,并降低其放疗耐药性,促进其凋亡。

关键词：川芎嗪 Yes相关蛋白/转录辅激活因子宫颈癌上皮间质转化放疗耐药性

Why is the Danger Cylinder Dangerous in the P3P Problem?

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自动化学报 2006年第4期32卷 504-511页

作者： zhang cai-xia HU Zhan-Yi National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing 100080 Institute of Image Processing and Pattern Recognition North China University of Technology Beijing 100041

The PnP problem is a widely used technique for pose determination in computer vision community,and finding out geometric conditions of multiple solutions is the ultimate and most desirable goal of the multi-solution analysis,which is also a key research issue of the *** this paper,we prove that given 3 control points,if the camera's optical center lies on the so-called“danger cylinder”and is enough far from the supporting plane of control points,the corresponding P3P problem must have 3 positive *** result can bring some new insights into a better understanding of the multi-solution *** example,it is shown in the literature that the solution of the P3P problem is instable if the optical center lies on this danger cylinder,we think such occurrence of triple-solution is the primary source of this instability.

关键词： The P3P problem the danger cylinder instability of solution

环糊精包覆物改性聚甲醛复合材料的结构与性能

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石化技术与应用 2024年第2期42卷 104-107页

作者：李荣方伟张彩霞国家能源集团宁夏煤业有限责任公司甲醇分公司宁夏银川750411

以环糊精和聚乙二醇-聚丙二醇-聚乙二醇三嵌段共聚物(PEG-PPG-PEG)为原料,通过滴加反应制备环糊精包覆PEG-PPG-PEG(DA)改性剂,再通过熔融共混挤出法制备DA改性聚甲醛(POM)复合材料,利用差示扫描量热仪、偏光显微镜、扫描电子显微镜、万... 详细信息

以环糊精和聚乙二醇-聚丙二醇-聚乙二醇三嵌段共聚物(PEG-PPG-PEG)为原料,通过滴加反应制备环糊精包覆PEG-PPG-PEG(DA)改性剂,再通过熔融共混挤出法制备DA改性聚甲醛(POM)复合材料,利用差示扫描量热仪、偏光显微镜、扫描电子显微镜、万能材料试验机、冲击试验机等仪器对改性复合材料进行结构表征和力学性能分析。结果表明:当DA质量分数为3.0%时,改性复合材料中DA以微小颗粒形式分散在POM基体中,类似海岛结构;与未改性POM树脂相比,在相同结晶温度下,改性复合材料的晶核出现时间缩短,晶核和球晶数量均增多,球晶尺寸变小;改性复合材料的结晶度有所提高,但添加不同质量分数的DA后,改性复合材料之间的结晶度差别不大;当DA添加质量分数依次为0.5%,1.0%,3.0%时,改性复合材料的拉伸强度、弯曲模量、简支梁缺口冲击强度均相应增大。

关键词：聚甲醛环糊精三嵌段共聚物改性剂复合材料力学性能

新工科背景下地方性院校本硕博贯通培养模式探究

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教育教学论坛 2024年第17期 9-12页

作者：程强张彩霞杨聪彬北京工业大学机械与能源工程学院北京100124

国家发展战略对创新型人才提出了新的需求,新工科推进驱动着高校人才培养模式的不断革新。本硕博贯通的创新人才培养模式正是适应高层次人才培养工作新要求而提出的。分析了国内现有本硕博贯通培养的现状,阐述了目前存在的问题,针对地... 详细信息

国家发展战略对创新型人才提出了新的需求,新工科推进驱动着高校人才培养模式的不断革新。本硕博贯通的创新人才培养模式正是适应高层次人才培养工作新要求而提出的。分析了国内现有本硕博贯通培养的现状,阐述了目前存在的问题,针对地方性院校进一步提出了如何做好本硕博教育贯通培养,从明确培养目标、优化培养机制与课程管理、加大科研引导、关注国际视野等方面提出了改进措施。

关键词：新工科本硕博贯通地方性院校创新人才培养

The characterization of acid and pepsin soluble collagen from ovine bones (Ujumuqin sheep)

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Journal of Integrative Agriculture 2018年第3期17卷 704-711页

作者： GAO Ling-ling WANG Zhen-yu LI Zheng zhang cai-xia zhang De-quan Institute of Food Science and Technology Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-products Processing Ministry of Agriculture

Ovine bones are the major by-products after slaughtered. The present study was conducted to extract and characterize acid soluble collagens （ASC） and pepsin soluble collagens （PSC） from ovine bones （Ujumuqin sheep）. Ovine bones collagen were identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis （SDS-PAGE） and liquid chromatography-tan- dem mass spectrometry （LC-MS/MS） as type I collagen. The results of Fourier transform infrared （FTIR） spectra analysis testified the existence of triple superhelical structure in both ASC and PSC, showing pepsin did not disrupt the triple helical structure of ovine bones collagen. Glycine, accounting for one-third of total amino acids, was the major amino acid for ovine bones collagen. Higher imino acid content was responsible for higher thermal denaturation temperature of ovine bones collagen compared to fish collagens. The isoelectric point of ASC was lower than PSC due to the higher content of acidic amino acids. Therefore, this study provides the potential reference for collagen extraction and application of ovine bones by-procduct.

关键词： ovine bones collagen characterization amino acid composition denaturation temperature

Application of EPNSim Graph in Making Simulation Models for an Integrated Steelmaking-Casting-Rolling

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Journal of Iron and Steel Research International 2000年第1期7卷 22-26页

作者： zhang cai-xia HE Cheng-hong HAN Jing-tao HE Yu-xin University of Science and Technology Beijing

The EPNSim Graph was used to establish simulation models for an integrated steelmaking-casting-rolling production *** simulation software was developed on the basis of the EPNSim Graph models and some production plans... 详细信息

关键词： production plan simulation schedule EPNSim Graph

护士-患者-照护者协同康复训练在促进腰椎骨折伴脊髓损伤患者康复中的作用分析

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颈腰痛杂志 2024年第2期45卷 348-351页

作者：李诗敏刘美帅张彩霞空军军医大学第二附属医院骨科手术室陕西西安720038

目的探讨护士-患者-照护者协同康复训练在促进腰椎骨折伴脊髓损伤(spinal cord injury,SCI)患者康复中的作用。方法使用随机数表法将2022年1月-2023年1月在空军军医大学第二附属医院就诊的68例腰椎骨折伴SCI患者分为对照组(n=34)和观察... 详细信息

目的探讨护士-患者-照护者协同康复训练在促进腰椎骨折伴脊髓损伤(spinal cord injury,SCI)患者康复中的作用。方法使用随机数表法将2022年1月-2023年1月在空军军医大学第二附属医院就诊的68例腰椎骨折伴SCI患者分为对照组(n=34)和观察组(n=34)。给予对照组常规护理,在此基础上给予观察组护士-患者-照护者协同康复训练干预。比较两组干预前后自我护理能力测量表(exercise of self-care agency scale,ESCA)评分、家庭支持自评量表(family support scale,PSS-Fa)评分、改良Barthel指数(modified barthel index,MBI)、功能独立性评定量表(function independent measure,FIM)评分。结果干预后,两组ESCA评分、PSS-Fa评分、MBI指数和FIM评分均显著上升(P<0.05),且观察组干预后ESCA评分、PSS-Fa评分、MBI指数和FIM评分均显著高于对照组(P<0.05)。结论护士-患者-照护者协同康复训练可有效提高腰椎骨折伴SCI患者自护能力和家庭支持水平,对于提高康复训练效果、促进患者自主生活能力恢复有积极作用。

关键词：腰椎骨折脊髓损伤护士-患者-照护者协同康复训练自护能力家庭支持康复水平

Different lymph node staging systems for predicting the prognosis of colorectal neuroendocrine neoplasms

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1745-1755页

作者： Yuan-Yi zhang Yue-Wei cai xia zhang Department of Pathology Zhaoqing Medical CollegeZhaoqing 526020Guangdong ProvinceChina Department of Emergency Zhaoqing Second People’s HospitalZhaoqing 526020Guangdong ProvinceChina Department of Pathology and Physiology Zhaoqing Medical CollegeZhaoqing 526020Guangdong ProvinceChina

BACKGROUND Colorectal neuroendocrine neoplasms(NENs)are a rare malignancy that primarily arises from the diffuse distribution of neuroendocrine cells in the colon and *** studies have pointed out that the status of lymph node may be used to predict the *** To investigate the predictive values of lymph node ratio(LNR),positive lymph node(PLN),and log odds of PLNs(LODDS)staging systems on the prognosis of colorectal NENs treated surgically,and compare their predictive *** This cohort study included 895 patients with colorectal NENs treated surgically from the Surveillance,Epidemiology,and End Results *** endpoint was mortality of patients with colorectal NENs treated surgically.X-tile software was utilized to identify most suitable thresholds for categorizing the LNR,PLN,and *** were selected in a random manner to form training and testing *** prognosis of surgically treating colorectal NENs was examined using multivariate cox analysis to assess the associations of LNR,PLN,and LODDS with the prognosis of colorectal NENs.C-index was used for assessing the predictive *** conducted a subgroup analysis to explore the different lymph node staging systems’predictive *** After adjusting all confounding factors,PLN,LNR and LODDS staging systems were linked with mortality in patients with colorectal NENs treated surgically(P<0.05).We found that LODDS staging had a higher prognostic value for patients with colorectal NENs treated surgically than PLN and LNR staging *** results were obtained in the different G staging subgroup ***,the area under the receiver operating characteristic curve values for LODDS staging system remained consistently higher than those of PLN or LNR,even at the 1-,2-,3-,4-,5-and 6-year follow-up *** LNR,PLN,and LODDS were found to significantly predict the prognosis of patients with colorectal NENs treated surgically.

关键词： Positive lymph node Lymph node ratio Log odds of positive lymph nodes Prognosis Colorectal neuroendocrine neoplasms

Color Doppler flow imaging diagnosis and treatment selection for erectile dysfunction

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Chinese Medical Journal 2011年第2期124卷 210-214页

作者： XUAN Xu-jun zhang cai-xia HUANG Jian Rong Lu SUN Peng LIU Hai-nan Department of Urology Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou Guangdong 510120 China Department of Minimally Invasive Urology Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China Department of Urology Qilu Hospital of Shandong University Jinan Shandong 250021 China

Background Targeted therapy for erectile dysfunction （ED） involves fewer screening tests and provides a variety of treatment choices for *** the advantage of targeted therapy in diagnosis and therapy for ED has been recognized,the rational mode for oriented ED therapy has not been *** study aimed to investigate targeted diagnosis and therapy for *** A total of 198 patients with ED were included in the *** intracavernosal vasoactive agent injection was given,color Doppler flow imaging was performed and penile rigidity was classified as Schramek grade 5 （10 minutes duration）,grade 4 （10 minutes duration）,grade 3 and grade 2,defining four patient groups as group Ⅴ （143 cases）,group Ⅳ （23 cases）,group Ⅲ （18 cases）,and group Ⅱ （14 cases）.Appropriate and acceptable treatment was recommended to patients according to erection *** In 198 patients with ED,the peak systolic velocity,end diastolic velocity,and resistance index in the cavemosal artery and dorsal artery and the flow velocity in the deep dorsal vein were not significantly different before injection （P 〉0.05）.After injection,peak systolic velocity,end diastolic velocity,and resistance index in the cavernosal artery were different among the four groups （P〈0.05）.Between each two groups,the difference in resistance index was significant （P 〈0.05）.The statistical differences in other indexes were not significant （P 〉0.05）.Selective targeted therapy based on erection grade by color Doppler flow imaging improved the clinical satisfaction rate to 91.91% （182/198）.Conclusions Based on the routine diagnosis of ED,blood flow indexes in the cavernosal artery are measured by color Doppler flow imaging following minimally invasive intercavernosal injection,which is combined with the Schramek grade of *** most appropriate and acceptable treatment is recommended according to the different groups,which improves the clinical satisfaction of treatment for ED and is an idea

关键词： erectile dysfunction color Doppler ultrasound targeted therapy penile rigidity