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Migration and fate of polycyclic aromatic hydrocarbons in bioretention systems with different media:experiments and simulations

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 17-33页

作者： Zhaoxin zhang Jiake Li Zhe Liu Yajiao Li bei zhang Chunbo Jiang Institute of Land Engineering and Technology Shaanxi Provincial Land Engineering Construction Group Co.Ltd.Xi’an 710075China State Key Laboratory of Eco-hydraulics in Northwest Arid Region of China Xi’an University of TechnologyXi’an 710048China School of Architecture and Civil Engineering Xi’an University of Science and TechnologyXi’an 710054China College of Landscape Architecture and Art Northwest A&F UniversityYangling 712100China

Polycyclic aromatic hydrocarbons(PAHs)present significant risks to human health owing to their carcinogenic,teratogenic,and mutagenic *** contamination of surface water with PAHs via runoff has become a prominent source of water *** the capacity of bioretention systems to remove PAHs from runoff is recognized,the dynamics of PAH migration and degradation in these systems are not *** study aims to explain the migration and fate of PAHs in bioretention systems through a series of experiments and model *** study constructed bioretention systems with three different media types and found that these systems achieved PAH load reductions exceeding 92%.Notably,naphthalene(NAP),fluoranthene(FLT),and pyrene(PYR)tended to accumulate in the media’s upper layer,at depths of 10 to 40 *** further analyze the migration and fate of PAHs during multi-site rainfall events and across prolonged operation,we applied the HYDRUS-1D model under three distinct *** findings of this study indicated that NAP degraded in 40 d,whereas FLT and PYR showed incomplete degradation after 120 *** continuous rainfall events,there was no clear pattern of PAH accumulation;however,FLT and PYR persisted in the bioretention *** combination of experimental and simulation findings highlights the inevitable accumulation of PAHs during extended use of bioretention *** research provides a theoretical basis for improving operational efficiency,advancing PAH degradation in bioretention systems,and reducing their toxicity.

关键词： Bioretention Polycyclic aromatic hydrocarbons HYDRUS-1D Model simulation Migration

Genomic profiling of colorectal cancer in large-scale Chinese patients:amplification and somatic mutations in ERBB2

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Oncology Research 2024年第9期32卷 1429-1438页

作者： YUZHI LIU EVELYNE BISCHOF ZHIQIN CHEN JIAHUAN ZHOU bei zhang DING zhang YONG GAO MING QUAN Department of Oncology Shanghai East HospitalTongji University School of MedicineShanghaiChina State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteDepartment of OncologyRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Jiangsu Hengrui Pharmaceuticals Co. Ltd.ShanghaiChina D Medicines Inc. ShanghaiChina

Objectives:Human epidermal growth factor receptor 2(HER2)-targeted therapies have demonstrated potential benefits for metastatic colorectal cancer(mCRC)patients with HER2 amplification,but are not satisfactory in cases of HER2 mutant ***:Consequently,further elucidation of amplifications and somatic mutations in erythroblastic oncogene B-2(ERBB2)is *** genomic profiling was conducted on 2454 Chinese CRC cases to evaluate genomic alterations in 733 cancer-related genes,tumor mutational burden,microsatellite instability,and programmed death ligand 1(PD-L1)***:Among 2454 CRC patients,85 cases(3.46%)exhibited ERBB2 amplification,and 55 cases(2.24%)carried ERBB2 mutation.p.R678Q(28%),p.V8421(24%),and p.S310F/Y(12%)were the most prevalent of the 16 detected mutation *** comparison to the ERBB2 altered(alt)group,KRAS/BRAF mutations were more prevalent in ERBB2 wild-type(wt)samples(ERBB2wt ***2alt,KRAS:50.9%vs.25.6%,p<0.05;BRAF:8.5%vs.2.3%,p<0.05).32.7%(18/55)of CRCs with ERBB2 mutation exhibited microsatellite instability high(MSI-H),while no cases with HER2 amplification displayed *** genes varied between ERBB2 copy number variation(CNV)and ERBB2 single nucleotide variant(SNV);TP53 alterations tended to co-occur with ERBB2 amplification(92.3%)as opposed to ERBB2 mutation(58.3%).KRAS and PIK3CA alterations were more prevalent in ERBB2 SNV cases(KRAS/PIK3CA:45.8%/31.2%)compared to ERBB2 amplification cases(KRAS/PIK3CA:14.1%/7.7%).Conclusion:Our study delineates the landscape of HER2 alterations in a large-scale cohort of CRC patients from *** findings enhance our understanding of the molecular features of Chinese CRC patients and offer valuable implications for further investigation.

关键词： Colorectal cancer ERBB2 HER2 Human epidermal growth factor receptor 2 Genetic profiling Precision oncology

Benzothiadiazole-based materials for organic solar cells

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Chinese Chemical Letters 2024年第1期35卷 3-15页

作者： Qiang bei bei zhang Kaifeng Wang Shiming zhang Guichuan Xing Clément Cabanetos Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech UniversityNanjing 211816China Jiangsu Seenbom Flexible Electronics Institute Co. Ltd.Nanjing 210043China Institute of Applied Physics and Materials Engineering University of MacaoMacao SAR 999078China University of Angers Angers 49045France Building Blocks for Future Electronics Laboratory(2BFUEL) IRL2002CNRS-Yonsei UniversitySeoul 03722Republic of Korea

The past few years have witnessed power conversion efficiency(PCE)of organic solar cells(OSCs)skyrocketing to the value of 20%due to the outstanding advantages of organic photoactive *** latter,which consist of donor and acceptor materials,indeed play important roles in OSCs,and particularly one building block has attracted considerable research attention,namely benzothiadiazole(BT).The diversity of OSCs based on the BT structure have indeed sprung up,and the progressive increase in PCE values is more than just eye-catching since it heralds a renewal and bright future of *** review analyzes significant studies that have led to these remarkable progresses and focuses on the most effective BT small-molecules and BT polymers for OSC reported in the last *** pivotal structure-property relationships,donor-acceptor matching criteria,and morphology control approaches are gathered and discussed in this ***,we summarize the remaining challenges and offer a personal perspective on the future advance and improvement of OSCs.

关键词： Organic solar cells Benzothiadiazole Donor Acceptor Polymer Non-fullerene acceptors

基于离心试验与离散元模拟的滑坡碎屑流冲击效应研究

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岩土工程学报 2024年第7期46卷 1498-1508,1515页

作者：张贝黄雨长安大学地质工程与测绘学院陕西西安710054 同济大学土木工程学院地下建筑与工程系上海200092

滑坡碎屑流物质组成的复杂性造成其对工程结构的冲击效应尚未被完全理解,特别是粒径大小与级配特征如何影响冲击力及其组成,以及拦挡结构设计中如何考虑粒径特征的影响,当前仍缺乏深入的研究。针对这些问题,开展了一系列离心试验与离散... 详细信息

滑坡碎屑流物质组成的复杂性造成其对工程结构的冲击效应尚未被完全理解,特别是粒径大小与级配特征如何影响冲击力及其组成,以及拦挡结构设计中如何考虑粒径特征的影响,当前仍缺乏深入的研究。针对这些问题,开展了一系列离心试验与离散元模拟分析,研究结果表明滑坡碎屑流的颗粒粒径控制着冲击力的波动行为,即随着粒径的增大,总冲击力的峰值越来越明显,且伴随着显著的离散冲击力值。小粒径颗粒对大粒径颗粒存在明显缓冲效应,且小颗粒在冲击过程中更容易进入大颗粒的孔隙,进而贡献作用力,因此粒径和级配特征同时控制着冲击力的绝对值。不同粒径特征控制着颗粒尺度上动量传递机制,进而改变了滑坡碎屑流的冲击效应,由此造成冲击动压力系数α随着Savage数的增大基本上呈现出递增的关系,因此建议采用Froude数与Savage数作为双控指标,辅助确定冲击动压力系数α。此外,通过分析冲击力合力作用位置,发现工程设计中可按总冲击力峰值及矩形分布荷载进行考虑。

关键词：滑坡碎屑流冲击效应拦挡结构离心模拟离散元模拟

Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model

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World Journal of Gastroenterology 2024年第5期30卷 471-484页

作者： Hui Hua Qian-Qian Zhao Miriam Nkesichi Kalagbor Guo-Zhi Yu Man Liu Zheng-Rui Bian bei-bei zhang Qian Yu Yin-Hai Xu Ren-Xian Tang Kui-Yang Zheng Chao Yan Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Demonstration Center for Experimental Basic Medical Science EducationLaboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Laboratory Medicine The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221002Jiangsu ProvinceChina

BACKGROUND Primary sclerosing cholangitis(PSC)is characterized by chronic inflammation and it predisposes to cholangiocarcinoma due to lack of effective treatment *** adeno-associated virus(rAAV)provides a promising platform for gene therapy on such kinds of diseases.A microRNA(miRNA)let-7a has been reported to be associated with the progress of PSC but the potential therapeutic implication of inhibition of let-7a on PSC has not been *** To investigate the therapeutic effects of inhibition of a miRNA let-7a transferred by recombinant adeno-associated virus 8(rAAV8)on a xenobiotic-induced mouse model of sclerosing *** A xenobiotic-induced mouse model of sclerosing cholangitis was induced by 0.1% 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine(DDC)feeding for 2 wk or 6 wk.A single dose of rAAV8-mediated anti-let-7a-5p sponges or scramble control was injected in vivo into mice onset of DDC *** sacrifice,the liver and the serum were collected from each *** hepatobiliary injuries,hepatic inflammation and fibrosis were *** targets of let-7a-5p and downstream molecule NF-κB were detected using Western *** rAAV8-mediated anti-let-7a-5p sponges can depress the expression of let-7a-5p in mice after DDC feeding for 2 wk or 6 *** reduced expression of let-7a-5p can alleviate hepato-biliary injuries indicated by serum markers,and prevent the proliferation of cholangiocytes and biliary ***,inhibition of let-7a mediated by rAAV8 can increase the expression of potential target molecules such as suppressor of cytokine signaling 1 and Dectin1,which consequently inhibit of NF-κB-mediated hepatic *** Our study demonstrates that a rAAV8 vector designed for liver-specific inhibition of let-7a-5p can potently ameliorate symptoms in a xenobiotic-induced mouse model of sclerosing cholangitis,which provides a possible clinical translation of PSC of human.

关键词： Primary sclerosing cholangitis Recombinant adeno-associated virus 8 Let-7a-5p Therapeutic effects Inflammation

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短视频平台上的金融风险传播与舆论危机管理

山西财经大学学报 2024年第S1期46卷 52-54页

作者：张蓓南昌大学公共政策与管理学院江西南昌330031

在当今信息爆炸时代,短视频平台成为了重要的信息传播渠道,同时伴随着金融风险的快速传播和舆论危机的潜在风险。为此,首先探究短视频平台上金融风险传播的特点与影响因素,之后对短视频平台上的舆论危机管理实践进行分析,并探讨用户参... 详细信息

在当今信息爆炸时代,短视频平台成为了重要的信息传播渠道,同时伴随着金融风险的快速传播和舆论危机的潜在风险。为此,首先探究短视频平台上金融风险传播的特点与影响因素,之后对短视频平台上的舆论危机管理实践进行分析,并探讨用户参与对管理策略的影响,最后通过揭示金融风险传播对舆论危机影响的机制提出有效的舆论危机管理策略,以期为短视频平台健康运营和社会信息良好传播提供有益启示。

关键词：短视频平台金融风险舆论危机

土工离心模拟高速滑坡碎屑流冲击过程的科氏效应研究

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中国科学：技术科学 2024年第4期54卷 734-746页

作者：张贝李文阳黄雨长安大学地质工程与测绘学院西安710054 同济大学土木工程学院上海200092

土工离心模拟是土木工程、地质工程等相关领域的重要技术.但在高速滑坡碎屑流模拟方面的应用仍然受限,主要原因在于科氏效应的影响难以避免且缺乏详细研究.本文特别针对高速滑坡碎屑流冲击效应这一防灾减灾工程重要问题,开展了一系列的... 详细信息

土工离心模拟是土木工程、地质工程等相关领域的重要技术.但在高速滑坡碎屑流模拟方面的应用仍然受限,主要原因在于科氏效应的影响难以避免且缺乏详细研究.本文特别针对高速滑坡碎屑流冲击效应这一防灾减灾工程重要问题,开展了一系列的物理离心试验与数值试验.相关结果表明,科氏加速度的方向对高速滑坡碎屑流冲击过程的影响更为显著,发散科氏作用强化了滑坡碎屑流与拦挡结构的相互作用,表现在其具有更高的流动性、更强的冲击效应、更大的堆积体高度.离心应力水平对压缩科氏效应作用效果的影响更为显著,且随着离心应力水平的增大,模拟结果向着无科氏条件影响结果的方向发展.因此,高速滑坡碎屑流冲击效应的土工离心模拟建议在发散科氏条件下开展,且不必刻意选取较小的离心应力水平.

关键词：离心模拟技术高速滑坡碎屑流冲击过程科氏效应离散元模拟

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知识密集型产业的多学科交叉创新机制研究

科学学研究 2024年第2期42卷 415-426页

作者：张贝贝尹西明余江中国科学院科技战略咨询研究院北京100190 北京理工大学管理与经济学院北京100081 教育部人文社会科学重点研究基地清华大学技术创新研究中心北京100084 中国科学院大学公共政策与管理学院北京100049

多学科交叉是知识密集型产业技术创新的突出特征,透彻了解多学科交叉创新机制是加快突破知识密集型产业技术“卡脖子”问题、实现高水平科技自立自强的重要议题。本研究聚焦芯片制造这一典型的知识密集型产业,基于2000-2020年的42785条... 详细信息

多学科交叉是知识密集型产业技术创新的突出特征,透彻了解多学科交叉创新机制是加快突破知识密集型产业技术“卡脖子”问题、实现高水平科技自立自强的重要议题。本研究聚焦芯片制造这一典型的知识密集型产业,基于2000-2020年的42785条芯片制造专利数据,实证探究多学科交叉对知识密集型产业技术创新的影响机制。研究发现:(1)学科系统均衡性与技术创新价值具有显著的倒“U”型关系,即“创新产生于混沌的边缘”。相较于“无中心型”和“绝对中心型”的学科交互模式,“主导-辅助型”学科交互模式更有利于技术创新价值的提升。(2)学科内容差异性能够显著提升技术创新价值。(3)由于知识约束与互补效应的存在,学科种类多样性与技术创新价值呈现显著的倒“U”型关系。研究结论为辩证推进多学科交叉创新,加快知识密集型产业关键核心技术突破,增强产业链供应链安全韧性,有效支撑科技自立自强提供重要理论和实践启示。

关键词：知识密集型产业学科种类多样性芯片学科系统均衡性学科内容差异性科技自立自强

Percheron动脉梗死2例报告及文献复习

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海军军医大学学报 2024年第1期45卷 122-126页

作者：卫维张蓓王林海军军医大学(第二军医大学)第三附属医院神经内科上海201805 西安医学院第一附属医院神经内科西安710077

目的报告2例Percheron动脉梗死病例,并对86例Percheron动脉梗死病例进行文献回顾,总结该病的临床特点。方法报告西安医学院第一附属医院收治的2例Percheron动脉梗死患者的临床诊治过程和转归。通过查阅国内外文献获得86例Percheron动脉... 详细信息

目的报告2例Percheron动脉梗死病例,并对86例Percheron动脉梗死病例进行文献回顾,总结该病的临床特点。方法报告西安医学院第一附属医院收治的2例Percheron动脉梗死患者的临床诊治过程和转归。通过查阅国内外文献获得86例Percheron动脉梗死病例数据,对88例患者的临床数据进行统计分析。结果纳入Percheron动脉梗死患者共88例,男41例(46.6%)、女47例(53.4%),年龄为6~93(58.7±18.9)岁。Org 10172急性脑卒中治疗试验分型为小动脉闭塞23例(26.1%)、心源性栓塞22例(25.0%)、其他原因22例(25.0%)、不明原因21例(23.9%)。未行静脉溶栓者80例(90.9%)。急性起病83例(94.3%)。临床表现为意识障碍80例(90.9%)、眼肌麻痹41例(46.6%)、言语障碍(构音障碍或丘脑性失语)37例(42.0%)、肢体运动功能障碍34例(38.6%)、瞳孔异常34例(38.6%)、头晕15例(17.0%)、记忆减退14例(15.9%)、共济失调5例(5.7%)、面神经麻痹3例(3.4%)。梗死部位以单纯丘脑梗死最多(44例,50.0%),其次为丘脑合并中脑梗死(35例,39.8%)。影像学表现为典型中脑“V”字征14例(15.9%)。治疗后病情好转73例(83.0%),死亡11例(12.5%),再发梗死2例(2.3%),病情无变化2例(2.3%)。年龄和梗死部位与预后有关(均P<0.01)。结论Percheron动脉梗死早期症状多变,急性期弥散加权成像提示丘脑和/或中脑可见高信号,可有典型中脑“V”字征。早期Percheron动脉梗死治疗可用静脉溶栓和其他缺血性脑卒中治疗方案,其预后与年龄和梗死部位有关。

关键词： Percheron动脉梗死丘脑旁正中动脉丘脑腹内侧综合征丘脑旁正中综合征