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Journal of Genetics and Genomics 2024年第9期51卷 947-956页

作者： zhan Liu Hui Zeng Huimin Xiang Shanjun Deng Xionglei He State Key Laboratory of Biocontrol School of Life SciencesSun Yat-Sen UniversityGuangzhouGuangdong 510275China

Unraveling the lineage relationships of all descendants from a zygote is fundamental to advancing our understanding of developmental and stem cell ***,existing cell barcoding technologies in zebrafish lack the resolution to capture the majority of cell divisions during embryogenesis.A recently developed method,a substitution mutation-aided lineage-tracing system(SMALT),successfully reconstructed high-resolution cell phylogenetic trees for Drosophila ***,we implement the SMALT system in zebrafish,recording a median of 14 substitution mutations on a one-kilobase-pair barcoding sequence for one-day post-fertilization *** this system,we reconstruct four cell lineage trees for zebrafish fin cells,encompassing both original and regenerated *** tree consists of hundreds of internal nodes with a median bootstrap support of 99%.Analysis of the obtained cell lineage trees reveals that regenerated fin cells mainly originate from cells in the same part of the *** multiple times sampling germ cells from the same individual,we show the stability of the germ cell pool and the early separation of germ cell and somatic cell *** system offers the potential for reconstructing high-quality cell phylogenies across diverse tissues,providing valuable insights into development and disease in zebrafish.

关键词： Lineage tracing Cellular barcoding Zebrafishcell phylogeny Fin regeneration Germcell lineage

Land-population-industry based village evolution and its influencing factors in the upper Tuojiang River

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Journal of Mountain Science 2024年第8期21卷 2790-2809页

作者： zhan Yunjun JI Yuxin HUANG Jiejun MA Changying MA Chuanqi School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China

With economic development and urbanization in China,the rural settlements have experienced great *** explore the evolution process of rural settlements in terms of land,population and industry can reveal the development law of rural spatial distribution,population structure and industrial economy in different stages and *** the development status and evolution characteristics of villages in the upper Tuojiang River basin in Southwest China in the past 2. years are of significant *** upper Tuojiang River basin includes the main types of terrain found in the Southwest region:mountainous,plains,and hills,exhibiting a certain typicality of geographical *** study took towns and townships at the town-level scale as the basic unit of research,and constructed an evaluation system for village evolution based on'land,population,and industry'.It employed Criteria Importance Through Inter-Criteria Correlation(CRITIC)analysis to examine the characteristics of village evolution in the area from 2.00 to 2.2.,and used geographic detector analysis to identify the leading factors affecting village *** results show that:(1)From 2.00 to 2.10,villages in the upper Tuojiang River basin experienced significant changes,and the pace of these transformations slowed from 2.10 to 2.2..(2.From a comprehensive perspective,from 2.00 to 2.2.,villages in hilly areas show a decline,while villages in plain areas near the city center show a positive urbanization development.(3)Road accessibility and distance from the city center are the main factors that explain the spatial differentiation of village evolution degree in the study *** study elucidates the spatiotemporal evolution characteristics of villages in the upper Tuojiang River basin and identifies the primary factors contributing to their changes,which will provide a reference for investigating the development of rural areas in different terrains of Southwest China.

关键词： Village evolution Land Population Industry Geographic detector

Bond behavior of the interface between concrete and basalt fiber reinforced polymer bar after freeze–thaw cycles

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Frontiers of Structural and Civil Engineering 2024年第4期18卷 630-641页

作者： Li HONG Mingming LI Congming DU Shenjiang HUANG Binggen zhan Qijun YU Department of Structural Engineering Hefei University of TechnologyHefei 230009China Key Laboratory of Performance Evolution and Control for Engineering Structures Tongji UniversityShanghai 200092China Engineering Research Center of Low-carbon Technology and Equipment for Cement-based Materials(Ministry of Education) Hefei University of TechnologyHefei 230009China Hefei Cement Research&Design Institute Corporation Ltd. Hefei 230051China

The shear bond of interface between concrete and basalt fiber reinforced polymer(BFRP)bars during freeze–thaw(F–T)cycles is crucial for the application of BFRP bar-reinforced concrete structures in cold *** this study,48 groups of pull-out specimens were designed to test the shear bond of the BFRP-concrete interface subjected to F–T *** effects of concrete strength,diameter,and embedment length of BFRP rebar were investigated under numerous F–T *** results showed that a larger diameter or longer embedment length of BFRP rebar resulted in lower interfacial shear bond behavior,such as interfacial bond strength,initial stiffness,and energy absorption,after the interface goes through F–T ***,higher concrete strength and fewer F–T cycles were beneficial for enhancing the interfacial bond ***,a three-dimensional(3D)interfacial model based on the finite element method was developed,and the interfacial bond behavior of the specimens was analyzed ***,a degradation bond strength subjected to F–T cycles was predicted by a proposed mechanical *** predictions were fully consistent with the tested *** model demonstrated accuracy in describing the shear bond behavior of the interface under numerous F–T cycles.

关键词： F-T cycle interface shear bond strength bond stress−slip curves bond degradation

Pre-reduction of WO_(3)-Co_(3)O_(4)by H_(2.-C_(2.H_4 in a fluidized bed

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Chinese Journal of Chemical Engineering 2024年第2期66卷 273-284页

作者： Huijun Shang Hengli Li Weijun Li Feng Pan zhan Du State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of Sciences(CAS)Beijing 100190China College of Chemical Engineering Nanjing Technology UniversityNanjing 211816China School of Chemistry and Chemical Engineering Shihezi UniversityShihezi 832003China College of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Chinalco Environmental Protection and Energy Conservation Group Co. Ltd.Xiong’an 071700China

In order to avoid the formation ofηphase(W_(6)Co_(6)C or W_(3)Co_(3)C)that adversely affects the sintering process and its products in the preparation process of ultra-fine WC-Co powder,a technical route of prereduction of WO_(3)-Co_(3)O_(4)to WO_(2.-Co and then deep reduction carbonization to WC-Co powder has been *** study mainly investigates the influence of gas partial pressure on the pre-reduction process of WO_(3)-Co_(3)O_(4)under a mixed atmosphere of H_(2.-C_(2.H_(4)-Ar at 600℃and establishes the kinetic equations of pre-reduction and carbon *** results indicate that increasing the partial pressure of hydrogen is conducive to the rapid and complete conversion of WO_(3) to WO_(2..High carbon content can be generated by the deposition of C_(2.H_(4),and it hinders the diffusion of the reducing gas;WO_(3)still cannot be completely reduced to WO_(2.as the partial pressure of C_(2.H_(4) increases to 60%.For the carbon evolution of C_(2.H_(4),the carbon amount is positively related to the H_(2.partial pressure,but it shows the highest amount and evolution rate when the ethylene partial pressure is 2.%.Based on the reduction rate curves of WO_(3) and carbon evolution rate curves of C_(2.H_(4),the rate equations of pre-reduction and carbon evolution of WO_(3)-Co_(3)O_(4)system at 600℃are *** pre-reduction reaction belongs to the first-order reaction,and its equation is expressed as follows:r=-(dw_(WO_(3)))/dt=(9±0.15)×10^(-2.×P_(H_(2.)^(0.44)P_(C_(2.H_(4))&(0.57)The carbon deposition rate equation of C_(2.H_(4) can be expressed as follows:r=-(dc_C)/dt=r_f-r_b≌7.35×10^(-2.×P_(C_(2.H_(4))^(0.31)

关键词： Fluidization WO_(3)-Co_(3)O_(4) Reduction Carbon deposition Rate equation

Experimental investigation of engineered geopolymer composite for structural strengthening against blast loads

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Defence Technology（防务技术） 2024年第2期32卷 496-509页

作者： Shan Liu Chunyuan Liu Yifei Hao Yi zhang Li Chen zhan Li Key Laboratory of Coast Civil Structure Safety of Ministry of Education Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Prefabricated Buildings and Intelligent Construction Hebei University of TechnologyTianjin 300400China Institute of Defense Engineering AMSPLABeijing 100850China Engineering Research Center of Safety and Protection of Explosion&Impact of Ministry of Education Southeast UniversityNanjing 211189JiangsuChina State Key Laboratory of Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of the PLANanjing 210007JiangsuChina

The recent increase in blast/bombing incidents all over the world has pushed the development of effective strengthening approaches to enhance the blast resistance of existing civil *** geopolymer composite(EGC)is a promising material featured by eco-friendly,fast-setting and strain-hardening characteristics for emergent strengthening and ***,the fiber optimization for preparing EGC and its protective effect on structural elements under blast scenarios are *** this study,laboratory tests were firstly conducted to evaluate the effects of fiber types on the properties of EGC in terms of workability,dry shrinkage,and mechanical properties in compression,tension and *** experimental results showed that EGC containing PE fiber exhibited suitable workability,acceptable dry shrinkage and superior mechanical properties compared with other types of *** that,a series of field tests were carried out to evaluate the effectiveness of EGC retrofitting layer on the enhancement of blast performance of typical *** tests include autoclaved aerated concrete(AAC)masonry walls subjected to vented gas explosion,reinforced AAC panels subjected to TNT explosion and plain concrete slabs subjected to contact *** was found that EGC could effectively enhance the blast resistance of structural elements in different *** AAC masonry walls and panels,with the existence of EGC,the integrity of specimens could be maintained,and their deflections and damage were significantly *** plain concrete slabs,the EGC overlay could reduce the diameter and depth of the crater and spallation of specimens.

关键词： Engineered geopolymer composites Fiber optimization Strengthening material Blast resistance Masonry wall Reinforced AAC panel Plain concrete slab

Effects of acupuncture on hypothalamic–pituitary–adrenal axis:Current status and future perspectives

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Journal of Integrative Medicine 2024年第4期22卷 445-458页

作者： Jia-yuan Zheng Jing Zhu Yu Wang zhan-zhuang Tian Department of Integrative Medicine and Neurobiology School of Basic Medical SciencesState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceInstitutes of Brain ScienceInstitute of Acupuncture ResearchAcademy of Integrative MedicineShanghai Key Laboratory for Acupuncture Mechanism and Acupoint FunctionShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Human Anatomy School of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

The hypothalamic–pituitary–adrenal(HPA) axis is a critical component of the neuroendocrine system,playing a central role in regulating the body's stress response and modulating various physiological processes. Dysregulation of HPA axis function disrupts the neuroendocrine equilibrium, resulting in impaired physiological functions. Acupuncture is recognized as a non-pharmacological type of therapy which has been confirmed to play an important role in modulating the HPA axis and thus favorably targets diseases with abnormal activation of the HPA axis. With numerous studies reporting the promising efficacy of acupuncture for neuroendocrine disorders, a comprehensive review in terms of the underlying molecular mechanism for acupuncture, especially in regulating the HPA axis, is currently in need. This review fills the need and summarizes recent breakthroughs, from the basic principles and the pathological changes of HPA axis dysfunction, to the molecular mechanisms by which acupuncture regulates the HPA axis. These mechanisms include the modulation of multiple neurotransmitters and their receptors, neuropeptides and their receptors, and microRNAs in the paraventricular nucleus,hippocampus, amygdala and pituitary gland, which alleviate the hyperfunctioning of the HPA *** review comprehensively summarizes the mechanism of acupuncture in regulating HPA axis dysfunction for the first time, providing new targets and prospects for further exploration of acupuncture.

关键词： Acupuncture Electroacupuncture Hypothalamic-pituitary-adrenal axis Mechanism Neurotransmitter microRNA

The mechanisms of thermal solidification agent promoting steam diversion in heavy oil reservoirs

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Petroleum Science 2024年第3期21卷 1902-1914页

作者： zhan-Xi Pang Qian-Hui Wang Qiang Meng Bo Wang Dong Liu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China Liaohe Oilfield Institute CNPC ChinaPanjin124000LiaoningChina Henan Oilfield Institute Sinopec ChinaNanyang473400HenanChina Tianjin Branch of China National Offshore Oil Company(CNOOC)Ltd. Tianjin300452China

At high cycles of steam huff&puff,oil distribution in reservoirs becomes stronger heterogeneity due to steam *** solidification agent can be used to solve this *** solution is a lowviscosity liquid at normal temperature,but it can be solidified above 80℃.The plugging degree is up to 99%at 2.0℃.The sweep efficiency reaches 59.2.,which is 7.3%higher than pure steam *** addition,simultaneous injection of viscosity reducer and/or nitrogen foams can further enhance oil *** mechanism of this technology depends on its strong plugging ability,which changes the flowing pattern of steam to effectively mobilize remaining *** reducer and nitrogen foams further expand the sweep range and extends the effective ***,thermal solidification agent can plug steam channeling paths and adjust steam flowing direction to significantly enhance oil recovery at high cycles of steam huff&puff.

关键词： Heavy oil reservoir Steam huff&puff Steam channeling Steam diversion Plugging performance Mechanism analysis

Automated identification of steel weld defects,a convolutional neural network improved machine learning approach

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 294-308页

作者： zhan SHU Ao WU Yuning SI Hanlin DONG Dejiang WANG Yifan LI School of Mechanics and Engineering Science Shanghai UniversityShanghai 200444China School of Civil Engineering Shanghai Normal UniversityShanghai 201418China Shanghai PinlanData Technology Co. Ltd.Shanghai 200072China

This paper proposes a machine-learning-based methodology to automatically classify different types of steel weld defects,including lack of the fusion,porosity,slag inclusion,and the qualified(no defects)*** methodology solves the shortcomings of existing detection methods,such as expensive equipment,complicated operation and inability to detect internal *** study first collected percussed data from welded steel members with or without weld ***,three methods,the Mel frequency cepstral coefficients,short-time Fourier transform(STFT),and continuous wavelet transform were implemented and compared to explore the most appropriate features for classification of weld *** and convolutional neural network-enhanced algorithms were used to classify,the extracted ***,experiments were designed and performed to validate the proposed *** showed that STFT achieved higher accuracies(up to 96.63%on average)in the weld status *** convolutional neural network-enhanced support vector machine(SVM)outperformed six other algorithms with an average accuracy of 95.8%.In addition,random forest and SVM were efficient approaches with a balanced trade-off between the accuracies and the computational efforts.

关键词： steel weld machine learning convolutional neural network weld defect detection classification task percussion

Driver at 10 MJ and 1 shot/30 min for inertial confinement fusion at high gain:Efficient,compact,low-cost,low laser-plasma instabilities,beam color selectable from 2./3ω/4ω,applicable to multiple laser fusion schemes

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Matter and Radiation at Extremes 2024年第4期9卷 4-7页

作者：隋展蓝可 Shanghai Institute of Laser Plasma China Academy of Engineering PhysicsShanghai 201800China Instituteof Applied Physics and Computational Mathematics Beijing 100094China

The achievement of ignition at the National Ignition Facility(NIF)has prompted a global wave of further research on inertial fusion energy(IFE).However,IFE requires a target gain G of 30-100,and it is hard to achieve fusion at such high gain with the energy,configuration,and technical approach of the ***,we present a conceptual design for a next-generation laser driver that is applicable to multiple laser fusion schemes and provides 10 MJ,2.3 PW at 3ω(or 2.,in which case the energy and power can be higher),and one shot per 30 min,with the aim of achieving G>*** is also efficient,compact,and low in cost,and it has low susceptibility to laser-plasma instabilities.

关键词： applicable compact instabilities

A study of the effect of local scour on the flow field near the spur dike

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 98-105页

作者： Yu-Tian Li Jie-Min zhan Wing-Hong Onyx Wai Department of Industrial Design School of Industrial Design and Ceramic ArtFoshan UniversityFoshan 528000China Department of Applied Mechanics and Engineering Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China

The flow field near a spur dike such as down flow and horseshoe vortex system(HVS)are susceptible to the topographic changes in the local scouring process,resulting in variation of the sediment transport with *** this study,large eddy simulations with fixed-bed at different scouring stages were conducted to investigate the changes in flow *** results imply that the bed deformation leads to an increase in flow rate per unit area,which represent the capability of sediment transportation by water,in the scour ***,the intensity of turbulent kinetic energy and bimodal motion near the sand bed induced by the HVS were also ***,the peak moments between the two sediment transport mechanisms were ***,understanding the complex feedback mechanism between topography and flow field is essential for the local scour problem.

关键词： Spur dike Local scour Large eddy simulation Down flow Horseshoe vortex system