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Prediction and analysis of albumin-bilirubin score combined with liver function index and carcinoembryonic antigen on liver metastasis of colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1670-1680页

作者： zhan-mei wang Shu-Ping Pan Jing-Jing zhang Jun Zhou Department of Medical Oncology Qilu Hospital(Qingdao)Cheeloo College MedicineShandong UniversityQingdao 266000Shandong ProvinceChina Department of Gastroenterology Feicheng People’s HospitalFeicheng 271600Shandong ProvinceChina Department of Anus and Intestine Surgery Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina Department of Oncology Qilu Hospital(Qingdao)Cheeloo College MedicineShandong UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a common malignant tumor,and liver metastasis is one of the main recurrence and metastasis modes that seriously affect patients’survival rate and quality of *** such as albumin bilirubin(ALBI)score,liver function index,and carcinoembryonic antigen(CEA)have shown some potential in the prediction of liver metastasis but have not been fully *** To evaluate its predictive value for liver metastasis of CRC by conducting the combined analysis of ALBI,liver function index,and CEA,and to provide a more accurate liver metastasis risk assessment tool for clinical treatment *** This study retrospectively analyzed the clinical data of patients with CRC who received surgical treatment in our hospital from January 2018 to July 2023 and were followed up for 24 *** to the follow-up results,the enrolled patients were divided into a liver metastasis group and a nonliver metastasis group and randomly divided into a modeling group and a verification group at a ratio of 2:*** risk factors for liver metastasis in patients with CRC were analyzed,a prediction model was constructed by least absolute shrinkage and selection operator(LASSO)logistic regression,internal validation was performed by the bootstrap method,the reliability of the prediction model was evaluated by subject-work characteristic curves,calibration curves,and clinical decision curves,and a column graph was drawn to show the prediction *** Of 130 patients were enrolled in the modeling group and 65 patients were enrolled in the verification group out of the 195 patients with CRC who fulfilled the inclusion and exclusion *** LASSO regression variable screening and logistic regression *** ALBI score,alanine aminotransferase(ALT),and CEA were found to be independent predictors of liver metastases in CRC patients[odds ratio(OR)=8.062,95%confidence interval(CI):2.545-25.540],(OR=1.037,95%CI:1.004-1.071)and(OR=1.0

关键词： Albumin-bilirubin Carcinoembryonic antigen Colorectal cancer Tumor metastasis Prediction model

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Immunotherapy combined with antiangiogenic agents in patients with advanced malignant pleural mesothelioma: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8284-8290页

作者： Tian-Tian Xuan Guang-Yi Li Si-Bo Meng zhan-mei wang Lin-Li Qu Department of Medical Oncology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266035Shandong ProvinceChina Department of Respiratory Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266035Shandong ProvinceChina

BACKGROUND Malignant pleural mesothelioma has limited therapeutic options and a poor outcome. Antiangiogenic agents might increase the efficacy of immunotherapy as second-line treatment of advanced-stage *** SUMMARY A patient with stage ⅢB pleural mesothelioma received second-line treatment with a combination of pembrolizumab, bevacizumab and chemotherapy following standard chemotherapy under the guidance of second-generation sequencing. He achieved a partial response after four cycles of treatment with progression-free survival of 5 mo. Pembrolizumab was suspended due to grade 2 immunerelated pneumonia, which was resolved by oral ***, disease progression was observed after immunotherapy rechallenge and anlotinib therapy. The patient had disease progression, multiorgan dysfuntion and died suddenly in October *** The combination of immune checkpoint inhibitor, anti-angiogenic agents and chemotherapy showed effective response for advanced pleural mesothelioma, but with adverse reactions.

关键词： Pleural mesothelioma Immune checkpoint inhibitor Next-generation Sequencing Immunerelated pneumonia Immunotherapy rechallenge Case report

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Establishment of NaLuF_(4):15%Tb-based low dose X-PDT agent and its application on efficient antitumor therapy

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 599-610页

作者： Yi Tian Zhiguang Fu Xiaosheng Zhu Chunjing zhan Jinwei Hu Li Fan Chaojun Song Qian Yang Yu wang mei Shi Department of Radiation Oncology Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China Department of Oncology Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Tumor Radiotherapy Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Gastroenterology Air Force Hospital of Southern Theater CommandGuangzhou 510062China Department of Pharmaceutical Chemistry and Analysis School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China Institue of Materia Medica School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China

X-ray excited photodynamic therapy(X-PDT)is the bravo answer of photodynamic therapy(PDT)for deep-seated tumors,as it employs X-ray as the irradiation source to overcome the limitation of light penetration ***,high X-ray irradiation dose caused organ lesions and side effects became the major barrier to X-PDT *** address this issue,this work employed a classic-al co-precipitation reaction to synthesize NaLuF_(4):15%Tb^(3+)(NLF)with an average particle size of(23.48±0.91)nm,which was then coupled with the photosensitizer merocyanine 540(MC540)to form the X-PDT system NLF-MC540 with high production of singlet *** system could induce antitumor efficacy to about 24%in relative low dose X-ray irradiation range(0.1-0.3 Gy).In vivo,when NLF-MC540 irradiated by 0.1 Gy X-ray,the tumor inhibition percentage reached 89.5%±5.7%.The therapeutic mechanism of low dose X-PDT was found.A significant increase of neutrophils in serum was found on the third day after *** immunohistochemical staining of tumor sections,the Ly6G^(+),CD8^(+),and CD11c^(+)cells infiltrated in the tumor microenvironment were *** the bilat-eral tumor model,the NLF-MC540 with 0.1 Gy X-ray irradiation could inhibit both the primary tumor and the distant tumor ***-tected by enzyme linked immunosorbent assay(ELISA),two cytokines IFN-γand TNF-αin serum were upregulated 7 and 6 times than negative control,*** by enzyme linked immune spot assay(ELISPOT),the number of immune cells attributable to the IFN-γand TNF-αlevels in the group of low dose X-PDT were 14 and 6 times greater than that in the negative control group,***,it conclude that low dose X-PDT system could successfully upregulate the levels of immune cells,stimulate the secretion of cy-tokines(especially IFN-γand TNF-α),activate antitumor immunity,and finally inhibit colon tumor growth.

关键词： X-ray excited photodynamic therapy singlet oxygen low dose X-Ray irradiation efficient antitumor therapy anti-tumor immunity

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Design,preparation,microstructure and mechanical property of the lightweight radiation-shielding Mg-Ta-Al composites basing differential temperature hot rolling

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Journal of Magnesium and Alloys 2024年第6期12卷 2433-2446页

作者： Wenbo Luo Songya Feng Xiuzhu Han Li Zhou Qinke Kong Zhiyong Xue Jianzhao wang mei zhan Xianhua Chen Fusheng Pan Institute for Advanced Materials North China Electric Power UniversityBeijing 102206China Beijing Institute of Spacecraft System Engineering Beijing 100094China Sinosteel Equipment&Engineering Co Ltd.Beijing100080China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Inner Mongolia 014030China School of Materials Science Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Chongqing UniversityChongqing 400045China

A novel lightweight,radiation-shielding Mg-Ta-Al layered metal-matrix composite(LMC)was successful designed by doping the extremely refractory metal(Ta)into Mg *** Mg-based LMCs sheets shows excellent radiation-dose shield effect,about 145 krad·a^(−1),which is about 17 times of traditional Mg alloy,while its surface density is only about 0.9 g·cm^(−2),reducing by 60%than that of pure *** quantitate relationship between radiation-dose and the materials’thickness was also confirmed to the logistic function when the surface density is in the range of 0.6-1.5 g·cm^(−2).Meantime,the rolling parameters,interface microstructure and mechanical properties in both as-rolled and annealing treated samples were *** sheets possess a special dissimilar atoms diffusion transitional zone containing an obvious inter-diffusion Mg-Al interface and the unique micro-corrugated Ta-Al interface,as well as a thin Al film with a thickness of about 10μ*** special zone could reduce the stress concentration and enhance the strength of Mg-Ta-Al *** interface bonding strength reaches up to 54-76 *** ultimate tensile strength(UTS)and yield strength(TYS)of the Mg-Ta-Al sheet were high to 413 MPa and 263 MPa,respectively,along with an elongation of 5.8%.The molecular dynamics(MD)analysis results show that the two interfaces exhibit different formation mechanism,the Mg-Al interface primarily depended on Mg/Al atoms diffusion basing point defects movement,while the Ta-Al interface with a micro-interlock pining shape formed by close-packed planes slipping during high temperature strain-induced deformation process.

关键词： Dissimilar metals composites Mg based alloys Radiation shielding Hot rolling Lightweight

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Flexible UV detectors based on in-situ hydrogen doped amorphous Ga_(2)O_(3) with high photo-to-dark current ratio

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Materials Futures 2024年第1期3卷 181-189页

作者： Yanxin Sui Huili Liang Wenxing Huo Xiaozhi zhan Tao Zhu Zengxia mei Songshan Lake Materials Laboratory DongguanGuangdong 523808People’s Republic of China Institute of Physics Chinese Academy of SciencesBeijing 100190People’s Republic of China Department of Biomedical Engineering Tianjin University92 Weijin RoadTianjin 300072People’s Republic of China China Spallation Neutron Source DongguanGuangdong 523803People’s Republic of China

Amorphous Ga_(2)O_(3)(a-Ga_(2)O_(3))has been attracting more and more attention due to its unique merits such as wide bandgap(∼4.9 eV),low growth temperature,large-scale uniformity,low cost and energy efficient,making it a powerful competitor in flexible deep ultraviolet(UV)*** the responsivity of the ever-reported a-Ga_(2)O_(3)UV photodetectors(PDs)is usually in the level of hundreds of A/W,it is often accompanied by a large dark current due to the presence of abundant oxygen vacancy(VO)defects,which severely limits the possibility to detect weak signals and achieve versatile *** this work,the VO defects in a-Ga_(2)O_(3)thin films are successfully passivated by in-situ hydrogen doping during the magnetron sputtering *** a result,the dark current of a-Ga_(2)O_(3)UV PD is remarkably suppressed to 5.17×10^(-11) A at a bias of 5 ***,the photocurrent of the corresponding device is still as high as 1.37×10^(-3)A,leading to a high photo-to-dark current ratio of 2.65×107 and the capability to detect the UV light with the intensity below 10 nW cm^(-2).Moreover,the H-doped a-Ga_(2)O_(3)thin films have also been deposited on polyethylene naphtholate substrates to construct flexible UV PDs,which exhibit no great degradation in bending states and fatigue *** results demonstrate that hydrogen doping can effectively improve the performance of a-Ga_(2)O_(3)UV PDs,further promoting its practical application in various areas.

关键词： Ga_(2)O_(3) hydrogen doping ultraviolet photodetector photo-to-dark current ratio neutron reflection

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Integrated gut microbiota,plasma metabolomics and network pharmacology to reveal the anti-ischemic stroke effect of cooked rhubarb

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Traditional Medicine Research 2024年第9期9卷 1-13页

作者： Ting Li Lan-Fang Tan Lin Shen Jie-Hui Kuang Si-Kai zhan Bang Liu Jia-Le Cai Sheng-wang Liang Ming-Hua Xian Shu-mei wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization Guangxi Institute of BotanyChinese Academy of SciencesGuilin 541006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527300China

Background:Cooked rhubarb(CR)is obtained by steaming raw rhubarb(Rheum palmatum L.,Rheum officinale Baill.,or Rheum tanguticum *** Balf.)with millet *** is used as a traditional Chinese medicine for treating cerebral stroke,where patients often face severe *** study explored the pharmacological effects and mechanisms of CR against ischemic stroke(IS)in *** used integrated analysis of gut microbiota,metabolomics,and network ***:The compounds in CR were identified using LC-MS/*** impact of CR on rat middle cerebral artery occlusion/reperfusion(MCAO/R)-induced cerebral infarct size and brain tissue pathology was assessed through 2,3,5-triphenyl tetrazolium chloride and HE *** in hemorheology were measured by evaluating blood viscosity,and serum levels of pro-inflammatory cytokine were also *** microbiota composition was analyzed through 16S rRNA gene *** metabolites were examined using untargeted metabolomics and Spearman correlation *** pseudo-germ-free test was used to determine whether tumour necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)improvement in IS are dependent on gut ***:In vivo studies showed CR enhances neurobehavioral function in MCAO/R rats and reduces cerebral infarction *** also ameliorates brain and intestinal barrier damage caused by *** also decreased inflammation and oxidative stress in IS ***,CR promotes the growth of Akkermansia and Verrucomicrobia,aiding in intestinal barrier ***,CR primarily influences the primary bile acid biosynthesis *** pseudo-germ-free experiment and network pharmacology confirmed TNF-αand IL-1βas potential *** relies on gut microbiota for its anti-inflammatory effects to improve ***:Cooked rhubarb offers neuroprotective benefits by enhancing beneficial bacteria abundance and regulating bile acid *** emerges as a potential therapeutic agent for

关键词： cooked rhubarb ischemic stroke gut microbiota metabolomics

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Effect of negative remodeling of the side branch ostium on the efficacy of a two-stent strategy for distal left main bifurcation lesions:an intravascular ultrasound study

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Journal of Geriatric Cardiology 2024年第5期21卷 506-522页

作者： Yi XU Tian XU Jia-Cong NONG Xiao-Han KONG Meng-Yao ZHAO Zhi-Jing GAO Yi-Fei wang Wei YOU Pei-Na MENG Yu-He ZHOU Xiang-Qi WU Zhi-Ming WU mei-En zhan Yan-Qing wang De-Feng PAN Fei YE Department of Cardiology Nanjing First HospitalNanjing Hospital Affiliated to Nanjing Medical UniversityNanjing Medical UniversityNanjingChina Department of Cardiology Clinical Medicine School of Nanjing UniversityNanjingChina Department of Cardiology Tianchang People’s HospitalTianchangChina Department of Cardiology the Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina

OBJECTIVES To investigate whether negative remodeling(NR) detected by intravascular ultrasound(IVUS) of the side branch ostium(SBO) would affect in-stent neointimal hyperplasia(NIH) at the one-year follow-up and the clinical outcome of target lesion failure(TLF) at the long-term follow-up for patients with left main bifurcation(LMb) lesions treated with a two-stent *** A total of 328 patients with de novo true complex LMb lesions who underwent a 2-stent strategy of percutaneous coronary intervention(PCI) treatment guided by IVUS were enrolled in this study. We divided the study into two phases. Of all the patients, 48 patients who had complete IVUS detection pre-and post-PCI and at the 1-year follow-up were enrolled in phase Ⅰ analysis, which aimed to analyze the correlation between NR and in-stent NIH at SBO at the 1-year follow-up. If the correlation was confirmed, the cutoff value of the remodeling index(RI) for predicting NIH ≥ 50% was analyzed next. The phase Ⅱ analysis focused on the incidence of TLF as the primary endpoint at the 1-to 5-year follow-up for all 328 patients by grouping based on the cutoff value of *** In phase I: according to the results of a binary logistic regression analysis and receiver operating characteristic(ROC) analysis, the RI cutoff value predicting percent NIH ≥ 50% was 0.85 based on the ROC curve analysis, with a sensitivity of 85.7%, a specificity of 88.3%, and an AUC of 0.893(0.778, 1.000), P = 0.002. In phase Ⅱ: the TLR rate(35.8% vs. 5.3%, P < 0.0001)was significantly higher in the several NR(s NR, defined as RI ≤ 0.85) group than in the non-s NR *** The NR of LCx O is associated with more in-stent NIH post-PCI for distal LMb lesions with a 2-stent strategy,and NR with RI ≤ 0.85 is linked to percent NIH area ≥ 50% at the 1-year follow-up and more TLF at the 5-year follow-up.

关键词： lesions remodeling intravascular

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Exploring the role of interleukin-6 receptor blockade in epilepsy and associated neuropsychiatric conditions through a mendelian randomization study

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World Journal of Psychiatry 2024年第8期14卷 1244-1253页

作者： Yan-mei Yu Gui-Hong Jin Chong Zhong Hao Qian Lei wang Feng zhan Department of Pediatrics The First People's Hospital of ChuzhouChuzhou 239001Anhui ProvinceChina Department of Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The interplay between inflammation,immune dysregulation,and the onset of neurological disorders,including epilepsy,has become increasingly ***(IL)-6,a pro-inflammatory cytokine,is suspected to not only mediate traditional inflammatory pathways but also contribute to neuroinflammatory responses that could underpin neuropsychiatric symptoms and broader psychiatric disorders in epilepsy *** role of IL-6 receptor(IL6R)blockade presents an intriguing target for therapeutic intervention due to its potential to attenuate these *** conditions due to *** Mendelian randomization(MR)analysis employing single nucleotide poly-morphisms(SNPs)in the vicinity of the IL6R gene(total individuals=408225)was used to evaluate the putative causal relationship between IL6R blockade and epilepsy(total cases/controls=12891/312803),focal epilepsy(cases/controls=7526/399290),and generalized epilepsy(cases/controls=1413/399287).SNP weights were determined by their effect on C-reactive protein(CRP)levels and integrated using inverse variance-weighted meta-analysis as surrogates for IL6R *** address potential outlier and pleiotropic influences,sensitivity analyses were conducted employing a variety of MR methods under different modeling *** The genetic simulation targeting IL6R blockade revealed a modest but significant reduction in overall epilepsy risk[inverse variance weighting:Odds ratio(OR):0.827;95%confidence interval(CI):0.685-1.000;P=0.05].Subtype analysis showed variability,with no significant effect observed in generalized,focal,or specific childhood and juvenile epilepsy *** the primary inflammatory marker CRP,the findings also suggested potential non-inflammatory pathways mediated by IL-6 signaling contributing to the neurobiological landscape of epilepsy,hinting at possible links to neuroinflammation,psychiatric symptoms,and associated mental *** The i

关键词： Epilepsy Interleukin-6 receptor blockade Mendelian randomization Neuroinflammation Psychiatric disorders

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基于背景拼接与纹理模板的全自动迷彩图案设计

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纺织学报 2024年第5期45卷 94-101页

作者：詹宇婷梅琛楠王焰肖红钟跃崎东华大学纺织学院上海201620 军事科学院系统工程研究院北京100010 东华大学纺织面料技术教育部重点实验室上海201620

为提高迷彩伪装图案的设计效率和环境适应性,利用背景拼接与纹理模板融合进行迷彩伪装图案的全自动化设计。通过将输入的若干背景图像自动组合为单张拼接图像,采用均值聚类法提取出背景拼接图像的主色;提出4种迷彩纹理模板自动设计方法... 详细信息

为提高迷彩伪装图案的设计效率和环境适应性,利用背景拼接与纹理模板融合进行迷彩伪装图案的全自动化设计。通过将输入的若干背景图像自动组合为单张拼接图像,采用均值聚类法提取出背景拼接图像的主色;提出4种迷彩纹理模板自动设计方法(多圆形随机分布法、WGN傅里叶频谱法、肌理图像生成法及分层云彩法),再对所得迷彩纹理模板进行色彩聚类与色彩替换,得到最终的迷彩伪装图案。为验证设计的有效性,针对丛林虚拟场景自动生成了4种伪装图案,并进行了伪装效果的主观和客观评价。结果表明,上述方法仅需17.0~71.0 s即可完成针对目标背景的迷彩图案设计,且最优方案为基于多圆形随机分布法纹理模板的迷彩图案;本文方法相对于普通迷彩伪装,其主观评价搜索时间增加了8.1%,基于Positioning and Focus Network(PF-Net)模型的客观评价发现概率降低了45%。

关键词：迷彩伪装图案设计均值聚类纹理模板伪装检测

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PbSb_(2)O_(6)热力学性质的第一性原理研究

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中国陶瓷 2024年第3期60卷 30-37页

作者：王红梅李姝曹战民北京科技大学冶金与生态工程学院北京100083

PbSb_(2)O_(6)的空间群为P-31m,由于其具有不规则多面体的特殊层状结构和隧道结构、价带和导带的杂化态以及深层氧化势,在光催化剂、玻璃材料和半导体等领域有着广阔的应用前景。当前对于PbSb_(2)O_(6)制备的研究较多,为了理解PbSb_(2)O... 详细信息

PbSb_(2)O_(6)的空间群为P-31m,由于其具有不规则多面体的特殊层状结构和隧道结构、价带和导带的杂化态以及深层氧化势,在光催化剂、玻璃材料和半导体等领域有着广阔的应用前景。当前对于PbSb_(2)O_(6)制备的研究较多,为了理解PbSb_(2)O_(6)在实际应用中的化学反应性和热力学稳定性条件,对其热力学性质的研究是有必要的。基于密度泛函理论第一性原理方法,对PbSb_(2)O_(6)的标准生成焓、熵、热容、热膨胀系数等进行了研究。

关键词： PbSb_(2)O_(6) 热力学性质密度泛函理论第一性原理

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