检索结果-南通市图书馆

Prediction and analysis of albumin-bilirubin score combined with liver function index and carcinoembryonic antigen on liver metastasis of colorectal cancer

引用

World Journal of Gastrointestinal Surgery 2024年第6期16卷 1670-1680页

作者： zhan-Mei Wang Shu-Ping Pan Jing-Jing zhang jun Zhou Department of Medical Oncology Qilu Hospital(Qingdao)Cheeloo College MedicineShandong UniversityQingdao 266000Shandong ProvinceChina Department of Gastroenterology Feicheng People’s HospitalFeicheng 271600Shandong ProvinceChina Department of Anus and Intestine Surgery Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina Department of Oncology Qilu Hospital(Qingdao)Cheeloo College MedicineShandong UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a common malignant tumor,and liver metastasis is one of the main recurrence and metastasis modes that seriously affect patients’survival rate and quality of *** such as albumin bilirubin(ALBI)score,liver function index,and carcinoembryonic antigen(CEA)have shown some potential in the prediction of liver metastasis but have not been fully *** To evaluate its predictive value for liver metastasis of CRC by conducting the combined analysis of ALBI,liver function index,and CEA,and to provide a more accurate liver metastasis risk assessment tool for clinical treatment *** This study retrospectively analyzed the clinical data of patients with CRC who received surgical treatment in our hospital from January 2018 to July 2023 and were followed up for 24 *** to the follow-up results,the enrolled patients were divided into a liver metastasis group and a nonliver metastasis group and randomly divided into a modeling group and a verification group at a ratio of 2:*** risk factors for liver metastasis in patients with CRC were analyzed,a prediction model was constructed by least absolute shrinkage and selection operator(LASSO)logistic regression,internal validation was performed by the bootstrap method,the reliability of the prediction model was evaluated by subject-work characteristic curves,calibration curves,and clinical decision curves,and a column graph was drawn to show the prediction *** Of 130 patients were enrolled in the modeling group and 65 patients were enrolled in the verification group out of the 195 patients with CRC who fulfilled the inclusion and exclusion *** LASSO regression variable screening and logistic regression *** ALBI score,alanine aminotransferase(ALT),and CEA were found to be independent predictors of liver metastases in CRC patients[odds ratio(OR)=8.062,95%confidence interval(CI):2.545-25.540],(OR=1.037,95%CI:1.004-1.071)and(OR=1.0

关键词： Albumin-bilirubin Carcinoembryonic antigen Colorectal cancer Tumor metastasis Prediction model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Single-shot phase retrieval for randomly fluctuated and obstructed vortex beams

引用

Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 72-80页

作者： Hao zhang jun’an Zhu Xingyuan Lu Zhiquan Hu Jianbo Gao Kun Liu Qiwen zhan yangjian Cai Chengliang Zhao School of Physical Science and Technology Soochow UniversitySuzhou 215006China School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shandong Provincial Engineering and Technical Center of Light Manipulations Shandong Provincial Key Laboratory of Optics and Photonic DeviceSchool of Physics and ElectronicsShandong Normal UniversityJinan 250358China Joint Research Center of Light Manipulation Science and Photonic Integrated Chip of East China Normal University and Shandong Normal University East China Normal UniversityShanghai 200241China

Vortex beams with orbital angular momentum play a crucial role in increasing the information capacity in optical *** magnitude of orbital angular momentum determines the ability of information *** practice,a vortex beam can encounter random objects or turbulence during free-space propagation,resulting in information ***,accurately measuring the orbital angular momentum of a randomly fluctuated and obstructed vortex beam is a considerable ***,we propose a single-shot method for the phase retrieval of a randomly fluctuated and obstructed vortex beam by combining the phase-shift theorem and self-reference *** results reveal that the sign and magnitude of the initial orbital angular momentum can be simultaneously determined based on their quantitative relation with the number of coherence singularities on the observation plane,thus addressing the effects of random occlusion and atmospheric *** proposed method considerably improved the accurate decoding of orbital angular momentum information in nonideal freespace optical communications.

关键词： optical vortex phase retrieve orbital angular momentum measurement antiturbulence antidisturbance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A bibliometric analysis of molybdenum-based nanomaterials in the biomedical field

引用

Tungsten 2024年第1期6卷 17-47页

作者： Zhi-Qiang Wang Ya-Wen Pan Jing Wu Hong-Bin Qi Shuang Zhu zhan-jun Gu School of Science China University of GeosciencesBeijing 100083China CAS Key Laboratory for Biomedical Eff ects of Nanomaterials and Nanosafety Institute of High Energy PhysicsBeijing 100049China CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaChinese Academy of SciencesBeijing 100190China College of Materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China

Molybdenum(Mo)-based nanomaterials have been widely used in biomedical fields due to their various nanostructures and unique physical/chemical *** various reviews have described the development of Mo-based materials in the biomedical field,an objective and comprehensive summary and analysis of research trends in this field is still ***,we used the bibliometric analysis method to analyze all relevant literature on the biological application of Mobased nanomaterials in recent ***,we use bibliometric tools to analyze the dataset by year,country/region,institution and research hotspot to obtain the research ***,based on objectively identified research hotspots,the biomedical applications of Mo-based nanomaterials are reviewed comprehensively,mainly including sensors,cancer imaging/therapy and antibacterial ***,we discussed the application prospects and challenges of Mo-based *** article provides a new perspective to understand the current research progress and further promote the development of Mobased nanomaterials in biomedical research.

关键词： Molybdenum Nanomaterial Biomedicine Bibliometric analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway

引用

Current Medical Science 2024年第2期44卷 333-345页

作者： jun-li ZHAO Lin ZHAO Qiu-nan zhan Miao LIU Ting zhanG Wen-wen CHU Department of Nephrology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghai 201318China Orthopedic Department Guangming Traditional Chinese Medicine Hospital of Pudong New AreaShanghai 201399China

Objective:Peritoneal fibrosis(PF)is the main cause of declining efficiency and ultrafiltration failure of the peritoneum,which restricts the long-term application of peritoneal dialysis(PD).This study aimed to investigate the therapeutic effects and mechanisms of bone marrow mesenchymal stem cells-derived exosomes(BMSC-Exos)on PF in response to ***:Small RNA sequencing analysis of BMSC-Exos was performed by second-generation sequencing.C57BL/6J mice were infused with 4.25%glucose-based peritoneal dialysis fluid(PDF)for 6 consecutive weeks to establish a PF model.A total of 36 mice were randomly divided into 6 groups:control group,1.5%PDF group,2.5%PDF group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment *** transcription quantitative polymerase chain reaction(RT-qPCR)was performed to measure the expression level of miR-27a-3p in BMSC-Exos and peritoneum of mice treated with different concentrations of *** and Masson staining were performed to evaluate the extent of *** therapeutic potential of BMSC-Exos for PF was examined through pathological examination,RT-qPCR,Western blotting,and peritoneal function ***-mesenchymal transition(EMT)of HMrSV5 was induced with 4.25%*** were divided into control group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment *** Counting Kit-8 assay was used to measure cell viability,and transwell migration assay was used to verify the capacity of BMSC-Exos to inhibit EMT in HMrSV5 ***:Small RNA sequencing analysis showed that miR-27a-3p was highly expressed in BMSC-derived exosomes compared to *** RT-qPCR results showed that the expression of miR-27a-3p was upregulated in BMSC-Exos,but decreased in PD *** found that PF was glucose concentration-dependently enhanced in the peritoneum of the PD *** with the control mice,the PD mice showed high solute transport and decreased ultrafiltration volume as well as an obvious f

关键词： peritoneal fibrosis bone marrow mesenchymal stem cell-derived exosomes miR-27a-3p TP53 epithelialmesenchymal transition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis

引用

Engineering 2024年第7期38卷 144-154页

作者： jun-Su Zhou Long Cheng Yuan Gao zhan-Peng Ge Bin Zhou Jing-Ya Li Jin-Xin Zhao Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

Four new norditerpenoid heterodimers with different dimerization patterns-namely,trigofragiloids A-C(denoted as compounds 1-3)and(+)-and(-)-trigofragiloid D(compound 4)-and three new phenanthrenone norditerpenoids-namely,trigofragiloids E-G(compounds 5-7)-were isolated from Trigonostemon *** 1 and 2 feature a novel heterodimeric carbon skeleton formed by the conjugation of a tetra-norditerpenoid and an ennea-norditerpenoid;they have been identified as class 2 atropisomers by means of quantum chemical *** 3 is an unprecedented phenylpropanoid-norditerpenoid adduct with a new dimerization ***(+)-and(-)-4 are the first example of S-shaped 1,4-dioxane-fused norditerpenoid *** by the structure elucidation of compound 4,two co-occurring analogues,actephilol A and epiactephilol A,were structurally revised as a pair of geometrical isomers and were identified as two pairs of enantiomers,(+)-and(-)-8 and(+)-and(-)-9,*** structures were characterized using a combined ***,compound 7 exhibits remarkable adenosine triphosphate-citrate lyase(ACLY)inhibition with a halfmaximal inhibition concentration(IC50)value of(0.46±0.11)lmol·L^(-1),as active as the positive control BMS-303141,and a molecular docking study offers deep insight into the interaction between compound 7 and ACLY.

关键词： Norditerpenoid heterodimer Trigonostemon fragilis Euphorbiaceae Trigofragiloid Structural revision Adenosine triphosphate-citrate lyase(ACLY) inhibitory activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fe-N-C heterogeneous Fenton-like catalyst for the degradation of tetracycline:Fe-N coordination and mechanism studies

引用

Chinese Chemical Letters 2024年第9期35卷 309-314页

作者： Weichen Zhu Wei Zuo Pu Wang Wei zhan jun zhang Lipin Li Yu Tian Hong Qi Rui Huang State Key Laboratory of Urban Water Resource and Environment(SKLUWRE) School of EnvironmentHarbin Institute of TechnologyHarbin 150090China Guangdong Yuehai Water Investment Co. Ltd.Shenzhen 518021China National Engineering Research Center of Urban Water Resources Co. Ltd.Harbin Institute of TechnologyHarbin 150090China

Fe-N-C materials have received increasing attention,due to its distinctive catalytic ***,the Fe-N coordination number dependence of catalytic ability and mechanism for H_(2)O_(2)activation remain ***,a series of Fe-N-C heterogeneous Fenton-like catalysts with different Fe-N coordination number were prepared for tetracycline *** results demonstrated that samples with Fe-N4 structure exhibited high *** excellent performance was mainly ascribed to the high adsorption capacity and the formation of superoxide radicals(•O_(2)^(−))catalyzed by Fe linked to pyridinic *** intermediates and degradation pathways of tetracycline degradation by Fe-N-C/H_(2)O_(2)system were analyzed by liquid chromatography coupled to tandem mass spectrometry(LC-MS/MS).Furthermore,we applied our Fe-N-C catalysts to treat simulated pharmaceutical wastewater with high tetracycline degradation capacity despite high concentrations of organic matter such as oxalic acid and various ionic *** work reveals the dependence of the activation H_(2)O_(2)on the Fe-N coordination environment and the degradation mechanism of these *** provides insights into the prospects for tuning the catalyst in practical applications.

关键词： H_(2)O_(2)activation Advanced oxidation process Superoxide radicals Degradation pathways EXAFS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of the energy budget of thermokarst lake in permafrost regions of the Qinghai-Tibet Plateau

引用

Advances in Climate Change Research 2024年第4期15卷 636-646页

作者： Ze-Yong GAO Fu-jun NIU Yi-Bo WANG Jing LUO Guo-An YIN Yun-Hu SHANG zhan-Ju LIN Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of ScienceLanzhou 730000China College of Earth and Environment Science Lanzhou UniversityLanzhou 73000China

Thermokarst lake formation accelerates permafrost degradation due to climate warming,thereby releasing significant amounts of carbon into the atmosphere,complicating hydrological cycles,and causing environmental ***,the energy transfer mechanism from the surface to the sediment of thermokarst lakes remains largely unexplored,thereby limiting our understanding of the magnitude and duration of biogeochemical processes and hydrological ***,herein,a typical thermokarst lake situated in the center of the Qinghai-Tibet Plateau(QTP)was selected for observation and energy budget *** results showed that the net radiation of the thermokarst lake surface was 95.1,156.9,and 32.3 W m^(-2) for the annual,ice-free,and ice-covered periods,respectively,and was approximately 76%of the net radiation consumed by latent heat *** in heat storage in the thermokarst lake initially increased from January to April,then decreased from April to December,with a maximum change of 48.1 W m^(-2) in *** annual average heat fuxes from lake water to sediments were 1.4 W m^(-2);higher heat fluxes occurred during the ice-free season at a range of 4.9-12.0 W m^(-2).The imbalance between heat absorption and release in the millennium scale caused the underlying permafrost of the thermokarst lake to completely *** present,the ground temperature beneath the lake bottom at a depth of 15 m has reached 2.0℃.The temperatures and vapor-pressure conditions of air and lake surfaces control the energy budget of the thermokarst *** findings indicate that changes in the hydrologic regime shifts and biogeochemical processes are more frequent under climate warming and permafrost degradation.

关键词： Qinghai-Tibet Plateau Thermokarst lake Energy budget Permafrost degradation Hydrological cycle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neoadjuvant chemotherapy with capecitabine combined with oxaliplatin for mid-low locally advanced rectal cancer with negative mesorectal fascia:Long-term outcomes of a prospective trial(PKUCH-R03 trial)

引用

Chinese Journal of Cancer Research 2024年第4期36卷 410-420页

作者： Nan Chen Minghe Zhao Yunfeng Yao Lin Wang Yifan Peng Tingting Sun Tiancheng zhan jun Zhao Aiwen Wu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Gastrointestinal Cancer CenterUnit IIIPeking University Cancer Hospital&InstituteBeijing 100142China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchGastrointestinal Cancer CenterUnit IIIPeking University Cancer Hospital&InstituteBeijing 100142China

Objective:To evaluate the safety and efficacy of neoadjuvant chemotherapy(NCT)in mid-low locally advanced rectal cancer with negative mesorectal fascia(MRF).Methods:This prospective,single-arm phaseⅡtrial was designed and conducted at Peking University Cancer *** patients who provided consent received 3 months of NCT(capecitabine and oxaliplatin,CapOX)followed by total mesorectal excision(TME).The primary endpoint was the rate of pathological complete response(pCR).Results:From January 2019 through December 2021,a total of 53 patients were enrolled,7.5%of whom experienced grade 3-4 adverse events during *** pCR rate was 17.0%for the entire cohort,and the overall rate of postoperative complications was 37.7%(1.9%of gradeⅢa patients).The 3-year disease-free survival rate was 91.4%,and 23.5%(12/51)of the patients suffered from major low anterior resection syndrome(LARS).Postoperative complications were independently associated with major ***:For patients with mid-low rectal cancer with negative MRF,3 months of NCT were found to yield a favorable tumor response with acceptable *** fair long-term survival,the NCT regimen could be associated with low rates of perioperative complications as well as acceptable anal function.

关键词： Neoadjuvant chemotherapy rectal cancer mesorectal fascia disease-free survival anal function

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation of water-soluble tantalum nanoparticles and their radiosensitization application

引用

Tungsten 2024年第4期6卷 748-758页

作者： Wang zhang Shuang-Long Du Zhi-Guo zhang Tao Wang Chun-Jian Su Xing-Hua Dong Shuang Zhu zhan-jun Gu College of Mechanical and Electronic Engineering Shandong University of Science and Technology CAS Key Laboratory for Biomedical Eff ects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Science GBA Research Innovation Institute for Nanotechnology CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Chinese Academy of Sciences

Radiation therapy(RT) that utilizes high dose of ionizing radiation to kill tumor cells is a common cancer treatment ***,the effectiveness of RT is limited by the tolerance of normal tissue surrounding the *** high atom number(Z) element-based radio sensitizers to increase energy deposit inside tumor cells can achieve better carcinoma *** nanoparticles(Ta NPs) exhibit good radiotherapy sensitization ***,achieving the water solubility of Ta NPs is *** study reported a mechanochemical method for obtaining Ta NPs modified with sodium hexametaphosphate(SHMP) for radiotherapy sensitization *** results showed that the water solubility of Ta NPs modified with SHMP was significantly *** biocompatibility and radio sensitizing ability are also verified at both cellular and animal levels.

关键词： Mechanochemical method Radiotherapy sensitization Sodium hexametaphosphate Tantalum nanoparticles

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Supramolecular systems for bioapplications:recent research progress in China

引用

Science China Chemistry 2024年第5期67卷 1397-1441页

作者： Yue-yang Liu Xiao-Yong Yu Yu-Chen Pan Hang Yin Shuang Chao Yujie Li He Ma Minzan Zuo Kun-Xu Teng jun-Li Hou Yong Chen Dong-Sheng Guo Ruibing Wang Yuxin Pei Zhichao Pei Jiang-Fei Xu Xiao-Yu Hu Chunju Li Qing-Zheng yang Leyong Wang Yu Liu zhan-Ting Li State Key Laboratory of Organometallic Chemistry Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional MoleculesShanghai Institute of Organic ChemistryChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200032China Department of Chemistry Fudan UniversityShanghai 200438China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryCollaborative Innovation Center of Chemical Science and EngineeringNankai UniversityTianjin 300071China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China Key Lab of Organic Optoelectronics&Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Radiopharmaceuticals Ministry of EducationCollege of ChemistryBeijing Normal UniversityBeijing 100875China Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China State Key Laboratory of Analytical Chemistry for Life Science Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Supramolecular systems feature dynamic,reversible and stimuli-responsive characteristics,which are not easily achieved by molecular *** last decade has witnessed tremendous advances in the investigations of supramolecular systems for various bioapplications,which include drug delivery,anticancer therapy,antibacterial therapy,photodynamic therapy,photothermal therapy,combination therapy,antidotes for residual drugs or toxins,and bioimaging and ***-guest chemistry has played a key role in the development of such bioactive supramolecular systems,and natural macrocycles(such as cyclodextrins),synthetic macrocycles(such as calixarenes,cucurbit[n]urils,and pillararenes),and porous framework polymers(such as supramolecular organic frameworks and flexible organic frameworks)have been most successfully used as hosts to build different kinds of host-guest systems for attaining designed *** self-assembly of rationally designed amphiphilic molecules,macromolecules and polymers represent another important approach for the construction of supramolecular architectures with advanced *** this review,we summarize the important contributions made by Chinese researchers in this field,with emphasis on those reported in the past five years.

关键词： host-guest chemistry drug delivery anticancer and antibacterial photodynamic therapy photothermal therapy antidote transmembrane channel bioimaging and biosensing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：