检索结果-南通市图书馆

Establishment of NaLuF_(4):15%Tb-based low dose X-PDT agent and its application on efficient antitumor therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 599-610页

作者： Yi Tian Zhiguang Fu Xiaosheng Zhu Chunjing zhan Jinwei hu Li Fan Chaojun Song Qian Yang Yu Wang Mei Shi Department of Radiation Oncology Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China Department of Oncology Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Tumor Radiotherapy Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Gastroenterology Air Force Hospital of Southern Theater CommandGuangzhou 510062China Department of Pharmaceutical Chemistry and Analysis School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China Institue of Materia Medica School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China

X-ray excited photodynamic therapy(X-PDT)is the bravo answer of photodynamic therapy(PDT)for deep-seated tumors,as it employs X-ray as the irradiation source to overcome the limitation of light penetration ***,high X-ray irradiation dose caused organ lesions and side effects became the major barrier to X-PDT *** address this issue,this work employed a classic-al co-precipitation reaction to synthesize NaLuF_(4):15%Tb^(3+)(NLF)with an average particle size of(23.48±0.91)nm,which was then coupled with the photosensitizer merocyanine 540(MC540)to form the X-PDT system NLF-MC540 with high production of singlet *** system could induce antitumor efficacy to about 24%in relative low dose X-ray irradiation range(0.1-0.3 Gy).In vivo,when NLF-MC540 irradiated by 0.1 Gy X-ray,the tumor inhibition percentage reached 89.5%±5.7%.The therapeutic mechanism of low dose X-PDT was found.A significant increase of neutrophils in serum was found on the third day after *** immunohistochemical staining of tumor sections,the Ly6G^(+),CD8^(+),and CD11c^(+)cells infiltrated in the tumor microenvironment were *** the bilat-eral tumor model,the NLF-MC540 with 0.1 Gy X-ray irradiation could inhibit both the primary tumor and the distant tumor ***-tected by enzyme linked immunosorbent assay(ELISA),two cytokines IFN-γand TNF-αin serum were upregulated 7 and 6 times than negative control,*** by enzyme linked immune spot assay(ELISPOT),the number of immune cells attributable to the IFN-γand TNF-αlevels in the group of low dose X-PDT were 14 and 6 times greater than that in the negative control group,***,it conclude that low dose X-PDT system could successfully upregulate the levels of immune cells,stimulate the secretion of cy-tokines(especially IFN-γand TNF-α),activate antitumor immunity,and finally inhibit colon tumor growth.

关键词： X-ray excited photodynamic therapy singlet oxygen low dose X-Ray irradiation efficient antitumor therapy anti-tumor immunity

Clinical efficacy and mechanism study of mid-frequency anti-snoring device in treating moderate obstructive sleep apnea-hypopnea syndrome

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第5期12卷 942-950页

作者： Bao Qian zhan-Jun Chen Yong-Sheng Wang Xiao-Yan hu Xiao-Biao hu Yong-hua Zheng Pulmonary Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China Radiology Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China

BACKGROUND Obstructive sleep apnea-hypopnea syndrome(OSAHS)is primarily caused by airway obstruction due to narrowing and blockage in the nasal and nasopha-ryngeal,oropharyngeal,soft palate,and tongue base *** mid-frequency anti-snoring device is a new technology based on sublingual nerve *** principle is to improve the degree of oropharyngeal airway stenosis in OSAHS patients under mid-frequency wave ***,there is a lack of clinical application and imaging *** We selected 50 patients diagnosed with moderate OSAHS in our hospital between July 2022 and August *** underwent a 4-wk treatment regimen involving the mid-frequency anti-snoring device during nighttime *** the treatment,we monitored and assessed the sleep apnea quality of life index and Epworth Sleepiness Scale ***,we performed computed tomo-graphy scans of the oropharynx in the awake state,during snoring,and while using the mid-frequency anti-snoring ***-sectional area measurements in different states were taken at the narrowest airway point in the soft palate posterior and retrolingual *** Compared to pretreatment measurements,patients exhibited a significant reduction in the apnea-hypopnea index,the percentage of time with oxygen saturation below 90%,snoring frequency,and the duration of the most prolonged apnea *** lowest oxygen saturation showed a notable increase,and both sleep apnea quality of life index and Epworth Sleepiness Scale scores *** computed tomography scans revealed that in OSAHS patients cross-sectional areas of the oropharyngeal airway in the soft palate posterior area and retrolingual area decreased during snoring compared to the awake ***,during mid-frequency anti-snoring device treatment,these areas increased compared to *** The mid-frequency anti-snoring device demonstrates the potential to enhance various sleep parameters in pat

关键词： Mid-frequency anti-snoring device Obstructive sleep apnea-hypopnea syndrome Sleep monitoring Oropharyngeal computed tomography Curative effect

Underestimated Methane Emissions from Solid Waste Disposal Sites Reveal Missed Greenhouse Gas Mitigation Opportunities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2024年第5期36卷 12-15页

作者： yao Wang Chuanbin Zhou Ziyang Lou Houhu zhang Abid hussain Liangtong zhan Ke Yin Mingliang Fang Xunchang Fei School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore 639798Singapore State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Nanjing Institute of Environmental Sciences Ministry of Ecology and EnvironmentNanjing 210042China Department of Civil and Environmental Engineering Carleton UniversityOttawaON K1S 5B6Canada Ministry of Education(MOE)Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang UniversityHangzhou 310058China Department of Environmental Engineering School of Biology and the EnvironmentNanjing Forestry UniversityNanjing 210037China Department of Environmental Science and Engineering Fudan UniversityShanghai 200433China

*** Cities are responsible for approximately 70%of all anthropogenic greenhouse gas(GHG)emissions and about 60%of all anthropogenic methane(CH4)emissions[1,2].Solid waste disposal sites(including landfills and dumpsites),which are prevalent in global cities,emit CH4 generated from the anaerobic biodegradation of municipal solid waste(MSW).Notably,the proportions of CH4 emissions from disposal sites surpass 50%of the total CH4 emissions in some megalopolises[3].CH4 has a high global warming potential(GWP),being 28 times stronger than carbon dioxide(CO_(2))over a 100-year period and 80 times stronger over a 20-year period[4].Understanding and mitigating CH4 emissions from solid waste disposal sites is particularly pertinent and pressing,considering that the latest Synthesis Report from the Intergovernmental Panel on Climate Change(IPCC)emphasizes that the current pace of mitigation and adaptation policies and measures falls short of restraining global temperature rise to under 1.5℃ within the 21st century[4].More than 150 countries signed the Global Methane Pledge at the United Nations Climate Change Conference in Glasgow(COP26),which aims to reduce global annual CH4 emissions by 30%by 2030,compared with emissions in 2020[5].

关键词： landfill Solid restrain

Influence of self-similar stresses on scenario earthquake construction:An example along the Tanlu Fault

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第5期67卷 1687-1697页

作者： Feng hu huajian yao Houyun YU Zeyu LU Jieyi HOU Song LUO Zhigang SHAO Xiaofei CHEN School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Mengcheng Geophysical National Field Scientific Observatory Hefei 230026China Department of Earth and Space Science Southern University of Science and TechnologyShenzhen 518055China Institute of Earthquake Prediction China Earthquake AdministrationBeijing 100036China

As a famous deep and large fault in eastern China,the Tanlu Fault passes through Anhui,Jiangsu,and Shandong and into northeastern *** is important to improve the understanding of seismic hazard assessments in areas near *** start a scenario earthquake simulation in the M7.5 earthquake potential area of the Xinyi-Sihong segment of the Tanlu *** fault rupture length and width are constrained according to the scaling law of large intraplate earthquakes,the background normal stress is depth dependent,and the initial shear stresses are determined using trial and error by matching the earthquake *** the 120 km rupture length of the M7.5 earthquake,we compare the horizontal uniform stress model and self-similar stress perturbation *** findings reveal that the seismic source time function of the horizontal uniform stress model is similar to that of the Haskell model and that of the self-similar stress perturbation model is more similar to that of a real earthquake *** compare the dynamic rupture simulation and ground motion results under four different stress conditions and find that the shorter the characteristic length of the self-similar function is,the rougher the initial *** the M7.5earthquake with an epicenter in the vicinity of Suqian,the Xinyi-Tancheng segment,which is located in the IX-intensity zone north of the epicenter,vibrates more strongly on the northern side than on the southern side due to the influence of the lowvelocity zone and the peak slip *** response spectra analysis at stations in the study area is useful for improving the earthquake resistance capability.

关键词： Scenario earthquakes Self-similar stress Tanlu Fault Dynamic rupture Ground motion

Sensitivity Improvements for Picosecond Ultrasonic Thickness Measurements in Gold and Tungsten Nanoscale Films

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nanomanufacturing and Metrology 2024年第2期7卷 1-12页

作者： Jiaqi Dong Chengyuan yao Yuanhao Zhu Shaojie Li Bowen Liu JinTao Fan Chunguang hu Youjian Song Minglie hu Key Laboratory of Opto-Electronic Information Science and Technology of Ministry of Education School of Precision Instruments and Opto-Electronics EngineeringTianjin UniversityTianjin 300072China State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072China

Picosecond ultrasonics,as a nondestructive and noncontact method,can be employed for nanoscale metallic film thickness *** sensitivity of the system,which determines the measurement precision and practicability of this technique,is often limited by the weak intensity of the ultrasonic *** solve this problem,we investigate the distinct mechanisms involved in picosecond ultrasonic thickness measurement for two types of metals,namely tungsten(W)and gold(Au).For thickness measurement in W films,theory and simulation show that optimizing the pump and probe laser wavelengths,which determine the intensity and shape of the ultrasonic signal,is critical to improving measurement sensitivity,while for Au film measurements,where acoustic-induced beam distortion is dominant,the signal intensity can be optimized by selecting an appropriate aperture size and sample *** above approaches are validated in experiments.A dual-wavelength pump-probe system is constructed based on a passively mode-locked ytterbium-doped fiber *** smoothing method and multipeak Gaussian fitting are employed for the extraction of ultrasonic *** measurement precision is achieved in a series of W and Au films with thicknesses of 43-750 *** work can be applied to various high-precision,noncontact measurements of metal film thickness in the semiconductor industry.

关键词： Picosecond ultrasonics Thickness measurement Optical pump-probe Beam distortion technique

M^(6)A modification in cardiovascular disease:With a focus on programmed cell death

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 272-284页

作者： Wen Li yao Liu Ruiyan Xu Yuan Zong Lu He Jun hu Guohua Li Institute of Cardiovascular Disease Key Laboratory for Arteriosclerology of Hunan ProvinceHunan International Scientific and Technological Cooperation Base of Arteriosclerotic DiseaseDepartment of PathophysiologyMOE Key Lab of Rare Pediatric DiseasesHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular Medicine The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Obstetrics and Gynecology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Cardiovascular Surgery The Second Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

N^(6)-methyladenosine(m^(6)A)methylation is one of the most predominant internal RNA modifications in eukaryotes and has become a hot spot in the field of epigenetics in recent *** diseases(CVDs)are a leading cause of death *** evidence demonstrates that RNA modifications,such as the m^(6)A modification,are associated with the development and progression of many diseases,including *** increasing body of studies has indicated that programmed cell death(PCD)plays a vital role in ***,the molecular mechanisms underlying m^(6)A modification and PCD in CVDs remain poorly ***,elaborating on the highly complex connections between the m^(6)A mechanisms and different PCD signaling pathways and clarifying the exact molecular mechanism of m^(6)A modification mediating PCD have significant meaning in developing new strategies for the prevention and therapy of *** is great potential for clinical application.

关键词： Apoptosis Autophagy Cardiovascular diseases Ferroptosis N^(6)-methyladenosine Programmed cell death Pyroptosis

Inpatient disease spectrum and clinical characteristics of surgical disorders in pediatric and adolescent gynecology:A single-institute study of 12 years data from China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第10期137卷 1240-1242页

作者： He huang Siyun Wang Ruixi zhan Ling Yin Yongchun hu Donglai Yang Yangyang Shi Department of Obstetrics and Gynecology Peking University First HospitalXicheng DistrictBeijing 100034China Department of Obstetrics and Gynecology Inner Mongolia Ulanqab Second HospitalUlanqabInner Mongolia 012000China Department of Obstetrics and Gynecology Jiujiang University Affiliated HospitalJiujiangJiangxi 332000China

To the Editor:Pediatric and adolescent gynecology(PAG)is a specialized branch of gynecology that focuses on reproductive health issues of women from infancy to adolescence.[1]In 1939,the hungarian Dobszayrst established the new *** then,the PAG subject has begun to develop and gradually matured in the past 80 *** PAG has witnessed signicant development in western countries,a substantial unmet need persists in addressing specic health concerns among children and adolescents with gynecological disorders.

关键词： adolescent disorders branch

Spatial and Temporal Distribution Characteristics of Solar Energy Resources in Tibet

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Energy Engineering 2024年第1期121卷 43-57页

作者： Yanbo Shen Yang Gao Yueming hu Xin yao Wenzheng Yu Yubing zhang Public Meteorological Service Center China Meteorological AdministrationBeijing100081China Center forWind and Solar Energy Resources China Meteorological AdministrationBeijing100081China School of Applied Meteorology Nanjing University of Information Science&TechnologyNanjing210044China School of Geographical Sciences Nanjing University of Information Science&TechnologyNanjing210044China

The Tibet Plateau is one of the regions with the richest solar energy resources in the *** the process of achieving carbon neutrality in China,the development and utilization of solar energy resources in the region will play an important *** this study,the gridded solar resource data with 1km resolution in Tibet were obtained by spatial correction and downscaling of SMARTS *** this basis,the spatial and temporal distribution characteristics of solar energy resources in the region in the past 30 years(1991–2020)are finely evaluated,and the annual global horizontal radiation resource is *** results show that:1)The average annual global horizontal radiation amount in Tibet is 1816 kWh/m^(2).More than 60%of the area belongs to the“Most abundant”(GHI≥1750 kWh/m^(2))area of China’s solar energy resources category A,and nearly 40%belongs to the“Quite abundant”(1400≤GHI<1750)area of China’s solar energy resource category B.2)In space,the solar energy resources in Tibet increased gradually from north to south and from east to ***,Central and Eastern Shigatse,Shannan,and Southwestern Ali are the most abundant cities,with a maximum annual radiation level of 2189 kWh/m2.3)In terms of time,the total horizontal radiation in Tibet was the highest in May and the lowest in December.74%of the total area belongs to the“Very stable”(R_(w)≥0.47)area of solar resource stability category A,and 26%belongs to the“stable”(0.36≤R_(w)<0.47)area of solar resource stability category *** energy resources in the region show the characteristics of both strong and *** solar energy resources in the region have shown a fluctuating downward trend over the past 30 years,with an average decline of about 12.86(kWh/m2)per decade.4)In terms of solar radiation resources reaching the earth’s surface,the theoretical total amount of annual horizontal radiation in Tibet is about 240.07 billion tons of standard coal or 222.91 billion kilowatts on average.

关键词： Tibet solar resource spatiotemporal distribution

Theta Oscillations Support Prefrontal-hippocampal Interactions in Sequential Working Memory

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第2期40卷 147-156页

作者： Minghong Su Kejia hu Wei Liu Yunhao Wu Tao Wang Chunyan Cao Bomin Sun Shikun zhan Zheng Ye Institute of Psychology Chinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Department of Neurosurgery Center for Functional NeurosurgeryRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Neuroscience Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China

The prefrontal cortex and hippocampus may support sequential working memory beyond episodic memory and spatial *** stereoelectroencephalography(SEEG)study investigated how the dorsolateral prefrontal cortex(DLPFC)interacts with the hippocampus in the online processing of sequential *** patients with epilepsy(eight women,age 27.6±8.2 years)completed a line ordering task with SEEG recordings over the DLPFC and the *** showed longer thinking times and more recall errors when asked to arrange random lines clockwise(random trials)than to maintain ordered lines(ordered trials)before recalling the orientation of a particular ***,the ordering-related increase in thinking time and recall error was associated with a transient theta power increase in the hippocampus and a sustained theta power increase in the DLPFC(3–10 Hz).In particular,the hippocampal theta power increase correlated with the memory precision of line ***,theta phase coherences between the DLPFC and hippocampus were enhanced for ordering,especially for more precisely memorized ***,the theta band DLPFC→hippocampus influence was selectively enhanced for ordering,especially for more precisely memorized *** study suggests that theta oscillations may support DLPFC-hippocampal interactions in the online processing of sequential information.

关键词： Sequential working memory Hippocampus Dorsolateral prefrontal cortex Theta oscillations Stereoelectroencephalography(SEEG) Phase coherence Granger causality