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Mechanism of Acupuncture and Moxibustion on Promoting Mucosal Healing in Ulcerative Colitis

Chinese Journal of Integrative Medicine 2023年第9期29卷 847-856页

作者： li Han YE Xiao-feng SU Yang-shuai HE Wei zhanG Jian-bin zhanG Qi zhan li-bin JING Xiang-hong Department of Acupuncture and Moxibustion Changzhou Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Chinese MedicineChangzhouJiangsu Province213002China Nanjing University of Chinese Medicine Nanjing210023China Research Center of Meridians Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing100700China Department of Acupuncture and Moxibustion the Second Affiliated Hospital of Nanjing University of Chinese MedicineNanjing211005China liaoning University of Chinese Medicine Shenyang116600China

The latest guideline about ulcerative colitis(UC) clinical practice stresses that mucosal healing, rather than anti-inflammation, is the main target in UC clinical management. Current mucosal dysfunction mainly closely relates to the endoscopic intestinal wall(mechanical barrier) injury with the imbalance between intestinal epithelial cells(IECs) regeneration and death, as well as tight junction(TJ) dysfunction. It is suggested that biological barrier(gut microbiota), chemical barrier(mucus protein layer, MUC) and immune barrier(immune cells) all take part in the imbalance, leading to mechanical barrier injury. Lots of experimental studies reported that acupuncture and moxibustion on UC recovery by adjusting the gut microbiota, MUC and immune cells on multiple targets and pathways, which contributes to the balance of IEC regeneration and death, as well as TJ structure recovery in animals. Moreover, the validity and superiority of acupuncture and moxibustion were also demonstrated in clinic. This paper aims to review the achievements of acupuncture and moxibustion on mucosal healing and analyse the underlying mechanisms.

关键词： acupuncture and moxibustion ulcerative colitis mucosal healing intestinal epithelial cells regeneration and death tight junction function gut microbiota review

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基于“脉络-血管系统”理论探讨肾纤维化的发病机制

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世界中西医结合杂志 2024年第6期19卷 1256-1259,1264页

作者：秦一冰吕静战丽彬杨冠琦辽宁中医药大学附属医院辽宁沈阳110032 辽宁中医药大学辽宁沈阳110847

慢性肾脏疾病日久可致肾纤维化,日久血管稀疏,目前尚无行之有效的治疗手段。络病理论起于先秦至汉的《黄帝内经》,由当代吴以岭院士团队传承发扬,形成系统的理论体系,并提出“脉络-血管系统”的理论。文中从络病理论出发探讨肾纤维化的... 详细信息

慢性肾脏疾病日久可致肾纤维化,日久血管稀疏,目前尚无行之有效的治疗手段。络病理论起于先秦至汉的《黄帝内经》,由当代吴以岭院士团队传承发扬,形成系统的理论体系,并提出“脉络-血管系统”的理论。文中从络病理论出发探讨肾纤维化的发病机制,认为肾络亏虚是肾纤维化的发病基础,肾络痹阻是肾纤维化的病机关键,毒损肾络贯穿肾纤维化始终,三者相互影响,互为因果。

关键词：脉络—血管系统肾纤维化发病机制

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On the two-layer high-level Green-Naghdi model in a general form

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Journal of Hydrodynamics 2024年第1期36卷 78-86页

作者： bin-bin Zhao Tian-yu zhang zhan Wang Wen-yang Duan Alexander Chesnokov Natalia Shmakova College of Shipbuilding Engineering Harbin Engineering UniversityHarbin150001China Qingdao Innovation and Development Center of Harbin Engineering University Qingdao266000China Lavrentyev Institute of Hydrodynamics NovosibirskRussia

The traditional high-level Green-Naghdi(HLGN)model,which uses the polynomial as the shape function to approximate the variation of the horizontal-and vertical-velocity components along the vertical direction for each-fluid layer,can accurately describe the large-amplitude internal waves in a two-layer system for the shallow configuration(h_(2)/λ■1,h_(1)/λ■1).However,for the cases of the deep configuration(h_(2)/λ■1,h_(1)/λ=O(1)),higher-order polynomial is needed to approximate the variation of the velocity components along the vertical direction for the lower-fluid ***,however,introduces additional unknowns,leading to a significant increase in computational *** paper,for the first time,derives a general form of the HLGN model for a two-layer fluid system,where the general form of the shape function is used during the *** obtaining the general form of the two-layer HLGN equations,corresponding solutions can be obtained by determining the reasonable shape ***-amplitude internal solitary waves in a deep configuration are studied by use of two different HLGN *** of the two HLGN models shows that the polynomial as the shape function for the upper-fluid layer and the production of exponential and polynomial as the shape function for the lower-fluid layer is a good *** comparing with Euler’s solutions and the laboratory measurements,the accuracy of the two-layer HLGN model is verified.

关键词： High-level Green-Naghdi(HLGN)model general form internal waves deep configuration

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Effect of Al_(2)O_(3)/SiO_(2) mass ratio and CaO content on viscosity and structure of slag for pyrometallurgical processing of spent automotive catalysts

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Journal of Iron and Steel Research International 2024年第3期31卷 608-621页

作者： Zhe Wang Qi-long Wei Cheng-bin Shi zhan-cheng Guo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The effect of Al_(2)O_(3)/SiO_(2) mass ratio and CaO content on the viscosity and structure of the CaO-Al_(2)O_(3)-SiO_(2)-6MgO-1.5ZrO_(2)-1.5CeO_(2) slag was *** results show that with the increase in Al_(2)O_(3)/SiO_(2) mass ratio,the viscous flow units within the slag gradually change from Si-O-Si to Al-O-Al and ***,the substitution of Al_(2)O_(3) for SiO_(2) leads to the transformation of Si-O bonds towards weaker Al-O bonds,which weaken the bond strength of the aluminosilicate networks,thus leading to a decrease in the viscosity of *** increase in CaO content effectively promotes the depolymerization of the aluminosilicate networks,resulting in a significant decrease in the viscosity of the *** slag with Al_(2)O_(3)/SiO_(2) of 0.7-1.5 and CaO of 30 wt.%shows promise as the reference slag system for the Fe-collection smelting of spent automotive catalysts due to its good comprehensive performance.

关键词： Aluminosilicate slag Al_(2)O_(3)/SiO_(2)mass ratio CaO content Viscosity Slag structure

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Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis

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Engineering 2024年第7期38卷 144-154页

作者： Jun-Su Zhou Long Cheng Yuan Gao zhan-Peng Ge bin Zhou Jing-Ya li Jin-Xin Zhao Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China

Four new norditerpenoid heterodimers with different dimerization patterns-namely,trigofragiloids A-C(denoted as compounds 1-3)and(+)-and(-)-trigofragiloid D(compound 4)-and three new phenanthrenone norditerpenoids-namely,trigofragiloids E-G(compounds 5-7)-were isolated from Trigonostemon *** 1 and 2 feature a novel heterodimeric carbon skeleton formed by the conjugation of a tetra-norditerpenoid and an ennea-norditerpenoid;they have been identified as class 2 atropisomers by means of quantum chemical *** 3 is an unprecedented phenylpropanoid-norditerpenoid adduct with a new dimerization ***(+)-and(-)-4 are the first example of S-shaped 1,4-dioxane-fused norditerpenoid *** by the structure elucidation of compound 4,two co-occurring analogues,actephilol A and epiactephilol A,were structurally revised as a pair of geometrical isomers and were identified as two pairs of enantiomers,(+)-and(-)-8 and(+)-and(-)-9,*** structures were characterized using a combined ***,compound 7 exhibits remarkable adenosine triphosphate-citrate lyase(ACLY)inhibition with a halfmaximal inhibition concentration(IC50)value of(0.46±0.11)lmol·L^(-1),as active as the positive control BMS-303141,and a molecular docking study offers deep insight into the interaction between compound 7 and ACLY.

关键词： Norditerpenoid heterodimer Trigonostemon fragilis Euphorbiaceae Trigofragiloid Structural revision Adenosine triphosphate-citrate lyase(ACLY) inhibitory activity

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Design and application of copper/lithium composite anodes for advanced lithium metal batteries

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Rare Metals 2024年第3期43卷 942-970页

作者： bin zhang Ji-Ping Ma Yang Zhao Tong li Jin-lin Yang zhan-ling zhang Shi-Zhong Wei Guang-Min Zhou School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471003China Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen InstituteTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

lithium(li)is a promising candidate for nextgeneration battery anode due to its high theoretical specific capacity and low reduction ***,safety issues derived from the uncontrolled growth of li dendrite and huge volume change of li hinder its practical application.C onstructing dendrite-free composite li anodes can significantly alleviate the above ***(Cu)-based materials have bee n widely used as substrates of the composite electrodes due to their chemical stability,excellent conductivity,and good mechanical ***/lithium(Cu/li)composite anodes significantly regulate the local current density and decrease li nucleation overp otential,realizing the uniform and dendrite-free li *** this review,Cu/li composite methods including electrodeposition,melting infusion,and mechanical rolling are systematically summarized and ***,design strategies of Cu-based current collectors for high performance Cu/li composite anodes are *** challenges and future development for Cu/li composite anodes are presented and *** hope that this review can provide a comprehensive understanding of Cu/li composite methods of the latest development of li metal anode and stimulate more research in the future.

关键词： lithium metal batteries Cu/li composite anode Electrodeposition Thermal melting infusion Mechanical rolling

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Adaptive and augmented active anomaly detection on dynamic network traffic streams

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Frontiers of Information Technology & Electronic Engineering 2024年第3期25卷 446-460页

作者： bin li Yijie WANG li CHENG National Key Laboratory of Parallel and Distributed Computing College of ComputerNational University of Defense TechnologyChangsha 410073China College of System Engineering National University of Defense TechnologyChangsha 410073China

Active anomaly detection queries labels of sampled instances and uses them to incrementally update the detection model,and has been widely adopted in detecting network ***,existing methods cannot achieve desirable performance on dynamic network traffic streams because(1)their query strategies cannot sample informative instances to make the detection model adapt to the evolving stream and(2)their model updating relies on limited query instances only and fails to leverage the enormous unlabeled instances on *** address these issues,we propose an active tree based model,adaptive and augmented active prior-knowledge forest(A3PF),for anomaly detection on network trafic streams.A prior-knowledge forest is constructed using prior knowledge of network attacks to find feature subspaces that better distinguish network anomalies from normal *** one hand,to make the model adapt to the evolving stream,a novel adaptive query strategy is designed to sample informative instances from two aspects:the changes in dynamic data distribution and the uncertainty of *** the other hand,based on the similarity of instances in the neighborhood,we devise an augmented update method to generate pseudo labels for the unlabeled neighbors of query instances,which enables usage of the enormous unlabeled instances during model *** experiments on two benchmarks,CIC-IDS2017 and UNSW-NB15,demonstrate that A3PF achieves significant improvements over previous active methods in terms of the area under the receiver operating characteristic curve(AUC-ROC)(20.9%and 21.5%)and the area under the precision-recall curve(AUC-PR)(44.6%and 64.1%).

关键词： Active anomaly detection Network traffic streams Pseudo labels Prior knowledge of network attacks

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Deep electrical structures of Qinzhou-Fangcheng Junction Zone in Guangxi and seismogenic environment of the 1936 lingshan M6^(3/4)earthquake

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Science China Earth Sciences 2024年第2期67卷 584-603页

作者： bin ZHOU Chunheng YAN Yan zhan Xiangyu SUN Sha li Xiang WEN Yajun MO Yongdong YUAN Yuan YUAN Meili HUANG Earthquake Agency of Guangxi Zhuang Autonomous Region Nanning530022China State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing100029China Guangxi Geophysical Survey Institute Liuzhou545005China

The tectonic position of the southwest section of the Qinzhou Bay-Hangzhou Bay Tectonic Junction Zone(QHTJZ)can be determined by examining the Qinzhou-Fangcheng Junction Zone(QFJZ)in *** zone is significant because it was the location of the largest earthquake ever recorded in the inland region of South China,specifically the 1936 lingshan M6^(3/4)earthquake in ***,this region serves as an optimal location for researching the origins of intraplate earthquakes in South *** study presents a display of a broadband magnetotelluric(MT)prospecting profile that traverses the Guangxi QFJZ and the lingshan earthquake zone,extending from the northwest(NW)to the southeast(SE).A resistivity structure model was generated using three-dimensional(3D)inversion technology along the *** main faults in QFJZ were analyzed in terms of their deep extension forms and tectonic *** analysis was performed by integrating the results obtained from geology,gravity,wave velocity ratio,Global Position System(GPS),and geothermal *** results showed that(1)the Dongzhong-Xiaodong fault(DXf),the eastern Fangcheng-lingshan fault(FLf2),and the eastern Hepu-Beiliu fault(HBf2)were all trans-crustal deep faults,and crust-mantle ductile shear zones developed in the deep *** electrical boundary zones,DXf and HBf2,were *** inclined towards the northwest,while HBf2 inclined towards the *** Fangchenglingshan fault(FLf)exhibits a tectonic style resembling a“flower”shape in the upper *** the deeper section,it is characterized by an electrical boundary zone that gradually slopes towards the southeast direction.(2)The Hunan-Guangxi Passive Continental Margin(HGPCM)on the NW side of DXf had a stratified resistivity structure and relatively stable Bouguer gravity anomalies,which conformed to the quasi-craton tectonic attribute of the local failure at the southeastern margin of the Yangtze Block(YB).The southeastern side of this bloc

关键词： South China Block Qinzhou-Fangcheng Junction Zone Magnetotelluric 1936 lingshan M6^(3/4)earthquake Deep seismogenic environment

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Effects of urban grass coverage on rainfall-induced runoff in Xi'an loess region in China

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Water Science and Engineering 2017年第4期10卷 320-325页

作者： Jing li, zhan-bin li Meng-jing Guo Peng li Sheng-dong Cheng State Key Laboratory Base of Eco-Hydraulic Engineering in Arid Areas Xi'an University of TechnologyXi'an 710048China

In this study, laboratory rainfall simulation experiments were conducted to investigate the regulatory effects of grass coverage on rainfallrunoff processes. A total of 80 grass blocks planted with well-grown manilagrass, together with their root systems, were sampled from an eastern suburban area of Xi'an City in the northwest arid area of China and sent to a laboratory for rainfall simulation experiments. The runoff and infiltration processes of a slope with different grass coverage ratios and vegetation patterns were analyzed. The results show that the runoff coefficient decreases with the increase of the grass coverage ratio, and the influence of grass coverage on the reduction of runoff shows a high degree of spatial variation. At a constant grass coverage ratio, as the area of grass coverage moves downward, the runoff coefficient, total runoff,and flood peak discharge gradually decrease, and the flood peak occurs later. With the increase of the grass coverage ratio, the flood peak discharge gradually decreases, and the flood peak occurs later as well. In conclusion, a high grass coverage ratio with the area of grass coverage located at the lower part of the slope will lead to satisfactory regulatory effects on rainfall-induced runoff.

关键词： Rainfall simulation Urban vegetation in arid area Rainfall-runoff process Regulatory effect Xi'an loess region

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Context‑dependent antioxidant defense system(ADS)‑based stress memory in response to recurrent environmental challenges in congeneric invasive species

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Marine life Science & Technology 2024年第2期6卷 315-330页

作者： Hanxi li Xuena Huang Aibin zhan Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Marine ecosystems are facing escalating environmental fluctuations owing to climate change and human activities,imposing pressures on marine *** withstand recurring environmental challenges,marine organisms,especially benthic species lacking behavioral choices to select optimal habitats,have to utilize well-established strategies such as the antioxidant defense system(ADS)to ensure their ***,understanding of the mechanisms governing the ADS-based response is essential for gaining insights into adaptive strategies for managing environmental *** we conducted a com-parative analysis of the physiological and transcriptional responses based on the ADS during two rounds of'hypersalinity-recovery'challenges in two model congeneric invasive ascidians,Ciona robusta and *** results demonstrated that *** exhibited higher tolerance and resistance to salinity stresses at the physiological level,while *** demonstrated heightened responses at the transcriptional *** observed distinct transcriptional responses,particularly in the utilization of two superoxide dismutase(SOD)*** Ciona species developed physiological stress memory with elevated total SOD(T-SOD)and glutathione(GSH)responses,while only *** demonstrated transcriptional stress *** regulatory distinctions within the Nrf2-Keap1 signalling pathway likely explain the formation disparity of transcriptional stress memory between both Ciona *** findings support the'context-dependent stress memory hypothesis',emphasizing the emergence of species-specific stress memory at diverse regulatory levels in response to recurrent environmental *** results enhance our understanding of the mechanisms of environmental challenge manage-ment in marine species,particularly those related to the ADS.

关键词： Antioxidant defense Ascidian Biological invasion Environmental stress Stress memory

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