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Chinese Medical Journal 2020年第15期133卷 1805-1814页

作者： Zhi-Hong Luo Meng-Wei Niu Shen-Hai Gong Guang-Yan Wu Teng Wang Fang-Zhao Wang Guo-Quan Wei zhan-ke he Yong Jiang Peng Chen Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515 China

Background:We previously found that the intestinal epithelial chemokine(C-C motif)ligand 7(CCL7)plays an important role in the development of toxin-induced acute liver *** detailed effects of intestinal epithelial CCL7 on chronic diseases;however,are still ***,we aimed to investigate the impact of intestinal epithelial CCL7 overexpression on high-fat diet(HFD)-induced obesity and steatohepatitis in ***:Intestinal epithelial CCL7 overexpression(CCL7tgIEC)mice and their wild-type(WT)littermates were fed with normal chow or HFD for 16 weeks to induce obesity and non-alcoholic fatty liver *** weight gain,as well as adipose tissue index were *** injury was monitored by histological analysis and real time polymerase chain *** microbial composition was analyzed by 16S rRNA gene ***:We found that the CCL7tgIEC mice on a HFD had markedly decreased weight gain(8.9 vs.17.0 g,Phepatic lipid accumulation and lower expression of inflammatory factors than WT mice.16S rRNA gene sequencing demonstrated that CCL7 overexpression in intestinal epithelial cells improved HFD-induced gut microbial ***:Our study revealed that CCL7 overexpression in the intestinal epithelium protects mice against the progression of diet-induced obesity,hepatic steatosis,and enteric dysbiosis.

关键词： Chemokine(C-C motif)ligand 7 Gut microbiota High-fat diet Obesity Steatohepatitis

Review on Security Defense Technology Research in Edge Computing Environment

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Chinese Journal of Electronics 2024年第1期33卷 1-18页

作者： ke SHANG Weizhen he Shuai zhanG National Digital Switching System Engineering and Technological R&D Center

Edge computing, which achieves quick data processing by sinking data computing and storage to the network edge, has grown rapidly along with the Internet of things. The new network architecture of edge computing brings new security challenges. Based on this, this paper investigates the edge computing security literature published in recent years and summarizes and analyzes research work on edge computing security from different attack surfaces. We start with the definition and architecture of edge computing. From the attack surface between device and edge server, as well as on edge servers, the research describes the security threats and defense methods of edge computing. In addition, the cause of the attack and the pros and cons of defense methods is introduced. The challenges and future research directions of edge computing are given.

关键词： Cloud computing Systems architecture Computer architecture Network architecture Data processing Security Servers

UAV maneuvering decision-making algorithm based on deep reinforcement learning under the guidance of expert experience

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Journal of Systems Engineering and Electronics 2024年第3期35卷 644-665页

作者： zhan Guang zhanG Kun LI ke PIAO Haiyin School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China Science and Technology on Electro-Optic Control Laboratory Luoyang 471009China

Autonomous umanned aerial vehicle(UAV) manipulation is necessary for the defense department to execute tactical missions given by commanders in the future unmanned battlefield. A large amount of research has been devoted to improving the autonomous decision-making ability of UAV in an interactive environment, where finding the optimal maneuvering decisionmaking policy became one of the key issues for enabling the intelligence of UAV. In this paper, we propose a maneuvering decision-making algorithm for autonomous air-delivery based on deep reinforcement learning under the guidance of expert experience. Specifically, we refine the guidance towards area and guidance towards specific point tasks for the air-delivery process based on the traditional air-to-surface fire control ***, we construct the UAV maneuvering decision-making model based on Markov decision processes(MDPs). Specifically, we present a reward shaping method for the guidance towards area and guidance towards specific point tasks using potential-based function and expert-guided advice. The proposed algorithm could accelerate the convergence of the maneuvering decision-making policy and increase the stability of the policy in terms of the output during the later stage of training process. The effectiveness of the proposed maneuvering decision-making policy is illustrated by the curves of training parameters and extensive experimental results for testing the trained policy.

关键词： unmanned aerial vehicle(UAV) maneuvering decision-making autonomous air-delivery deep reinforcement learning reward shaping expert experience

Driver at 10 MJ and 1 shot/30 min for inertial confinement fusion at high gain:Efficient,compact,low-cost,low laser-plasma instabilities,beam color selectable from 2ω/3ω/4ω,applicable to multiple laser fusion schemes

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Matter and Radiation at Extremes 2024年第4期9卷 4-7页

作者：隋展蓝可 Shanghai Institute of Laser Plasma China Academy of Engineering PhysicsShanghai 201800China Instituteof Applied Physics and Computational Mathematics Beijing 100094China

The achievement of ignition at the National Ignition Facility(NIF)has prompted a global wave of further research on inertial fusion energy(IFE).However,IFE requires a target gain G of 30-100,and it is hard to achieve fusion at such high gain with the energy,configuration,and technical approach of the ***,we present a conceptual design for a next-generation laser driver that is applicable to multiple laser fusion schemes and provides 10 MJ,2-3 PW at 3ω(or 2ω,in which case the energy and power can be higher),and one shot per 30 min,with the aim of achieving G>*** is also efficient,compact,and low in cost,and it has low susceptibility to laser-plasma instabilities.

关键词： applicable compact instabilities

Aero-structural design of joined-wing aircraft based on high-fidelity model

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Chinese Journal of Aeronautics 2024年第4期37卷 363-377页

作者： Cheng he Fengjiang zhan Luchuang MA Gang CheN Jianying MA Unmanned Air Vehicle Research Institute Nanjing University of Aeronautics and AstronauticsNanjing 210016China key Laboratory of Advanced Technology for Small and Medium-sized UAV Ministry of Industry and Information TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016China Aerospace System Engineering Shanghai Shanghai 201108China

The joined-wing configuration reduces induced drag and structural weight by connecting the rear wing to the front *** addition,the rear wing can replace the role of the horizontal tail of a conventional aircraft,thus eliminating the aerodynamic drag and weight associated with the horizontal *** particular shape creates a highly coupled relationship between aerodynamics and structure,which must be fully considered during the overall design process to enhance aircraft *** this research,an aero-structural design model of the joined-wing aircraft is constructed based on high-fidelity computational fluid dynamics and structural finite element *** model is able to obtain accurate aerodynamic loads for the non-planar wing and to simulate the statically indeterminate structure of the closed wing *** influence of the joined-wing shape parameters on the aerodynamic and structural disciplines,as well as the influence of geometric nonlinear characteristics,deformation constraints and buckling constraints on the structural weight are all taken into *** model is applied to complete the aero-structural design optimization of a high-altitude long-endurance joined-wing aircraft,and wind tunnel tests are *** test results verify the credibility of the design model proposed and the validity of the design environment.

关键词： Joined-wing configuration Aircraft design Aero-structural design Finite element Wind tunnel test

New insights into the correlations between circulating tumor cells and target organ metastasis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 211-233页

作者： Qinru zhan Bixia Liu Xiaohua Situ Yuting Luo Tongze Fu Yanxia Wang Zhongpeng Xie Lijuan Ren Ying Zhu Weiling he Zunfu ke Department of Pathology The First Affiliated Hospital of Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Institute of Precision Medicine The First Affiliated Hospital of Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Zhongshan School of Medicine Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Department of Radiology The First Affiliated Hospital of Sun Yat-sen University510000 GuangzhouGuangdongP.R.China Department of Microbiology and Immunology Weill Cornell MedicineNew YorkNY 10065USA School of Medicine Xiang’an Hospital of Xiamen UniversityXiamen University361000 XiamenFujianP.R.China

Organ-specific metastasis is the primary cause of cancer patient *** distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their *** an intermediate stage of metastasis,circulating tumor cells(CTCs)are released into the bloodstream from primary and metastatic *** harboring aggressive or metastatic features can extravasate to remote sites for continuous colonizing growth,leading to further *** the past decade,numerous studies demonstrated that CTCs exhibited huge clinical value including predicting distant metastasis,assessing prognosis and monitoring treatment response et ***,increasingly numerous experiments are dedicated to identifying the key molecules on or inside CTCs and exploring how they mediate CTC-related organ-specific *** on the above molecules,more and more inhibitors are being developed to target CTCs and being utilized to completely clean CTCs,which should provide promising prospects to administer advanced ***,the application of various nanomaterials and microfluidic technologies in CTCs enrichment technology has assisted to improve our deep insights into the phenotypic characteristics and biological functions of CTCs as a potential therapy target,which may pave the way for us to make practical clinical *** the present review,we mainly focus on the role of CTCs being involved in targeted organ metastasis,especially the latest molecular mechanism research and clinical intervention strategies related to CTCs.

关键词： metastasis organs insight

MARS and RNAcmap3:The Master Database of All Possible RNA Sequences Integrated with RNAcmap for RNA Homology Search

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 143-150页

作者： ke Chen Thomas Litfin Jaswinder Singh Jian zhan Yaoqi Zhou Institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhen 518055China Peking University Shenzhen Graduate School Shenzhen 518055China University of Science and Technology of China Hefei 230026China Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China Institute for Glycomics Griffith UniversitySouthportQLD 4222Australia

sequences found in the huge,integrated database of protein sequences(Big Fantastic Database).In contrast,the existing nucleotide databases were not consolidated to facilitate wider and deeper homology ***,we built a comprehensive database by incorporating the non-coding RNA(ncRNA)sequences from RNAcentral,the transcriptome assembly and metagenome assembly from metagenomics RAST(MG-RAST),the genomic sequences from Genome Warehouse(GWH),and the genomic sequences from MGnify,in addition to the nucleotide(nt)database and its subsets in National Center of Biotechnology Information(NCBI).The resulting Master database of All possible RNA sequences(MARS)is 20-fold larger than NCBI’s nt database or 60-fold larger than *** new dataset along with a new split-search strategy allows a substantial improvement in homology search over existing state-of-the-art *** also yields more accurate and more sensitive multiple sequence alignments(MSAs)than manually curated MSAs from Rfam for the majority of structured RNAs mapped to *** results indicate that MARS coupled with the fully automatic homology search tool RNAcmap will be useful for improved structural and functional inference of ncRNAs and RNA language models based on *** is accessible at https://***/omix/release/OMIX003037,and RNAcmap3 is accessible at http://***/download/.

关键词： RNA sequence database Homology search Secondary structure MARS RNAcmap3

Creep-Resistant Covalent Adaptable Networks with Excellent Selfhealing and Reprocessing Performance via Phase-Locked Dynamic Covalent Benzopyrazole-Urea Bonds

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Chinese Journal of Polymer Science 2024年第10期42卷 1545-1556,I0013页

作者： Miao Xie Xiao-Rong Wang zhan-Hua Wang he-Sheng Xia State key Laboratory of Polymer Materials Engineering Polymer Research InstituteSichuan UniversityChengdu610065China School of Petrochemical Engineering Liaoning Petrochemical UniversityFushun113001China

Covalent adaptive networks(CANs)are capable of undergoing segment rearrangement after being heated,which endows the materials with excellent self-healing and reprocessing performance,providing an efficient solution to the environment pollution caused by the plastic *** main challenge remains in developing CANs with both excellent reprocessing performance and creep-resistance *** this study,a series of CANs containing dynamic covalent benzopyrazole-urea bonds were developed based on the addition reaction between benzopyrazole and isocyanate *** calculation confirmed that relatively low dissociation energy is obtained through undergoing a five-member ring transition state,confirming excellent dynamic property of the benzopyrazole-urea *** verified by the FTIR results,this nice dynamic property can be well maintained after incorporating the benzopyrazole-urea bonds into polymer *** self-healing and reprocessing performance is observed by the 3-ABP/PDMS elastomers owing to the dynamic benzopyrazole-urea *** separation induced by the aggregation of the hard segments locked the benzopyrazole-urea bonds,which also makes the elastomers display excellent creep-resistance *** hard phase locking strategy provides an efficient approach to design CANs materials with both excellent reprocessing and creep-resistance performance.

关键词： Covalent adaptive networks Self-healing polymer Dynamic covalent bond

Achieving single-cell-resolution lineage tracing in zebrafish by continuous barcoding mutations during embryogenesis

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Journal of Genetics and Genomics 2024年第9期51卷 947-956页

作者： zhan Liu Hui Zeng Huimin Xiang Shanjun Deng Xionglei he State key Laboratory of Biocontrol School of Life SciencesSun Yat-Sen UniversityGuangzhouGuangdong 510275China

Unraveling the lineage relationships of all descendants from a zygote is fundamental to advancing our understanding of developmental and stem cell ***,existing cell barcoding technologies in zebrafish lack the resolution to capture the majority of cell divisions during embryogenesis.A recently developed method,a substitution mutation-aided lineage-tracing system(SMALT),successfully reconstructed high-resolution cell phylogenetic trees for Drosophila ***,we implement the SMALT system in zebrafish,recording a median of 14 substitution mutations on a one-kilobase-pair barcoding sequence for one-day post-fertilization *** this system,we reconstruct four cell lineage trees for zebrafish fin cells,encompassing both original and regenerated *** tree consists of hundreds of internal nodes with a median bootstrap support of 99%.Analysis of the obtained cell lineage trees reveals that regenerated fin cells mainly originate from cells in the same part of the *** multiple times sampling germ cells from the same individual,we show the stability of the germ cell pool and the early separation of germ cell and somatic cell *** system offers the potential for reconstructing high-quality cell phylogenies across diverse tissues,providing valuable insights into development and disease in zebrafish.

关键词： Lineage tracing Cellular barcoding Zebrafishcell phylogeny Fin regeneration Germcell lineage

Smart Contract Vulnerability Detection Method Based on Feature Graph and Multiple Attention Mechanisms

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Computers, Materials & Continua 2024年第5期79卷 3023-3045页

作者： Zhenxiang he Zhenyu Zhao ke Chen Yanlin Liu School of Cyber Security Gansu University of Political Science and LawLanzhou730070China

The fast-paced development of blockchain technology is ***,the security concerns of smart contracts represent a significant challenge to the stability and dependability of the entire blockchain *** smart contract vulnerability detection primarily relies on static analysis tools,which are less efficient and *** deep learning methods have improved detection efficiency,they are unable to fully utilize the static relationships within ***,we have adopted the advantages of the above two methods,combining feature extraction mode of tools with deep learning ***,we have constructed corresponding feature extraction mode for different vulnerabilities,which are used to extract feature graphs from the source code of smart ***,the node features in feature graphs are fed into a graph convolutional neural network for training,and the edge features are processed using a method that combines attentionmechanismwith gated ***,the revised node features and edge features are concatenated through amulti-head *** result of the splicing is a global representation of the entire feature *** method was tested on three types of data:Timestamp vulnerabilities,reentrancy vulnerabilities,and access control vulnerabilities,where the F1 score of our method reaches 84.63%,92.55%,and 61.36%.The results indicate that our method surpasses most others in detecting smart contract vulnerabilities.

关键词： Blockchain smart contracts deep learning graph neural networks