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The RING finger protein family in health and disease

Signal Transduction and Targeted Therapy 2022年第9期7卷 3436-3458页

作者： Chunmei Cai Yan-Dong Tang jingbo zhai Chunfu Zheng Research Center for High Altitude Medicine School of MedicalQinghai UniversityXiningChina State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research Institute of Chinese Academy of Agricultural SciencesHarbinChina Medical College Inner Mongolia Minzu UniversityTongliao 028000China Key Laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous Region Tongliao 028000China The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock School of Life SciencesInner Mongolia UniversityHohhotChina Department of Immunology School of Basic Medical SciencesFujian Medical UniversityFuzhouChina Department of Microbiology Immunology and Infectious DiseasesUniversity of CalgaryCalgaryAlbertaCanada

Ubiquitination is a highly conserved and fundamental posttranslational modification(PTM)in all eukaryotes regulating thousands of *** RING(really interesting new gene)finger(RNF)protein,containing the RING domain,exerts E3 ubiquitin ligase that mediates the covalent attachment of ubiquitin(Ub)to target *** reviews have summarized the critical roles of the tripartite-motif(TRIM)protein family,a subgroup of RNF proteins,in various diseases,including cancer,inflammatory,infectious,and neuropsychiatric *** for TRIMs,since numerous studies over the past decades have delineated that other RNF proteins also exert widespread involvement in several diseases,their importance should not be *** review summarizes the potential contribution of dysregulated RNF proteins,except for TRIMs,to the pathogenesis of some diseases,including cancer,autoimmune diseases,and neurodegenerative *** viral infection is broadly involved in the induction and development of those diseases,this manuscript also highlights the regulatory roles of RNF proteins,excluding TRIMs,in the antiviral immune *** addition,we further discuss the potential intervention strategies targeting other RNF proteins for the prevention and therapeutics of those human diseases.

关键词： prevention involvement summarized

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Estimated cancer incidence and mortality in Hebei province,2012

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Chinese Journal of Cancer Research 2016年第3期28卷 286-300页

作者： Yutong He Di Liang Daojuan Li jingbo zhai Junqing Zhu Jing Jin Denggui Wen Baoen Shan Cancer Institute the Fourth Hospital of Hebei Medical University/the Tumor Hospital of Hebei Province Shijiazhuang 050011 China Disease Control and Prevention Office Health and Family Planning Commission of Hebei Shijiazhuang 050011 china Non-communicable disease Institute Hebei Provincial Center of Disease Control and Prevention Shijiazhuang 050011 China

Objective： This study estimates the numbers of new cancer cases and cancer deaths in Hebei province using incidence and mortality data from 9 population-based cancer registries in 2012. Methods： The data of new diagnosed cancer cases and cancer deaths in 2012 were collected from 9 population-based cancer registries of Hebei province in 2015. All the data met the National Central Cancer Registry of China （NCCR） criteria of data quality. The pooled data analysis was stratified by areas （urban/ rural）, gender, age group （0, 1-4, 5-9, 10-14 85＋） and cancer type. New cancer cases and deaths in Hebei province were estimated using age-specific rates and corresponding provincial population in 2012. The 10 most common cancers in different groups and the cumulative rates were calculated. Chinese population census in 2000 and Segi＇s population were used for age-standardized incidence/mortality rates. Results： All cancer registries covered 4,986,847 populations, 6.84% of Hebei provincial population （2,098,547 in urban and 2,888,300 in rural areas）. The percentage of cases morphologically verified （MV%） and death certificate-only cases （DCO%） were 76.40% and 4.72%, respectively. The mortality to incidence rate ratio （M/I） was 0.64. In 2012, it is estimated that there were about 187,900 new diagnosed cancer cases and 119,800 cancer deaths in Hebei province. The incidence rate of cancer was 258.12/100,000 （275.75/100,000 in males, 239.78/100,000 in females）, and the age-standardized incidence rates by Chinese standard population （ASIRC） and by world standard population （ASIRW） were 210.65/100,000 and 208.50/100,000, with the cumulative incidence rates （0-74 years old） of 24.46%. The cancer incidence and ASIRC were 256.99/100,000 and 211.32/100,000 in urban areas and 258.94/100,000 and 209.99/100,000 in rural areas, respectively. The cancer mortality rate was 164.63/100,000 （201.85/100,000 in males, 125.92/100,000 in females）. Age- standardized mortality rates by Chinese standard p

关键词： Cancer registry cancer incidence mortality Hebei province

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Exploration of the common gene and potential molecular mechanisms between Herpes simplex virus 1 infection and Alzheimer's disease

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Genes & Diseases 2023年第3期10卷 746-749页

作者： Weizheng Liang Xiushen Li Hao Wang Shuangqing Wang Qingxue Meng Ruoqing Feng jingbo zhai Mengzhou Xue Chunfu Zheng Institute of Animal Health Guangdong Academy of Agricultural SciencesKey Laboratory of Livestock Disease Prevention of Guangdong ProvinceScientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong ProvinceMinistry of Agriculture and Rural AffairsGuangzhouGuangdong 510640China Central Laboratory The First Affiliated Hospital of Hebei North UniversityZhangjiakouHebei 075000China Department of Obstetrics and Gynecology Shenzhen University General HospitalShenzhenGuangdong 518055China Shenzhen Key Laboratory Shenzhen University General HospitalShenzhenGuangdong 518055China Department of Neurology Shenzhen University General HospitalShenzhen UniversityShenzhenGuangdong 518055China Key Laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous Region TongliaoMongolia 028000China Department of Cerebrovascular Diseases The Second Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450001China Department of Microbiology Immunology and Infectious DiseasesUniversity of CalgaryCalgaryAlberta T2N 1N4Canada

Herpes simplex virus 1(HSV-1)is highly *** than 70%of the world's population has been infected with HSV-1.1 Most patients with HSV-1 have no obvious clinical ***,HSV-1 infection can lead to serious complications in pe... 详细信息

关键词： infection Alzheimer simplex

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RNA sensors:Recent progress on studying of RLRs family

RNA sensors:Recent progress on studying of RLRs family

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第十一届全国免疫学学术大会

作者： zhai jingbo Lu Changlong Brucellosis institute Inner Mongolia Uni.for the Nationalities Dept.of Immunol.China Med.Uni.

The innate nonspecific immunity is one of the first and most important lines of defense against viral infection. Toll-like receptors(TLRs) and retinoic acid-inducible gene I(RIG-I)-like receptors(RLRs) are two main receptor families detecting viral nucleic acid. So far, three RLR family members were well characterized: RIG-I, MDA5 and LGP2. RLR constitute a family of cytoplasmic helicases, which recognized intracellular single-stranded and double-stranded RNA that is introduced to cytosol during viral infection and replication. In this work we review the current knowledge about the pattern recognition and signaling mechanisms of RIG-I and MDA5 and their signaling pathways for the activation of type I interferons and pro-inflammatory cytokines synthesis.

关键词： RNA sensors RLRs Signaling pathway

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RNA sensors:Recent progress on studying of Protein Kinase PKR

RNA sensors:Recent progress on studying of Protein Kinase PK...

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第十一届全国免疫学学术大会

作者： zhai jingbo Lu Changlong Brucellosis institute Inner Mongolia Uni.for the Nationalities Dept.of Immunol.China Med.Uni.

PKR is a serine/threonine kinase that phosphorylates the α-subunit of eukaryotic translation initiation factor 2α(eIF2α) and autophosphorylated. PKR binds viral ds RNA and inhibits translation, which results in a decrease in total cellular and viral protein synthesis, thereby effectively reducing viral replication through PKR/e IF-2αpathway. In addition, PKR has a role in signal transduction and transcriptional control through activation of the inhibitor of IκB(inhibitor of NF-κB)/NF-κB(nuclear factor κB) pathway. There is a relationship between tumor growth and PKR activity, PKR is considered a target for cancer therapy. PKR is a crucial determinant of the host defensemechanism, acting at various levels and sensing whether thecell lives or dies. Emerging studies will provide further insightsinto the mode of PKR action, as well as its potential utility asan antiviral and antitumor effector molecule.

关键词： RNA sensors Protein kinase PKR PKR/eIF-2α pathway Target of cancer therapy

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以患者为中心的中医药防治慢性病临床诊疗方案遴选与评价方法学框架

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中国循证医学杂志 2023年第4期23卷 439-443页

作者：翟静波天津中医药大学公共卫生与健康科学学院天津301617

慢性病的防控是我国亟待解决的重大需求。中医药在防治慢性病方面具有独特优势。但是,中医药防治慢性病临床诊疗方案遴选与评价过程中的患者参与度可能存在不足。近些年,以患者为中心的临床研究成为热点。本研究提出一种以患者为中心的... 详细信息

慢性病的防控是我国亟待解决的重大需求。中医药在防治慢性病方面具有独特优势。但是,中医药防治慢性病临床诊疗方案遴选与评价过程中的患者参与度可能存在不足。近些年,以患者为中心的临床研究成为热点。本研究提出一种以患者为中心的中医药防治慢性病临床诊疗方案遴选与评价方法学框架。该方法学框架以循证医学实践模式为基础,融入以患者为中心的研究方法,有望为筛选符合患者需求的中医药防治慢性病临床诊疗方案、提高中医药服务效益、完善价格政策、医保目录更新等提供科学依据。

关键词：患者中医药慢性病诊疗方案评价方法

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Noteworthy impacts of COVID-19 pandemic on cancer screening:A systematic review

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Fundamental Research 2024年第3期4卷 484-494页

作者： Huilin Wang Min Yang Wei Xiong Quan Wang Bobo Zheng Yang Bai Kaiyong Zou Jibin Li Jiansong Ren Wanqing Chen jingbo zhai Jiang Li Office for Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Comprehensive Intervention National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gynecology Endocrine&Reproductive Center National Clinical Research Center for Obstetric&Gynecologic Diseases Department of Obstetrics and GynecologyPeking Union Medical College HospitalPeking Union Medical College/Chinese Academy of Medical SciencesBeijing 100005China Ambulatory Surgery Center of Xijing Hospital Fourth Military Medical UniversityXi'an 710068China Department of General Surgery Shaanxi Provincial People’s HospitalXi'an 710068China College of Clinical Medicine Capital Medical UniversityBeijing 100069China School of Public Health Tianjin University of Traditional Chinese MedicineTianjin 301617China

The sudden onset of the coronavirus disease 2019(COVID-19)in January 2020 has affected essential global health ***-screening services that can reduce cancer mortality are strongly ***,the specific role of COVID-19 in cancer screening is not fully *** study aimed to assess the efficiency of global cancer screening programs before and during the COVID-19 pandemic and to promote potential cancer-screening strategies for the next *** searches in PubMed,Embase,and Web of Science,and manual searches were performed between January 1,2020 and March 1,*** studies that reported the number of participants who underwent cancer screening before and during the COVID-19 pandemic were *** methodological quality of the included studies was assessed using the Newcastle-Ottawa *** in cancer-screening rates were estimated using the incidence rate ratio(IRR).Fifty-five cohort studies were included in this *** screening rates of colorectal cancer using invasive screening methods(Pooled IRR=0.52,95%CI:0.42 to 0.65,p<0.01),cervical cancer(Pooled IRR=0.56,95%CI:0.47 to 0.67,p<0.01),breast cancer(Pooled IRR=0.57,95%CI:0.49 to 0.66,p<0.01)and prostate cancer(Pooled IRR=0.71,95%CI:0.56 to 0.90,p<0.01)during the COVID-19 pandemic were significantly lower than those before the COVID-19 *** screening rates of lung cancer(Pooled IRR=0.77,95%CI:0.58 to 1.03,p=0.08)and colorectal cancer using noninvasive screening methods(Pooled IRR=0.74,95%CI:0.50 to 1.09,p=0.13)were reduced with no statistical *** subgroup analyses revealed that the reduction in cancer-screening rates varied across *** results suggest that the COVID-19 pandemic has had a noteworthy impact on colorectal,cervical,breast,and prostate cancer *** innovative cancer-screening technologies is important to promote the efficiency of cancer-screening services in the post-COVID-19 era and prepare fo

关键词： Cancer screening COVID-19 pandemic Cohort study Incidence rate ratio Meta-analysis

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高产蛹虫草诱变菌株发酵条件优化及放大

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食品与生物技术学报 2014年第8期33卷 884-890页

作者：翟景波内蒙古民族大学医学院内蒙古通辽028042 中国医科大学基础医学院辽宁沈阳110001

考察高产蛹虫草诱变菌株放大发酵条件,为产业化奠定实验基础。以蛹虫草菌丝体干重、多糖、腺苷和虫草酸质量浓度为指标,采用单因素试验的方法优化5 L发酵罐发酵条件:搅拌转速、发酵培养基初始pH值和接种量,并在此条件下重复4次实验,以... 详细信息

考察高产蛹虫草诱变菌株放大发酵条件,为产业化奠定实验基础。以蛹虫草菌丝体干重、多糖、腺苷和虫草酸质量浓度为指标,采用单因素试验的方法优化5 L发酵罐发酵条件:搅拌转速、发酵培养基初始pH值和接种量,并在此条件下重复4次实验,以考察发酵条件的稳定性;进一步考察15 L和100 L发酵罐发酵条件。5 L发酵罐发酵条件为:转速250 r/min、起始pH值7、接种体积分数6%,发酵温度26℃,通气量250 L/h,菌丝体干重、多糖、腺苷和虫草酸质量浓度分别达到23.29 g/L、0.94 g/L、162.84 mg/L和2.06 g/L,4次重复实验发酵条件稳定(P<0.01)。15 L发酵罐的最佳发酵时间为72 h,菌丝体干重、多糖、腺苷和虫草酸质量浓度分别达到30.84g/L、1.10 g/L、233.22 mg/L和1.89 g/L;100 L发酵罐的最佳发酵时间为47 h,菌丝体干重、多糖、腺苷和虫草酸质量浓度分别达到32.05 g/L、1.33 g/L、187.20 mg/L和3.51 g/L。5 L发酵罐发酵条件稳定,以菌丝体干重、多糖、腺苷和虫草酸质量浓度为综合考察指标,分别绘制了高产蛹虫草诱变菌株15 L、100 L发酵罐发酵生长曲线,为生产提供了数据依据。

关键词：高产蛹虫草诱变菌株放大发酵单因素试验发酵生长曲线

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破产程序检察监督的正当性及其实现路径

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北京理工大学学报（社会科学版） 2024年第4期26卷 141-151页

作者：翟静波西南政法大学经济法学院重庆401120

检察机关介入破产案件进行监督,是中国破产法律制度实践中逐步生发出来的新现象。部分地方司法机关陆续出台破产案件检察监督规范,在制度设计上进行探索,但实践效果乏善可陈,原因是制度定位不清、规则可操作性不强。有必要展开对实践中... 详细信息

检察机关介入破产案件进行监督,是中国破产法律制度实践中逐步生发出来的新现象。部分地方司法机关陆续出台破产案件检察监督规范,在制度设计上进行探索,但实践效果乏善可陈,原因是制度定位不清、规则可操作性不强。有必要展开对实践中检察权能与程序配置的历史考察,厘清破产检察监督的发展演变与价值定位,从权利救济、监督需要和治理回应等三个维度揭示检察监督介入破产案件的正当性与法理根据。应强化破产案件中法律监督者的参与地位,从规则完善与机制优化层面来保证破产检察监督的实际效果。

关键词：企业破产检察监督法律监督检察权府院联动

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循证搜索引擎:SUMSearch与TRIP database

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中国循证医学杂志 2023年第8期23卷 988-992页

作者：思金华翟静波天津中医药大学天津301617

SUMSearch与TRIP database是查询循证医学临床证据的元搜索引擎。本文系统介绍SUMSearch与TRIP database的主要内容和检索方法,旨在为临床循证实践提供快捷检索资源和技术帮助。

关键词：循证医学搜索引擎 SUMSearch TRIP database

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