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A compact X-band backward traveling-wave accelerating structure

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Nuclear Science and Techniques 2024年第5期35卷 13-29页

作者： Xian-Cai Lin Hao zha Jia-Ru Shi Qiang gao Fang-Jun Hu Qing-Zhu Li Huai-Bi chen Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

Very high-energy electrons(VHEEs)are potential candidates for FLASH radiotherapy for deep-seated *** proposed a compact VHEE facility based on an X-band high-gradient high-power *** this study,we investigated and realized the first X-band backward traveling-wave(BTW)accelerating structure as the buncher for a VHEE facility.A method for calculating the parameters of single cell from the field distribution was introduced to simplify the design of the BTW ***-domain circuit equations were applied to calculate the transient beam parameters of the buncher in the unsteady state.A prototype of the BTW structure with a thermionic cathode-diode electron gun was designed,fabricated,and tested at high power at the Tsinghua X-band high-power test *** structure successfully operated with 5-MW microwave pulses from the pulse compressor and outputted electron bunches with an energy of 8 MeV and a pulsed current of 108 mA.

关键词： Backward traveling-wave accelerating structure Equivalent circuit model High-power test Very high-energy electron radiotherapy

Circularly polarized light emission and detection by chiral inorganic semiconductors

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Frontiers of Optoelectronics 2024年第2期17卷 43-49页

作者： zha Li Wancai Li Dehui Li Wei Tang Huageng Liang Huaibing Song Chao chen Liang gao Jiang Tang Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China International Health Care Center National Center for Global Health and MedicineTokyo 162‑8655Japan Hepato‑Biliary‑Pancreatic Surgery Division Department of SurgeryThe University of Tokyo HospitalTokyo 113‑8655Japan Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Faculty of Materials Science and Chemistry China University of GeosciencesWuhan 430074China

Chiral inorganic semiconductors with high dissymmetric factor are highly desirable,but it is generally difficult to induce chiral structure in inorganic semiconductors because of their structure rigidity and *** this study,we introduced chiral ZnO film as hard template to transfer chirality to CsPbBr_(3) film and PbS quantum dots(QDs)for circularly polarized light(CPL)emission and detection,*** prepared CsPbBr_(3)/ZnO thin film exhibited CPL emission at 520 nm and the PbS QDs/ZnO film realized CPL detection at 780 nm,featuring high dissymmetric factor up to around *** electron transition based mechanism is responsible for chirality transfer.

关键词： High dissymmetric factor Circularly polarized light emission Semiconductor Hard template,Chirality

Molecular Dynamics-Based Simulation of Polyethylene Pipe Degradation in High Temperature and High Pressure Conditions

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Fluid Dynamics & Materials Processing 2024年第9期20卷 2139-2161页

作者： guowei Feng Qing Li Yang Wang Nan Lin Sixi zha Hang Dong Ping chen Minjun Zheng School of Mechanical Engineering Xinjiang UniversityUrumqi830046China Xinjiang Yian Special Inspection Engineering Company Limited Urumqi830063China Xinjiang Uygur Autonomous Region Inspection Institute of Special Equipment Urumqi830000China Pressure Pipe Department China Special Equipment Inspection and Research InstituteBeijing100013China Tarim Oilfield Branch Company Korla841000China Yimai Cai Oil and gas Management Area Tarim Oilfield Branch OfficeKorla841000China

High-density polyethylene(HDPE)pipes have gradually become the first choice for gas networks because of their excellent *** the use of pipes increases,there will unavoidably be a significant amount of waste generated when the pipes cease their operation life,which,if improperly handled,might result in major environmental contamination *** this study,the thermal degradation of polyethylene materials is simulated for different pressures(10,50,100,and 150 MPa)and temperatures(2300,2500,2700,and 2900 K)in the framework of Reactive Force Field(ReaxFF)molecular dynamics *** main gas products,density,energy,and the mean square displacement with temperature and pressure are also *** findings indicate that raising the temperature leads to an increase in the production of gas products,while changing the pressure has an impact on the direction in which the products are generated;the faster the temperature drops,the less dense the air;both temperature and pressure increase impact the system’s energy conversion or distribution mechanism,changing the system’s potential energy as well as its total energy;the rate at which molecules diffuse increases with temperature,and decreases with *** results of this investigation provide a theoretical basis for the development of the pyrolytic treatment of polyethylene waste materials.

关键词： ReaxFF MD high-density polyethylene degradation temperature pressure

Elevated peripheral levels of receptor-interacting protein kinase 1(RIPK1)and IL-8 as biomarkers of human amyotrophic lateral sclerosis

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Signal Transduction and Targeted Therapy 2024年第1期9卷 271-278页

作者： Jun Wei Min Li Zhi Ye Xinqian Hu Xiaoyan He Jia Wang gaofeng chen chengyu Zou Daichao Xu Hongbing zha.g Junying Yuan Yunhong zha Institute of Neural Regeneration and Repair and Department of Neurology The First College of Clinical Medical ScienceYichang Central HospitalCollege of Basic Medical ScienceChina Three Gorges UniversityHubei Province Clinical Medical Research Center for Rare Diseases of Nervous SystemYichang 443000China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai Key Laboratory of Aging StudiesShanghai 201210China State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemDepartment of PhysiologyInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Amyotrophic lateral sclerosis(ALS)is a devastating fatal neurodegenerative disease with no ***-interacting protein kinase 1(RIPK1)has been proposed to mediate pathogenesis of *** has been identified as an old drug that can also inhibit RIPK1 *** conducted a drug-repurposing biomarker study of primidone as a RIPK1 inhibitor using SOD1g93A mice and ALS ***1g93A mice treated with primidone showed significant delay of symptomatic onset and improved motor ***-hundred-sixty-two ALS participants dosed daily with primidone(62.5 mg)completed 24-week follow-up.A significant reduction was showed in serum levels of RIPK1 and IL-8,which were significantly higher in ALS patients than that of healthy controls(Pggests that serum levels of RIPK1 and IL-8 in peripheral can be used as clinical biomarkers for the activation of RIPK1 in central nervous system in human ALS *** primidone may provide a promising therapeutic strategy for *** effect of primidone for the treatment of other inflammatory diseases may also be considered,since the activation of RIPK1 has been implicated in mediating a variety of inflammatory diseases including COVID-19-associated cytokine release syndrome(CRS).(ChiCTR2200060149).

关键词： RIPK1 diseases Serum

Simulation Study of Solid Rocket Motor C/C Throat Liner Ablation Based on Two Regions

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Journal of Power and Energy Engineering 2024年第4期12卷 1-19页

作者： guanneng chen Yihua Xu Xiaojiang zha Hemeng Shi Bing Liu School of Aircraft Engineering Nanchang Hangkong University Nanchang China

Based on the ablation micro-morphological characteristics, thermo-chemical ablation mechanism, and mechanical stripping mechanism, a dual-region solid rocket motor C/C throat liner ablation model and physical model are established. The ablation program was written and the experimental data of 70 lb BATES engine platform was used for model validation. The relative errors between the simulation calculation results and the experimental results were −6.83% - 10.20%. The ablation program was applied to study the effects of combustion chamber temperature, pressure, oxidation component concentration, throat particle concentration and particle scouring angle on the nozzle throat liner, which provides a reference for the design of the nozzle throat liner and the estimation of solid rocket motor ablation.

关键词： Dual-Area Ablation Model C/C Throat Liner Ablation Environment Ablation Program

Tet methylcytosine dioxygenase 2(TET2)deficiency elicits EgFR-TKI(tyrosine kinase inhibitors)resistance in non-small cell lung cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1706-1720页

作者： Jian zha.g Kejia zhao Wenjing Zhou Ran Kang Shiyou Wei Yueli Shu cheng Yu Yin Ku Yonghong Mao Hao Luo Juqin Yang Jiandong Mei Qiang Pu Senyi Deng Zhengyu zha.gang Yuan Shensi Shen Yaohui chen Lunxu Liu Department of Thoracic Surgery and Institute of Thoracic Oncology West China Hospital of Sichuan UniversityChengdu 610097China Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer Sichuan UniversityChengdu 610097China Biobank of West China Hospital Sichuan UniversityChengdu 610041China

Despite epidermal growth factor receptor(EgFR)tyrosine kinase inhibitors(TKl)have shown remarkable efficacy in patients with EgFR-mutant non-small cell lung cancer(NSCLC),acquired resistance inevitably develops,limiting clinical *** found that TET2 was poly-ubiquitinated by E3 ligase CUL7^(FBXW11) and degraded in EgFR-TKI resistant NSCLC *** perturbationof TET2 rendered parental cells more tolerant to TKI ***2 was stabilized by MEK1 phosphorylation at Ser 1107,while MEK1 inactivation promoted its proteasome degradation by enhancing the recruitment of CUL7^(FBXW11),Loss of TET2 resulted in the upregulation of TNF/NF-kB signaling that confers the EgFR-TKI *** or pharmacological inhibition of NF-kB attenuate the TKI resistance both in vitro and in *** findings exemplified how a cell growth controlling kinase MEK1 leveraged the epigenetic homeostasis by regulating TET2,and demonstrated an alternative path of non-mutational acquired EgFR-TKI resistance modulated by TET2 ***,combined strategy exploiting EgFR-TKI and inhibitors of TET2/NF-κB axis holds therapeutic potential for treating NSCLC patients who suffered from this resistance.

关键词： TET2 TKI resistance

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冷却塔定向拆除时剩余支柱的轴力计算方法

哈尔滨工业大学学报 2024年第2期56卷 10-17页

作者：查晓雄汪凯超陈德劲哈尔滨工业大学(深圳)土木与环境工程学院广东深圳518055

为了使冷却塔的定向拆除更加安全可控,对冷却塔保留柱轴向力的计算方法展开研究。根据力的相似关系给出支柱轴向力与其Z向力之间的关系式,基于平截面假定推导保留柱Z向力的计算公式;利用有限元研究环梁和支柱的弹性模量、支柱高度、保... 详细信息

为了使冷却塔的定向拆除更加安全可控,对冷却塔保留柱轴向力的计算方法展开研究。根据力的相似关系给出支柱轴向力与其Z向力之间的关系式,基于平截面假定推导保留柱Z向力的计算公式;利用有限元研究环梁和支柱的弹性模量、支柱高度、保留柱数量以及相邻柱柱顶所对应的圆心角5种参数对保留柱Z向力的影响;根据有限元的结果对保留柱Z向力的计算公式进行修正,并研究修正后公式的适用性。结果表明:爆破后的冷却塔在所有保留柱上并不满足平截面假定;在实际工程范围内,上述5种参数不影响保留柱Z向力的分布规律为Z向力沿着y轴方向上的分布形态始终“两端受压,中间受拉”,且保留柱中的最大压力始终出现在第n排保留柱上,最大拉力始终出现在第(n-4)排保留柱上;当爆破圆心角为200°~240°时,修正后计算值的相对误差在21%以内,且该公式在不同冷却塔上具有良好的适用性。保留柱轴向力的计算公式从力学角度为冷却塔的拆除提供了理论支撑,增加了拆除工作的安全性。

关键词：自然通风冷却塔钢筋混凝土结构建筑拆除爆破拆除轴力

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钢管混凝土超大型冷却塔抗倒塌性能研究

华中科技大学学报（自然科学版） 2024年第2期52卷 134-141页

作者：查晓雄汪凯超陈德劲哈尔滨工业大学(深圳)土木与环境工程学院广东深圳518055

提出一种施工性能优异的钢管混凝土冷却塔,并对其抗倒塌性能展开研究.首先,给出钢管混凝土冷却塔几何设计的计算公式;然后,利用有限元研究该冷却塔在不同缺口圆心角(删除支柱所对应的圆心角)下的倒塌原因及倒塌形态,从倒塌的难易程度、... 详细信息

提出一种施工性能优异的钢管混凝土冷却塔,并对其抗倒塌性能展开研究.首先,给出钢管混凝土冷却塔几何设计的计算公式;然后,利用有限元研究该冷却塔在不同缺口圆心角(删除支柱所对应的圆心角)下的倒塌原因及倒塌形态,从倒塌的难易程度、影响范围及动能大小三个方面对比了钢管混凝土和钢筋混凝土冷却塔的抗倒塌性能.研究结果表明:钢管混凝土冷却塔的倒塌主要由筒壁的局部失稳引起;仅当缺口圆心角超过126°时,冷却塔才会发生整体倒塌破坏;钢管混凝土冷却塔的抗倒塌性能优于钢筋混凝土冷却塔,即相对于钢筋混凝土冷却塔,钢管混凝土冷却塔开始发生倒塌时的缺口圆心角较大,倒塌过程中的动能峰值仅为钢筋混凝土冷却塔的1/10左右,且倒塌后的废墟尺寸较小.

关键词：自然通风冷却塔超大型钢混凝土组合结构抗倒塌性能倒塌形态

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高压直流输电系统可靠性分析方法综述

电力系统保护与控制 2024年第9期52卷 174-187页

作者：李康黄萌查晓明陈蓉珺综合能源电力装备及系统安全湖北省重点实验室湖北武汉430072 武汉大学电气与自动化学院湖北武汉430072 国家电网有限公司直流技术中心北京100052

高压直流输电系统因具有输送容量大、能耗低且能实现电力系统非同步互联等优势而得到广泛应用,其可靠性分析可为系统提供重要的运维及决策依据。因此,围绕现阶段国内外高压直流输电系统可靠性分析方法进行了归纳总结。首先阐述了传统直... 详细信息

高压直流输电系统因具有输送容量大、能耗低且能实现电力系统非同步互联等优势而得到广泛应用,其可靠性分析可为系统提供重要的运维及决策依据。因此,围绕现阶段国内外高压直流输电系统可靠性分析方法进行了归纳总结。首先阐述了传统直流输电、柔性直流输电系统的组成差异,并对输电系统常用的可靠性指标作了相应归纳。其次,从统计法、手册法、状态空间法及其他方法等层面出发,分别对高压直流输电系统可靠性建模的基本原理及研究现状进行了分析,对各类方法的优缺点进行了对比,并探讨了柔性直流输电系统在可靠性分析方面存在的新挑战。最后,针对当前研究中存在的不足,对高压直流输电系统可靠性分析方法进行讨论与展望。

关键词：传统直流输电柔性直流输电可靠性分析统计法手册法状态空间法

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