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Surfactant-enhanced electrochemical detection of bisphenol A based on Au on ZnO/reduced graphene oxide sensor

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Rare Metals 2023年第4期42卷 1274-1282页

作者： Ai-Yun zha.Qing-Bing zha.zhi Li Hong-Min zha.g Xue-Feng Ma wen Xie Ming-Shan Zhu Department of Nephrology The First Affiliated Hospital of Jinan UniversityGuangzhou510630China Department of Clinical Laboratory The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People’s Hospital)Heyuan517000China Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan UniversityGuangzhou510630China Guangdong Key Laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou511443China

Bisphenol A(BPA),one of the most commonly used plastic organic monomers,is widely used in manufacturing food packaging and ***,the gradual emissions of BPA from manufacturing plastic products bring great potential in human health threats,which urgently need to develop a simple and rapid method for detecting *** bromide(CTAB),a typical surfactant,is used to enhance the electrochemical detection of trace endocrine disruptors due to the fact that it can effectively enrich and absorb hydrophobic phenolic compounds through the hydrophobicity of its long-chain *** on these,the present study reports a ternary composite of Au on zinc oxide/reduced graphene oxide nanosheets(Au/ZnO/rGO)as electrochemical sensor for detecting BP *** the addition of CTAB,the analytic performances toward BP A detection are significantly improved 3.8 times compared with those without *** pH,accumulation potential and time are ***,the electrochemical activity of CTAB/Au/ZnO/rGO sensor is also evaluated by cyclic voltammetry(CV),electrochemical impedance spectroscopy(EIS),differential pulse voltammetry(DPV)and scan *** sensor displays two linear range from 10to 1340 nmol·L^(-1)and 1340 to 10,000 nmol·L^(-1),and a low detection limit of 4.95 nmol·L^(-1).Lastly,the sensor also exhibits good reproducibility,selectivity and potential practical application for BPA detection in real samples.

关键词： Bisphenol A(BPA) Cetyltrimethylammonium bromide(TAB) Electrochemical detection(ED) Electron transmission

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

Clinical and genetic diagnosis of autosomal dominant osteopetrosis typeⅡin a Chinese family:A case report

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World Journal of Clinical Cases 2023年第3期11卷 700-708页

作者： Hong-Ping Gong Yan Ren Pan-Pan zha.wen-Yan zha.g Jin zha.g zhi-wen zha.g Chun Wang International Medical Center Ward General Practice Medical CenterSichuan University West China HospitalChengdu 610041Sichuan ProvinceChina Department of Endocrinology and Metabolism Sichuan University West China HospitalChengdu 610041Sichuan ProvinceChina Department of Pathology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Endocrinology and Metabolism The People’s Hospital of LeshanLeshan 614003Sichuan ProvinceChina

BACKGROUND Osteopetrosis is a rare genetic disorder characterized by increased bone density due to defective bone resorption of ***,80%of autosomal dominant osteopetrosis type II(ADO-II)patients were usually affected by heterozygous dominant mutations in the chloride voltage-gated channel 7(ClCN7)gene and present early-onset osteoarthritis or recurrent *** this study,we report a case of persistent joint pain without bone injury or underlying *** SUMMARY We report a 53-year-old female with joint pain who was accidentally diagnosed with *** clinical diagnosis was based on increased bone density and typical radiographic *** heterozygous mutations in the ClCN7 and Tcell immune regulator 1(TCIRG1)genes by whole exome sequencing were identified in the patient and her *** missense mutation(c.857G>A)occurred in the CLCN7 gene p.R286Q,which is highly conserved across *** TCIRG1 gene point mutation(c.714-20G>A)in intron 7(near the splicing site of exon 7)had no effect on subsequent *** This ADO-II case had a pathogenic CLCN7 mutation and late onset without the usual clinical *** the diagnosis and assessment of the prognosis for osteopetrosis,genetic analysis is advised.

关键词： Osteopetrosis Autosomal dominant osteopetrosis typeⅡ Diagnosis Genetic analysis Case report

ZnCl_2-assisted Synthesis of ZnSe Polycrystal

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Journal of Materials Science & Technology 2012年第4期28卷 373-378页

作者： Changyou Liu Tao Wang Gangqiang zha.zhi Gu Wanqi Jie State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710072China

A chemical-assisted element direct-reaction method is developed to synthesize ZnSe compound semiconductor material at a relatively low temperature （-1000 ℃）. ZnSe polycrystal was obtained in the closed-tube systems with Zn-Se, Zn-Se-Zn（NHa）2CI2, ZnoSe-NH4CI and Zn-Se-ZnCI2. The as-synthesized samples were tested by X-ray diffraction （XRD）, thermogravimetric analysis （TGA） and analyzed by thermodynamic numerical method. The results demonstrate that the synthesis efficiency is higher than 99.96% for Zn-Se-ZnCl2 system at around 1000 ℃ for 3 weeks. It also exhibits that not only temperature, but also low apparent ratio of volume and surface area of the source materials and higher ZnCl2 content are required to achieve high synthesis efficiency. A SeCI transporting reaction synthesis process is proposed based on the thermodynamic analysis.

关键词： Crystallites Growth from vapor Zinc compounds Semiconducting II-VI materials

Physical simulation of bubble refinement in bottom blowing process with mechanical agitation

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Journal of Iron and Steel Research International 2020年第10期27卷 1137-1144页

作者： Jian-ming Su zhi-he Dou Ting-an zha.Yan Liu Key Laboratory of Ecological Metallurgy of Multi-metal Intergrown Ores of Ministry of Education Northeastern UniversityShenyang 110819LiaoningChina

In order to increase the contact area and promote the mass transfer process of gas and liquid,the process of the bubble refine-ment in a metallurgical reactor with mechanical agitation was studied by physical *** on the capillary number,a prediction equation for the bubble refinement was *** effects of the gas flow rate,the stirring speed and thestirring depth on the bubble refinement in the reactor were discussed in *** distribution of the bubble diameter in thereactor was obtained under different *** results show that when the stirring speed reaches 300 r/min,the bubblediamcter mainly distributes in the range of 1-2 mm.A higher gas flow rate may increase the number of bubbles in the meltand promote the bubble refinement *** mechanism of bubble refinement under mechanical agitation was *** the results indicated that the stirring speed.,the blade area and the blade inclination are the main influencing factors.

关键词： Physical simulation Bottom blowing process Mechanical agitation Gas-liquid two-phase flow Bubble refinement

Theoretical analysis and application of polymer-matrix field grading materials in HVDC cable terminals

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High Voltage 2017年第1期2卷 39-46页

作者： Peng Han Jun-Wei zha.Si-Jiao Wang zhi-Min Dang Department of Polymer Science and Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China State Key Laboratory of Power System and Department of Electrical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China

The distortion and uneven distribution of electric field in high-voltage direct current(HVDC)terminal insulator is the key problem for stable running of the power transmission *** flexible materials filled polymer-matrix composites with non-linear conductivity have also been considered to modify the distribution of electric field in cable *** factors having influence on the non-linear conductivity will be analysed in this review.

关键词： field conductivity matrix

晋西黄土区不同植被恢复阶段土壤生态化学计量特征

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水土保持研究 2025年第1期32卷 30-38+47页

作者：高连炜张红丽查同刚北京林业大学水土保持学院水利部水土保持监测中心

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌... 详细信息

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林、先锋阔叶林、针叶林)的5种林(草)地为研究对象，通过调查采样和室内分析，探究土壤生态化学计量特征随植被恢复的进程变化及其影响因素。[结果](1)随着植被的恢复，先锋阔叶林和针叶林阶段的SOC含量较上一阶段增加19.8%,土壤TN含量较上一阶段增加17.6%,而土壤TP含量较上一阶段减少12.4%;(2)随着植被恢复的发展，土壤C∶P和N∶P显著增加，C∶N的变化无明显规律，在先锋阔叶林和针叶林阶段的土壤C∶P较上一阶段增加26.6%;先锋阔叶林和针叶林阶段在0—40 cm土层的土壤N∶P较上一阶段增加40.2%,40—100 cm土层的土壤N∶P较上一阶段增加35.7%;土壤C∶N在不同植被恢复阶段间的变化未见明显规律，研究区土壤逐渐由C,N的限制转变为P的限制；(3)各植被恢复阶段土壤C∶P和N∶P主要与砂粒含量呈显著负相关，与孔隙度呈显著正相关，土壤C∶N与其他因子的相关性不明显。[结论]植被恢复有利于土壤C,N含量增加，改善土壤理化性质，在植被恢复过程应同时注重P元素的调控，以提高晋西黄土区植被生态恢复水平。

关键词：植被恢复土壤养分生态化学计量特征

Advances in biotechnological production of santalenes and santalols

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Chinese Herbal Medicines 2021年第1期13卷 90-97页

作者： wen-long zha.Jia-chen Zi Biotechnological Institute of Chinese Materia Medica Jinan UniversityGuangzhou 510632China College of Pharmacy Jinan UniversityGuangzhou 510632China

Sandalwood essential oil has been widely used not only as natural medicines but also in perfumery and food industries, with sesquiterpenoids as its major components including(Z)-a-santalol and(Z)-bsantalol and so on. The mature heartwoods of Santalum album, Santalum austrocaledonicum and Santalum spicatum are the major plant resources for extracting sandalwood essential oil, which have been overexploited. Synthetic biology approaches have been successfully applied to produce natural products on large scale. In this review, we summarize biosynthetic enzymes of santalenes and santalols, including various santalene synthases(STSs) and cytochrome P450 monooxygenases(CYPs), and then highlight the advances of biotechnological production of santalenes and santalols in heterologous hosts, especially metabolic engineering strategies for constructing santalene-and santalol-producing Saccharomyces cerevisiae.

关键词： biosynthesis biotechnological production sandalwood oil santalenes santalols

A green and efficient access to aryl nitriles via an electrochemical anodic oxidation

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Chinese Chemical Letters 2014年第8期25卷 1112-1114页

作者： Jia-Qian Ye Zhen-Lei zha.g Zheng-Gen zha.zhi-Yong Wang Hefei National Laboratory for Physical Sciences at Microscale CAS Key Laboratory of Soft Matter Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology University of Science and Technology of China

The nitrile functionality is a key building block in synthetic chemistry, and has wide applications in pharmaceuticals. However, traditional methodologies for the synthesis of nitriles are limited to harsh reaction conditions. Herein, we report a new and efficient access to aryl nitriles by an electrochemical synthesis. Compared with the conventional synthetic methods, this electrochemical synthesis is more environmentally friendly and easier to handle.

关键词： Eletrochemistry Anodic oxidation Aryl nitrile