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Shengmaisan combined with Liuwei Dihuang Decoction alleviates chronic intermittent hypoxia-induced cognitive impairment by activating the EPO/EPOR/JAK2 signaling pathway

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Chinese Journal of Natural Medicines 2024年第5期22卷 426-440页

作者： SI Jianchao CHEN Xue QI Kerong LI Dongli LIU Bingbing zheng yuying JI Ensheng YANG Shengchang Department of Physiology Hebei University of Chinese MedicineShijiazhuang 050000China Hebei Technology Innovation Center of TCM Combined Hydrogen Medicine Shijiazhuang 050000China Department of Geriatrics First People’s Hospital of XiaoganXiaogan 432000China

Chronic intermittent hypoxia(CIH),a principal pathophysiological aspect of obstructive sleep apnea(OSA),is associated with cognitive *** evidence suggests that a combination of Shengmaisan and Liuwei Dihuang Decoctions(SMS-LD)can enhance cognitive function by nourishing yin and strengthening the *** study aimed to assess the efficacy and underlying mechanisms of SMS-LD in addressing cognitive impairments induced by *** exposed C57BL/6N mice to CIH for five weeks(20%-5%O_(2),5 min/cycle,8 h/day)and administered SMS-LD intragastrically(15.0 or 30 g·kg^(-1)·day)30 min before each CIH ***,AG490,a JJanus kinase 2(JAK2)inhibitor,was administered via intracerebroventricular *** function was evaluated using the Morris water maze,while synaptic and mitochondrial structures were examined by transmission electron *** stress levels were determined using DHE staining,and the activation of the erythropoietin(ER)/ER receptor(EPOR)/JAK2 signaling pathway was analyzed through immunohistochemistry and Western *** further investigate molecular mechanisms,HT22 cells were treated in vitro with either SMS-LD medicated serum alone or in combination with AG490 and then exposed to CIH for 48 *** results indicate that SMS-LD significantly mitigated CIH-induced cognitive impairments in ***,SMS-LD treatment enhanced dendritic spine density,ameliorated mitochondrial dysfunction,reduced oxidative stress,and activated the EPO/EPOR/JAK2 signaling ***,AG490 negated SMS-LD’s neuroprotective and cognitive improvement effects under CIH *** findings suggest that SMS-LD’s beneficial impact on cognitive impairment and synaptic and mitochondrial integrity under CIH conditions may predominantly be attributed to the activation of the EPO/EPOR/JAK2 signaling pathway.

关键词： Chronic intermittent hypoxia Cognitive impairment Shengmaisan Liuwei Dihuang Decoction Oxidative stress EPO/EPOR/JAK2 signaling pathway

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Systematic engineering of BiVO_(4)photoanode for efficient photoelectrochemical water oxidation

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Carbon Energy 2024年第4期6卷 12-21页

作者： Zhiting Liang Meng Li Kai‐Hang Ye Tongxin Tang Zhan Lin yuying zheng Yongchao Huang Hongbing Ji Shanqing Zhang Guangzhou Key Laboratory of Clean Transportation Energy Chemistry School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhouChina Chemical Engineering Guangdong Laboratory Jieyang Branch of ChemistryJieyangChina Key Laboratory for Water Quality and Conservation of the Pearl River Delta Institute of Environmental Research at Greater Bay AreaMinistry of EducationGuangzhou UniversityGuangzhouChina State Key Laboratory Breeding Base of Green‐Chemical Synthesis Technology Institute of Green Petroleum Processing and Light Hydrocarbon ConversionCollege of Chemical EngineeringZhejiang University of TechnologyHangzhouChina School of Environment and Science Centre for Catalysis and Clean EnergyGriffith UniversityGold Coast CampusSouthportQueenslandAustralia

BiVO_(4)is one of the most promising photoanode materials for photoelectrochemical(PEC)solar energy conversion,but it still suffers from poor photocurrent density due to insufficient light‐harvesting efficiency(LHE),weak photogenerated charge separation efficiency(Φ_(Sep)),and low water oxidation efficiency(Φ_(OX)).Herein,we tackle these challenges of the BiVO_(4)photoanodes using systematic engineering,including catalysis engineering,bandgap engineering,and morphology *** particular,we deposit a NiCoO_(x)layer onto the BiVO_(4)photoanode as the oxygen evolution catalyst to enhance theΦ_(OX)of Fe‐g‐C_(3)N_(4)/BiVO_(4)for PEC water oxidation,and incorporate Fe‐doped graphite‐phase C_(3)N_(4)(Fe‐g‐C_(3)N_(4))into the BiVO_(4)photoanode to optimize the bandgap and surface areas to subsequently expand the light absorption range of the photoanode from 530 to 690 nm,increase the LHE andΦ_(Sep),and further improve the oxygen evolution reaction activity of the NiCoO_(x)catalytic ***,the maximum photocurrent density of the as‐prepared NiCoO_(x)/Fe‐g‐C_(3)N_(4)/BiVO_(4)is remarkably boosted from 4.6 to 7.4 mA cm^(−2).This work suggests that the proposed systematic engineering strategy is exceptionally promising for improving LHE,Φ_(Sep),andΦ_(OX)of BiVO_(4)‐based photoanodes,which will substantially benefit the design,preparation,and large‐scale application of next‐generation high‐performance photoanodes.

关键词： bismuth vanadate carbon nitride charge separation heterojunction water oxidation

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Shengmaisan combined with Liuwei Dihuang Decoction alleviates chronic intermittent hypoxia-induced cognitive impairment by activating the EPO/EPOR/JAK2 signaling pathway

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Chinese Journal of Natural Medicines 2024年第5期 426-440页

作者： SI Jianchao CHEN Xue QI Kerong LI Dongli LIU Bingbing zheng yuying JI Ensheng YANG Shengchang Department of Physiology Hebei University of Chinese Medicine Department of Geriatrics First People's Hospital of Xiaogan Hebei Technology Innovation Center of TCM Combined Hydrogen Medicine

Chronic intermittent hypoxia（CIH）, a principal pathophysiological aspect of obstructive sleep apnea（OSA）, is associated with cognitive deficits. Clinical evidence suggests that a combination of Shengmaisan and Liuwei Dihuang Decoctions（SMSLD） can enhance cognitive function by nourishing yin and strengthening the kidneys. This study aimed to assess the efficacy and underlying mechanisms of SMS-LD in addressing cognitive impairments induced by CIH. We exposed C57BL/6N mice to CIH for five weeks（20%-5% O2, 5 min/cycle, 8 h/day） and administered SMS-LD intragastrically(15.0 or 30 g·kg-1·day) 30 min before each CIH session. Additionally, AG490, a JJanus kinase 2（JAK2） inhibitor, was administered via intracerebroventricular injection. Cognitive function was evaluated using the Morris water maze, while synaptic and mitochondrial structures were examined by transmission electron microscopy. Oxidative stress levels were determined using DHE staining, and the activation of the erythropoietin（ER）/ER receptor（EPOR）/JAK2 signaling pathway was analyzed through immunohistochemistry and Western blotting. To further investigate molecular mechanisms, HT22 cells were treated in vitro with either SMS-LD medicated serum alone or in combination with AG490 and then exposed to CIH for 48 h. Our results indicate that SMS-LD significantly mitigated CIH-induced cognitive impairments in mice. Specifically, SMS-LD treatment enhanced dendritic spine density, ameliorated mitochondrial dysfunction, reduced oxidative stress, and activated the EPO/EPOR/JAK2 signaling pathway. Conversely, AG490 negated SMS-LD's neuroprotective and cognitive improvement effects under CIH conditions. These findings suggest that SMS-LD's beneficial impact on cognitive impairment and synaptic and mitochondrial integrity under CIH conditions may predominantly be attributed to the activation of the EPO/EPOR/JAK2 signaling pathway.

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鄂西神农架冰雪体育旅游产业高质量发展探析

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体育科技文献通报 2024年第6期32卷 131-133,151页

作者：王欣睿郑玉莹吉林体育学院研究处吉林长春130022

高质量发展是推进冰雪体育旅游产业发展的战略选择。本文采用文献资料、逻辑分析法等研究方法,分析了鄂西神农架冰雪体育旅游产业高质量发展的优势和劣势,并针对性地提出了未来发展路径。研究认为,鄂西神农架发展冰雪体育旅游产业具备... 详细信息

高质量发展是推进冰雪体育旅游产业发展的战略选择。本文采用文献资料、逻辑分析法等研究方法,分析了鄂西神农架冰雪体育旅游产业高质量发展的优势和劣势,并针对性地提出了未来发展路径。研究认为,鄂西神农架发展冰雪体育旅游产业具备地理位置、区域经济建设、群众、政策支持等方面优势,存在消费结构不平衡、未形成完整产业链、相关专业人才短缺、配套设施相对落后等劣势。为更好地推进鄂西神农架冰雪体育旅游产业高质量发展,需要从以下几个方面形成合力:重视冰雪体育旅游消费需求转变;提升冰雪体育旅游产业链水平;拓宽冰雪专业人才储备;冰雪体育旅游配套设施逐步完善。

关键词：冰雪体育旅游产业高质量发展神农架

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城中村流动儿童校园人际关系与社会适应的关系:歧视知觉的中介作用

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心理月刊 2024年第15期 11-15页

作者：张景宏郑煜迎张媛媛广州新华学院资源与城乡规划学院广东广州510520 广东省华南城乡经济社会发展研究院广东广州510520

目的探讨城中村流动儿童校园人际互动状况及歧视知觉在人际关系与社会适应间的中介作用。方法通过运用半结构式访谈、问卷、图形绘画等方法,于2020年9月~2021年9月对广州市柯木塱社区流动儿童展开调研。结果(1)对社会适应水平的3个测量... 详细信息

目的探讨城中村流动儿童校园人际互动状况及歧视知觉在人际关系与社会适应间的中介作用。方法通过运用半结构式访谈、问卷、图形绘画等方法,于2020年9月~2021年9月对广州市柯木塱社区流动儿童展开调研。结果(1)对社会适应水平的3个测量分指标进行因素分析,方差总解释率为79.95%,分指标的因子载荷分别为总体自尊-0.920、消极情感0.878、问题行为0.884;(2)校园人际关系对城中村流动儿童社会适应水平存在显著正向影响,个体歧视和群体歧视则和社会适应水平存在显著的负向影响,人际关系、歧视知觉和社会适应三者之间的相关系数分别为0.733、-0.859、-0.735;(3)社会经济地位通过个体歧视知觉对城中村流动儿童社会适应水平有显著影响,中介效应量为-1.850。结论城中村流动儿童的歧视知觉主要来源于师生关系,良好的校园人际关系能够显著提升儿童社会适应水平,建议教师与家长应注重对流动儿童的关注与交流。

关键词：城中村流动儿童歧视知觉结构方程模型

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Preparation and Characterization of Gd^(3+)-doped Monodisperse TiO_2 Hollow Microsphere

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Journal of the Chinese Ceramic Society 2015年第4期2卷 204-212页

作者： JI Feng SHANG Pengbo zheng yuying College of Chemical Engineering and Technology Tianjin University College of Materials Science and Engineering Fuzhou University

Gd^(3+)-doped monodisperse TiO_2 hollow microspheres with various molar ratios of Gd^(3+)/TBOT were synthesized via a novel process, which involved the preparation of SiO_2 templates, deposition of Gd^(3+)-doped TiO_2 by sol-gel, SiO_2 coating, heat treatment to induce crystallization of TiO_2, and finally etching away the inner SiO_2 templates and outer SiO_2 layers. The synthesized samples were characterized by transmission electron microscopy(TEM), scanning electron microscopy(SEM), X-ray diffraction(XRD), diffuse reflection spectroscopy(DRS), specific surface area measurement(BET) and X-ray photoelectron spectroscopy(XPS), respectively. The photocatalytic activity of Gd^(3+)-doped samples was evaluated via photocatalytic degradation of Methyl orange under UV irradiation. The results show that the SiO_2 layers prevent aggregation of TiO_2 hollow microspheresand improve the thermal stability of the synthesized samples. Also, the photocatalytic activity of monodisperse TiO_2 hollow microspheres can be enhanced at the optimal molar ration of Gd^(3+)/TBOT of 0.7%.

关键词： Gd3+-doped hollow microsphere titania monodisperse photocatalysis

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专业赋能“走出去”金融服务——浅析银行转开保函业务风险及防控措施

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海外投资与出口信贷 2024年第4期 28-32页

作者：郑雨莹李萌徐冠楠孙洋中国进出口银行运营管理部

跨境保函在支持企业开展国际经贸合作方面具有“开山斧”作用。随着“一带一路”倡议实施，跨境保函蓬勃发展，但其面临的风险也值得关注。本文聚焦跨境保函中的转开保函产品，选取代表性案例，对常见风险进行梳理，针对不同风险点提出... 详细信息

跨境保函在支持企业开展国际经贸合作方面具有“开山斧”作用。随着“一带一路”倡议实施，跨境保函蓬勃发展，但其面临的风险也值得关注。本文聚焦跨境保函中的转开保函产品，选取代表性案例，对常见风险进行梳理，针对不同风险点提出应对措施，为转开保函风险识别防范提供意见和建议。

关键词：跨境转开保函保函风险防控 “一带一路” 高质量发展

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临床医学八年制后阶段临床能力培养与住院医师规范化培训结合的可行性研究

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中国高等医学教育 2024年第3期 4-6页

作者：陈旻敏余情郑玉英白浩鸣复旦大学附属中山医院上海200032

目的:为夯实八年制医学生临床实践能力,某高校附属三级甲等教学医院探索开展临床医学八年制临床能力培养与住院医师规范化培训衔接,进行了培养模式的创新实践。方法:按照第一年住院医师规范化培训标准,对临床医学八年制后阶段学生进行... 详细信息

目的:为夯实八年制医学生临床实践能力,某高校附属三级甲等教学医院探索开展临床医学八年制临床能力培养与住院医师规范化培训衔接,进行了培养模式的创新实践。方法:按照第一年住院医师规范化培训标准,对临床医学八年制后阶段学生进行为期一年的临床轮转培训,并采取住院医师规范化、标准化、同质化的培训管理。结论:八年制医学教育的后阶段培养以本科学历为起点,与住院医师规范化培训衔接保证其专业学位培养的主要方向,与住院医师规范化培训同质化管理保证临床轮转和临床岗位胜任力的质量,医学生毕业后有利于有效衔接住院医师规范化培训和临床博士后项目。

关键词：八年制医学教育住院医师规范化培训专业学位

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考虑悬浮导向间隙变化的长定子直线同步电机力性能分析

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微特电机 2024年第4期52卷 22-27页

作者：郑宇滢卢琴芬周颖鞠录峰浙江大学电气工程学院杭州310027 中国青岛四方机车车辆股份有限公司青岛266000

常导高速磁浮列车长定子直线同步电机由于特殊的分离结构,气隙由悬浮与导向系统决定,导致牵引力与悬浮力容易受到悬浮与导向系统性能的影响。研究了一个长定子段下垂、悬浮磁极模块纵向倾斜和横向偏移三种工况对气隙的影响,基于有限元... 详细信息

常导高速磁浮列车长定子直线同步电机由于特殊的分离结构,气隙由悬浮与导向系统决定,导致牵引力与悬浮力容易受到悬浮与导向系统性能的影响。研究了一个长定子段下垂、悬浮磁极模块纵向倾斜和横向偏移三种工况对气隙的影响,基于有限元软件建立了2D与3D有限元模型,计算分析了长定子直线同步电机的牵引力和悬浮力,揭示了气隙变化对力的影响规律。分析结果可以为高速磁浮列车的牵引系统设计与控制提供参考。

关键词：高速磁浮列车长定子直线同步电机气隙变化悬浮力牵引力

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Densely quaternized anion exchange membranes synthesized from Ullmann coupling extension of ionic segments for vanadium redox flow batteries

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Science China Materials 2019年第2期62卷 211-224页

作者： Yu Chen Qilang Lin yuying zheng Yan Yu Dongyang Chen College of Materials Science and Engineering Fuzhou University Key Laboratory of Eco-materials Advanced Technology (Fuzhou University)

Membranes with high ion conductivity and selectivity are important for vanadium redox flow ***, densely quaternized anion exchange membranes based on quaternary ammonium functionalized octa-benzylmethyl-containing poly(fluorenyl ether ketone)s(QA-OMPFEKs) were prepared from the(i) condensation polymerization of a newly developed octa-benzylmethyl-containing bisphenol monomer via Ullmann coupling,(ii) bromination at the benzylmethyl sites using N-bromosuccinimide, and(iii)quaternization of the bromomethyl groups using trimethylamine. The QA-OMPFEK-20 with an ion exchange capacity(IEC) of 1.66 mmolg^-1 exhibited a higher SO42-conductivity(9.62mScm^-1) than that of the QA-TMPFEK-40(4.82mScm^-1) at room temperature, which had a slightly higher IEC of 1.73 mmolg-1but much lower QA *** enhanced SO42-conductivity of QA-OMPFEK-20 was attributed to the ion-segregated structure arising from the densely anchored QA groups, which was validated by SAXS observation. Furthermore, the QA-OMPFEK-20 showed much lower VO2+permeability(1.24×10^-14m^2s^-1) than QA-TMPFEK-40(5.40×10^-13m^2s^-1) and Nafion N212(5.36×10^-12m^2s^-1), leading to improved Coulombic and energy efficiencies in Vanadium redox flow batteries(VRFBs). Therefore, the Ullmann coupling extension is a valuable approach for the development of high performance anion exchange membranes for VRFBs.

关键词： anion exchange membranes quaternary ammonium poly(fluorenyl ether ketone)s Ullmann coupling extension phase separation

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