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Validity and reliability of Chinese version of Fatigue Impact Scale in cerebral infarction patients

Neural Regeneration Research 2008年第2期3卷 177-181页

作者： Chunwei Wu zhandong liu Yongbo Zhang Jimei Li Dexin Wang Department of Neurology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

BACKGROUND： Post-stroke fatigue has received much attention recently. Three evaluation scales are available, including the Fatigue Impact Scale （FIS）. Yet none of these has been proven to be of use in the evaluation of psychological quality after post-stroke fatigue. OBJECTIVE： To introduce FIS into China, and to evaluate the validity and reliability of the Chinese Version in patients with cerebral infarction. DESIGN： Scale evaluation. SETTING： Department of Rehabilitation, Beijing Friendship Hospital, Capital Medical University. PARTICIPANTS： A total of 330 patients with cerebral infarction were selected from the Department of Neurology, Beijing Friendship Hospital, Capital Medical University from June 2005 to December 2006. All patients met diagnostic standards from the Fourth National Cerebrovascular Disease Academic Meeting of China Medical Association and were diagnosed with CT or MRI examination. Patients who were not willing to accept scale evaluation were excluded. METHODS： The English version of FIS was translated into Chinese and subsequently translated back to English again. FIS was given to the discharged patients, and they returned them upon completion. In-patients completed and immediately returned the FIS. Validity and reliability of the retrieved scales were ascertained with descriptive and inference analysis. MAIN OUTCOME MEASURES： Total scores and subscale scores of FIS. RESULTS： Out of 330 questionnaires, 214 valid questionnaires were deemed valid in total. Six components were extracted in factor analysis, and the total cumulative contribution was 73.919%, which suggested the questionnaire was valid. After correlation analysis, 6 components were divided into 3 subscales, including cognitive, physical, and social, which was the same as the English version. The Cronbach α value for the three subscales was 0.937 7, 0.918 8, and 0.940 6, respectively （〉 0.7）. CONCLUSION： The reliability and validity of the Chinese version of FIS met with

关键词： cerebral infarction fatigue validity reliability scales

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Synthesis and biological evaluation of novel tricyclic matrinic derivatives as potential anti-filovirus agents

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Acta Pharmaceutica Sinica B 2018年第4期8卷 629-638页

作者： Xin Zhang Qiang liu Qianqian Li Yinghong Li zhandong liu Hongbin Deng Sheng Tang Yanxiang Wang Youchun Wang Danqing Song Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Science & Peking Union Medical College Division of HIV/AIDS and Sex-transmitted Virus Vaccines National Institutes for Food and Drug Control Department of Neurology Beijing Friendship HospitalCapital Medical University

Twenty-six novel tricyclic sophoridinic and matrinic derivatives containing a common chlorinated benzene fragment were designed, synthesized and evaluated for their anti-ebolavirus(EBOV)activities. Structure–activity relationship analysis indicated:(i) 12 N-dichlorobenzyl motif was beneficial for the activity;(ii) the chiral configuration at C5 atom might not affect the activity much. Among the target compounds, compound 7d exhibited the most potent potency against EBOV with an IC_(50) value of 5.29 μmol/L and an SI value of over 37.8. Further in vivo anti-EBOV assay of 7d identified its high effectiveness, and in vivo anti-MARV assay of 7d suggested its inspiring broad-spectrum anti-filovirus activity. The results provided powerful information on further strategic optimization and development of this kind of compounds against filoviruses.

关键词： Sophoridinic Matrinic Structure-activity relationship EBOV Filovirus

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Design and Application of RFID Technology in Container Port

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信息工程期刊（中英文版） 2014年第2期4卷 26-37页

作者： Jifeng Qian zhandong liu Xia Xie Department of Military Logistics Military Transportation University Tianjin 300161 China College of Traffic and Transportation Beijing Jiaotong University Beijing 100044 China

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降雨特性和覆盖方式对麦田土壤水分的影响

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农业工程学报 2012年第13期28卷 113-120页

作者：刘战东高阳刘祖贵段爱旺中国农业科学院农田灌溉研究所新乡453003 农业部作物需水与调控重点开放实验室新乡453003 中国农业科学院研究生院北京100081

为探明不同降雨特性和覆盖方式对冬小麦土壤水分的影响,利用人工模拟降雨器,模拟40和60mm/h2种降雨强度,在大田设置地膜覆盖(PM)、秸秆覆盖(覆盖量分别为1500、4500、7500和10500kg/hm2,即SM15、SM45、SM75和SM105),同时设置无覆盖处理... 详细信息

为探明不同降雨特性和覆盖方式对冬小麦土壤水分的影响,利用人工模拟降雨器,模拟40和60mm/h2种降雨强度,在大田设置地膜覆盖(PM)、秸秆覆盖(覆盖量分别为1500、4500、7500和10500kg/hm2,即SM15、SM45、SM75和SM105),同时设置无覆盖处理作为对照(CK),研究不同降雨强度和覆盖方式对雨后冬小麦0～60cm土层土壤水分分布和降雨土壤蓄积量的影响。结果表明:模拟降雨前各覆盖处理土壤含水率均比CK高,其中0～20cm土层土壤含水率差异显著(PSM75>SM45>SM15>CK>PM,其中SM105和SM75均显著高于CK(P<0.05),PM则显著低于CK(P<0.05);受植株冠层降雨截留的影响,同等降雨条件下,同一覆盖处理拔节前降雨土壤蓄积量大于拔节后的;相比60mm/h降雨强度,40mm/h降雨强度下各处理拔节前、后降雨土壤蓄积量变化幅度较大。

关键词：土壤含水率降雨冬小麦模拟降雨覆盖蓄积量

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间作条件下水分在作物间的分配与利用研究进展

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农业工程学报 2007年第7期23卷 281-285页

作者：高阳段爱旺刘浩刘战东申孝军中国农业科学院农田灌溉研究所新乡453003

了解作物在地上和地下与水分的相互作用对于研究间作系统的性能是很重要的。该文对近年来国内外对间作系统内水分在作物间的分配与利用的研究成果作了简单的综述,包括水分在间作作物间的分配、间作条件下作物需水量的估算模型和间作条... 详细信息

了解作物在地上和地下与水分的相互作用对于研究间作系统的性能是很重要的。该文对近年来国内外对间作系统内水分在作物间的分配与利用的研究成果作了简单的综述,包括水分在间作作物间的分配、间作条件下作物需水量的估算模型和间作条件下的根系吸水模型。指出了此项研究存在的问题,进而对其今后研究方向和发展趋势进行了展望。

关键词：间作系统水分利用资源水分分配

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Antithrombin gene Arg197Stop mutation-associated venous sinus thrombosis in a Chinese family

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Neural Regeneration Research 2011年第20期6卷 1575-1579页

作者： Ang Li Tianhui liu zhandong liu Jimei Li Chunling Zhang Jun Chen Jinmei Sun Yanfei Han Lili Wang Dexin Wang Qiming Xue Baoen Wang Department of Critical Care Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China Liver Research Center Beijing Friendship Hspital Capital Medical University Beijing 100050 China Department of Neurology Health Care Center Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Neurology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

This study sought to elucidate the genetic correlation of cerebral venous sinus thrombosis caused by a hereditary antithrombin deficiency in a Chinese family, at the genetic and protein levels. A nonsense mutation from C to T on locus 6431 in exon 3B of the antithrombin gene was observed, leading to an arginine （CGA） to stop codon （TGA） change in the protein. This is the first report of this mutation in China. Ineffective heparin therapy in the propositus patient is associated with a lack of heparin binding sites after antithrombin gene mutation. Characteristic low intracranial pressure in the acute phase might be specific to this patient with cerebral venous sinus thrombosis.

关键词： antithrombin cerebral venous sinus thrombosis intracranial hypotension nonsense mutation brain edema

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慢性疲劳综合征相关焦虑及抑郁的研究进展

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中国全科医学 2023年第35期26卷 4477-4482页

作者：刘欣怡刘占东首都医科大学附属北京友谊医院医保神经内科北京市100050

疾病与疲劳的关系持续受到广泛关注,且疲劳已成为重要的公共卫生问题,2019年5月世界卫生组织将“过劳”列入《国际疾病分类》中,并于2022年在全球生效。慢性疲劳综合征(CFS)则是更早提出的疾病概念,到目前为止,该病的病因和发病机制尚... 详细信息

疾病与疲劳的关系持续受到广泛关注,且疲劳已成为重要的公共卫生问题,2019年5月世界卫生组织将“过劳”列入《国际疾病分类》中,并于2022年在全球生效。慢性疲劳综合征(CFS)则是更早提出的疾病概念,到目前为止,该病的病因和发病机制尚不清楚,也缺乏特异性的治疗方法。主要原因除了该病涉及多个系统外,其症状表现还通常与焦虑、抑郁难以区分,这也明显增加了该病诊疗及研究的复杂性。本文结合现有的研究文献,初步探讨了CFS与焦虑、抑郁的相关研究特点,从生物学指标研究现状、影像学异常和治疗等方面,进一步探讨了CFS的指标变化特征与焦虑、抑郁的异同点,旨在为CFS诊断及分型提供新的思路,并为开展该病的临床和基础研究提供建议。

关键词：疲劳综合征,慢性焦虑抑郁神经内分泌系统免疫炎症氧化性应激脑功能综述

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春玉米品种和种植密度对植株性状和耗水特性的影响

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农业工程学报 2012年第11期28卷 125-131页

作者：刘战东肖俊夫于景春刘祖贵南纪琴中国农业科学院农田灌溉研究所新乡453003 辽宁省建平县灌溉试验站建平122400

品种和种植密度是辽西地区春玉米节水高产栽培的参考依据。以稀植型品种丹玉12(DY12)和密植型品种中地77(ZD77)为试验材料,各设4个种植密度处理,研究了种植密度对玉米植株性状、耗水量、产量性状、水分利用效率(WUE)的影响,同时比较两... 详细信息

品种和种植密度是辽西地区春玉米节水高产栽培的参考依据。以稀植型品种丹玉12(DY12)和密植型品种中地77(ZD77)为试验材料,各设4个种植密度处理,研究了种植密度对玉米植株性状、耗水量、产量性状、水分利用效率(WUE)的影响,同时比较两类型品种之间的差异。结果表明:随着种植密度增加,两品种茎粗、单株叶面积均逐渐降低,株高、群体叶面积指数(Leafarea index,LAI)逐渐增加,DY12茎粗和ZD77株高差异分别达到显著水平(P<0.05);同一种植密度条件下,DY12的茎粗、株高均大于ZD77,而ZD77的LAI大于DY12表现出较强的耐密性。玉米全生育期耗水量随种植密度的增加而增加,同一种植密度条件下,ZD77小于DY12。产量随着种植密度的增加先增加后减少。除穗粗、穗行数及百粒质量外,种植密度对DY12其余产量性状的影响达到显著水平(P<0.05);而种植密度对ZD77各产量性状的影响均不显著。在WUE方面,DY12随种植密度的增加先增大后减小,当种植密度为45000株/hm2时,WUE达到最大值(2.48kg/m3);ZD77则随种植密度的增加而减少。该地区生产上应选择密植型春玉米品种进行合理密植,可以达到明显的节水增产效果。

关键词：土壤水分试验春玉米品种种植密度植株性状耗水量水分利用效率

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