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Study of the influence of virtual guard ring width on the performance of SPAD detectors in 180 nm standard CMOS technology

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Journal of Semiconductors 2023年第11期44卷 83-88页

作者： Danlu Liu Ming Li Tang Xu Jie dong Yuming Fang Yue Xu College of Integrated Circuit Science and Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China national and Local Joint Engineering Laboratory of RF Integration&Micro-Assembly Technology Nanjing 210023China

The influence of the virtual guard ring width(GRW)on the performance of the p-well/deep n-well single-photon avalanche diode(SPAD)in a 180 nm standard CMOS process was *** simulation demonstrates that the electric field strength and current density in the guard ring are obviously enhanced when GRW is decreased to 1μ*** is experimentally found that,compared with an SPAD with GRW=2μm,the dark count rate(DCR)and afterpulsing probability(AP)of the SPAD with GRW=1μm is significantly increased by 2.7 times and twofold,respectively,meanwhile,its photon detection probability(PDP)is saturated and hard to be promoted at over 2 V excess bias *** the fill factor(FF)can be enlarged by reducing GRW,the dark noise of devices is negatively affected due to the enhanced trap-assisted tunneling(TAT)effect in the 1μm guard ring *** comparison,the SPAD with GRW=2μm can achieve a better trade-off between the FF and noise *** study provides a design guideline for guard rings to realize a low-noise SPAD for large-array applications.

关键词： single-photon avalanche diode(SPAD) virtual guard ring dark count rate(DCR) photon detection probability(PDP) afterpulsing probability(AP)

基于逐段曲线回归分析的息票剥离法的研究及应用

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数学的实践与认识 2009年第23期39卷 1-9页

作者：董继国河北师范大学数学与信息科学学院河北石家庄050016

对一般息票剥离法(Bootstrap m ethod)进行了改进,将其在两个最近期间之间的利率利用线性关系进行估计,扩展为由回归分析逐段拟合曲线给予预测和估值.并给出了模型需要修正的情况和一个一般的修正方法.最后与n elson-S iegel模型构造收... 详细信息

对一般息票剥离法(Bootstrap m ethod)进行了改进,将其在两个最近期间之间的利率利用线性关系进行估计,扩展为由回归分析逐段拟合曲线给予预测和估值.并给出了模型需要修正的情况和一个一般的修正方法.最后与n elson-S iegel模型构造收益率曲线的方法进行了对比实证分析,并给出了相应的分析结果.

关键词：逐段曲线回归息票剥离法利率期限结构

Effects of somatostatin analogues on human sphincter of Oddi pressure

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 302-305页

作者： Shuo-dong Wu, zhen-Hai zhang, Jing Kong, Yan-Jun Li, Jun-zhe Jin, Wei Wang, dong-Yan Li and Min-Fei Wang Shenyang, China no.2 Department of General Surgery, Second Affilia- ted Hospital, China Medical University, Shenyang 110004, China Department of General Surgery Second Affiliated Hospital China Medical University Shenyang 110004 China. wushuodong@***

BACKGROUnD: Somatostatin, a neuropeptide and hor- mone , exists in the biliary tract of several species. The effects of somatostatin and its analogues on the sphincter of Oddi motility have been controversial. The aim of this study was to observe the action of stilamin and sandostatin on the sphincter of Oddi via choledochofiberscope manometry. METHODS: Twenty patients who had had'T' duct after cholecystectomy and choledochotomy were divided into 2 groups randomly: stilamin and sandostatin. They were subjected to manometry via a choledochofiberscope through the'T' duct tract. The following data recorded in- cluded duodenal pressure (DP), sphincter of Oddi basal pressure (SOBP), sphincter of Oddi contractive amplitude (SOCA), frequency of the sphincter of Oddi (SOF), dura- tion of the sphincter of Oddi, and the common bile duct pressure (CBDP). RESULTS: After intravenous administration of stilamin at a dose of 250 μg/h, the mean SOCA increased from 89.18 (26.50) to 128.57(54.21) mmHg (P nistration of stilamin at a dose of 500 μg/h the mean SO- CA declined to 92.18(42.81) mmHg (Pnd mean SOBP declined from 17.63(13.36) to 8.16(4.01) mmHg (Pned from 9.25(2.45) to 7.46(1.52) n/min, it was not significantly influenced. After intravenous administration of sandostatin at a dose of 100 μg, the mean CBDP increased obviously. COnCLUSIOnS: Intravenous administration of stilamin at a dose of 250 μg/h stimulates the motility of the sphincter of Oddi whereas the injection of stilamin at a dose of 500 μg/h inhibits its motility. Intravenous injection of sandosta- tin of 100 μg has no effect on the sphincter of Oddi.

关键词： biliary manometry via choledochofiberoscopy sphincter of Oddi somatostatin stilamin sandostatin

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胃癌D2根治术与全胃系膜切除术的解析

中华胃肠外科杂志 2013年第1期16卷 8-11页

作者：房学东吉林大学第二医院基本外科长春130041

全系膜切除作为肿瘤外科的一种手术理念,目前已得到外科同道的广泛接受。而对于不同的器官,所谓全系膜的范围或标准是什么,除结直肠以外尚未完全明确。针对胃而言,其系膜构造复杂,且胚胎期系膜与成体后的解剖学系膜差异也较大,即使按照... 详细信息

全系膜切除作为肿瘤外科的一种手术理念,目前已得到外科同道的广泛接受。而对于不同的器官,所谓全系膜的范围或标准是什么,除结直肠以外尚未完全明确。针对胃而言,其系膜构造复杂,且胚胎期系膜与成体后的解剖学系膜差异也较大,即使按照其解剖学系膜的范围来施行切除术，与目前推广的标准D2根治术相比，范围也相对过大。为此,我们提出外科系膜这一概念,即全系膜切除的实质应为全外科系膜切除。在临床实践中我们发现,胃与结直肠存在许多的对称相似性，通过对胃的延展、折叠等变形，即可在某种程度上实现其向结直肠的转变。转变后的胃不仅在形态、而且在血管分布、淋巴回流和系膜构成等方面均与结直肠存在惊人的吻合。在此基础上，我们提出胃的外科系膜范围，即肝胃韧带、肝十二指肠韧带、肝胰皱襞、脾胰皱襞、胃膈韧带、脾胃韧带、胃结肠韧带及大网膜等。这个范围与目前推广的D2根治术的范围也相吻合。本文还进一步探讨了胃癌的n分期。我们通过胃与结直肠的对照研究，将胃所属淋巴结重新归纳,即胃周、中间和根部3群，从而弥合了东西方学者长期存在的歧义。另外，我们也认同外科系膜以外淋巴转移的存在,即所谓的侧方转移。我们认为，关于胃肠癌的n分期,首先要界定系膜内、外淋巴结转移,如果存在系膜外淋巴结转移（侧方转移），应直接归入M1期，除非有证据显示侧方转移存在，否则不提倡进行扩大的侧方清扫。对于系膜内淋巴结转移,可依照目前nCCn规定的按淋巴结转移数量来划分（n1-3）。

关键词：胃肿瘤外科系膜全胃系膜切除术

橡胶粉-聚丙烯纤维复合改性微表处混合料技术性能研究

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公路工程 2015年第1期40卷 79-83,132页

作者：董哲通辽市交通工程局内蒙古通辽028000

针对普通微表处混合料抗疲劳性能、低温抗裂、降噪环保差等问题,提出采用橡胶粉与聚丙烯纤维复配方案,并研究了橡胶粉等量替代矿粉条件下不同橡胶粉掺量对橡胶粉-纤维微表处混合料的施工性能、长期使用性能以及降噪效果的影响。基于以... 详细信息

针对普通微表处混合料抗疲劳性能、低温抗裂、降噪环保差等问题,提出采用橡胶粉与聚丙烯纤维复配方案,并研究了橡胶粉等量替代矿粉条件下不同橡胶粉掺量对橡胶粉-纤维微表处混合料的施工性能、长期使用性能以及降噪效果的影响。基于以上研究本文推荐采用2.5‰聚丙烯纤维＋3%-5%橡胶粉复合改性方案。

关键词：微表处混合料施工性能长期使用性能降噪环保

Ultra-fast and high-efficient synthesis of caffeic acid phenethyl ester by microwave assistant ionic liquids catalysis

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Oil Crop Science 2017年第4期2卷 244-250页

作者： zhe dong Shi Wang Mingming zheng Chunfang Xu Fenghong Huang Oil Crops Research Institute Chinese Academy of Agricultural SciencesKey Laboratory of Oilseeds ProcessingMinistry of AgricultureHubei Key Laboratory of Lipid Chemistry and NutritionOil Crops and Lipids Process Technology National &Local Joint Engineering Laboratory

Caffeic acid phenethyl ester (CAPE), a natural and rare ingredient with several biological activities, was successfully synthesized from caffeic acid (CA) and phenylethanol (PE) by microwave assistant coupled with ionic liquids (ILs) catalysis. Four ILs, acted as both solvent and catalyst in this chemical synthesis, were optimized. Among them, [Bmim] [PF6] was the best with the highest CA conversion. 95% conversion was achieved under substrate molar ratio 4:1 (PE/CA, n/n), IL content 7:1 (IL/CA, w/w), microwave power 200 W, at 135 oC for 7 min. This study might be attributed to developing new chemical reaction system to produce caffeic acid derived esters.

关键词： caffeic acid phenethyl ester caffeic acid phenylethanol esterification ionic liquids microwave

QuEChERS-HPLC-MS/MS法检测谷物酸奶中伏马毒素

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中国乳品工业 2020年第6期48卷 52-55页

作者：董基肇庆学院食品与制药工程学院广东肇庆526061

建立一种快速、高效的QuEChERS-HPLC-MS/MS测定谷物酸奶中3种伏马毒素的方法。样品前处理采用乙腈-水溶剂提取,经SiO2+C18+MgSO4净化后检测。以0.1%甲酸-乙腈作为流动相,在质谱检测器的MRM-IDA-EPI监测模式下进行分析。结果表明,3种伏... 详细信息

建立一种快速、高效的QuEChERS-HPLC-MS/MS测定谷物酸奶中3种伏马毒素的方法。样品前处理采用乙腈-水溶剂提取,经SiO2+C18+MgSO4净化后检测。以0.1%甲酸-乙腈作为流动相,在质谱检测器的MRM-IDA-EPI监测模式下进行分析。结果表明,3种伏马毒素在1.0~50.0 ng/mL浓度范围内线性良好,相关系数r2为0.9992~0.9996,检出限为0.3~0.5μg/kg,定量限为1.0~1.5μg/kg。在10,50和100μg/kg三个添加水平进行加标回收试验(n=5),回收率达到84.2%~104%。该方法具有前处理简单、净化效果好、灵敏度高和检测速度快的优点,适用于谷物酸奶中3种伏马毒素的分析和定量检测。

关键词： QuEChERS 高效液相色谱谷源性酸奶伏马毒素

Co3+的电氧化合成及其在对甲砜基苯甲酸制备中的应用

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精细化工 2019年第11期36卷 2330-2335页

作者：冯柏成初晓东董静静金岩青岛科技大学化工学院

以七水硫酸钴、浓硫酸、硫酸铵为原料,电氧化合成Co^3+,用Co^3+氧化对甲砜基甲苯合成对甲砜基苯甲酸。考察了电极材料、电解温度、电流密度、硫酸浓度以及电解液循环套用对电极反应和硫酸浓度、Co^3+与对甲砜基甲苯物质的量比对氧化反... 详细信息

以七水硫酸钴、浓硫酸、硫酸铵为原料,电氧化合成Co^3+,用Co^3+氧化对甲砜基甲苯合成对甲砜基苯甲酸。考察了电极材料、电解温度、电流密度、硫酸浓度以及电解液循环套用对电极反应和硫酸浓度、Co^3+与对甲砜基甲苯物质的量比对氧化反应的影响。结果表明,在选用阳极二氧化铅、阴极铅为电极板,陶瓷膜作为阳离子交换膜,电解液浓度为c(Co^2+)=0.5 mol/L、c (硫酸)=4.0 mol/L、c (硫酸铵)=0.15 mol/L,电极间距(d)为2 cm、电流密度(J)为350 A/m2、电解温度(T)为10℃时,电解液Co^2+转化率可达80%,电解氧化电流效率达67.5%。在进行对甲砜基甲苯的氧化时,控制电解液浓度为c(Co^3+)=0.4 mol/L、c(硫酸)=4.0 mol/L、c(硫酸铵)=0.15 mol/L,n(Co^3+)∶n(对甲砜基甲苯)=6∶1,使得反应温度为30℃,反应时间为30 min,对甲砜基苯甲酸的收率可达97.8%,精制后纯度在98.5%以上。

关键词：电氧化对甲砜基苯甲酸绿色化工精细化工中间体

Analysis of textbook outcomes for ampullary carcinoma patients following pancreaticoduodenectomy

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2259-2271页

作者： Xiao-Jie zhang He Fei Chun-Guang Guo Chong-Yuan Sun Ze-Feng Li zheng Li Ying-Tai Chen Xu Che dong-Bing zhao Department of Pancreatic and Gastric Surgical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Hepatobiliary and Pancreatic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen518116China

BACKGROUnD Textbook outcomes(TOs)have been used to assess the quality of surgical treatment for many digestive tumours but not ampullary carcinoma(AC).AIM To discuss the factors associated with achieving a TO and further explore the prognostic value of a TO for AC patients undergoing curative pancreaticoduodenectomy(PD).METHODS Patients who underwent PD at the China national Cancer Center between 1998 and 2020 were identified.A TO was defined by R0 resection,examination of≥12 Lymph nodes,no prolonged hospitalization,no intensive care unit treatment,no postoperative complications,and no 30-day readmission or *** regression analysis was used to identify the prognostic value of a TO for overall survival(OS)and recurrence-free survival(RFS).Logistic regression was used to identify predictors of a *** rate of a TO and of each indicator were compared in patients who underwent surgery before and after *** Ultimately,only 24.3%of 272 AC patients achieved a TO.A TO was independently associated with improved OS[hazard ratio(HR):0.443,95%confidence interval(95%CI):0.276-0.711,P=0.001]and RFS(HR:0.379,95%CI:0.228-0.629,Pn the Cox regression *** independently associated with a TO included a year of surgery between 2010 and 2020(OR:4.549,95%CI:2.064-10.028,Pnd n1 stage disease(OR:2.251,95%CI:1.023-4.954,P=0.044).In addition,the TO rate was significantly higher in patients who underwent surgery after 2010(Pn in those who underwent surgery before *** Only approximately a quarter(24.3%)of AC patients achieved a TO following PD.A TO was independently related to favourable oncological outcomes in AC and should be considered as an outcome measure for the quality of *** multicentre research is warranted to better elucidate its impact.

关键词： Ampullary carcinoma Textbook outcomes Pancreaticoduodenectomy Prognosis