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原发性膜性肾病预防性抗凝治疗研究进展

医药导报 2024年第3期43卷 418-423页

作者：李炼郑星月武刘芸尹琪楠韩丽珠雷洋边原电子科技大学医学院成都610054 四川省医学科学院·四川省人民医院/电子科技大学附属医院药学部·个体化药物治疗四川省重点实验室成都610072

原发性膜性肾病血栓形成的风险较高,血栓形成通常发生在病程早期。血栓的形成与多种因素相关,目前普遍认为低蛋白血症为其独立风险因素,其他风险因素包括蛋白尿、M型磷脂酶A2受体抗体、D-二聚体等。虽然预防性抗凝被认为是原发性膜性肾... 详细信息

原发性膜性肾病血栓形成的风险较高,血栓形成通常发生在病程早期。血栓的形成与多种因素相关,目前普遍认为低蛋白血症为其独立风险因素,其他风险因素包括蛋白尿、M型磷脂酶A2受体抗体、D-二聚体等。虽然预防性抗凝被认为是原发性膜性肾病的一般支持治疗,但目前在时机选择、血清白蛋白阈值确定以及治疗方案制定等方面仍存在争议。该文对上述问题相关文献进行综述,以期为形成该类患者血栓防治标准提供参考,为临床实践提供参考。

关键词：原发性膜性肾病血栓栓塞预防性抗凝血清白蛋白

First-principles simulations of iron with nitrogen:from surface adsorption to bulk diffusion

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功能材料信息 2013年第4期10卷 8-21页

作者： MH wu XH Liu 顾剑锋 zh Jin School of Materials Science and Engineering Shanghai Jiao Tong University

Adsorption,absorption and diffusion pathways of nitrogen are studied for ferromagnetic body-centered cubic iron via spin-polarized density functional theory in combination with the climbing image nudged elastic band *** computed data suggest that,depending on the coverage of N atoms,N prefers to stay on particular surface *** pinned down well below the surface,N prefers to move into octahedral interstices rather than tetrahedral ***,the tetrahedral interstices are crucial because they act as transition states and yield the saddle point energies of the corresponding minimum energy *** comparison with carbon,we found that nitrogen prefers a different pathway from the(1 0 0)surface to the subsurface due to its strong repulsive interaction with Fe ions.

关键词：氮铁磁体立方铁密度泛函理论

珠海市2020—2023年大气PM2.5的元素特征及健康风险评价

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现代预防医学 2024年第2期51卷 226-232页

作者：张瑰吴雨蔓职佳音林丽玲江倩文黄利群珠海市疾病预防控制中心威斯康星大学麦迪逊分校统计学院新乡医学院公共卫生学院

目的了解珠海市近年来大气PM2.5的元素特征及其健康风险，为珠海市污染治理提供相关依据。方法于2020年4月—2023年3月在珠海市3个行政区每月定期采集PM2.5样本，共取得756份样品，通过ICP-MS法对PM2.5中元素含量进行测量，并采用美国... 详细信息

目的了解珠海市近年来大气PM2.5的元素特征及其健康风险，为珠海市污染治理提供相关依据。方法于2020年4月—2023年3月在珠海市3个行政区每月定期采集PM2.5样本，共取得756份样品，通过ICP-MS法对PM2.5中元素含量进行测量，并采用美国EPA吸入暴露模型计算健康风险。结果每月在34种元素范围内对珠海市PM2.5样本进行分析，大部分元素质量浓度表现为夏季低，冬季高的特点，其中重金属元素3年间年均浓度由大到小依次为锌(64.1 ng/m3)>锰(14.2 ng/m3)>铅(10.9 ng/m3)>铜(6.57 ng/m3)>砷(2.41 ng/m3)>镍(1.91 ng/m3)>钒(1.83 ng/m3)>铬(1.62 ng/m3)>锑(1.21 ng/m3)>镉(0.54 ng/m3)>铊(0.13 ng/m3)>钴(0.12 ng/m3)>汞(4.88×10-3ng/m3)。与之前珠海市的相关研究比较，各元素质量浓度均有所下降，但锑、铝、砷、铬、镍、硒有再次上涨的趋势。对6种致癌元素铬、钴、镍、砷、钼和镉，10种非致癌元素铝、钒、锰、铜、锌、硒、锑、钡、汞和铅进行健康评价，结果显示非致癌元素风险均在人群可接受水平(HQ≤1),致癌元素铬和砷存在致癌风险(R>10-6)。结论珠海市大气PM2.5非致癌元素健康风险均在人群可接受水平，致癌元素铬和砷存在致癌风险，需重点关注。从元素质量浓度来看，燃料和交通污染仍是治理重点。

关键词：大气污染 PM2.5 健康风险评价

国产新型静脉射频闭合治疗系统与进口系统应用效果的随机对照研究

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中华外科杂志 2024年第3期62卷 223-228页

作者：唐明珺周玲羽贾晓坚吴劲进楼炎波金明娟朱越锋浙江大学医学院附属第四医院血管外科义乌322000 浙江大学医学院公共卫生学院杭州310000 浙江大学医学院附属邵逸夫医院血管外科杭州310016

目的比较国产新型静脉射频闭合治疗系统与进口系统治疗原发性下肢静脉曲张的应用效果。方法本研究为单中心、前瞻性、非劣效性随机对照试验。纳入2021年1月至2022年1月浙江大学医学院附属第四医院血管外科收治的符合纳入和排除标准的原... 详细信息

目的比较国产新型静脉射频闭合治疗系统与进口系统治疗原发性下肢静脉曲张的应用效果。方法本研究为单中心、前瞻性、非劣效性随机对照试验。纳入2021年1月至2022年1月浙江大学医学院附属第四医院血管外科收治的符合纳入和排除标准的原发性下肢静脉曲张患者,按1∶1随机分为两组,分别接受国产新型静脉射频闭合治疗系统和进口静脉射频闭合治疗系统治疗。对两组的技术成功率、系统操作性能、术后6个月内的不良事件和严重不良事件(SAE)发生率、术后6个月目标静脉闭合率等进行比较。定量资料的比较采用Mann-Whitney U检验,分类资料的比较采用χ^(2)检验、Fisher确切概率法或非劣效性检验。结果研究共纳入80例患者,试验组41例,对照组39例。其中男性27例,女性53例;年龄[M(IQR)]55(23)岁(范围:40~78岁);左下肢48例,右下肢32例。两组技术成功率均为100%,术中均未出现系统操作故障。试验组和对照组术后6个月内不良事件发生率[58.5%(24/41)比61.5%(24/39),χ^(2)=0.075,P=0.784]、SAE发生率[7.3%(3/41)比5.1%(2/39),χ^(2)=0.163,P=0.686]的差异均无统计学意义。两组各发生1例器械相关不良事件,试验组1例患者术后发生静脉内热致血栓,口服利伐沙班片后痊愈;对照组1例术后右大腿上段疼痛1 d余,外用镇痛、消肿药物后痊愈。未发生器械相关SAE。试验组术后6个月血管闭合率为100%(38/38),对照组为97.4%(37/38),试验组与对照组术后6个月目标静脉闭合率差值为2.6%(95%CI:-3.19~8.45,Z=4.865,P<0.01),差值的95%CI低限大于非劣效界值-10.0%。结论国产新型静脉射频闭合治疗系统在原发性下肢静脉曲张患者中的早期应用效果不劣于进口静脉射频闭合治疗系统。

关键词：静脉曲张下肢射频消融应用效果国产静脉射频闭合治疗系统

Abrogation of Hn RNP L enhances anti-PD-1 therapy efficacy via diminishing PD-L1 and promoting CD8^(+) T cell-mediated ferroptosis in castration-resistant prostate cancer

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Acta Pharmaceutica Sinica B 2022年第2期12卷 692-707页

作者： Xumin zhou Libin Zou Hangyu Liao Junqi Luo Taowei Yang Jun wu Wenbin Chen Kaihui wu Shengren Cen Daojun Lv Fangpeng Shu Yu Yang Chun Li Bingkun Li Xiangming Mao Department of Urology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China Second Department of Hepatobiliary Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China Nursing Department Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Urology Minimally Invasive Surgery Centerthe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Urology Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623China Department of Urology Peking University Shenzhen HospitalShenzhen 518036China

Owing to incurable castration-resistant prostate cancer(CRPC)ultimately developing after treating with androgen deprivation therapy(ADT),it is vital to devise new therapeutic strategies to treat *** that target programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for human cancers with clinical ***,many patients,especially prostate cancer,fail to respond to anti-PD-1/PD-L1 treatment,so it is an urgent need to seek a support strategy for improving the traditional PD-1/PD-L1 targeting *** the present study,analyzing the data from our prostate cancer tissue microarray,we found that PD-L1 expression was positively correlated with the expression of heterogeneous nuclear ribonucleoprotein L(Hn RNP L).Hence,we further investigated the potential role of Hn RNP L on the PD-L1 expression,the sensitivity of cancer cells to T-cell killing and the synergistic effect with anti-PD-1 therapy in ***,Hn RNP L knockdown effectively decreased PD-L1 expression and recovered the sensitivity of cancer cells to T-cell killing in vitro and in vivo,on the contrary,Hn RNP L overexpression led to the opposite effect in CRPC *** addition,consistent with the previous study,we revealed that ferroptosis played a critical role in T-cell-induced cancer cell death,and Hn RNP L promoted the cancer immune escape partly through targeting YY1/PD-L1 axis and inhibiting ferroptosis in CRPC ***,Hn RNP L knockdown enhanced antitumor immunity by recruiting infiltrating CD8^(+)T cells and synergized with anti-PD-1 therapy in CRPC *** study provided biological evidence that Hn RNP L knockdown might be a novel therapeutic agent in PD-L1/PD-1 blockade strategy that enhanced anti-tumor immune response in CRPC.

关键词： HnRNP L PD-L1 YY1 Ferroptosis Immune escape Immune checkpoint blockade Anti-PD-1 therapy Castration-resistant prostate cancer

Evaluation of Reference Genes for Quantitative Real-Time PCR Analysis in Manila Clam Ruditapes philippinarum Under Hypoxic Stress

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Journal of Ocean University of China 2023年第4期22卷 1059-1067页

作者： JING Hao zhOU Liqing GONG Miao TU Kang LIU zhihong wu Biao SUN Xiujun College of Fisheries and Life Science Shanghai Ocean UniversityShanghai 201306China State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdao 266071China Laboratory for Marine Fisheries Science and Food Production Processes Laoshan LaboratoryQingdao 266237China School of Marine Science and Fisheries Jiangsu Ocean UniversityLianyungang 222005China Putian Institute of Aquaculture Science of Fujian Province Putian 351100China

Quantitative real-time PCR(qRT-PCR)has been widely used for gene expression analysis,and selection of reference genes is a key point to obtain accurate *** find out optimal reference genes for qRT-PCR in Manila clam Ruditapes philippinarum in response to hypoxia,different tissues were used and compared to evaluate the stability of candidate reference genes under low oxygen stress(DO 0.5mgL^(−1) and DO 2.0mgL^(−1))and normal condition(DO 7.5mgL^(−1)).Seven candidate reference genes were selected to evaluate the stability of their expression *** reference genes were evaluated by Delta Ct,BestKeeper,NormFinder and geNorm,and then screened by RefFinder *** hypoxic stress of 0.5mgL^(−1),the most suitable reference gene for gill and hepatopancreas was RPL31,and the optimal reference genes for axe foot and adductor muscle were TUB and HIS,*** hypoxic stress of 2.0mgL^(−1),the most stable reference gene for gill and hepatopancreas was RPL31,and the optimal reference genes for axe foot and adductor muscle were RPS23 and EF1A,*** the normal condition,HIS and EF1A were identified as the optimal internal reference genes in gill and hepatopancreas respectively,and GFRP2 was the best internal reference gene for axe foot and adductor *** present findings will provide important basis for the selection of reference genes for qRT-PCR analysis of gene expression level in bivalves under hypoxic stress,which might be helpful for the analysis of other molluscs too.

关键词： clam reference gene hypoxia quantitative real-time PCR

Fabrication of electrospun bilayer separators for lithium-sulfur batteries:A surface and structure dual modification strategy

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Science China(Technological Sciences) 2022年第12期65卷 3029-3038页

作者： XU Ming zhANG XiaoQing YUAN Wei HUANG HongLin wu YaoPeng WAN zhenPing LU LongSheng TANG Yong School of Mechanical&Automotive Engineering South China University of TechnologyGuangzhou 510640China

The severe shuttle effect problem of soluble polysulfides greatly hinders the development of long-life lithium-sulfur(Li-S)batteries,which can be improved by separator *** study develops a bilayer separator based on an effective surface and structure dual modification *** bilayer separator(named as TCNFs/SPNFs)is constructed by the integration of a carbon-based nanofiber layer(surface modification layer)with a polymer-based nanofiber layer(structure modification layer)through a facile electrospinning *** excellent electrolyte wettability of the nanofibers accelerates lithium-ion migration,while the good electronic conductivity of the carbon layer facilitates fast electron *** TiO_(2)and SiO_(2)nanoparticles embedded in the separator provide abundant active sites for immobilizing the *** to these synergistic effects,this multi-functional separator helps inhibit the shuttling problem and thus enhances the active sulfur *** as-prepared battery with the TCNFs/SPNFs separator delivers significantly enhanced the electrochemical performances,producing a low capacity decay rate of 0.061%per cycle at 1 C over 1000 cycles and an admirable rate capacity of 886.7 mAh g^(-1)at 2 *** with a high sulfur loading of 4.8 mg cm^(-2),a remarkable areal capacity of 6.0 mAh cm^(-2)is *** work is believed to provide a promising strategy to develop novel separators for high-performance Li-S batteries.

关键词： lithium-sulfur battery bilayer separator surface and structure dual modification strategy electrospinning nanofiber

Tea domain transcription factor TEAD4 mitigatesTGF-β signaling and hepatocellular carcinomaprogression independently of YAP

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Journal of Molecular Cell Biology 2023年第2期15卷 3-16页

作者： Weicheng Luo Yi Li Yi Zeng Yining Li Minzhang Cheng Cheng zhang Fei Li Yiqing wu Chunhong Huang Xiaolong Yang Joachim Kremerskothen Jianmin zhang Chunbo zhang Shuo Tu zhihua Li zhĳun Luo zhenghong Lin Xiaohua Yan Department of Biochemistry and Molecular Biology School of Basic Medical SciencesNanchang University Jiangxi Medical CollegeNanchang 330031China Department of Rheumatology and Clinical Immunology Jiangxi Provincial People’s HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang 330006China Center for Experimental Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Pathology and Molecular Medicine Queen’s UniversityKingstonON K7L 3N6Canada Department of Nephrology Hypertension and RheumatologyUniversity Hospital MünsterMünster 48149Germany Department of Cancer Genetics&Genomics Roswell Park Comprehensive Cancer CenterElm and Carlton StreetsBuffaloNY 14203USA School of Pharmacy Nanchang University Jiangxi Medical CollegeNanchang 330008China Key Laboratory of Breast Diseases of Jiangxi Province Nanchang People’s HospitalNanchang 330025China Department of Pathology School of Basic Medical SciencesNanchang University Jiangxi Medical CollegeNanchang 330006China School of Life Sciences Chongqing UniversityChongqing 405200China

Tea domain transcription factor 4 (TEAD4) plays a pivotal role in tissue development and homeostasis by interacting with Yesassociated protein (YAP) in response to Hippo signaling inactivation. TEAD4 and YAP can also cooperate with transforminggrowth factor-β (TGF-β)-activated Smad proteins to regulate gene transcription. Yet, it remains unclear whether TEAD4 playsa YAP-independent role in TGF-β signaling. Here, we unveil a novel tumor suppressive function of TEAD4 in liver cancer viamitigating TGF-β signaling. Ectopic TEAD4 inhibited TGF-β-induced signal transduction, Smad transcriptional activity, and targetgene transcription, consequently suppressing hepatocellular carcinoma cell proliferation and migration in vitro and xenografttumorgrowth in mice. Consistently, depletion of endogenous TEAD4 by siRNAs enhanced TGF-β signaling in cancer cells. Mechanistically,TEAD4 associates with receptor-regulated Smads (Smad2/3) and Smad4 in the nucleus, thereby impairing the binding of Smad2/3to the histone acetyltransferase p300. Intriguingly, these negative effects of TEAD4 on TGF-β/Smad signaling are independent ofYAP, as impairing the TEAD4–YAP interaction through point mutagenesis or depletion of YAP and/or its paralog TAZ has little ***, these results unravel a novel function of TEAD4 in fine tuning TGF-β signaling and liver cancer progression in a YAPindependent manner.

关键词： TGF-β TEAD4 p300 signaling regulation transcriptional activity hepatocellular carcinoma

Overexpression/amplification of HER-2/neu is uncommon in hepatocellular carcinoma

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第二军医大学学报 2005年第11期26卷 1320-1320页

作者： Xian zh zhang SH Cong WM wu WQ wu MC Department of Pathology Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China