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Circulating HER2 extracellular domain(ECD) predicts a poor prognosis for metastatic breast cancer patients

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Circulating HER2 extracellular domain(ECD) predicts a poor p...

国家级“乳腺癌诊治新进展”学习班暨学术年会

作者： Shao XY Xu XH Wang S huang J Cai JF Cao WM Chen zh huang P Lou CJ Ling ZQ Han MX Wang XJ zhejiang Cancer Research Institute Zhejiang Cancer Hospital

Background:Amplification or overexpression of HER2 has been shown to play an important role in approximately 30%of breast cancers and is strongly associated with increased recurrence and a worse *** HER2 extracellular domain(ECD) may be cleaved and shed from the surface of breast cancer cells and serum HER2 ECD levels can be detected by enzyme-linked immunosorbent assay (ELISA).In this study,we explored the relationship between circulating HER2 ECD and tissue HER2

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蓄热介质对太阳能热风发电集热器性能的影响

动力工程 2008年第4期28卷 647-650页

作者：黄惠兰张华安恩科姚秀平邬志敏上海理工大学动力工程学院同济大学热能工程系上海200092 上海电力学院热能工程系上海200093

分别以沙子、石子以及石子与充水黑色密封管的组合作为蓄热介质,搭建了太阳能集热器试验装置并进行了相应的试验研究,得出了不同蓄热介质的吸放热特性及其对集热器内空气进出口温差、集热器效率的影响规律.结果表明:在相同的平均辐射强... 详细信息

分别以沙子、石子以及石子与充水黑色密封管的组合作为蓄热介质,搭建了太阳能集热器试验装置并进行了相应的试验研究,得出了不同蓄热介质的吸放热特性及其对集热器内空气进出口温差、集热器效率的影响规律.结果表明:在相同的平均辐射强度下,石子与充水黑色密封管组合集热器的蓄热性能好,且集热器空气进出口温差及集热器效率最大,为太阳能热风发电系统集热器地面蓄热材料的选用提供了依据.

关键词：能源系统工程太阳能热风发电集热器蓄热介质热效率

Impacts of solid physical properties on the performances of a slurry external airlift loop reactor integrating mixing and separation

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Chinese Journal of Chemical Engineering 2023年第3期55卷 1-12页

作者： Tian zhang Qingshan huang Shujun Geng Aqiang Chen Yan Liu Haidong zhang School of Chemical Engineering Hebei University of TechnologyTianjin 300130China Key Laboratory of Biofuels Qingdao Institute of Bioenergy and Bioprocess Technology(QIBEBT)Chinese Academy of Sciences(CAS)Qingdao 266101China Dalian National Laboratory for Clean Energy(DNL) Dalian 116023China Innovation Academy for Green Manufacture Institute of Process EngineeringCASBeijing 100190China Synthetic Biology Technology Innovation Center of Shandong Province Qingdao 266101China Shandong Energy Institute Qingdao 266101China

Solid physical properties are vital for the design, optimization, and scale-up of gas–liquid–solid multiphase reactors. The complex and interactional effects of the solid physical properties, including particle diameter, density, wettability, and sphericity, on the hydrodynamic behaviors in a new external airlift loop reactor(EALR) integrating mixing and separation are decoupled in this work. Two semi-empirical equations are proposed and validated to predict the overall gas holdup and liquid circulating velocity satisfactorily, and then the individual influence of such solid physical properties is further investigated. The results demonstrate that both the overall gas holdup in the riser and the liquid circulating velocity in the downcomer increase with the contact angle, but decrease with particle size, density, and ***, the impact of the particle size on the liquid circulating velocity is also profoundly revealed on a micro-level considering the particle size distribution. Moreover, the axial solid concentration distribution is discussed, and the uniformity of the slurry is described by the mixing index of the solid particles. The results show that a more homogeneous mixture can be achieved by adding finer particles other than attaining violent turbulence. Therefore, this work lays a foundation for the design, scale-up, and industrialization of the EALRs.

关键词： Slurry reactor Hydrodynamics Particle Mixing Solid physical property

基于CO_(2)活化的竹基多孔炭催化还原Cr(VI)的性能研究

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林产化学与工业 2024年第3期44卷 61-68页

作者：连媛王汉琛方兆丰何晨露黄彪林冠烽福建农林大学材料工程学院福建福州350002

以竹粉为原料、CO_(2)为活化剂制备竹基多孔炭(zh-100),并用于催化还原Cr(VI)。分析了反应温度、催化剂用量、还原剂甲酸用量、Cr(VI)初始质量浓度对竹基多孔炭催化活性的影响,采用XPS、XRD和交流阻抗测试技术对反应前后的多孔炭进行表... 详细信息

以竹粉为原料、CO_(2)为活化剂制备竹基多孔炭(zh-100),并用于催化还原Cr(VI)。分析了反应温度、催化剂用量、还原剂甲酸用量、Cr(VI)初始质量浓度对竹基多孔炭催化活性的影响,采用XPS、XRD和交流阻抗测试技术对反应前后的多孔炭进行表征,以揭示其催化还原Cr(VI)的作用机制。结果表明:竹基多孔炭催化还原Cr(VI)的最佳实验条件为Cr(VI)初始质量浓度120 mg/L、温度60℃、zh-100炭催化剂添加量0.1 g,还原剂甲酸添加量1.5 mL,在该条件下反应10 min,Cr(VI)还原率高达99.44%;重复使用3次后,zh-100的催化还原能力略有下降,但仍能在30 min内达到99.22%的Cr(VI)还原率。分析发现,Cr(VI)的去除过程包括物理吸附和化学还原,其中以化学还原占主导;催化剂重复使用性能下降原因包括表面官能团消耗、碳微晶排列无序化及阻抗增大,zh-100对Cr(VI)的催化还原机制为官能团介导和类石墨微晶介导。

关键词：竹粉竹基多孔炭铬催化

基于城市医联体、县域医共体背景下三级胸痛中心建设实践与体会

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中国医院 2024年第4期28卷 96-98页

作者：张沈英婕王刚黄文韬吕晓皑孙华琴浙江中医药大学附属第一医院(浙江省中医院) 浙江省杭州市310006 安吉县中医医院浙江省杭州市313399 杭州医学院存济口腔医学院浙江省杭州市311399

目的:探索基于城市医联体、县域医共体“双体贯通”模式下三级胸痛中心建设方法。方法:通过“资金-人才-技术”一体下沉,实现由浙江省中医院牵头,紧密型医联体单位安吉县中医医院连结,基层一级医疗机构医共体单位天荒坪镇卫生院布点,“... 详细信息

目的:探索基于城市医联体、县域医共体“双体贯通”模式下三级胸痛中心建设方法。方法:通过“资金-人才-技术”一体下沉,实现由浙江省中医院牵头,紧密型医联体单位安吉县中医医院连结,基层一级医疗机构医共体单位天荒坪镇卫生院布点,“双体贯通”模式下的三级胸痛中心。结果:浙江省中医院、安吉县中医医院、天荒坪镇卫生院陆续通过中国胸痛中心认证,后两者成为县域内首家基层版胸痛中心及胸痛救治单元,规范形成委员会、诊断鉴别制度、评估救治流程,大幅提升县域内急性心肌梗死救治能力、救治例数、救治效率。结论:“双体贯通”模式下三级胸痛中心建设成效显著且方法具有较强实操性和可复制性,在服务连续性方面可推广延伸,在医疗专业性方面需夯实持续,在信息支持性方面可复制深化。

关键词：医联体医共体双体贯通胸痛中心

Detection of Human Epididymis Protein 4(HE4) in Human Serum Samples Using a Specific Monoclonal Antibody-Based Sandwich Enzyme-Linked Immunosorbent Assay(ELISA)

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Detection of Human Epididymis Protein 4(HE4) in Human Serum ...

第九届全国免疫学学术大会

作者： zhi-qiang Lv zh Dun Wen-ji zhang Yu-ming zhang Shu-hong Luo Jian-ming Fang Ruo-Pan huang South China Biochip Research Center

The human epididymis protein 4(HE4may have a higher specificity in detection of non-malignant ***,it is essential to develop an immunoassay to detect ***:In our study,a fusion gene was constructed encoded with the HE4 ***,the protein produced in the bacterial cells(***)was used to immunize mice in order to generate hybridomas specific to *** supernatants were screened and four positive anti-HE4 cell lines which were *** cell lines produce monoclonal antibodies to HE4 epitopes,as demonstrated in the western blot for the recognition of a specific band by HE4 antibody and direct *** the antibodies cultivated,we successfully developed several good pair ***,we measured HE4 levels in 60 clinical human serum samples using a new method incorporating ***:Compared with the FDA-approved kit(Roche),our results showed a strong positive correlation to those two ***:In summary,the high-sensitivity antibodies were screened against HE4,and a sandwich ELISA was developed as an accurate and feasible analytical tool for rapid detection of HE4 in human serum samples,which is especially valuable for diagnosing ovarian carcinomas.

关键词： HE4 monoclonal antibody sandwich ELISA ovarian cancer immunoassay

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海军医学杂志 2024年第9期45卷 929-935页

作者：赵东波王亮黄樱巩萱珠海市人民医院(暨南大学附属珠海医院)内分泌科广东珠海519000 中南大学湘雅医院骨科

目的基于基因组芯片数据,研究自噬相关基因(ARG)在原发性老年性骨质疏松症(OP)骨髓间充质干细胞的表达水平,并探讨其在基因组的调控作用网络。方法从GSE35959中分析原发性老年性OP骨髓间充质干细胞的差异表达基因(DEG),结合人类自噬... 详细信息

目的基于基因组芯片数据,研究自噬相关基因(ARG)在原发性老年性骨质疏松症(OP)骨髓间充质干细胞的表达水平,并探讨其在基因组的调控作用网络。方法从GSE35959中分析原发性老年性OP骨髓间充质干细胞的差异表达基因(DEG),结合人类自噬数据库(HADb)筛选出原发性老年性OP骨髓间充质干细胞差异表达的自噬相关基因(AR-DEG),利用STRING 11.0数据库建立蛋白质-蛋白质相互作用网络(PPI),利用Network Analyst建立转录因子-基因-miRNA共表达网络和环境化学物-AR-DEGs调控网络。结果 2 866个原发性老年性OP的DEG参与了该疾病的发生发展,其中上调基因2 592个(90.44%),下调基因274个(9.56%)。获得31个原发性老年性OP的AR-DEG,均呈高表达状态。肿瘤蛋白53(TP53)、表皮生长因子受体(EGFR)、泛素C(UBC)、周期蛋白依赖激酶抑制因子1A(CDKN1A)对原发性老年性OP具有重要的生物学作用。自噬机制影响原发性老年性OP过程中,会受到转录因子、miRNA、环境因素的深度影响。结论自噬相关基因的过表达参与了原发性老年性OP发生进展的过程,该过程与免疫功能具有一定联系,且受到多种转录因子、miRNA、微量元素和环境化学物的影响,但上述调节机制仍需要深入研究探讨。

关键词：原发性老年性骨质疏松症自噬调控网络

学前留守儿童的心理资本和亲子关系的现状——基于家庭动力画测量

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湖南第一师范学院学报 2018年第3期18卷 55-60,75页

作者：黄任之湖南第一师范学院教育科学学院湖南长沙410205

目的:为了更好地考察家长的心理资本的水平及学前留守儿童的亲子关系,了解留守家庭和非留守家庭内部的人际关系差异,探索留守生活中心理资本水平对亲子关系发展的潜在影响。方法:采用主题为"我和爸爸妈妈"的家庭动力画任务,对3-7岁的40... 详细信息

目的:为了更好地考察家长的心理资本的水平及学前留守儿童的亲子关系,了解留守家庭和非留守家庭内部的人际关系差异,探索留守生活中心理资本水平对亲子关系发展的潜在影响。方法:采用主题为"我和爸爸妈妈"的家庭动力画任务,对3-7岁的400名留守儿童和非留守儿童(各占50%))进行测量。同时,请带班幼师填写每名儿童的家庭信息和心理资本问卷。结论:家长外出打工,留守家庭的第一抚养人的职业、学历和整个家庭的收入都显著地低于非留守家庭。留守儿童在自立顽强方面得分高于非留守儿童,而在其余四个维度和总分上显著地低于非留守儿童。在家庭动力画的头部、附件和其他指标上,非留守儿童的得分显著地高于留守儿童;而在不安全感指标上,非留守儿童的得分显著地低于留守儿童。结论:留守家庭的结构和功能都弱于非留守家庭,留守儿童在家庭动力画上绘图能力弱于非留守儿童,家庭动力画可以测量出留守儿童在亲子关系上缺乏安全感。

关键词：家庭动力画学前留守儿童亲子关系心理资本

Effects of epitopes combination and adjuvants on immune responses to anti-Alzheimer disease DNA vaccines in mice

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第二军医大学学报 2006年第5期27卷 589-589页

作者： He Y Sun SH Chen RW Guo YJ He XW huang L Chen zh Shi K zhu WJ Department of Medical Genetics College of Basic Medical Sciences Second Military Medical University Shanghai 200433 China

Alzheimer disease (AD) is a neurodegenerative disorder characterized by neuropathological hallmarks including deposits of the beta-amyloid peptide (AssP). Studies have shown that immunization with Abeta42 peptide reduces both the spatial memory impairments and Alzheimer disease-like neuropathologic changes in Alzheimer disease transgenic mice, but can cause side effect of a cell-mediated autoimmune meningoencephalitis. Recently, some studies showed that DNA vaccination could be used to generate an antibody response to Abeta without the adverse cell-mediated immune effect. In the current study, we generate four DNA vaccine plasmlds (pV-GE1, pV-GE2, pV-GE3, and pV-GE4) against Alzheimer disease by separately fusing Abeta epitope sequences (coding for EFGH, DAEFGH, EFGH + EFGH, and EFGH + DAEFGH) with IgG heavy chain coding region of mouse. Meanwhile, the full-length gene Abeta encoding plasmid (pV-Abeta), empty vector (pVAX) and synthetic AssP were also included as control. The sera of BALB/c mice immunized via intramuscular with plasmids and peptide were tested by indirect ELISA for auto-AssP immunoreactivity. The results showed that all the DNA vaccine plasmids induced AssP-specific antibodies; moreover pV-GE2 and pV-Abeta constructs elicited higher antibody titers than other constructs (P<0.05). To further enhance the immune response, GM-CSF encoding plasmid (pGM-CSF) and purified BCG-DNA were used as molecular adjuvants. BCG-DNA could enhance humoral and cellular immune responses simultaneously and did not alter the phenotype of the immune responses,

关键词：老年痴呆抗原免疫反应 DNA疫苗