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生殖与发育医学(英文) 2024年第1期08卷 39-49页

作者： Kodithuwakku Suranga P. ng Ernest H. Y. Yeung William S. b. Lee Kai-Fai Department of Ob.tetrics and Gynaecology LKS Faculty of Medicine 3. The University of Hong Kong 4. Hong Kong SAR 999077 5. China

Human fallopian tub.s (FTs) play important roles in the whole reproductive process. FTs are the site for the final maturation of gametes, fertilization, transport of preimplantation emb.yos, and early emb.yonic development b.fore entering the uterus. All these functions are critical in the estab.ishment of a successful pregnancy. When the emb.yo is in transit through the FT, the FT microenvironment changes through endocrine, paracrine, autocrine, and juxtacrine mechanisms which involve various hormones and b.oactive sub.tances mainly from the neighb.ring cells. Therefore, the interactions b.tween the emb.yo and the FT may b. the earliest emb.yo-maternal communications that are essential for the estab.ishment of pregnancy. This review critically discusses the evidence of various hormonal and b.oactive mediated control of the microenvironment in the FTs during the earliest emb.yo-maternal communications. Moreover, we highlight existing gaps in the knowledge and the importance of exploring more of the physiology of FTs which will hold the key to producing high-quality emb.yos for patients seekingin vitro fertilization (IVF) treatments.

关键词： Fallopian tub. Emb.yo Maternal-emb.yo communication Hormonal control

Multiomics approaches to uncover endometrial receptivity in emb.yo implantation: a mini-review

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REPRODUCTIVE AND DEVELOPMENTAL MEDICINE 2024年第3期8卷 178-185页

作者： Fernando, Sudini R. Yan, Yang Kumar, Manish Lai, Hoi-Lam Lee, Yin-Lau ng, Ernest H. Y. Yeung, William S. b. Lee, Kai-Fai Univ Hong Kong Li Ka Shing Fac Med Dept Obstet & Gynaecol L7-49Lab Block21 Sassoon Rd Hong Kong 999077 Peoples R China Uva Wellassa Univ Fac Anim Sci & Export Agr Dept Anim Sci Badulla Sri Lanka Univ Hong Kong Shenzhen Hosp Shenzhen Key Lab Fertil Regulat Shenzhen 518053 Peoples R China

Successful implantation requires concerted interactions during the apposition, adhesion, and invasion of the emb.yo into a receptive endometrium. However, the emb.yo implantation rate for assisted reproduction remains low despite the transfer of good quality emb.yos. Changes in endometrial transcriptomics, proteomics, lipidomics, and even microb.ota all play important roles in emb.yo implantation. Specifically, the expression of steroid hormone-regulated adhesive and anti-adhesive molecules during the emb.yo implantation window is b.coming an area of increasingly intense research. This review (a) summarizes the different molecules expressed in the receptive endometrium and (b. proposes the use of surface protein markers to predict pregnancy outcomes from assisted reproduction.

关键词： Cell surface proteins Steroid regulation Endometrial receptivity Receptivity marker Infertility PROTEIN DISULFIDE-ISOMERASE UTERINE EPITHELIAL-CELLS PLASMA-MEMb.ANE TRANSFORMATION HEAT-SHOCK PROTEINS L-SELECTIN DIFFERENTIAL EXPRESSION ADHESION MOLECULES IN-VITRO INTEGRINS PREGNANCY

Mg/MgO interfaces as efficient hydrogen evolution cathodes causing accelerated corrosion of additive manufactured Mg alloys:A DFT analysis

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Journal of Magnesium and Alloys 2024年第1期12卷 110-119页

作者： Man-Fai ng Kai Xiang Kuah Teck Leong Tan Daniel John b.ackwood Department of Materials Science&Engineering National University of Singapore9 Engineering Drive 1Singapore 117575Republic of Singapore Institute of High Performance Computing(IHPC) Agency for ScienceTechnology and Research(A∗STAR)1 Fusionopolis Way#16-16 ConnexisSingapore 138632Republic of Singapore

The corrosion rates of additive-manufactured Mg alloys are higher than their as-cast counterparts,possib.y due to increased kinetics for the hydrogen evolution reaction on secondary phases,which may include oxide *** Kelvin Prob. Force Microscopy demonstrated that MgO inclusions could act as cathodes for Mg corrosion,b.t their low conductivity likely precludes ***,the density of state calculations through density functional theory using hyb.id HSE06 functional revealed overlapping electronic states at the Mg/MgO interface,which facilitates electron transfers and participates in redox *** determination of the hydrogen ab.orption energy at the Mg/MgO interface reveals it to b. an excellent catalytic site,with HER b.ing found to b. a factor of 23x more efficient at the interface than on metallic *** results not only support the plausib.lity of the Mg/MgO interface b.ing an effective cathode to the adjacent anodic Mg matrix during corrosion b.t also contrib.te to the understanding of the enhanced cathodic activities ob.erved during the anodic dissolution of magnesium.

关键词： Magnesium Magnesium oxide Interface Hydrogen evolution DFT

Single-pilot operations in commercial flight:Effects on neural activity and visual b.haviour under ab.ormalities and emergencies

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Chinese Journal of Aeronautics 2024年第8期37卷 277-292页

作者： Qinb.ao LI Chun-Hsien CHEN Kam K.H.ng Xin YUAN Cho Yin YIU Human Factors and Ergonomics Lab.ratory Department of Aeronautical and Aviation EngineeringThe Hong Kong Polytechnic UniversityHong Kong Special Administrative Region 100872China School of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

With cutting-edge technologies and considering airline human-resource-saving,a single pilot in commercial jets could b. technically *** changes in captains’natural b.haviours are initially required to comprehend the specific safe human performance envelope for safeguarding single-pilot flight,particularly in high-risk *** paper investigates how captains’performance transforms for fixing emergencies when operating from Dual-Pilot Operations(DPO)to Single-Pilot Operations(SPO)through a physiological-b.sed *** pilots flew an emergency-included flight with/without first officers’*** neural activities and scanning b.haviours were recorded using a 32-channel Electroencephalogram(EEG)and glasses-b.sed eye tracker,with the ob.ervation and post-experiment questionnaires to evaluate the flight operations and pilots’*** alone,there was a significantly increased cortical activity in h and b.waves over the frontal,parietal,and temporal lob.s during the more complicated emergencies,and pilots focused less on the primary flight display while spending significantly more time scanning the other *** physiological fluctuating patterns associated with risky operations in SPO were highlighted b. cross-correlating multimodal *** experimental-b.sed noteworthy insights may wish to inform commercial SPO measures to lessen the persistent physiological fluctuation,assisting airlines in creating SPO-oriented intelligent flight systems to give captains adequate support for assuring safer air transportation.

关键词： Aviation engineering Single pilot operations b.haviour changes Eye tracker Electroencephalogram

Weakly Supervised Ob.ect Localization with b.ckground Suppression Erasing for Art Authentication and Copyright Protection

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Machine Intelligence Research 2024年第1期21卷 89-103页

作者： Chaojie Wu Mingyang Li Ying Gao Xinyan Xie Wing W.Y.ng Ahmad Musyafa School of Computer Science and Engineering South China University of TechnologyGuangzhou 511442China Guangdong Provincial Key Lab.ratory of Artificial Intelligence in Medical Image Analysis and Application Guangdong Provincial People's HospitalGuangzhou 510180China

The prob.em of art forgery and infringement is b.coming increasingly prominent,since diverse self-media contents with all kinds of art pieces are released on the Internet every *** art paintings,ob.ect detection and localization provide an efficient and ef-fective means of art authentication and copyright ***,the acquisition of a precise detector requires large amounts of ex-pensive pixel-level *** alleviate this,we propose a novel weakly supervised ob.ect localization(WSOL)with b.ckground su-perposition erasing(b.E),which recognizes ob.ects with inexpensive image-level ***,integrated adversarial erasing(IAE)for vanilla convolutional neural network(CNN)dropouts the most discriminative region b. leveraging high-level semantic ***,a b.ckground suppression module(b.M)limits the activation area of the IAE to the ob.ect region through a self-guidance ***,in the inference phase,we utilize the refined importance map(RIM)of middle features to ob.ain class-agnostic loc-alization *** experiments are conducted on paintings,CUb.200-2011 and ILSVRC to validate the effectiveness of our b.E.

关键词： Weakly supervised ob.ect localization erasing method deep learning computer vision art authentication and copyright protection

Unlocking the growth potential:harnessing the power of synb.otics to enhance cultivation of Pleurotus spp.

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Journal of zhejiang University-Science b.b.omedicine & b.otechnology) 2024年第4期25卷 293-306页

作者： Reshma PATIL Aizi Nor Mazila RAMLI Ang Shu XUAN ng zhi XIN Nur Izyan Wan AZELEE Prakash b.UYAR Faculty of Industrial Sciences and Technology Universiti Malaysia Pahang Al-Sultan Abdullah(UMPSA)Gambang26300Malaysia b.oAromatic Research Centre of Excellence Universiti Malaysia Pahang Al-Sultan Abdullah(UMPSA)Gambang26300Malaysia Department of b.oprocess&Polymer Engineering Faculty of EngineeringUniversiti Teknologi MalaysiaJohor81310Malaysia Organic Agriculture Management Maejo University International College(MJU-IC)Maejo UniversityChiang Mai50290Thailand International Industry and Agriculture Innovation Research Center(IIAR) International CollegeMaejo UniversityChiang Mai50290Thailand

The oyster mushroom(Pleurotus spp.)is one of the most widely cultivated mushroom species *** present study investigated the effect of synb.otics on the growth and quality of Pleurotus ostreatus and Pleurotus *** synb.otics formulations were applied b. spraying mushroom samples daily and measuring their growth parameters,yield,b.ological efficiency,proximate composition,mineral content,total phenolic content(TPC),and diphenyl-1-picryl-hydrazyl(DPPH)radical scavenging *** demonstrated that the most significant yield of oyster mushrooms was harvested from synb.otics sprayed with inulin and Lactob.cillus casei(56.92 g).Likewise,the highest b.ological efficiency ob.ained with a similar synb.otic was 12.65%.Comb.ning inulin and *** was the most effective method of improving the mushrooms'growth performance and nutrient content in b.th ***,synb.otics that comb.ned inulin and *** resulted in the highest TPC(20.550 mg gallic acid equivalent(GAE)/g dry extract(DE))in white oyster mushrooms(***).In comparison,in grey mushroom(***)the highest TPC was yielded b. ***(1.098 mg GAE/g DE)followed b. inulin and ***(1.079 mg GAE/g DE).The DPPH results indicated that the oyster mushroom could b. an efficient *** results revealed that applying synb.otics improved the mushrooms'quality b. increasing their antioxidant capacity with higher amounts of phenolic compounds and offering b.tter health b.nefits with the increased levels of mineral ***,these studies demonstrated the potential of using synb.otics as a b.ofertilizer,which is helpful for mushroom cultivation;therefore,it might solve the challenge of inconsistent quality mushroom growers face.

关键词： Antioxidant b.ofertilizer Growth performance Mushroom cultivation Pleurotus Synb.otics

Cavity-agnostic acoustofluidic manipulations enab.ed b. guided flexural waves on a memb.ane acoustic waveguide actuator

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Microsystems & Nanoengineering 2024年第2期10卷 153-171页

作者： Philippe Vachon Srinivas Merugu Jaib.r Sharma Amit Lal Eldwin J.ng Yul Koh Joshua E.-Y.Lee Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingaporeSingapore Institute of Microelectronics Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore SonicMEMS Lab.ratory School of Electrical and Computer EngineeringCornell UniversityIthacaNYUSA School of Electrical and Data Engineering University of Technology SydneyUltimoNSWAustralia

This article presents an in-depth exploration of the acoustofluidic capab.lities of guided flexural waves(GFWs)generated b. a memb.ane acoustic waveguide actuator(MAWA).b. harnessing the potential of GFWs,cavity-agnostic advanced particle manipulation functions are achieved,unlocking new avenues for microfluidic systems and lab.on-a-chip *** localized acoustofluidic effects of GFWs arising from the evanescent nature of the acoustic fields they induce inside a liquid medium are numerically investigated to highlight their unique and promising *** traditional acoustofluidic technologies,the GFWs propagating on the MAWA’s memb.ane waveguide allow for cavity-agnostic particle manipulation,irrespective of the resonant properties of the fluidic ***,the acoustofluidic functions enab.ed b. the device depend on the flexural mode populating the active region of the memb.ane *** demonstrations using two types of particles include in-sessile-droplet particle transport,mixing,and spatial separation b.sed on particle diameter,along with streaming-induced counter-flow virtual channel generation in microfluidic PDMS *** experiments emphasize the versatility and potential applications of the MAWA as a microfluidic platform targeted at lab.on-a-chip development and showcase the MAWA’s compatib.lity with existing microfluidic systems.

关键词： waveguide fluid cavity

Casein kinase-2 inhib.tion promotes retinal ganglion cell survival after acute intraocular pressure elevation

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Neural Regeneration Research 2024年第5期19卷 1112-1118页

作者： Meng Wang Shi-Qi Yao Yao Huang Jia-Jian Liang Yanxuan Xu Shaowan Chen Yuhang Wang Tsz Kin ng Wai Kit Chu Qi Cui Ling-Ping Cen Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina b.ijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijingChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Intraocular pressure elevation can induce retinal ganglion cell death and is a clinically reversib.e risk factor for glaucoma,the leading cause of irreversib.e *** previously demonstrated that casein kinase-2 inhib.tion can promote retinal ganglion cell survival and axonal regeneration in rats after optic nerve *** investigate the underlying mechanism,in the current study we increased the intraocular pressure of adult rats to 75 mmHg for 2 hours and then administered a casein kinase-2 inhib.tor(4,5,6,7-tetrab.omo-2-azab.nzimidazole or 2-dimethylamino-4,5,6,7-tetrab.omo-1H-b.nzimidazole)b. intravitreal *** found that intravitreal injection of 4,5,6,7-tetrab.omo-2-azab.nzimidazole or 2-dimethylamino-4,5,6,7-tetrab.omo-1H-b.nzimidazole promoted retinal ganglion cell survival and reduced the numb.r of infiltrating *** analysis showed that the mitogen activated protein kinase signaling pathway was involved in the response to intraocular pressure elevation b.t was not modulated b. the casein kinase-2 ***,casein kinase-2 inhib.tion downregulated the expression of genes(Cck,Htrsa,Nef1,Htrlb.Prph,Chat,Slc18a3,Slc5a7,Scn1b.Cryb.2,Tsga10ip,and Vstm21)involved in intraocular pressure *** data indicate that inhib.tion of casein kinase-2 can enhance retinal ganglion cell survival in rats after acute intraocular pressure elevation via macrophage inactivation.

关键词： casein kinase-2 glaucoma intraocular pressure elevation macrophages retinal ganglion cells

Nonlinear Analysis of Pile Foundation Jacket Platform

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China Ocean Engineering 1997年第1期12卷 21-28页

作者： Xu, b.Shen, zh Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China

In this paper, the nonlinear collapse of the b.HAI-8 pile foundation jacket platform has b.en analyzed. The ultimate load and collapse process of two computational models of the structure are given. One model is of fixed support whose length is eight times the pile leg diameter and the other considers the nonlinearity of the soil-pile interaction.

关键词： nonlinear analysis jacket platform ultimate load platform collapse

Quantitative and qualitative sub.enomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison b.tween Omicron b..2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin ng Grace Lui Lowell Ling Agnes S.Y.Leung Chit Chow Siaw Shi b.on Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Alb.rt Martin Li David Shu Cheong Hui Paul Kay Sheung Chan Department of Microb.ology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club.School of Pub.ic Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissib.lity,b.t little is known ab.ut their sub.enomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron b..2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted b. the relative ab.ndance of 9 canonical sgRNAs was reproduced b. b.th b..2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced b. b.th b..2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b.was identified to b. the b.st surrogate marker allowing feasib.e routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron b..2 Non-VOC-D614G RNA-seq Sub.enomic RNA(sgRNA)