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Study on deformation mechanism of Ti-2Al-2.5Zr alloy tube in the flattening test

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Journal of Materials Science & Technology 2021年第31期90卷 108-120页

作者： Shengkun wang gang Jin Yuntao Wu Xiao Liu gang Chen School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China Nuclear and Radiation Safety Center MEE54#Beijing 100082China School of Chemical Engineering Sichuan UniversitySichuan 610065China Nuclear Power Institute of China ChengduSichuan 610015China

The flattening test,using one pair paralleled plates to flatten tube structure radially,is generally employed to examine the ductility of tube used in once through steam generator(OTSG).This study focuses on the stress condition and deformation mechanism analysis on the concentrated stress regions of Ti-2 Al-2.5 Zr alloy tube during the flattening ***,the finite element analysis was performed using the commercial software ABAQUS to determine the stress ***,the Electron BackScattered Diffraction(EBSD)was implemented to observe the microstructure evolution of Ti-2 Al-2.5 Zr ***,Schmid law was employed to analyze the activated deformation mechanism under condition of the complex *** was found that the condition of the complex stress in stress concentration regions,including tension and compression regions,can be simplified into two directional stresses *** grains whose c-axis is nearly towards TD and ND,the strain is mainly accommodated by prismatic slip,whereas in grains whose c-axis deviates about 45°from ND to TD mainly by basal ***{10-12}extensive twin and corresponding parent grain orientation mainly relied on the stress ***,the intergranular twin pairs connected at common grain boundaries(GBs)with high strain compatibility were found at low angle GBs,which were activated under a combination of macro stress and strain compatibility effect.

关键词： Ti-2Al-2.5Zr alloy tube Flattening test EBSD Stress condition Deformation mechanism Schmid factor Twin pairs Strain compatibility effect

基于城市医联体、县域医共体背景下三级胸痛中心建设实践与体会

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中国医院 2024年第4期28卷 96-98页

作者：张沈英婕王刚黄文韬吕晓皑孙华琴浙江中医药大学附属第一医院(浙江省中医院) 浙江省杭州市310006 安吉县中医医院浙江省杭州市313399 杭州医学院存济口腔医学院浙江省杭州市311399

目的:探索基于城市医联体、县域医共体“双体贯通”模式下三级胸痛中心建设方法。方法:通过“资金-人才-技术”一体下沉,实现由浙江省中医院牵头,紧密型医联体单位安吉县中医医院连结,基层一级医疗机构医共体单位天荒坪镇卫生院布点,“... 详细信息

目的:探索基于城市医联体、县域医共体“双体贯通”模式下三级胸痛中心建设方法。方法:通过“资金-人才-技术”一体下沉,实现由浙江省中医院牵头,紧密型医联体单位安吉县中医医院连结,基层一级医疗机构医共体单位天荒坪镇卫生院布点,“双体贯通”模式下的三级胸痛中心。结果:浙江省中医院、安吉县中医医院、天荒坪镇卫生院陆续通过中国胸痛中心认证,后两者成为县域内首家基层版胸痛中心及胸痛救治单元,规范形成委员会、诊断鉴别制度、评估救治流程,大幅提升县域内急性心肌梗死救治能力、救治例数、救治效率。结论:“双体贯通”模式下三级胸痛中心建设成效显著且方法具有较强实操性和可复制性,在服务连续性方面可推广延伸,在医疗专业性方面需夯实持续,在信息支持性方面可复制深化。

关键词：医联体医共体双体贯通胸痛中心

山东传统武术海外传播历程、困境及发展对策研究

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武术研究 2024年第5期9卷 22-26页

作者：孔祥贺孙刚山东师范大学体育学院山东济南250358

山东作为中华文化的主要发祥地之一,孕育了多姿多彩的齐鲁传统武术。新时代,随着文化全球化的不断发展,山东传统武术海外传播将会成为中国文化“走出去”的重要载体。文章运用文献资料法和逻辑分析法等研究方法,运用历史学和传播学等理... 详细信息

山东作为中华文化的主要发祥地之一,孕育了多姿多彩的齐鲁传统武术。新时代,随着文化全球化的不断发展,山东传统武术海外传播将会成为中国文化“走出去”的重要载体。文章运用文献资料法和逻辑分析法等研究方法,运用历史学和传播学等理论知识,对山东传统武术在海外的传播历程进行归纳总结,发现当下山东传统武术海外传播存在显著的中西文化差异,价值思维存在异同;传播人才相对短缺,传承意识有待提升足;管理体系有待完善,反馈机制缺乏等多种困境。基于此,文章提出尊重文化差异,加强武术文化传播;培养武术传播的复合型人才;加强武术海外传播组织管理;打造山东拳种国际化品牌形象等发展对策。

关键词：山东传统武术海外传播传播历程

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Capturing dynamic biological signals via bio-mimicking hydrogel for precise remodeling of soft tissue

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Bioactive Materials 2021年第12期6卷 4506-4516页

作者： zhengwei Cai Qimanguli Saiding Liang Cheng Liucheng zhang zhen wang Fei wang Xinliang Chen gang Chen Lianfu Deng Wenguo Cui Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025PR China Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials Department of OrthopaedicsThe Second Affiliated Hospital of Jiaxing University1518 North Huancheng RoadJiaxing314000China Shanghai Key Laboratory of Embryo Original Diseases The International Peace Maternal and Child Health HospitalSchool of MedicineShanghai Jiao Tong University910 Hengshan RoadShanghai200030PR China

Soft tissue remodeling is a sophisticated process that sequentially provides dynamic biological signals to guide cell ***,capturing these signals within hydrogel and directing over time has still been unrealized owing to the poor comprehension of physiological ***,a bio-mimicking hydrogel is designed via thiol-ene click reaction to capture the early physical signal triggered by inflammation,and the chemical signals provided with chemokine and natural adhesion sites,which guaranteed the precise soft tissue *** bio-mimicking hydrogel efficiently facilitated cell anchoring,migration,and invasion in the 3D matrix due to the permissive space and the interaction with integrin ***,the covalently grafted chemokine-like peptide is optimal for colonization and functional differentiation of endothelial cells through a HIF-1αdependent signal ***,the early polarization of macrophages,collagen deposition and angiogenesis in rat acute wound model,and the increased blood perfusion in mouse skin flap model have confirmed that the bio-mimicking hydrogel realized precise soft tissue remodeling and opens new avenues for the phased repair of different tissues such as nerve,myocardium,and even bone.

关键词： Biological signals Physiological phase Hydrogel Chemotactic Soft tissue remodeling

New types of topological superconductors under local magnetic symmetries

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National Science Review 2021年第5期8卷 85-90页

作者： Jinyu Zou Qing Xie zhida Song gang Xu Wuhan National High Magnetic Field Center & School of Physics Huazhong University of Science and Technology Department of Physics Princeton University

We classify gapped topological superconducting(TSC) phases of one-dimensional quantum wires with local magnetic symmetries, in which the time-reversal symmetry T is broken, but its combinations with certain crystalline symmetries, such as MxT, C2zT, C4zT and C6zT, are preserved. Our results demonstrate that an equivalent BDI class TSC can be realized in the MxT or C2zT superconducting wire,which is characterized by a chiral Zcinvariant. More interestingly, we also find two types of totally new TSC phases in the C4zT and C6zT superinducting wires, which are beyond the known AZ class, and are characterized by a helical Z~h invariant and Z~h ⊕Zcinvariants, respectively. In the Z~h TSC phase, Z pairs of Majorana zero modes(MZMs) are protected at each end. In the C6zT case, the MZMs can be either chiral or helical, and even helical-chiral coexisting. The minimal models preserving C4zT or C6zT symmetry are presented to illustrate their novel TSC properties and MZMs.

关键词： topological superconductor magnetic symmetry Majorana zero mode superconducting wire

RAD51AP1基因表达在三阴性乳腺癌脑转移中的生物信息分析

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诊断学理论与实践 2024年第2期23卷 146-154页

作者：欧丹蔡钢陈佳艺上海交通大学医学院附属瑞金医院放射治疗科上海200025

目的:采用生物信息分析筛选三阴性乳腺癌脑转移相关差异性表达基因(differentially expressed genes,DEG),并探索影响预后的潜在作用机制。方法:在基因表达数据库(Gene Expression Omnibus, GEO)检索获得GSE76250(三阴性乳腺癌组织与正... 详细信息

目的:采用生物信息分析筛选三阴性乳腺癌脑转移相关差异性表达基因(differentially expressed genes,DEG),并探索影响预后的潜在作用机制。方法:在基因表达数据库(Gene Expression Omnibus, GEO)检索获得GSE76250(三阴性乳腺癌组织与正常乳腺组织)和GSE125989(三阴性乳腺癌脑转移病灶组织与三阴性乳腺癌原发灶组织) 2个数据集,筛选DEG。采用GO(Gene Ontology)分析和KEGG(Kyoto Encyclopedia of Genes and Genomes)分析寻找潜在的三阴性乳腺癌脑转移相关基因。通过癌症基因组图谱(The Cancer Genome Atlas, TCGA)数据库中的临床组织样本,验证相关基因表达水平与乳腺癌预后间的关系,并使用KEGG的基因集进行基因富集分析,评估DEG可能参与的信号通路。结果:在GSE125989和GSE76250数据集中共筛选出52个DEG,蛋白质相互作用网络(protein-protein interaction, PPI)分析提示RAD51AP1为三阴性乳腺癌脑转移的重要相关基因。TCGA数据分析显示,相较于癌旁组织RAD51AP1在乳腺癌组织中高表达;不同分子分型中,基底样型中乳腺癌PAD51AP1高表达。以RAD51AP1在癌组织表达中位数[log2(TPM+1)=3.85],将乳腺癌患者分为高表达和低表达组,生存分析显示,高表达患者的中位生存期差于低表达者[3 873 d比3 945 d,P<0.05,HR=1.40(1.01~1.94)]。通过GO、KEGG、基因富集分析(gene set enrichment analysis, GSEA)发现,RAD51AP1在细胞周期、DNA复制、错配修复等信号通路中有富集明显。基于细胞周期和DNA损伤修复信号通路相关蛋白信息构建PPI,筛选与RAD51AP1直接相互作用的蛋白质,其中增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)与RAD51AP1的相关性较强(R=0.715,P<0.001)。结论:RAD51AP1在三阴性乳腺癌及其脑转移组织中高表达,可能作为潜在的诊断三阴性乳腺癌及预后不良的生物标志物,且其异常表达介导乳腺癌脑转移进程可能与PCNA相关。

关键词：三阴性乳腺癌脑转移生物信息学分析 RAD51AP1

高光效小麦群体提高氮素吸收利用和产量的机理

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植物营养与肥料学报 2024年第1期30卷 27-35页

作者：丁永刚陈欢曹承富乔玉强赵竹李玮张向前杜世州安徽省农业科学院作物研究所安徽合肥230031

[目的]研究通过调整小麦种植密度构建高光能利用效率群体,促进群体氮素积累、分配和转运的效果和机理,为充分利用光能提高小麦产量提供理论依据。[方法]试验于2018—2019年在安徽省濉溪县和蒙城县进行,以分蘖能力强(安1302)和弱(皖垦麦0... 详细信息

[目的]研究通过调整小麦种植密度构建高光能利用效率群体,促进群体氮素积累、分配和转运的效果和机理,为充分利用光能提高小麦产量提供理论依据。[方法]试验于2018—2019年在安徽省濉溪县和蒙城县进行,以分蘖能力强(安1302)和弱(皖垦麦0622)的品种为材料,设置180×10^(4)株/hm^(2) (D1)、240×10^(4)株/hm^(2)(D2)、300×10^(4)株/hm^(2)(D3)、360×10^(4)株/hm^(2) (D4)4个种植密度,调查了群体籽粒产量、光合有效辐射截获率和截获量、光合有效辐射转化率,以此为基础,将小麦群体分为光效率高、中、低3个类型,比较了不同光效率类型群体的叶面积指数、花前氮素积累和转运量、花后(乳熟期)氮素积累量。[结果]品种、密度及其互作效应显著影响小麦群体的光能利用率和籽粒产量。高光效型群体的光能利用率和籽粒产量分别达1.4%和9.7 t/hm^(2),分别比中、低效型群体提高5%、14%和1%、5%。不同群体间开花期、乳熟期光合有效辐射截获率、开花期至乳熟期光合有效辐射截获量差异不显著,高光效型群体开花期至乳熟期光合有效辐射转化率高于中、低效型群体,达2.34 g/MJ。高光效型群体开花期、乳熟期叶面积指数及开花期茎秆叶鞘、叶片、单位叶面积氮素积累量均不同程度高于其他类型群体,分别达7.24、4.53及63.9 kg/hm^(2)、79.5 kg/hm^(2)和143.78μg/cm^(2)。此外,高光效型群体中群体和单茎花前氮素转运量分别为129 kg/hm^(2)和15 mg,均显著高于中、低效型群体,主要为茎秆+叶鞘和叶片氮素转运量较高,各营养器官间氮素转运率差异不显著,且高光效型群体成熟期个体营养器官仍保持较高的氮素积累量。[结论]高光效型群体开花期茎秆+叶鞘、叶片以及单位叶面积氮素积累量高,提高了开花期的叶面积指数,有利于光能的吸收和利用。虽然高光效型群体茎秆+叶鞘和叶片中的氮素转运量较高,其花后营养器官的氮素积累量依然较高,有助于维持花后较大叶面积指数,有效提升花后光合有效辐射转化率,获得更高的小麦籽粒产量。

关键词：小麦光能利用率光能资源利用氮素吸收叶面积指数产量

Interobserver agreement for contrast-enhanced ultrasound of liver imaging reporting and data system:A systematic review and metaanalysis

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World Journal of Clinical Cases 2020年第22期8卷 5589-5602页

作者： Jun Li Ming Chen Zi-Jing wang Shu-gang Li Meng Jiang Long Shi Chun-Li Cao Tian Sang Xin-Wu Cui Christoph F Dietrich Department of Medical Ultrasound The First Affiliated Hospital of Medical CollegeShihezi UniversityShihezi 832008Xinjiang Uygur Autonomous RegionChina Department of Child Adolescent Health and Maternal HealthSchool of Public HealthCapital Medical UniversityBeijing 100069BeijingChina Department of Medical Ultrasound Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Medical Ultrasound The Second People's Hospital of JiangmenJingmen 448000Hubei ProvinceChina Department of Medical Ultrasound Sino-German Tongji-Caritas Research Center of Ultrasound in MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Internal Medicine Hirslanden ClinicBerne 27804Switzerland

BACKGROUND Hepatocellular carcinoma is the most common primary liver *** the results of previous studies,Liver Imaging Reporting and Data System(LIRADS)on contrast-enhanced ultrasound(CEUS)has shown satisfactory diagnostic ***,a unified conclusion on the interobserver stability of this innovative ultrasound imaging has not been *** present metaanalysis examined the interobserver agreement of CEUS LI-RADS to provide some reference for subsequent related *** To evaluate the interobserver agreement of LI-RADS on CEUS and analyze the sources of heterogeneity between *** Relevant papers on the subject of interobserver agreement on CEUS LI-RADS published before March 1,2020 in China and other countries were *** studies were filtered,and the diagnostic criteria were *** selected references were analyzed using the“meta”and“metafor”packages of R software version *** Eight studies were ultimately included in the present ***-analysis results revealed that the summary Kappa value of included studies was 0.76[95%confidence interval,0.67-0.83],which shows substantial *** I2 statistics also confirmed the substantial heterogeneity(I2=91.30%,95%confidence interval,85.3%-94.9%,P<0.01).Meta-regression identified the variables,including the method of patient enrollment,method of consistency testing,and patient race,which explained the substantial study *** CEUS LI-RADS demonstrated overall substantial interobserver agreement,but heterogeneous results between studies were also *** clinical investigations should consider a modified recommendation about the experimental design.

关键词： Contrast-enhanced ultrasound Liver imaging reporting and data system Interobserver agreement Systematic review Diagnosis Meta-analysis

Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2202-2218页

作者： Huitong Ruan Yongfang Li Cheng wang Yixu Jiang Yulong Han Yiwei Li Dandan zheng Jing Ye gang Chen Guo-yuan Yang Lianfu Deng Ming Guo Xingcai zhang Yaohui Tang Wenguo Cui Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials Department of Orthopaedicsthe Second Affiliated Hospital of Jiaxing UniversityJiaxing 314000China Department of Rehabilitation Medicine Ruijin HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Med-X Research Institute and School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA

Central nervous system(CNS)injuries,including stroke,traumatic brain injury,and spinal cord injury,are essential causes of death and long-term disability and are difficult to cure,mainly due to the limited neuron regeneration and the glial scar ***,we apply extracellular vesicles(EVs)secreted by M2 microglia to improve the differentiation of neural stem cells(NSCs)at the injured site,and simultaneously modify them with the injured vascular targeting peptide(DA7R)and the stem cell recruiting factor(SDF-1)on their surface via copper-free click chemistry to recruit NSCs,inducing their neuronal differentiation,and serving as the nanocarriers at the injured site(Dual-EV).Results prove that the Dual-EV could target human umbilical vascular endothelial cells(HUVECs),recruit NSCs,and promote the neuronal differentiation of NSCs in ***,10 miRNAs are found to be upregulated in Dual-M2-EVs compared to Dual-M0-EVs via bioinformatic analysis,and further NSC differentiation experiment by flow cytometry reveals that among these miRNAs,miR30b-3p,miR-222-3p,miR-129-5p,and miR-155-5p may exert effect of inducing NSC to differentiate into *** vivo experiments show that Dual-EV nanocarriers achieve improved accumulation in the ischemic area of stroke model mice,potentiate NSCs recruitment,and increase *** work provides new insights for the treatment of neuronal regeneration after CNS injuries as well as endogenous stem cells,and the click chemistry EV/peptide/chemokine and related nanocarriers for improving human health.

关键词： Central nervous system injuries Stroke Neural stem cell Neurogenesis Click chemistry Extracellular vesicles Microglia Targeted delivery